• Korean Journal of Applied Biomechanics
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• v.34 no.2
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• pp.81-92
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• 2024

Objective: The purpose of this study was to analyze the impact acceleration, shock attenuation and biomechanical variables at various running speed. Method: 20 subjects (height: 176.15 ± 0.63 cm, weight: 70.95 ± 9.77 kg, age: 27.00 ± 4.65 yrs.) participated in this study. The subjects ran at four different speeds (2.5 m/s, 3.0 m/s, 3.5 m/s, 4.0 m/s). Three-dimensional accelerometers were attached to the distal tibia, sternum and head. Gait parameters, biomechanical variables (lower extremity joint angle, moment, power and ground reaction force) and acceleration variables (impact acceleration, shock attenuation) were calculated during the stance phase of the running. Repeated measures ANOVA was used with an alpha level of .05. Results: In gait parameters, decreased stance time, increasing stride length and stride frequency with increasing running speed. And at swing time 2.5 m/s and 4.0 m/s was decreased compared to 3.0 m/s and 3.5 m/s. Biomechanical variables statistically increased with increasing running speed except knee joint ROM, maximum ankle dorsiflexion moment, and maximum hip flexion moment. In acceleration variables as the running speed increased (2.5 m/s to 4.0 m/s), the impact acceleration on the distal tibia increased by more than twice, while the sternum and head increased by approximately 1.1 and 1.2 times, respectively. And shock attenuation (tibia to head) increased as the running speed increased. Conclusion: When running speed increases, the magnitude and increasing rate of sternum and head acceleration are lower compared to the proximal tibia, while shock attenuation increases. This suggests that limiting trunk movement and increasing lower limb movement effectively reduce impact from increased shock. However, to fully understand the body's mechanism for reducing shock, further studies are needed with accelerometers attached to more segments to examine their relationship with kinematic variables.

• Geomechanics and Engineering
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• v.37 no.4
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• pp.341-358
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• 2024

This paper reports several plane-strain trapdoor tests conducted to investigate the effects of reinforcement on soil arching development under localized surface loading with a loading plate width three times the trapdoor width. An analogical soil composed of aluminum rods with three different diameters was used as the backfill and Kraft paper with two different stiffness values was used as the reinforcement material. Four reinforcement arrangements were investigated: (1) no reinforcement, (2) one low stiffness reinforcement R1, (3) one high stiffness reinforcement R2, and (4) two low stiffness reinforcements R1 with a backfill layer in between. The stiffness of R2 was approximately twice that of R1; therefore, two R1 had approximately the same total stiffness as one R2. Test results indicate that the use of reinforcement minimized soil arching degradation under localized surface loading. Soil arching with reinforcement degraded more at unloading stages as compared to that at loading stages. The use of stiffer reinforcement had the advantages of more effectively minimizing soil arching degradation. As compared to one high stiffness reinforcement layer, two low stiffness reinforcement layers with a backfill layer of certain thickness in between promoted soil arching under localized surface loading. Due to different states of soil arching development with and without reinforcement, an analytical multi-stage soil arching model available in the literature was selected in this study to calculate the average vertical pressures acting on the trapdoor or on the deflected reinforcement section under both the backfill self-weight and localized surface loading.

• Korean Journal of Radiology
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• v.20 no.4
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• pp.599-608
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• 2019

Objective: To evaluate the effectiveness of computed tomography (CT) Hounsfield unit histogram analysis (HUHA) in postoperative pancreatic fistula (PF) prediction. Materials and Methods: Fifty-four patients (33 males and 21 females; mean age, 65.6 years; age range, 37-89 years) who had undergone preoperative CT and pancreaticoduodenectomy were included in this retrospective study. Two radiologists measured mean CT Hounsfield unit (CTHU) values by drawing regions of interest (ROIs) at the level of the pancreaticojejunostomy site on preoperative pre-contrast images. The HUHA values were arbitrarily divided into three categories, comprising HUHA-A ≤ 0 HU, 0 HU < HUHA-B < 30 HU, and HUHA-C ≥ 30 HU. Each HUHA value within the ROI was calculated as a percentage of the entire area using commercial 3-dimensional analysis software. Pancreas texture was evaluated as soft or hard by manual palpation. Results: Fifteen patients (27.8%) had clinically relevant PFs. The PF group had significantly higher HUHA-A (p < 0.01) and significantly lower mean CTHU (p < 0.01) values than those of the non-PF group. The HUHA-A value had a moderately strong correlation with PF occurrence (r = 0.60, p < 0.01), whereas the mean CTHU had a weak negative correlation with PF occurrence (r = -0.27, p < 0.01). The HUHA-A and mean CTHU areas under the curve (AUCs) for predicting PF occurrence were 0.86 and 0.65, respectively, with significant difference (p < 0.01). The HUHA-A and mean CTHU AUCs for predicting pancreatic softness were 0.86 and 0.64, respectively, with significant difference (p < 0.01). Conclusion: The HUHA-A values on preoperative pre-contrast CT images demonstrate a strong correlation with PF occurrence.

