• 대한임상검사과학회지
• /
• 제45권1호
• /
• pp.32-36
• /
• 2013

The thyroid is the organ that has the greatest risk of malignant tumors among the endocrine tumors. The papillary carcinoma occupies 80% of the entire thyroid tumors. Immunohistochemical staining of galectin-3 has usually been used in differentiating papillary carcinoma and follicular carcinoma. The p53 gene of the cell cycle is a tumor suppressor gene acting in on the control points. The cyclin D1 genes in the cell cycle, involved in the implementation of G1 and S phase, plays an important role in the progression of thyroid tumors. This research compares and analyzes correlation between papillary carcinoma, follicular carcinoma, p53, cyclin D1 and galectin-3 gene expression patterns. In a total of 30 cases from papillary carcinoma, 21 cases from p53 (70%), 27 cases in galectin-3 (90%), and 26 cases in cyclin D1 (86.7%) showed positive rate. The galectin-3 staining investigated, showed a significant difference between a papillary carcinoma and a follicular carcinoma. Follicular carcinoma from 15 cases, p53 in 13 cases (86.7%), galectin-3 in 5 cases (33.3%) and cyclin D1 in 12 cases (80%) showed a positive rate. The cyclin D1 in follicular carcinoma and staining between the p53 that had correlation was also investigated. In this study, as the examples of the expression of the 27 cases of galectin-3 (90%) in papillary carcinoma and 5 cases in follicular carcinoma (33.3%) indicate, it was concluded that there is a difference in the expression on both carcinoma. In addition, cyclin D1 and p53 has a positive rate in follicular carcinoma, when cyclin D1 in 12 cases (80%), there was a significant correlation that was investigated. Distinguishing between papillary carcinoma and follicular carcinoma can be identified by the expression of galectin-3. It is considered to get results that are more accurate in follicular carcinoma diagnosis depending on whether the cyclin D1 and p53 is expressed or not.

• 대한상부위장관⦁헬리코박터학회지
• /
• 제18권4호
• /
• pp.258-263
• /
• 2018

Follicular lymphoma is the most common form of low-grade B cell lymphoma. Follicular lymphoma occurs predominantly at lymph node sites and rarely in the gastrointestinal tract. Rare gastrointestinal follicular lymphoma is most commonly found in the small intestine, especially in the duodenum, and appears as multiple granules. However, gastric follicular lymphoma mostly appears as a subepithelial tumor. We observed two primary gastric follicular lymphomas that resembled subepithelial tumors located in the body of the stomach. Endoscopic ultrasound revealed hypoechoic lesions located in the submucosa layer. Since endoscopic forceps biopsies were inconclusive, we performed endoscopic submucosal dissection, which resulted in a final pathologic diagnosis of follicular lymphoma. Because of the indolent nature of gastrointestinal follicular lymphoma, the "watch and wait" strategy can be applied in the early phase. The identification of endoscopic characteristics of gastric follicular lymphoma can be helpful for differential diagnosis and decision of treatment strategy. Therefore, we report two cases of primary gastrointestinal follicular lymphoma diagnosed following endoscopic submucosal dissection.

• Clinical and Experimental Reproductive Medicine
• /
• 제18권1호
• /
• pp.13-21
• /
• 1991

To investigate the factors that affect the fertilization and cleavage rates of mature oocytes, 44 patients undergoing controlled ovarian hyperstimulation(COH) with FSH/hMG/hCG regimen for IVF - ET were analyzed. During follicular phase, serum LH levels were measured by radioimmunoassay and bioassay. Based on the mean follicular immunoactive LH(i-LH) and bioactive LH(b-LH) levels, patients were divided into 3 groups, respectively. There were no significant differences in basal serum FSH levels on menstrual cycle day 3, serum estradiol($E_2$) and progesterone ($P_4$) levels on the day of hCG administration, and the numbers of follicles aspirated and oocytes retrieved among groups. In relation to the mean follicular i-LH levels, the fertilization and cleavage rates of mature oocytes did not show a significant difference among groups. However, in groups with higher mean follicular b-LH levels, the fertilization and cleavage rates were reduced significantly. During late follicular phase, day-to-day variance in b-LH levels was not significant, but there was a significant difference among groups. There was no significant correlation between serum P. and b-LH levels. These data suggest that the fertilization and cleavage rates of mature oocytes are adversely affected by the raised mean follicular b-LH levels, and monitoring of serum b-LH levels is more useful in COH when compared with i-LH. It appears that the reduced rates are not due to the attenuated endogenous LH surge.

