• 생물정신의학
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• 제15권2호
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• pp.101-109
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• 2008

목 적 이 연구는 수컷과 암컷 생쥐에서 amisulpride를 투여하였을 때 먹이 섭취량, 체중 및 대사 지표에 대한 영향을 risperidone 및 정상 대조군과 비교하여 알아보고자 하였다. 방 법 수컷과 암컷 C57BL/6형 생쥐를 저용량 amisulpride 투여군(1.5mg/kg), 고용량 amisulpride투여군(15mg/kg), risperidone 투여군(0.1mg/kg)과 Vehicle군으로 나누었다. 약물은 21일간 매일 하루에 한 번 복강 주사를 통해 투여되었다. 체중은 일주일에 한 번씩 측정하였으며 먹이 섭취량은 매일 측정하였다. Triglyceride(TG), glucose, insulin 그리고 prolactin은 실험 종료 시에 측정하였다(실험 22일). 결 과 암컷 생쥐의 경우, 저용량과 고용량의 amisulpride 투여군에서는 유의한 체중 증가를 보였으며, risperidone 역시 유의한 체중 증가를 보였다. 그러나, 두 amisulpride군의 증가량은 risperidone군의 증가량에 비해 수치적으로 작았다. 수컷 생쥐의 경우, 고용량의 amisulpride만이 유의한 체중 증가를 가져왔다. 체중 증가를 보였던 집단 중에서, 고용량의 amisulpride를 투여하였던 수컷 생쥐만이 유의하게 증가된 먹이 섭취량과 연관성이 있었다. 암컷 생쥐에서 체중 증가를 보였던 군들은 먹이 섭취량과 유의한 상관성을 보이지 않았다. 수컷 생쥐에서, 두 개의 amisulpride 투여군 모두는 vehicle에 비해 유의하게 높은 혈장 insulin 수치를 보였다. 암컷과 수컷 생쥐에서, 저용량과 고용량의 amisulpride 투여군은 vehicle과 비교하여 유의하게 높은 혈장 prolactin수치를 보였다. Triglyceride는 모든 집단에서 유의하게 변화하지 않았으며 glucose는 수컷 risperidone 투여군에서만 유의하게 변화하였다. 결 론 Amisulpride는 암수 생쥐에서 체중 증가를 일으키지만, 대사 이상에 대한 결과는 성별에 따라 차이가 있었다. 본 연구의 결과는 amisulpride에 의한 체중 증가에 암수 생쥐에서 서로 다른 기전이 작용할 가능성을 시사한다.

• 한국축산식품학회지
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• 제44권2호
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• pp.255-268
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• 2024

Probiotic products have long been recognized for their health benefits. Additionally, milk has held a longstanding reputation as a dairy product that offers high-quality proteins and essential micronutrients. As awareness of the impact of food on health grows, interest in functional products such as probiotic dairy products is on the rise. Fermentation, a time-honored technique used to enhance nutritional value and food preservation, has been used for centuries to increase nutritional value and is one of the oldest food processing methods. Historically, fermented dairy products have been used as convenient vehicle for the consumption of probiotics. However, addressing the potential drawbacks of fermentation has recently led to increase in research on probiotic dairy drinks prepared without fermentation. These non-fermented dairy drinks have the advantage of maintaining the original flavors of milk drinks, containing potential health functional probiotics, and being an alternative dairy product that is helpful for probiotics intake. Currently, research on plant-based dairy products is rapidly increasing in the market. These developments might suggest the potential for novel forms of non-fermented dairy beverages with substantial prospects in the food market. This review aims to provide an overview of milk-based dairy beverages, both fermented and non-fermented, and discuss the potential of non-fermented dairy products. This exploration paves the way for innovative approaches to deliver probiotics and nutrition to consumers.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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• pp.114-114
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• 2001

