• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 12th Asian Congress of Fluid Mechanics
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• pp.43.2-43.2
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• 2008

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1994년도 춘계공동학술대회논문집; 창원대학교; 08월 09일 Apr. 1994
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• pp.478-478
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• 1994

• 한국막학회:학술대회논문집
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• 한국막학회 2001년도 추계 총회 및 학술발표회(한국막학회)
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• pp.146-148
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• 2001

• 생명과학회지
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• 제19권5호
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• pp.620-624
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• 2009

동면 개시인자로 알려진 DADLE는 여러 연구에 의해 in vivo와 in vitro 상에서 유사 동면 상태를 야기한다. 본 연구는 인체혈구암세포인 U937 세포주의 세포 사멸과 세포 주기 둥에 대한 DADLE의 영향을 살펴보았다. DADLE가 처리된 U937세포는 8${\sim}6$10 ${\mu}$M의 높은 농도에서 세포 증식이 감소하였으며, 0${\sim}6$ ${\mu}$M의 낮은 농도에서 영향이 없었다. DNA flow cytometer를 이용하여 세포 주기를 분석해본 결과 DADLE에 의한 세포 주기 억제가 관찰되었다. DADLE처리에 따른 세포 증식률 감소 및 세포 주기 억제효과를 전사 수준에서 조사한 결과 Bcl-XL, c-IAP-2의 발현 및 survivin의 발현 감소가 관찰되었으며, COX-2의 발현 역시 COX-1의 변화 없이 감소함을 확인하였다. 또한, cyclin E 와 cdk-2, -4 그리고 -6의 발현 역시 감소하는 것을 관찰하였다. Telomere 조절 관련 유전자의 경우도 c-myc과 TERT의 감소, 그리고 TEP-1가 증가하는 현상을 관찰하였다. 이상의 결과는 DADLE를 U937 암세포주에 처리했을 때 세포 주기의 억제를 통하여 life-time을 증가시킬 가능성을 시사하며 이에 관한 지속적인 연구가 필요할 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8419-8423
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• 2016

Purpose: Anti-cancer activity evaluation of aqueous extract of CRUEL (herbomineral formulation) capsules on renal cell carcinoma cell lines, and exploration of mechanisms of cell death. Materials and Methods: To detect the cytotoxic dose concentration in renal cell carcinoma (RCC) cells, MTT assays were performed and morphological changes after treatment were observed by inverted microscopy. Drug effects against RCC cell lines were assessed with reference to cell cycle distribution (flow cytometry), anti-metastatic potential (wound healing assay) and autophagy(RT-PCR). Results: CRUEL showed anti-proliferative effects against RCC tumor cell lines with an IC50 value of ${\approx}4mg/mL$ in vitro., while inducing cell cycle arrest at S-phase of cell cycle and inhibiting wound healing. LC3 was found to be up-regulated after drug treatment in RT-PCR resulting in an autophagy mode of cell death. Conclusions: This study provides the experimental validation for antitumor activity of CRUEL.

• 대한세포병리학회지
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• 제8권1호
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• pp.20-26
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• 1997

The specificity of cytologic examination in effusions is high but the sensitivity is low. Therefore, various ancillary methods for the detection of malignant cells in effusions have been proposed. The presence of an aneuploid cell population is generally considered diagnostic of malignancy. The purpose of this study is to determine whether the routine use of flow cytometry adds to standard cytologic evaluation in effusions. We did flow cytometric DNA analysis in 76 effusions(28 malignant and 48 benign fluids). All the 48 benign effusions were diploid. There were 12(42.9%) aneuploid and 16(67.1%) diploid malignant effusions. Based on these results flow cytometric DNA analysis had a sensitivity of 42.9% and a specificity of 100%. These results suggest that flow cytometric DNA analysis may be a useful adjunct to conventional cytology, but its principal limitation is us relatively low sensitivity.

• 한국대기환경학회지
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• 제19권6호
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• pp.733-743
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• 2003

The flow field in multiple fluid sphere systems was studied analytically. The expanded zero vorticity cell model based on Kuwabara's theory (1959) was applied and the effects of gas slippage at the collecting surface were considered. Also, the solid sphere system was extended to fluid sphere including the effects of the induced internal circulation inside the liquid droplet spheres or gas bubble systems. As a result, the obtained analytic solution was converged to the existing solutions for flow field around solid and bubble sphere systems with proper boundary conditions. Based on the resolved flow field, the terminal velocity around the collecting fluid spheres was obtained. Subsequently, this study evaluated the most general solution for flow field around the multiple fluid sphere systems. The obtained flow field in multiple fluid sphere could be used as a fundamental consideration of wet scrubber design and devices for removing particles by fluid-fluid interactions.

• 한국해양공학회지
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• 제6권2호
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• pp.143-150
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• 1992

Numerical simulation is made of a stably stratified salt-water solution due to lateral heating in an equilateral trapezoidal enclosure using boundary-fitted coordinate in grid generation. Results show four types of the global fluid pattern depending on the buoyancy ratio in the enclosure, i.e., unicell flow pattern for the low buoyancy ratio, layered flow pattern for the increasing buoyancy ratio, layered flow pattern with stagnant zone for the relatively high buoyancy ratio and stagnant flow pattern for the much higher buoyancy ratio.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2006년도 추계학술대회
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• pp.320-323
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• 2006

A numerical study is made of a manifold and bipolar plate in polymer electrolyte fuel cells, the aim of the present study is to describe the characteristics of flow pattern In manifold and bipolar plate. The present work shows that the flow pattern in the bipolar plate is affected by the penetration flow through GDL characterized by clamping pressure and GDL intrusion in to a channel area. Manifold geometry also affects the flow distribution. The recirculation flow by bent duct destroy even distribution In manifold, the present work shows that corner rounding can improve the manifold performance.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.597-600
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• 2002

In general, the function of intake structure, whether it be a open channel, a fully wetted tunnel, a sump or a tank, is to supply an evenly distributed flow to a pump station. An even distribution of flow, characterized by strong local flow, can result in formation of surface or submerged vortices, and with certain low values of submergence, may introduce air into pump, causing a reduction of capacity and efficiency, an increase in vibration and additional noise. Uneven flow distribution can also increase or decrease the power consumption with a change in total developed head. To avoid these sump problems pump station designers are considered intake structure dimensions, such as approaching upstream, baffle size, sump width, width of pump cell and so on. From this background, flow characteristics of intake within sump are Investigated numerically to obtain the optimal sump design data. The sump model is designed in accordance with HI code.