• 말소리와 음성과학
• /
• 제6권3호
• /
• pp.41-48
• /
• 2014

This study investigated the differences between emotional parameters BDI, VHI, STAI-X-I and STAI-X-II according to the menstrual cycles of the female and the relation between changes of the depression index and voice characteristics (jitter, shimmer, CPP, HNR, $pF0{\cdot}F1{\cdot}F2{\cdot}F3$, sF0, sF4, sB1, $H1_{c/u}$, $A1_u$, $A3_c$, $H1A3_{c/u}$, $H1A1_u$). Twenty three females ($30{\pm}4.4$ years old) living in Seoul and Gyeonggi Province were participated in this study to answer the questionnaires and record their voice. The participants prolonged /a/ vowel for 5 seconds in a natural condition for their voice recording. Voice data were analyzed using the Matlab and Praat program. A t-test and a correlation analysis were conducted by using SPSS for the statistical analysis. The results are as follows. First, the BDI is significantly higher in group I (lurear phase contrast the menstrual period) and group II (follicular phase against the menstrual period) than group III (luteal phase for follicular phase) (p<.05). Second, shimmer, CPP, pF0 showed a statistically high correlation regarding the BDI in group I (lurear phase contrast the menstrual period). Voice parameters may be useful as supplement in evaluating the emotional change in the phase of menstrual cycle.

• 한국의류학회지
• /
• 제25권2호
• /
• pp.287-292
• /
• 2001

This study was conducted to investigate preferred clothing selected by females for thermal comfort in follicular phase (FP) and luteal phase (LP) of the menstrual cycle. Eight healthy college students volunteered as subjects. They stayed for 60 minutes at $25^{\circ}C$, 55%RH (stage 1) for baseline followed by a 60 minute stay at 2$0^{\circ}C$, 55%RH (stage 2) in a climatic chamber. Obtained results were analyzed using paired t-test and repeated measures of ANOVA. Arm and hand skin temperatures were maintained higher in FP than in LP, while mean skin temperature did not show any significant difference between FP and LP. The subjects selected additional clothing faster in FP than in LP. Six of the subjects wore heavier clothing in FP than in LP, while two of them wore heavier in LP than in FP.

• Clinical and Experimental Reproductive Medicine
• /
• 제14권2호
• /
• pp.127-137
• /
• 1987

Steroid hormone profiles during luteal phases after in vitro fertilization(IVF) and embryo transfer(ET) have been evaluated in 83 cycles stimulated by pure follicle-stimulating hormone/human menopausal gonadotropin/human chorionic gonadotropin, in which 13 patients became pregnant. Serum estradiol($E_2$) and progesterone($P_4$) levels were determined on days 2, 5, 7 and 9 after laparoscopic follicle aspiration. The follicular $E_2$ peak was slightly higher in pregnancies than in failures. Positive correlations were observed between the follicular $E_2$ peaks and the $P_4$ levels on days 5 and 7 of the luteal phase in pregnancies, but no correlation was found in failures. The $E_2$ and $P_4$ levels on days 5 and 7 of the luteal phase were significantly higher in pregnancies than in failures, but not different on days 2 and 9. Values of the $P_4/E_2$ ratio were similar between the two groups. The luteal phase durations were 12 to 19 days and no correlation was observed between the lengths of luteal phase and the luteal $E_2$ or $P_4$ concentrations. These data suggest that high $P_4$ levels in the mid-luteal phase, which have positive correlations with the follicular $E_2$ peaks, might have a favorable influence on the pregnancy success in human IVF.

• Clinical and Experimental Reproductive Medicine
• /
• 제23권3호
• /
• pp.277-282
• /
• 1996

Serum inhibin concentrations, determimed by radioimmunoassay, were measured in women undergoing pituitary suppression with Decapeptyl and subsequently ovarian stimulation with Highly Purified-Metrodin(HP-FSH) to appraise follicular development. Early follicular basal serum inhibin level correlated with the number of oocytes retrieved(r=0.89, n=8, p<0.05). The number of oocytes retrieved showed a significant correlation with serum inhibin level on the day of hCG administration(r=0.73, n=8, p<0.05). The number of mature oocytes showed a significant correlation with serum inhibin level on the day of hCG administration(r=0.73, n=8, p<0.05). These data suggest that: (1) In the early follicular phase, basal serum inhibin may be a valid index to predict ensuing follicular growth : (2) In the preovulatory phase, maximum serum inhibin may be one of the indexes of follicular development during hyperstimulation cycles.

• Asian-Australasian Journal of Animal Sciences
• /
• 제13권8호
• /
• pp.1059-1062
• /
• 2000