Di-n-butyl phthalate (DBP) is not only a plasticizer and solvent used in industry but also one of endocrine disruptor chemicals, a low level contaminant found in a wide variety of different media ranging from drinking water to infant formulae. To evaluate the cytotoxic function of NK cells in mice after contact with DBP, C57BL/6 female mice were orally dosed with di-n-butyl phthalate (250, 500, or 750 mg/kg body weight) for 14 consecutive days, and the control mice were administered vehicle (corn oil).(omitted)

• 한국환경과학회지
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• 제29권8호
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• pp.837-846
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• 2020

In present study, we investigated the antidiabetic effect of Momordica charantia(as well known "bitter melon"). This study was conducted to determine antidiabetic mechanism of Bitter Melon Extract (BME). We measured blood glucose, insulin, glucagon level in a Sprague-Dawley rat model of high-fat diet/streptozotocin(HFD/STZ)-induced diabetes. Five experimental groups were used: normal, HFD/STZ, BME 62.5 mg/kg HFD/STZ, BME 125 mg/kg HFD/STZ and BME 250 mg/kg HFD/STZ. BME was orally administered to the rats every other day for 9 weeks. Results showed that fasting blood glucose levels were significantly lower in the BME 125 mg/kg(150.17 ± 20.22 mg/dL) and 250 mg/kg(124.17 ± 22.17 mg/dL) groups than in the vehicle group(188.83 ± 26.63 mg/dL)(p<0.05). In addition, glucagon levels were lower in the three BME treatment groups than in the vehicle group(p<0.05). Oral glucose tolerance tests revealed that the BME 250 mg/kg group had significantly(p<0.05) reduced 120-minute blood glucose levels and areas under the curve. Our results suggest that BME induces antidiabetic effects via the reduction of glucagon and blood glucose levels.

• 생명과학회지
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• 제19권4호
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• pp.532-537
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• 2009

알코올 의존과 N-methyl-D-aspartate (NMDA) 수용체와 밀접한 관계가 있을 수 있다는 연구들이 있는데, 즉 NMDA 수용체가 알코올의 금단, 내성의 발생과 관련이 있다는 연구 결과들이다. 그러나 NMDA 수용체 길항제가 알코올 의존의 재발 예방에 효과가 있을 것이라는 것에 대해서는 아직 논란이 되고 있다. 본 연구는 유전적으로 알코올을 선호하는 C57BL/6형 생쥐를 이용하여 유한접근법으로 NMDA 수용체 길항제인 memantine을 5, 25, 50 mg/kg으로 각각 투여하였을 때 알코올 섭취량에 미치는 영향을 알아보고자 하였다. 알코올 의존화된 C57BL/6형 수컷 생쥐를 5군으로 나눈 뒤, 12일간 각 군에 vehicle, naltrexone 1.0 mg/kg, memantine 5, 25, 50 mg/kg으로 각각 투여하면서 알코올의 섭취량, 물 섭취량, 사료 섭취량 및 체중을 조사하였다. 본 연구의 결과, 2시간 알코올 섭취량의 12일간 변화에 대해 vehicle 투여군과 naltrexone, memantine 5, 25, 50 mg/kg 투여군 각각의 군을 repeated measure ANOVA를 이용하여 비교하였을 때, naltrexone (df=4, F=11.827, p<0.01), memantine 5 mg/kg (df=4, F=7.999, p<0.01), memantine 25 mg/kg (df=4, F=6.199, p<0.05) 및 memantine 50 mg/kg (df=4, F=10.522, p<0.01) 투여군에서 각각 유의한 군과 일수의 상호작용을 보였다. 그러나 22시간 물 섭취량, 24시간 사료섭취량 및 체중의 12일간 변화에 대해서는 vehicle 투여군과 memantine 투여군 3군 각각에서 유의한 상호작용이 없었다. 한편, vehicle 투여군과 naltrexone 투여군 간에는 체중의 변화에서 유의한 군과 일수의 상호작용을 보였고, 22시간 물 섭취량 및 24시간 사료 섭취량에서는 유의한 상호 작용이 없었다. 이상의 결과는 NMDA 수용체 길항제인 memantine을 생쥐에게 투여하였을 때 알코올 섭취량에 영향을 줄 수 있다는 것을 의미한다. 이는 앞으로 부작용은 적으면서 치료 효과는 우수한 알코올 의존 재발 예방 치료제 개발의 가능성을 제안하고 있다.