• Food Science of Animal Resources
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• v.44 no.3
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• pp.533-550
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• 2024

Peptides with bioactive effects are being researched for various purposes. However, there is a lack of overall research on pork-derived peptides. In this study, we reviewed the process of obtaining bioactive peptides, available analytical methods, and the study of bioactive peptides derived from pork. Pepsin and trypsin, two representative protein digestive enzymes in the body, are hydrolyzed by other cofactors to produce peptides. Bicinchoninic acid assay, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, chromatography, and in vitro digestion simulation systems are utilized to analyze bioactive peptides for protein digestibility and molecular weight distribution. Pork-derived peptides mainly exhibit antioxidant and antihypertensive activities. The antioxidant activity of bioactive peptides increases the accessibility of amino acid residues by disrupting the three-dimensional structure of proteins, affecting free radical scavenging, reactive oxygen species inactivation, and metal ion chelating. In addition, the antihypertensive activity decreases angiotensin II production by inhibiting angiotensin converting enzyme and suppresses blood pressure by blocking the AT1 receptor. Pork-derived bioactive peptides, primarily obtained using papain and pepsin, exhibit significant antioxidant and antihypertensive activities, with most having low molecular weights below 1 kDa. This study may aid in the future development of bioactive peptides and serve as a valuable reference for pork-derived peptides.

• Journal of Animal Science and Technology
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• v.66 no.1
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• pp.1-30
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• 2024

Interest and investment in cultivated meat are increasing because of the realization that it can effectively supply sufficient food resources and reduce the use of livestock. Nevertheless, accurate information on the specific technologies used for cultivated meat production and the characteristics of cultivated meat is lacking. Authorization for the use of cultivated meat is already underway in the United States, Singapore, and Israel, and other major countries are also expected to approve cultivated meat as food once the details of the intricate process of producing cultivated meat, which encompasses stages such as cell proliferation, differentiation, maturation, and assembly, is thoroughly established. The development and standardization of mass production processes and safety evaluations must precede the industrialization and use of cultivated meat as food. However, the technology for the industrialization of cultivated meat is still in its nascent stage, and the mass production process has not yet been established. The mass production process of cultivated meat may not be easy to disclose because it is related to the interests of several companies or research teams. However, the overall research flow shows that equipment development for mass production and cell acquisition, proliferation, and differentiation, as well as for three-dimensional production supports and bioreactors have not yet been completed. Therefore, additional research on the mass production process and safety of cultivated meat is essential. The consumer's trust in the cultivated meat products and production technologies recently disclosed by some companies should also be analyzed and considered for guiding future developments in this industry. Furthermore, close monitoring by academia and the government will be necessary to identify fraud in the cultivated meat industry.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.1 s.53
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• pp.125-134
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• 2009

This paper deals with the free vibrations of circular strip foundations which have uniform solid rectangular cross-section. The ground which supports circular strips was modeled as the two parameter elastic foundation. Differential equations governing the flexural-torsional free vibrations of circular strips supported by such foundation were derived, and solved numerically for obtaining the natural frequencies and mode shapes. Boundary condition of free-free ends was considered for numerical examples. Four lowest natural frequencies according to the variations of five system parameters i.e. subtended angle, depth ratio, contact ratio, elasticity ratio and soil parameter are reported in the non-dimensional forms. Also, typical mode shapes of both deformations and stress resultants are presented in the figures. Experiment was conducted for validating the theory developed in this study.

