• Title/Summary/Keyword: force-based

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Force Transmission in Cellular Adherens Junction Visualized by Engineered FRET Alpha-catenin Sensor (형광공명에너지전이 알파카테닌 센서를 활용한 세포 부착접합부에서의 힘 전달 이미징)

  • Jang, Yoon-Kwan;Suh, Jung-Soo;Suk, Myungeun;Kim, Tae-Jin
    • Korean Chemical Engineering Research
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    • v.59 no.3
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    • pp.366-372
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    • 2021
  • Cadherin-Catenin complex is thought to play an essential role in the transmission of force at adherens junction. Due to the lack of proper tools to visualize and detect mechanical force signals, the underlying mechanism by which the cadherin-catenin complex regulates force transmission at intercellular junctions remains elusive. In this study, we visualize cadherin-mediated force transmission using an engineered α-Catenin sensor based on fluorescence resonance energy transfer. Our results reveal that α-catenin is a key force transducer in cadherin-mediated mechanotransduction at cell-cell junctions. Thus, our finding will provide important insights for studying the effects of chemical and physical signals on cell-cell communication and the relationship between physiological and pathological phenomena.

Numerical analysis of unsteady hydrodynamic performance of pump-jet propulsor in oblique flow

  • Qiu, Chengcheng;Pan, Guang;Huang, Qiaogao;Shi, Yao
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.12 no.1
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    • pp.102-115
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    • 2020
  • In this study, the SST k - ω turbulence model and the sliding mesh technology based on RANS method have been adopted to simulate the exciting force and hydrodynamic of a pump-jet propulsor in different oblique inflow angle (0°, 10°, 20°, 30°) and different advance ratio (J = 0.95, J = 1.18, J = 1.58).The fully structured grid and full channel model have been adopted to improved computational accuracy. The classical skewed marine propeller E779A with different advance ratio was carried out to verify the accuracy of the numerical simulation method. The grid independence was verified. The time-domain data of pump-jet propulsor exciting force including bearing force and fluctuating pressure in different working conditions was monitored, and then which was converted to frequency domain data by fast Fourier transform (FFT). The variation laws of bearing force and fluctuating pressure in different advance ratio and different oblique flow angle has been presented. The influence of the peak of pulsation pressure in different oblique flow angle and different advance ratio has been presented. The results show that the exciting force increases with the increase of the advance ratio, the closer which is to the rotor domain and the closer to the blades tip, the greater the variation of the pulsating pressure. At the same time, the exciting force decrease with the oblique flow angle increases. And the vertical and transverse forces will change more obviously, which is the main cause of the exciting force. In addition, the pressure distribution and the velocity distribution of rotor blades tip in different oblique flow angles has been investigated.

Nanoscale quantitative mechanical mapping of poly dimethylsiloxane in a time dependent fashion

  • Zhang, Shuting;Ji, Yu;Ma, Chunhua
    • Advances in nano research
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    • v.10 no.3
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    • pp.253-261
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    • 2021
  • Polydimethylsiloxane (PDMS) is one of the most widely adopted silicon-based organic polymeric elastomers. Elastomeric nanostructures are normally required to accomplish an explicit mechanical role and correspondingly their mechanical properties are crucial to affect device and material performance. Despite its wide application, the mechanical properties of PDMS are yet fully understood. In particular, the time dependent mechanical response of PDMS has not been fully elucidated. Here, utilizing state-of-the-art PeakForce Quantitative Nanomechanical Mapping (PFQNM) together with Force Volume (FV) and Fast Force Volume (FFV), the elastic moduli of PDMS samples were assessed in a time-dependent fashion. Specifically, the acquisition frequency was discretely changed four orders of magnitude from 0.1 Hz up to 2 kHz. Careful calibrations were done. Force data were fitted with a linearized DMT contact mechanics model considering surface adhesion force. Increased Young's modulus was discovered with increasing acquisition frequency. It was measured 878 ± 274 kPa at 0.1 Hz and increased to 4586 ± 758 kPa at 2 kHz. The robust local probing of mechanical measurement as well as unprecedented high-resolution topography imaging open new avenues for quantitative nanomechanical mapping of soft polymers, and can be extended to soft biological systems.

