• The Journal of Korean Medicine
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• v.23 no.3
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• pp.63-73
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• 2002

Objective : This study aimed to investigate the effects Samyoo-tang Extract (SE) on the vascular systems, including changes in blood pressure and regional cerebral blood flow (rCBF), of male Sprague-Dawley rats. Methods : The changes in rCBF were determined by Laser-Doppler flowmetry through the opened cranial method and norepinephrine (NE)-induced blood vessel contractions were determined by physiograph in the pulmonary artery of isolated rabbits. Results and Conclusion : 1. Contractions evoked by NE ($ED_{50}$) were inhibited significantly by SE in the pulmonary artery. 2. SE inhibited the relaxation of NE induced contractions pretreated with propranolol. 3. SE did not inhibit the relaxation of NE induced contractions pretreated with ODQ and L-NNA. 4. Blood pressure was not affected by SE in rats. 5. rCBF was increased by SE in a dose-dependent manner. 6. Pretreatment with propranolol was increased by SE in a dose-dependent manner in blond pressure. 7. Pretreatment with methylene blue, ODQ and L-NNA did not inhibit SE induced increased in rCBF. These results indicate that SE can relax NE-induced contraction of rabbit blood vessels and increased the changes of rCBF in rats, that relate to the sympathetic nerve system.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.12
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• pp.1716-1723
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• 2003

A stereoscopic PIV(Particle Image Velocimetry) technique was employed to measure the 3 dimensional flow structure of turbulent wake behind a marine propeller with 5 blades. The out-of-plane velocity component was determined using two CCD cameras with the angular displacement configuration. Four hundred instantaneous velocity fields were measured for each of four different blade phases and ensemble averaged to investigate the spatial evolution of the propeller wake in the near-wake region from the trailing edge to one propeller diameter(D) downstream. The phase-averaged velocity fields show the potential wake and the viscous wake developed along the blade surfaces. Tip vortices were generated periodically and the slipstream contraction occurs in the near-wake region. The out-of-plane velocity component and strain rate have large values at the locations of tip and trailing vortices. As the flow goes downstream, the turbulence intensity, the strength of tip vortices and the magnitude of out-of-plane velocity component at trailing vortices are decreased due to viscous dissipation, turbulence diffusion and blade-to-blade interaction.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1864-1869
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• 2003

A novel piezoelectric micropump using active check valves in place of conventional passive check valves in inlet and outlet has been proposed and investigated. It actively controls open/close motion of check valves using piezoelectric actuator for expansion/contraction of pump chamber. In this paper, bi-directional flow characteristics and load characteristics are experimentally investigated using an adequate timing control for valve closing motion with a prototype micropump fabricated with the effective size of $17{\times}8{\times}11mm^{3}$. From the experimental results, it is ascertained that optimal values of phase shift against voltage to drive pump chamber for realization of a miniaturized but powerful micropump, are $15^{\circ}$ in inlet check valve and $195^{\circ}$ in outlet. Based on the obtained results, a sheet-type active shuttle valve that has a unified valve-body for inlet and outlet check valves is proposed. A micropump with the effective size of $10{\times}10{\times}10mm^{3}$ is fabricated and basic characteristics are experimentally investigated.

• Journal of the Korean Society of Propulsion Engineers
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• v.10 no.1
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• pp.23-29
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• 2006

In an annular injection supersonic ejector, the supersonic primary flow is injected along the side wall, therefore a funnel-shaped shock wave is generated by the contraction angle of the mixing chamber. In the present study, we developed a simple funnel shock wave model using 2-D wedge and conical shock wave relations. In result, the secondary flow pressure can be predicted more accurately than using a simple 2-D wedge shock wave model. Through the same analysis, the compression ratio and the adiabatic efficiency according to the entrainment ratio were calculated.

• Journal of Biomedical Engineering Research
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• v.17 no.1
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• pp.43-48
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• 1996

We investigated the energistics of the physiological heart model by comparing predictive indexes of the myocardial oxygen consumption (MOC), such as tension-time index (R), tension-time or force-time inteual (FTI), rate-pressure product (RPP), pressure-work index, and systolic pressure-volume area (PVA) when using the electro-hydraulic left ventricular device (LVAD). We developed the model of LVAD incorporated the closed-loop cardiovascular system with a baroreceptor which can control heart rate and time-varying elastance of left and right ventricles. On considering the benefit of the LVAD, the effects of various operation modes, especially timing of assistance, were evaluated using this coupled computer model. Overall results of the computer simulation shows that our LVAD can unload the ischemic (less contractile) heart by decreasing the MU and increasing coronary flow. Because the pump ejection at the end diastolic phase of the natural heart may increase the afterload of the left ventricle, the control scheme of our LVAD must prohibit ejecting at this time. Since the increment of coronary flow is proportional to the peak aortic pressure after ventricle contraction, the LVAD must eject immediately following the closure of the aortic valve to increase oxygen availability.

• Journal of Surface Science and Engineering
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• v.33 no.5
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• pp.373-380
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• 2000

The flow melting behavior of the electrolytic tinplate during reflow treatment was investigated in terms of morphology and structure of coating layers which were electrodeposited with variation of electrolyte temperature. It was commonly found that the nucleation density of the electrodeposits showed little difference with the electrolyte temperature, and the growth of electrodeposited tin occurred along <100> direction of (002) plane. At low electrolyte temperature, the (002) plane of tin nucleated paralleling to the substrate and grew perpendicularly to the substrate, which rendered porous rod-like deposits. With increasing the temperature, the (002) plane nucleated declining $15^{\circ}$ to the substrate and also grew to the normal <100> direction, which enabled lateral growth of the tin crystals and rendered compact deposits. During reflow treatment, the matte deposit transformed to the reflowed state via transition regions consisted of contraction, island formation, and wetting . The matte deposits formed at low temperature exhibited wide transition regions because of poor thermal transfer between crystals due to their porous nature. While that formed at high temperature transformed very rapidly to the reflowed state by enhanced thermal transfer between the compact crystals.