• Structural Engineering and Mechanics
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• v.91 no.6
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• pp.551-565
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• 2024

This study presents a methodical investigation into improving structural designs through the analytical examination of the dynamic behavior of functionally graded plates (FGPs) resting on viscoelastic foundations. By employing a four variable first-order shear deformation theory, the study computes non-dimensional frequencies for a variety of porous FGPs with diverse graded patterns and porosity distributions. Different gradient patterns of the plates are considered, and three distinct functions-sigmoid (S-FGM), exponential (E-FGM), and power-law (P-FGM)-are utilized to assess material performance in specific directions. The equations of motion are derived and solved using both Navier's method and Hamilton's principle. Analytical solutions for vibration frequency are provided to validate the proposed methodology against existing literature. Furthermore, a comprehensive parametric analysis is conducted, taking into account various factors such as ceramic material, porosity distribution, gradient index, length-to-thickness ratio, gradient pattern, and damping coefficient. The findings suggest that enhancing the damping coefficient of the viscoelastic foundation can significantly improve the free-vibrational response of functionally graded material plates.

• Investigative Magnetic Resonance Imaging
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• v.22 no.1
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• pp.1-9
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• 2018

Purpose: This study was designed to optimize the flip angle (FA) and scan timing of the hepatobiliary phase (HBP) using the 3D T1-weighted, gradient-echo (GRE) imaging with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) technique on gadoxetic acid-enhanced 3T liver MR imaging. Materials and Methods: Sixty-two patients who underwent gadoxetic acid-enhanced 3T liver MR imaging were included in this study. Four 3D T1-weighted GRE imaging studies using the CAIPIRINHA technique and FAs of $9^{\circ}$ and $13^{\circ}$ were acquired during HBP at 15 and 20 min after intravenous injection of gadoxetic acid. Two abdominal radiologists, who were blinded to the FA and the timing of image acquisition, assessed the sharpness of liver edge, hepatic vessel clarity, lesion conspicuity, artifact severity, and overall image quality using a five-point scale. Quantitative analysis was performed by another radiologist to estimate the relative liver enhancement (RLE) and the signal-to-noise ratio (SNR). Statistical analyses were performed using the Wilcoxon signed rank test and one-way analysis of variance. Results: The scores of the HBP with an FA of $13^{\circ}$ during the same delayed time were significantly higher than those of the HBP with an FA of $9^{\circ}$ in all the assessment items (P < 0.01). In terms of the delay time, images at the same FA obtained with a 20-min-HBP showed better quality than those obtained with a 15-min-HBP. There was no significant difference in qualitative scores between the 20-min-HBP and the 15-min-HBP images in the non-liver cirrhosis (LC) group except for the hepatic vessel clarity score with $9^{\circ}$ FA. In the quantitative analysis, a statistically significant difference was found in the degree of RLE in the four HBP images (P = 0.012). However, in the subgroup analysis, no significant difference in RLE was found in the four HBP images in either the LC or the non-LC groups. The SNR did not differ significantly in the four HBP images. In the subgroup analysis, 20-min-HBP imaging with a $13^{\circ}$ FA showed the highest SNR value in the LC-group, whereas 15-min-HBP imaging with a $13^{\circ}$ FA showed the best value of SNR in the non-LC group. Conclusion: The use of a moderately high FA improves the image quality and lesion conspicuity on 3D, T1-weighted GRE imaging using the CAIPIRINHA technique on gadoxetic acid, 3T liver MR imaging. In patients with normal liver function, the 15-min-HBP with a $13^{\circ}$ FA represents a feasible option without a significant decrease in image quality.