Force Control of Hybrid Actuator Comprising DC Motor and MR Brake (DC 모터와 MR 브레이크로 이루어진 하이브리드 구동기의 힘 제어)

  • Choy, Ick;Kwon, Dong-Soo;An, Jin-Ung
    • The Transactions of the Korean Institute of Power Electronics
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    • v.11 no.1
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    • pp.46-55
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    • 2006
  • This paper presents the control method for the hybrid actuator comprising a DC motor and an MR brake. Generally, a DC motor as an active actuator has a small power to weight ratio and goes unstable with higher force control gain due to its saturation limit. In order to cope with this instability and make the transparency higher, this paper proposes a hybrid actuator which consists of a DC motor and an MR brake as a passive actuator and its force control method based on network theory. A DC motor actively produces the output corresponding to the signs of the input currents. On the other hand, an MR brake passively resists against the external load independent of the sign changes of the input currents. This characteristics is widely known as 'passive' This paper suggests a force control method based on passivity concept in network theory for the hybrid actuator and verified its performance and stability through the experiments.

Navigation Technique of Unmanned Vehicle Using Potential Field Method (포텐셜 필드 기법을 이용한 무인차량의 자율항법 개발)

  • Lee, Sang-Won;Moon, Young-Geun;Kim, Sung-Hyun;Lee, Min-Cheol
    • Transactions of the Korean Society of Automotive Engineers
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    • v.19 no.4
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    • pp.8-15
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    • 2011
  • This paper proposes a real-time navigation algorithm which integrates the artificial potential field (APF) for an unmanned vehicle in the unknown environment. This approach uses repulsive potential function around the obstacles to force the vehicle away and an attractive potential function around the goal to attract the vehicle. In this research, laser range finder is used as range sensor. An obstacle detected by the sensor creates repulsive vector. Differential global positioning system (DGPS) and digital compass are used to measure the current vehicle position and orientation. The measured vehicle position is also used to create attractive vector. This paper proposes a new concept of potential field based navigation which controls unmanned vehicle's speed and steering. The magnitude of repulsive force based on the proposed algorithm is designed not to be over the magnitude of attractive force while the magnitude is increased linearly as being closer to obstacle. Consequently, the vehicle experiences a generalized force toward the negative gradient of the total potential. This force drives the vehicle downhill towards its goal configuration until the vehicle reaches minimum potential and it stops. The effectiveness of the proposed APF for unmanned vehicle is verified through simulation and experiment.

Network-adaptive Transport Scheme for Transparency of Force-reflecting Teleoperation (힘 반향 원격제어 시스템의 투명성을 위한 네트워크 적응형 전송 기법)

  • Lee, Seok-Hee;Seo, Chang-Hoon;Ryu, Je-Ha;Kim, Jong-Won
    • 한국HCI학회:학술대회논문집
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    • 2009.02a
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    • pp.45-51
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    • 2009
  • In this paper, a transparency analysis and network-adaptive transport scheme are proposed in order to improve transparency of EBA-based force-reflecting teleoperation. EBA guarantees stability of force-reflecting teleoperation over network delay and loss but has limitation that it cannot overcome transparency deterioration of haptic interactions. The proposed transparency analysis quantifies the force feedback distortion caused by network delay and loss. Based on the analysis, the proposed haptic data synchronization and transmission rate control schemes adapt synchronization delay and transmission rate to current network state for more transparent haptic interaction. Through Matlab/Simulink simulations, it is confirmed that the proposed analysis provides an acceptable quantification method about haptic interaction quality and that the proposed haptic data transport scheme effectively improves haptic interaction quality with respect to network delays and losses.

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An Experimental and Numerical Study on the Fracture Behavior of Air conditioner Impellers (에어컨 임펠러의 파손 거동에 관한 실험 및 수치적 연구)

  • Koh, Byung-Kab;Lee, Sung-Chul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.12
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    • pp.3533-3539
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    • 2009
  • An air conditioner impeller has been used to suck the warm air and to blow the chilled air by the centrifugal force induced from the rotation of it. To check the possibility of the fracture due to resonance, both numerical and experimental approach was carried out. For the structural analysis, the commercial code ANSYS based on the Finite Element Method was employed. The possibility of the fracture is the resonance between the natural frequency of impeller and characteristic frequency due to the aerodynamic forces. Experiment was carried out to see the natural frequency and numerical analysis based on the Vortex Element Method is performed to get the characteristic frequency. Comparing the natural frequencies that are calculated as described, we believe that resonance occurs.