The objective of the investigation was to study the effect of intramuscular $PGF_2\;{\alpha}$ and GnRH on estrus behavior and ovarian response in Murrah buffalo heifers. Twelve Murrah buffalo heifers at 32 months of age that had not exhibited behavioral estrus symptom were included in the experiment. Out of 12,4 heifers were in follicular phase (plasma estradiol $57.05{\pm}12.52pg/ml$), another 4 heifers were in luteal phase (Plasma progesterone $2.24{\pm}0.25ng/ml$) while the ovaries of remaining four heifers were inactive (estradiol $23.70{\pm}1.66pg/ml$and progesterone $0.32{\pm}0.06ng/ml$). $PGF_2\;{\alpha}$ (25 mg, Lutalyse, im) and GnRH (200 ug, Fertagyl, iv) was administered to each heifer at interval of 10 days. The plasma progesterone concentration decreased within 48 hrs after $PGF_2\;{\alpha}$ injection and followed thereafter with follicular growth, estrus and ovulation. GnRH administration induced follicular growth, elevation of plasma estradiol concentration with subsequent exhibition of behavioral estrus in 2 out of 4 heifers having inactive ovary. The observation reveals that Murrah buffalo heifers at 32 months of age have developed receptors for $PGF_2\;{\alpha}$ and GnRH on ovarian and pituitary tissue respectively and response the single injection of $PGF_2\;{\alpha}$ and GnRH similar to the mature cycling animals.

• 한국식품영양과학회지
• /
• 제34권2호
• /
• pp.190-195
• /
• 2005

본 연구에서는 월경전 불쾌기분장애 그룹과 무증상 그룹으로 나누어 여성 24명을 대상으로4주 동안 식이 섭취량 및 체구성성분이 월경주기에 따라 변화하는지를 알아보고자 하였고 이에 본 결과를 요약하였다. 월경주기에 따른 식이섭취량은 PMDD 그룹과 NPS 그룹에 상관없이 난포기보다 황체기와 생리기에 유의적으로 증가하였으나(p<0.01), 그룹 간에서는 통계적으로 유의한 차이는 나타나지 않았으며, 탄수화물 섭취량은 PMDD 그룹과 NPS 그룹에 상관없이 난포기보다 황체기와 생리기에 유의적으로 증가하였으나(p<0.05), 그룹간에서는 통계적으로 유의한 차이는 나타나지 않았고, 단백질 섭취량은 PMDD 그룹과 NPS 그룹에 상관없이 난포기보다 황체기에 유의적으로 증가하였으나(p<0.01), 그룹간에서는 통계적으로 유의한 차이는 나타나지 않았으며, 지방 섭취량은 PMDD그룹과 NPS그룹에 상관없이 주기 간 차이가 없는 것으로 나타났으며 그룹 간에도 통계적으로 유의한 차이는 나타나지 않았다. 월경주기에 따른 체중은 PMDD그룹과 NPS그룹에 상관없이 난포기보다 황체기와 생리기에서 유의적으로 증가한 것으로 나타났으나(p<0.001), 그룹간에서는 통계적으로 유의한 차이는 나타나지 않았으며, 체수분은 PMDD 그룹과 NPS 그룹에 상관없이 난포기보다 황체기와 생리기에서 유의적으로 증가한 것으로 나타났으나(p<0.05), 그룹 간에서는 통계적으로 유의한 차이는 나타나지 않았다. 체지방량은 PMDD그룹과 NPS 그룹에 상관없이 난포기보다 황체기에서 유의적으로 증가한 것으로 나타났으나(p<0.05), 그룹 간에서는 통계적으로 유의한 차이는 나타나지 않았다. 이와 같은 결과는 여성의 식이섭취량, 혈당 및 체구성성분은 월경주기의 변화에 영향을 받는 것으로 보이며 월경주기에 작용하는 변인과를 관련시켜 월경전증후군의 치료 또는 관리방법에 활용될 수 있을 것으로 사료되며, 앞으로 이에 관한 보다 체계적인 연구가 활발하게 이루어지길 기대한다.

• Reproductive and Developmental Biology
• /
• 제37권3호
• /
• pp.149-154
• /
• 2013

The aim of this study was to evaluate the changes of protein patterns in granulosa cells and corpus luteum in ovaries during the estrus cycle in cows. The estrus cycle was devided into five steps of follicular, ovulatory, early-luteal, mid-luteal and late-luteal phases. In results, 61 spots of total 85 spots were repeated on follicular phase and 51 spots of total 114 spots were repeated on ovulatory phase. The 40 spots of total 129 spots were repeated on early-luteal phase and 49 spots of total 104 spots were repeated on mid-luteal phase. Also 41 spots of total 60 spots were repeated on late-luteal phase. On the other hands, the 16 spots were indicated difference in follicular phase and ovulation phase had a difference 10 spots. It was showed difference No. 103 spot in ovulation phase, No. 135 spot in early-luteal phase and No. 175 and 176 spots in mid-luteal phase. Also, the 11 spots were expressed specifically in mid-luteal phase and No. 178 and 179 spots were difference of expression in late-luteal phase. We confirmed that there were 7 spots for ovulation, 4 spots for luteinization and 2 spots for luteolysis. Spot No. 89~93 in ovulation phase were transferrin, and spot No.94~98 were HSP60. Spot No. 103 was Dusty PK, spot No. 135 was OGDC-E2, and spot No. 175 and 176 were Rab GDI beta from luteinization. Spot No. 178 and 179 in luteolysis were vimentin. This results suggest that will be help to basic data about infertility.