• Journal of the Korean Geotechnical Society
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• v.21 no.2
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• pp.113-120
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• 2005

An understanding of soil-structure interaction is the key to rational and economical design for laterally loaded drilled shafts. It is very difficult to formulate the ultimate lateral capacity into a general equation because of the inherent soil nonlincarity, nonhomogeneity, and complexity enhanced by the three dimensional and asymmetric nature of the problem though extensive research works on the behavior of deep foundations subjected to lateral loads have been conducted for several decades. This study reviews the four most well known methods (i.e., Reese, Broms, Hansen, and Davidson) among many design methods according to the specific site conditions, the drilled shaft geometric characteristics (D/B ratios), and the loading conditions. And the hyperbolic lateral capacities (H$_h$) interpreted by the hyperbolic transformation of the load-displacement curves obtained from model tests carried out as a part of this research have been compared with the ultimate lateral capacities (Hu) predicted by the four methods. The H$_u$ / H$_h$ ratios from Reese's and Hansen's methods are 0.966 and 1.015, respectively, which shows both the two methods yield results very close to the test results. Whereas the H$_u$ predicted by Davidson's method is larger than H$_h$ by about $30\%$, the C.0.V. of the predicted lateral capacities by Davidson is the smallest among the four. Broms' method, the simplest among the few methods, gives H$_u$ / H$_h$ : 0.896, which estimates the ultimate lateral capacity smaller than the others because some other resisting sources against lateral loading are neglected in this method. But it results in one of the most reliable methods with the smallest S.D. in predicting the ultimate lateral capacity. Conclusively, none of the four can be superior to the others in a sense of the accuracy of predicting the ultimate lateral capacity. Also, regardless of how sophisticated or complicated the calculating procedures are, the reliability in the lateral capacity predictions seems to be a different issue.

• The Journal of Korean Academy of Prosthodontics
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• v.41 no.6
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• pp.720-731
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• 2003

Statement of problem. The importance of fixture design and surface treatment. Purpose. The clinical success of dental in plants is affected by many factors such like as degree of osseointegration, the effective load dispersion for the prostheses, and a lot of attempts have been made to overcome the difficulties. In this study, efforts were made to find the possibility of clinical acceptance of the dental implants of newly designed surface and resorbable blast media surcace. Materials and methods. In this study, two groups of custom-made, screw-shaped implants were prepared. The first with the consisting of Branemark clone design and the other with the new design. These implants were divided into four groups according to the kinds of surface treatment. Four implants($AVANA^{(R)}$, Osstem, Busan, Korea)of each group were installed in twenty rabbits. Group A was consisted of Branemark done implant left as machined, Group B with Branemark clone implants with RBM(Resorbable blast media) surface, Group C with newly designed implants left as machined and Group D with newly designed implants with RBM surface. One of the twenty rabbits died from inflammation and the observation was made for six weeks. Specimens from four groups were observed using scanning electron microscopy with 40, 100, 1000 magnification power and microsurface structures were measured by white-light scanning interferometry for three dimensional surface roughness measurements(Accura $2000^{(R)}$, Intek-Plus, Korea.). Removal torque was measured in 17 rabbits using digital torque gauge(MGT 12R, Mark-10 corp., NY, U.S.A.) immediately after the sacrifice and two rabbits were used for the histologic preparation(EXAKT $310^{(R)}$, Heraeus Kulzer, wehrheim, Germany) of specimens and observed under light microscope. Resonance frequency measurement($Osstell^{(R)}$) was taken with the 19 rabbits at the beginning of the implant fixation and immediately after the sacrifice. Results. Following results were taken from the experiment. 1. The surface of the RBM implants as seen with SEM had rough and irregular pattern with reticular formation compared to that of fumed specimens showing different surface topographies. 2. The newly designed implant with RBM surface had high removal torque value among four groups with no statistical significance. The average removal torque was $49.95{\pm}6.70Ncm$ in Group A, $51.15{\pm}4.40Ncm$ in Group B, $50.78{\pm}9.37Ncm$ in Group C, $51.09{\pm}4.69Ncm$ in Group D. 3. The RFA values were $70.8{\pm}4.3Hz$ in Group A, $71.8{\pm}3.1Hz$ in Group B, $70.9{\pm}2.5Hz$, $72.7{\pm}2.5Hz$ in Group D. Higher values were noted in the groups which had surface treatment compared to the untreated groups with no statistical significance. 4. The results from the histomorphometric evaluation showed a mean percentage of bone-to-implant contact of $45{\pm}0.5%$ in Group A, $55{\pm}3%$ in Group B, $49.5{\pm}0.5%$ in Group C, and $55{\pm}3%$ in Group D. Quite amount of newly formed bone were observed at the surface RBM-treated implants in bone marrow space.