• BMB Reports
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• v.48 no.3
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• pp.131-138
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• 2015

Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the development of the process. To date, mammalian HDACs are divided into four classes: I, II, III, and IV. By structural similarities, class II HDACs are then subdivided into IIa and IIb. Among class I and II HDACs, HDAC2, 4, 5, and 9 have been reported to be involved in hypertrophic responses; HDAC4, 5, and 9 are negative regulators, whereas HDAC2 is a pro-hypertrophic mediator. The molecular function and regulation of class IIa HDACs depend largely on the phosphorylation-mediated cytosolic redistribution, whereas those of HDAC2 take place primarily in the nucleus. In response to stresses, posttranslational modification (PTM) processes, dynamic modifications after the translation of proteins, are involved in the regulation of the activities of those hypertrophy-related HDACs. In this article, we briefly review 1) the activation of HDAC2 in the development of cardiac hypertrophy and 2) the PTM of HDAC2 and its implications in the regulation of HDAC2 activity.

• BMB Reports
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• v.42 no.7
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• pp.450-455
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• 2009

The "stage albinism line of winter wheat" FA85 was a specific natural mutant strain on leaf color. This physiological mutation was controlled by cytogene. In order to reveal the genetic and biochemical mechanism of albinism, 2-DE was used to investigate the difference of chloroplast protein expression pattern between FA85 and its parent wheat Aibian 1. From the results of 2-DE gels analysis, approximately 683 spots were detected on each gel, and 57 spots were expressed differently at least two-fold. Using MALDI-TOF/TOF MS, 14 of 57 spots were identified, which could be categorized into four classes: carbon metabolism, energy metabolism, defense/stress response and signal transduction. Compared with the parent wheat, the expression of ATPase-$\gamma$ and GP1-$\alpha$ was up-regulated in FA85, and of other proteins was down-regulated. Together, we concluded that the expression of chloroplast proteins had changed obviously in FA85, which might be related to the leaf color mutant.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.12
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• pp.2116-2124
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• 2001

It's required mechanical properties of in-service facilities to maintain safety operation in power plants as well as chemical plants. In this studdy the four classes of the thermally aged 1Cr-lMo-0.25V specimens were prepared using an artificially accelerated aging method at 630$\^{C}$. Ultrasonic tests, tensile tests, K$\_$IC/ tests and hardness tests were performed in order to evaluate the degree of degradation of the material. The mechanical properties were decreased as degraded, but the attenuation coefficient and the harmonic generation level of a ultrasonic signal were increased. Expecially the nonlinear parameter derived from the harmonic generation level is sensitive and will be a good parameter to evaluate the material degradation.

• Journal of Gifted/Talented Education
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• v.8 no.2
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• pp.175-191
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• 1998

The purpose and content of Chonnam National University Center for Science Talented Education program and students' responses were described. The program was developed with the purpose of providing various learning opportunities for science talented students according to the level of their learning abilities. Students are given a variety of activities based on their potentials and interest. The program was developed in four subjects, such as mathematics, information science, science Ⅰ (physics and earth science), and science Ⅱ (biology and chemistry). Each subject consisted of simple inquiry, advanced one, and project, even though it had its own distinctions. Students were selected for each subject based on two criteria, that is, achievements in school science or mathematics (the upper 3 percent of the 8th grade students) and examination scores. Means and standard deviations for each subject were as follows: 51.8 and 13.3 for Science Ⅰ, 53.1 and 13.9 for Science Ⅱ, 36.7 and 10.7 for mathematics and 36.4 and 12.5 for information science. Thirty hours of summer classes were performed, and a survey was administered to obtain students' responses concerning difficulty, interest, teaching and content of the program. They gave relatively favourable responses in most area, but lack of time for studying was revealed in mathematics and information science. Further study in needed to get detailed and more accurate results of our program.

• Journal of Korean Biological Nursing Science
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• v.13 no.2
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• pp.102-108
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• 2011

Purpose: The purpose of this study was to examine the effects of first clinical training on stress, anxiety and changes in autonomic nervous system in nursing students. Methods: Seventy-four nursing students were assigned to the experimental group (n=36) that had two weeks of clinical training, and the control group (n=38) that had only two weeks of regular classes. Perceived stress, state anxiety and heart rate variability (HRV) were measured at the beginning and end of the experiment. Results: Perceived stress in the experimental group was significantly higher than in the control group. However, State anxiety was not significantly different between the two groups. All indices of HRV except LF/HF ratio were significantly different between the two groups. LF norm in the experimental group was significantly higher than in the control group, and HF norm in the experimental group was significantly lower than in the control group. Conclusion: Based on these results, it can be suggested that clinical training increases the perceived stress and affects the changes in autonomic nervous system in nursing students.