• International Journal of Naval Architecture and Ocean Engineering
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• v.7 no.3
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• pp.595-609
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• 2015

The wake characteristics of Contra-Rotating Propeller (CRP) were investigated using numerical simulation and flow measurement. The numerical simulation was carried out with a commercial CFD code based on a Reynolds Averaged Navier-Stokes (RANS) equations solver, and the flow measurement was performed with Stereoscopic Particle Image Velocimetry (SPIV) system. The simulation results were validated through the comparison with the experiment results measured around the leading edge of rudder to investigate the effect of propeller operation under the conditions without propeller, with forward propeller alone, and with both forward and aft propellers. The evolution of CRP wake was analyzed through velocity and vorticity contours on three transverse planes and one longitudinal plane based on CFD results. The trajectories of propeller tip vortex core in the cases with and without aft propeller were also compared, and larger wake contraction with CRP was confirmed.

• International Journal of Fluid Machinery and Systems
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• v.3 no.2
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• pp.113-121
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• 2010

LES(Large Eddy Simulation) with a cavitation model was performed to calculate an unsteady flow for a mixed flow pump with a closed type impeller. First, the comparison between the numerical and experimental results was done to evaluate a computational accuracy. Second, the torque acting on the blade was calculated by simulation to investigate how the cavitation caused the fluctuation of torque. The absolute pressure around the leading edge on the suction side of blade surface had positive impulsive peaks in both the numerical and experimental results. The simulation showed that those peaks were caused by the cavitaion which contracted and vanished around the leading edge. The absolute pressure was predicted by simulation with -10% error. The absolute pressure around the trailing edge on the suction side of blade surface had no impulsive peaks in both the numerical and experimental results, because the absolute pressure was 100 times higher than the saturated vapor pressure. The simulation results showed that the cavitation was generated around the throat, then contracted and finally vanished. The simulated pump had five throats and cavitation behaviors such as contraction and vanishing around five throats were different from each other. For instance, the cavitations around those five throats were not vanished at the same time. When the cavitation was contracted and finally vanished, the absolute pressure on the blade surface was increased. When the cavitation was contracted around the throat located on the pressure side of blade surface, the pressure became high on the pressure side of blade surface. It caused the 1.4 times higher impulsive peak in the torque than the averaged value. On the other hand, when the cavitation was contracted around the throat located on the suction side of blade surface, the pressure became high on the suction side of blade surface. It caused the 0.4 times lower impulsive peak in the torque than the averaged value. The cavitation around the throat caused the large fluctuation in torque acting on the blade.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.6
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• pp.809-816
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• 1997

The present study was designed to investigate whether endogenous nitric oxide(EDNO) is involved in submandibular vasodilation and salivation induced by parasympathetic nerve stimulation. Effects of $N^w$-nitro-L-arginine-methyl ester (L-NAME) which blocks the synthesis of EDNO from L-arginine on the submandibular vasodilation and salivation induced by chords stimulation or administration of various vasodilators were examined in anesthetized cats. Effect of L-NAME on $K^+$ efflux induced by carbachol was also examined using the excised submandibular slice in vitro. In the submandibular slices, acetylcholine$(10^{-5}\;mol/L)$ or vasoactive intestinal polypeptide$(VIP,\;10^{-5}\;mol/L)$ increased $NO_2$ contents, which was Prevented by pretreatment with L-NAME. Salivary secretion in response to the chords stimulation$(3\;V,\;1\;msec,\;10{\sim}20\;Hz)$ was completely blocked by treatment with atropine(1 mg/kg). Increased blood flow response to the low frequency(1, 2, 5 Hz) stimulation was significantly reduced, whereas the blood flow induced by the higher frequency(10,20 Hz) stimulation was not affected. Lingual-arterial infusion of L-NAME(100 mg/kg) significantly diminished the vasodilatory and salivary responses to the chorda stimulation at all stimuli frequencies used. Intra-arterial infusion of L-NAME(100 mg/kg markedly diminished the vasodilatory responses to acetylcholine$(5\;{\mu}g/kg)$, VIP$(5\;{\mu}g/kg)$ or bradykinin$(5\;{\mu}g/kg)$. In the excised submandibular slice, $K^+$ efflux in response to carbachol$(10^{-5}\;mol/L)$ was significantly decrease by pretreatment with L-NAME$(10^{-5}\;mol/L)$. In the isolated submandibular artery precontracted with phenylephrine$(10^{-5}\;mol/L)$, the vasorelaxation induced by ACh$(10^{-7}\;mol/L)$ was reversed into a contraction by methylene blue$(10^{-4}\;mol/L)$. These results suggest that EDNO may play an important role in vasodilation and secretion of the submandibular gland.

• Journal of the Korea Convergence Society
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• v.6 no.3
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• pp.13-18
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• 2015

This paper is the study on the safe design of joint controling the pressure and temperature by connecting between pipes laying with the flexible joint. This study aims at decreasing the excessive pressure applied in the pipe and preventing the accident occurrence in order to solve the pipe damage by extraction and contraction due to the pressure of open air and transport gas. The flow properties of each model are investigated through the simulation analysis by applying three kinds of the flexible joints. When transport gas passes the flexible joint, the flow characteristics of heat, pressure and velocity at pipe laying are analyzed. It is thought to be contributed to the safe design due to the shape of the flexible joint by using the result of this study. And it is possible to be grafted onto the convergence technique at design and show the esthetic sense.