• Environmental and Resource Economics Review
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• v.16 no.3
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• pp.629-641
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• 2007

Chinese government has implemented the West Development Strategy since 1999 to boost the region's growth and prevent the environmental degradation. Until now, the regional economy and living standard in Western China have been greatly improved, while it also indicated by the State Council that the ecological environment still deteriorated with part improvement, and pressure of water shortage increased. The paper focus on the relationship of GDP per capita and the volume of industrial waste water discharge of all the 12 provinces in Western China from 1989 to 2004, by the expanded EKC model in the cubic form. Results show that they mainly have down trend in the whole sample space but small up trend in the recent years. That means controlling of industrial wastewater discharge is still an important task to be insisted in the Western China.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.2 no.3
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• pp.134-142
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• 1990

A wide-angle approximation in the parabolic equation method is presented to calculate wave transformation in the shallow water. The parabolic approximation to the mild-slope equation is obtain-ed by the use of a splitting matrix, which leads to a generalized equation in form. A numerical model based on a finite difference scheme is presented and computational results are provided to test the model against the laboratory measurements of circular and elliptical shoals. The numerical results are in good agreement with most of experimental data. Therefore it can be concluded that the model shows greater capability to reproduce the characteristics of waves in the refractive focus.

• Journal of the Korean Data and Information Science Society
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• v.27 no.5
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• pp.1423-1431
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• 2016

When the sample size in a certain domain is too small to produce adequate information, small area model with random effects is usually used. Also, if we do not consider an inherent pattern which data possess, it considerably affects inference. In this paper, we mainly focus on modeling to handle increased variation of the Current Population Survey (CPS) median income as the Internal Revenue Service (IRS) mean income increases. In a hierarchical Bayesian framework, most estimations are carried out through the Gibbs sampler while the grid method is used to generate parameters from non-standard form. Numerical study indicates that the performance of proposed model is better than that of CPS method in terms of four comparison measurements.

• ETRI Journal
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• v.36 no.4
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• pp.625-634
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• 2014

This paper studies a dual-hop multiple-access relay network where two independent source nodes transmit information to a common destination node with the aid of multiple single-antenna amplify-and-forward relays. Each relay node is subject to an individual power constraint. We focus on the design of distributed beamforming schemes for the relays to support the transmission rate requirements of the two sources. To this end, we first characterize the achievable rate region for this network via solving a sequence of corner point optimization problems proposed in this paper. We also develop several low-complexity suboptimal schemes in closed form. Two inner bounds of the achievable rate region are theoretically shown to be approximately optimal in two special scenarios. Finally, numerical results demonstrate the effectiveness of our proposed approaches.

• Bulletin of the Korean Chemical Society
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• v.28 no.11
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• pp.1902-1909
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• 2007

This account reports an overview of our findings in homogeneous Pd-catalyzed reactions. Herein we describe the new design in reactions of Group 14 element compounds and in homogeneous nanosize Pd catalysts. In the early stages of our study, we developed Pd-catalyzed transformations of allylic esters with disilanes, silylcyanides and acylsilanes to the corresponding silylation, cyanation and acylation products, respectively. We also developed a Pd-catalyzed three component coupling reaction of Group 14 element compounds involving 1,3-diene and acid chlorides to form β,γ-unsaturated ketone as a single product. Recently, we focus our attention on modifying the catalytic environment by nanosize Pd in order to improve the performance of Pd catalysts. These nanosystems realize efficient catalytic environment with remarkable enhancement in catalytic activity and unprecedented selectivity.

• Speech Sciences
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• v.1
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• pp.39-53
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• 1997

As the segmental phonetic output is derived from its underlying form, the phonetic surface of intonation could also be derived from its underlying tone melody. In order to show clearly the phonological processes (in fact, we need more than just phonological processes) involved in the generation of intonational surface, we need to formalize the description of those processes. This paper firstly examines different types of sentence-final intonation contour in Korean, and then attempt to formalize the intonational behavior of those contours. In this attempt, we will investigate what kinds of linguistic information participate in deciding the shapes of the. contours and what kinds of tonological processes the underlying tone melody undergoes before it takes the surface shape. In this analysis of intonation contours, we focus on the linguistic structure rather than the acoustic property, adopting just two tones L and H as phonological tones, with four phonetic pitches.

• Journal of the Korean Institute of Landscape Architecture International Edition
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• no.1
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• pp.183-191
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• 2001

The purpose of this study is to provide guidelines for planning, designing and managing neighborhood parks. Results form POE(Post-Occupancy-Evaluation) and RPOE(Re-Post-Occupancy-Evaluation) are analyzed for this study. Bundang Central Park in Bundang Newtown was selected for this study. This study compared the previous POE completed in 1996 with a RPOE conducted in 2001 to find out how the user, proximate environmental context, and the park administration changed in time and apply feedback for purposes of immediate problem solving. The results of this study showed that RPOE has to be initiated and utilized periodically as a device and the guideline for neighborhood park design, conservation, administration and operation.

• Journal of Korean Neurosurgical Society
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• v.64 no.3
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• pp.367-373
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• 2021

Secondary neurulation (SN) is a critical process to form the neural tube in the posterior region of the body including the tail. SN is distinct from the anteriorly occurring primary neurulation (PN); whereas the PN proceeds by folding an epithelial neural plate, SN precursors arise from a specified epiblast by epithelial-to-mesenchymal transition (EMT), and undergo self-renewal in the tail bud. They finally differentiate into the neural tube through mesenchymal-to-epithelial transition (MET). We here overview recent progresses in the studies of SN with a particular focus on the regulation of cell lineage, self-renewal, and EMT/MET. Cellular mechanisms underlying SN help to understand the functional diversity of the tail in vertebrates.

• Journal of Industrial Technology
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• v.42 no.1
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• pp.29-36
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• 2022

The CRISPR system has revolutionized gene editing field. Cas9-mediated gene editing such as Indel induction or HDR enable targeted gene disruption or precise correction of mutation. Moreover, CRISPR-based new editing tools have been developed such as base editors. In this review, we focus on gene editing in human pluripotent stem cells, which is principal technique for gene correction therapy and disease modeling. Pluripotent stem cell-specific drug YM155 enabled selection of target gene-edited pluripotent stem cells. Also, we discussed base editing for treatment of congenital retina disease. Adenine base editor delivery as RNP form provide an approach for genetic disease treatment with safe and precise in vivo gene correction.

• BMB Reports
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• v.56 no.4
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• pp.225-233
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• 2023

Hepatocellular carcinoma (HCC) is a very common form of cancer worldwide and is often fatal. Although the histopathology of HCC is characterized by metabolic pathophysiology, fibrosis, and cirrhosis, the focus of treatment has been on eliminating HCC. Recently, three-dimensional (3D) multicellular hepatic spheroid (MCHS) models have provided a) new therapeutic strategies for progressive fibrotic liver diseases, such as antifibrotic and anti-inflammatory drugs, b) molecular targets, and c) treatments for metabolic dysregulation. MCHS models provide a potent anti-cancer tool because they can mimic a) tumor complexity and heterogeneity, b) the 3D context of tumor cells, and c) the gradients of physiological parameters that are characteristic of tumors in vivo. However, the information provided by an multicelluar tumor spheroid (MCTS) model must always be considered in the context of tumors in vivo. This mini-review summarizes what is known about tumor HCC heterogeneity and complexity and the advances provided by MCHS models for innovations in drug development to combat liver diseases.