• The Korean Journal of Emergency Medical Services
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• v.17 no.3
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• pp.149-168
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• 2013

Purpose: The purpose of this study is to develop a safety health education program for the upper graders of elementary school children and to evaluate the program. Methods: The study was designed for learner centered safety education and heath education based on a theory of lifelong education. After a model development of the program was set up, five major units were selected after five stages of program planning, design, acting, evaluation and feedback: school safety, traffic safety, home safety, life safety, and first-aid. Twenty things were selected as what to teach, and a lesson plan of 12 sessions was mapped out by arranging what to teach. The subjects in this study were 114 elementary school students who were in five different sixth-grade classes. Each class received education for five days, in four sessions each, according to the program. Results: The learners showed improvement in safety consciousness, safety knowledge, self-efficacy and safety behavior after they received education according to the safety health education program, and they expressed a lot of satisfaction with the program. Conclusion: It is important to develop the lifelong education for safety health education for the elementary school children.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.4
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• pp.151-159
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• 2001

As huge energy transfer systems like a nuclear power plant, steam power plant and petrochemical plant are operated for a long time, mechanical properties are changed by degradation. The life time of the systems can be affected by the mechanical properties. BI(Ball Indentation) test has a potential to replace conventional fracture tests like a uniaxial tensile test, fracture toughness test, hardness test and so on. In this paper, we would like to present the ageing evaluation technique by the BI method. The four classes of the thermally aged 1Cr-!mo-0.25V specimens were prepared using an artificially accelerated aging method. Tensile tests, fracture toughness tests, hardness tests and BI tests were performed. The results of the BI tests were in good agreement with fracture characteristics by a standard fracture test method within 5%. The IDE(Indentation Deformation Energy) of a BI technique as a new parameter for evaluating a degradation was suggested and the new IDE parameter clearly depicts the degradation degree.

• Journal of the Korean Society of Earth Science Education
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• v.4 no.1
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• pp.20-31
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• 2011

The purpose of this study is to examine the effect of PBL-based astronomical observation on the science process skills and scientific attitudes in elementary science-gifted students. To verify research problems, the subjects of this study were forth-grade students selected from one classes of an elementary science-gifted class in Busan National University of education : the research group is composed of twenty students who were participated in PBL-based astronomical observation program. During four weeks, the PBL-based astronomical observation program instruction was executed in the reasearch group. Post-test showed following results: First, the research group showed a significant improvement in the science process skill. We look into detailly this, the research group showed a significant improvement in the basis science skill. The sub-factor 'expectation' of the science process skill effects a significant improvement. Second, the research group showed a significant improvement in the scientific attitudes. In conclusion, PBL-based astronomical observation program was more effective on science process skill and scientific attitudes. However, since the study has a limit on an object of the study and the applied program, the additional studies need to be conducted with an extended comparative group and program.

• Geomechanics and Engineering
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• v.11 no.4
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• pp.515-530
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• 2016

In this paper, five different quantitative parameters were proposed for the characterization of the primary roughness which is the component of surface morphology that prevails during large strike-slip faults of more than 50 m. These parameters are mostly the anisotropic properties of rock surface morphology at various scales: (i) coefficient ($k_a$) and degree (${\delta}_a$) of apparent structural anisotropy of surface; (ii) coefficient ($k_r$) and degree (${\delta}_r$) of real structural anisotropy of surface; (iii) surface anisotropy function P(${\varphi}$); and (iv) degree of surface waviness ($W_s$). The coefficient and degree of apparent structural anisotropy allow qualifying the anisotropy/isotropy of a discontinuity according to a classification into four classes: anisotropic, moderately anisotropic/isotropic and isotropic. The coefficient and degree of real structural anisotropy of surface captures directly the actual surface anisotropy using geostatistical method. The anisotropy function predicts directional geometric properties of a surface of discontinuity from measurements in two orthogonal directions. These predicted data may subsequently be used to highlight the anisotropy/isotropy of the surface (radar plot). The degree of surface waviness allows qualifying the undulation of anisotropic surfaces. The proposed quantitative parameters allows their application at both lab and field scales.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.12
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• pp.85-87
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• 1994

In this paper, we present an object-oriented stereotactic radiosurgery planning system, which accepts medical images such as CT and angiography, transforms the coordinates to a reference frame coordinate, calculates dose distributions, and finally displays isodose curves over the images. The user finds an adequate one for radiosurgeries after performing computer simulations on different treatment parameter sets. The object-oriented design concept was fully applied to the system composed of seven manager objects of different classes: a patient information manager, a user-interface manager, a coordinate transformation manager, a blackboard manager, a dose calculation manager, an isodose curve display manager, and a report manager. All the user interactions are carried out through the use of mouse buttons. The performance of the system was verified by four physicians and two medical physicists, and now is being used in two clinical sites.