• Journal of Preventive Medicine and Public Health
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• 제47권3호
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• pp.177-181
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• 2014

Objectives: A salmonellosis outbreak occurred within a community of Gyeongju residents who ingested catered food from a wedding in June 2009. We aimed to epidemiologically investigate the probable vehicle of the infection. Methods: We conducted a retrospective cohort study on 34 local residents who ingested the wedding food. Results: Among the 34 residents, 31 (91.2%) reported symptoms of infection after eating the food. Among all of the wedding foods, pan-fried foods were highly associated with the diarrheal attack rate. On bacteriological examination, Salmonella species were detected in the pan-fried foods among the leftover foods and in 17 of the 31 stool specimens from the cases. There were five different types of pan-fried foods, but the onset of symptoms was independent of the ingredients used. We found that the pan-fried food was prepared at a food store in Seoul and that eggs were a common ingredient. Conclusions: The major cause of the salmonellosis in this population was presumed to be the pan-fried food prepared with contaminated eggs. These food items might have been partially undercooked because of their irregular shape, which allowed the Salmonella species to survive and multiply before ingestion.

• 식품과학과 산업
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• 제49권4호
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• pp.40-63
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• 2016

John Glenn, America's first man to eat anything in the near-weightless environment of Earth orbit, found the task of eating fairly easy. With improved packaging came improved food quality and menus. By the time of the Apollo Program, the quality and variety of food increased even further. Apollo astronauts were the first to have hot water, which made rehydrating foods easier and improved the food's taste. Thermostabilized pouches were also introduced on Apollo. The task of eating in space got a big boost in Skylab. It also had a food freezer and refrigerator a convenience offered by no other vehicle before or since. Two different food systems will be used for future long-duration missions to other planets, one for traveling to and from the distant body and one for use on the surface of the moon or Mars. The transit food system will be similar to the space station food system with the exception that products with three-to five-year shelf lives will be needed. Thus, this part of the trip will be similar to what occurs aboard space missions now. The surface food system, be it lunar or planetary, will be quite different. It will be similar to a vegetarian diet that someone could cook on Earth. Once crew members arrive on the surface and establish living quarters, they can start growing crops. Once the crops are processed into edible ingredients, cooking will be done in the spacecraft's galley to make the food items. Disposal of used food packaging will be an issue since there will be no Progress vehicles to send off and incinerate into the Earth's atmosphere. Packaging materials will be used that have less mass but sufficient barrier properties for oxygen and water to maintain shelf life as those now in use.

• 한국식품위생안전성학회지
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• 제29권4호
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• pp.383-390
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• 2014

The safety of a new natural plant composition (ADP) was assessed on the genotoxicity study and 14-day repeat dose toxicity study. ADP contains a mixed water extract obtained from the mixture of Phellodendron cortex (Phellodendron amurense) and Anemarrhena rhizoma (Anemarrhena asphodeloides), and poses the contractile properties mediated by alpha-adrenoceptor of the prostate and urethra as well as antioxidant and anti-inflammatory properties. In order to evaluate genetic safety, in vivo micronucleus test was performed in ICR mice orally administered with three dose levels of 1250, 2500, 5000 mg/kg body weight, and vehicle and positive control. In the 14 days study, Sprague-Dawley rats were treated with ADP at the dose levels of 500, 1000, 2000 mg/kg once a day, and clinical signs, body weights, hematology, serum biochemistry, necropsy findings and organ weights were monitored and examined. In experimental results, ADP treatment, compared with vehicle control, did not induce the micronucleated erythrocytes from mouse bone marrow. In the 14 days study, any significant and toxicological differences in all measurements of parameters were not observed in ADP treatment groups of animals, compared with vehicle treatment. The No-Observed-Adverse-Effect-Level (NOAEL) of ADP in the 14 days study was determined to be greater than 2000 mg/kg/day in both sexes.