A Signal Characteristic Based Cluster Scheme for Aeronautical Ad Hoc Networks

  • Tian, Yu;Ma, Linhua;Ru, Le;Tang, Hong;Song, Bo
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.8 no.10
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    • pp.3439-3457
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    • 2014
  • Clustering is an effective method for improving the performance of large scale mobile ad hoc networks. However, when the moving speed is very fast, the topology changes quickly, which leads to frequent cluster topology updates. The drastically increasing control overheads severely threaten the throughput of the network. SCBCS (Signal Characteristic Based Cluster Scheme) is proposed as a method to potentially reduce the control overheads caused by cluster formation and maintenance in aeronautical ad hoc networks. Each node periodically broadcasts Hello packets. The Hello packets can be replaced by data packets, which preserve bandwidth. The characteristics of the received packets, such as the Doppler shift and the power of two successive Hello packets, help to calculate the relative speed and direction of motion. Then, the link connection lifetime is estimated by the relative speed and direction of motion. In the clustering formation procedure, the node with the longest estimated link connection time to its one-hop neighbors is chosen as the cluster head. In the cluster maintenance procedure, re-affiliation and re-clustering schemes are designed to keep the clusters more stable. The re-clustering phenomenon is reduced by limiting the ripple effect. Simulations have shown that SCBCS prolongs the link connection lifetime and the cluster lifetime, which can reduce the topology update overheads in highly dynamic aeronautical ad hoc networks.

Determination of critical excitation in seismic analysis of structures

  • Kamgar, Reza;Rahgozar, Reza
    • Earthquakes and Structures
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    • v.9 no.4
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    • pp.875-891
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    • 2015
  • Earthquake can occur anywhere in the world and it is essential to design important members in special structures based on maximum possible forces that can be produced in them under severe earthquake. In addition, since the earthquake is an accidental phenomena and there are no similar earthquakes, therefore the possibility of strong earthquakes should be taken into account in earthquake-resistant design of important structures. Based on this viewpoint, finding the critical acceleration which maximizes internal forces is an essential factor in structural design. This paper proposes critical excitation method to compute the critical acceleration in design of important members in special structures. These critical accelerations are computed so that the columns' internal shear force at the base of the structure at each time step is maximized under constraints on ground motion. Among computed critical accelerations (of each time step), the one which produces maximum internal shear force is selected. A numerical example presents to show the efficiency of critical excitation method in determining the maximum internal shear force and base moment under variety of constraints. The results show that these method can be used to compute the resonant earthquake which have large enough effective duration of earthquake strong motion (between 12.86 sec to 13.38 sec) and produce the internal shear force and base moment for specific column greater than the same value for selected earthquakes in constructing the critical excitation (for different cases about 2.78 to 1.29 times the San Fernando earthquake). Therefore, a group of them can be utilized in developing the response spectrum for design of special structures.

Chaotic particle swarm optimization in optimal active control of shear buildings

  • Gharebaghi, Saeed Asil;Zangooeia, Ehsan
    • Structural Engineering and Mechanics
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    • v.61 no.3
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    • pp.347-357
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    • 2017
  • The applications of active control is being more popular nowadays. Several control algorithms have been developed to determine optimum control force. In this paper, a Chaotic Particle Swarm Optimization (CPSO) technique, based on Logistic map, is used to compute the optimum control force of active tendon system. A chaotic exploration is used to search the solution space for optimum control force. The response control of Multi-Degree of Freedom (MDOF) shear buildings, equipped with active tendons, is introduced as an optimization problem, based on Instantaneous Optimal Active Control algorithm. Three MDOFs are simulated in this paper. Two examples out of three, which have been previously controlled using Lattice type Probabilistic Neural Network (LPNN) and Block Pulse Functions (BPFs), are taken from prior works in order to compare the efficiency of the current method. In the present study, a maximum allowable value of control force is added to the original problem. Later, a twenty-story shear building, as the third and more realistic example, is considered and controlled. Besides, the required Central Processing Unit (CPU) time of CPSO control algorithm is investigated. Although the CPU time of LPNN and BPFs methods of prior works is not available, the results show that a full state measurement is necessary, especially when there are more than three control devices. The results show that CPSO algorithm has a good performance, especially in the presence of the cut-off limit of tendon force; therefore, can widely be used in the field of optimum active control of actual buildings.