• 한국환경생태학회지
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• 제21권6호
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• pp.526-535
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• 2007

본 연구는 2004년도 2월에서 3월까지 철원분지의 민간인통제지역에서 두루미와 재두루미의 차량에 대한 반응 행동과 함께 방해요인과 먹이와의 수지균형에 관하여 실시하였다. 재두루미의 도로로부터의 평균취식거리는 두루미에 비하여 가까웠다. 두루미와 재두루미 모두 무리크기가 클수록 도로로부터 떨어진 평균거리는 증가하였다. 두루미와 재두루미는 차량의 근거리 정지에 대하여 경계, 걷기, 뛰기, 비행의 반응을 보였으며, 도로에서 가까울수록 차량에 대하여 민감하게 반응하였다. 도로에서 멀수록 차량의 정지에 대한 반응 시간은 두루미와 재두루미 모두 감소하였다. 차량의 정지에 대하여 반응을 보이지 않는 반응역치거리는 두루미와 재두루미 모두 250m이었다. 두루미는 200m내에서 재두루미에 비하여 민감하게 반응하였다. 도로 교통량이 증가함에 따라 동일거리에서의 반응시간은 변화가 없었지만, 도로인근 지역에서 멀어지게 하고 해당지역을 취식지로 이용하지 않게 하는 영향이 있었다. 두루미와 재두루미가 차량 통행 등의 방해요인에도 불구하고 낙곡을 취식했던 것은 도로인근 지역의 잔존 낙곡의 밀도가 높았기 때문이었다.

• 한국한의학연구원논문집
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• 제16권2호
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• pp.143-157
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• 2010

Objectives : The objective of this study was to access the effect of Artemisiae capillaris herba Extracts on the organogenetic reproductive toxicity of New Zealand White rabbits when administered by oral gavage. Methods : Gestational New Zealand White rabbits were dosed from 6 days of gestation to 18 days of gestation. It was conducted in accordance with the recommendations of the KFDA Guideline for Detection of Toxicity to Reproduction for Medicinal Products. In addition, serum AST, ALT, LDH and ALP levels were detected with their necropsy and histopathological observation Results: No significant changes of body weights, gains and food consumption were demonstrated in all dosed groups compared to those of vehicle control group except for 2,000mg/kg-dosing group, which showed significantly increase of body weight compared to that of vehicle control group. Normal gross findings were demonstrated in all tested groups. No significant changes of number of corpora lutea, implantation, implantation rate, number of fetal death, loss rate of post-implantation, number of live youngs at C-section, survival rate of post-implantation, number of male live youngs at C-section, number of female live youngs, sex ratio of live young, external anomalies of live youngs and body weight of live youngs were demonstrated in all dosed groups compared to those of vehicle control group. Although some visceral variations such as thymic reminant in the neck, dilation of renal pelvis, dilated ureter and malpositioned left common carotid artery, no significant changes were demonstrated in all dosed groups compared to that of vehicle control group. Some malformations and variation were demonstrated with retardations. However, no significant changes were demonstrated in all dosed groups compared to that of vehicle control group. In addition, similar ossification numbers were detected in sternebrae, metacarpals, metatarsals, phalanges, cervical vertebrae, and sacral and caudal vertebrae. No Artemisiae capillaris herba Extracts treatment-related changes of serum AST, ALT, LDH and ALP levels were demonstrated in all dosed levels in this study. Conclusions : We could conclude that oral administration of Artemisiae capillaris herba Extracts hasn't an influence on the organogenetic reproductive toxicity.