• BMB Reports
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• 제41권1호
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• pp.11-22
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• 2008

Apoptosis (programmed cell death) is a cellular self-destruction mechanism that is essential for a variety of biological events, such as developmental sculpturing, tissue homeostasis, and the removal of unwanted cells. Mitochondria play a crucial role in regulating cell death. $Ca^{2+}$ has long been recognized as a participant in apoptotic pathways. Mitochondria are known to modulate and synchronize $Ca^{2+}$ signaling. Massive accumulation of $Ca^{2+}$ in the mitochondria leads to apoptosis. The $Ca^{2+}$ dynamics of ER and mitochondria appear to be modulated by the Bcl-2 family proteins, key factors involved in apoptosis. The number and morphology of mitochondria are precisely controlled through mitochondrial fusion and fission process by numerous mitochondria-shaping proteins. Mitochondrial fission accompanies apoptotic cell death and appears to be important for progression of the apoptotic pathway. Here, we highlight and discuss the role of mitochondrial calcium handling and mitochondrial fusion and fission machinery in apoptosis.

• Journal of applied mathematics & informatics
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• 제42권1호
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• pp.213-221
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• 2024

A family of sixth-order multiple-root solver have been developed and the special case of weight function is investigated. The dynamical analysis of selected iterative schemes with uniparametric polynomial weight function are studied using Möbius conjugacy map applied to the form ((z - A)(z - B))^m and the stability surfaces of the strange fixed points for the conjugacy map are displayed. The numerical results are shown through various parameter spaces.

• Molecules and Cells
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• 제37권12호
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• pp.851-856
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• 2014

ATAD2, a remarkably conserved, yet poorly characterized factor is found upregulated and associated with poor prognosis in a variety of independent cancers in human. Studies conducted on the yeast Saccharomyces cerevisiae ATAD2 homologue, Yta7, are now indicating that the members of this family may primarily be regulators of chromatin dynamics and that their action on gene expression could only be one facet of their general activity. In this review, we present an overview of the literature on Yta7 and discuss the possibility of translating these findings into other organisms to further define the involvement of ATAD2 and other members of its family in regulating chromatin structure and function both in normal and pathological situations.

• 건축역사연구
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• 제27권2호
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• pp.17-28
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• 2018

This study explores the space and society of Seorin-bang(瑞麟坊), using the Hanseong-bu family registry from the Gwangmu period to demonstrate the urban organizational units used during the late Joseon dynasty known as Seo(署)-Bang(坊)-Gye(契)-Dong(洞)-Tong(統)-Ho(戶). It seeks to examine how Seorin-bang's space and society changed with time. First, the study offers approximate demarcation for Gye and Dong through spatial verification of Bang-Gye-Dong-Tong-Ho of Seorin-bang in late Joseon Dynasty, whose precise locations were formerly undetermined. Second, it explores the relationships between Bang-Gye-Dong-Tong-Ho which has been widely understood to be hierarchical by previous studies, and classifies the relationship dynamics between Gye and Dong into four types. Third, the study finds that Seorin-bang retained much of its urban structure including roads, plots, and streams and maintained stable population distribution under the Japanese colonial rule, and continuously served as place of residency for many throughout the Gwangmu period. This study has major implications in that it illustrates space and society of Seorin-bang by converting the family registry from the late Joseon Dynasty into spatial data, and observes its changes subsequent to the Japanese colonial rule.

• 한국가족관계학회지
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• 제23권3호
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• pp.51-76
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• 2018

Objectives: This study was to examine literature on postdivorce partnership focused on cohabiting & Living Apart Together(LAT) and prospect postdivorce partnership in Korea in the near future. Method: For this study, domestic and foreign literature were reviewed especially on recent studies on living apart together(LAT). Results: Reviewed overseas studies showed that studies on cohabitation and Living Apart Together(LAT) were increased and prevalent in the divorced as an alternative marriage type following divorce partnership and many research have been proceeded on definition and classification and dynamics in those relationships. Especially studies are on the rise recently on LAT with importance demographically and academically among middle and older people. In comparison to overseas studies, very little research on partnership following divorce, especially on LAT in Korea. Conclusion: Considering increasing divorce rate rapidly in the milddle aged in Korea, it is expected that LAT following divorce might be emerged in the divorced in Korea. Therefore, it is needed to pay a lot of attention to cohabitation following divorce and Living Apart Together(LAT) as a postdivorce partnership and as an alternative type of marriage and to be treated as a significant phenomenon socially and academically.

• 천문학회보
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• 제46권2호
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• pp.48.1-48.1
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• 2021

The Main-belt asteroid (298) Baptistina (hereafter 'Baptistina') is regarded as an X- (or C-) type asteroid and the largest member of the Baptistina asteroid family. Its basic physical properties play an important role in understanding the rotational evolution and orbital dynamics of the Baptistina family. In this study, we determined the physical characteristics of Baptistina from the optical observations. We conducted BVRI and R band photometric observations from 2017 to 2021 for a total of 47 nights using the 0.5 - 2.0 m-class telescopes. As a result, the color indices of Baptistina were derived as, , and ; this result is consistent with the previous classification of Baptistina as an X- (or C-) type. We also determined absolute magnitude () and slope parameter () by using a simplified version of the IAU H & G function (Bowell et al. 1989) are mag and respectively. We calculated the effective radius of Baptistina of km considering the visual geometric albedo of 0.131 from the NEOWISE data. Using the light-curve inversion method, the sidereal rotation period of 16.224235 h and the 3D shape model with a pole orientation (,) were also determined. In this presentation we will introduce our observations and results, and also discuss about the physical properties of Baptistina asteroid family members such as color indices.

• 가족자원경영과 정책
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• 제14권3호
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• pp.69-85
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• 2010

The purpose of this study is to investigate the home-health-care workers licensing education course in Seoul, Korea. Based on the previous research, a conceptual model was suggested explaining the dynamics of perceived educational service quality (SERVQUAL), educational satisfaction and the occupational readiness. The data set for this study drawn from the 297 self-administered surveys were analyzed with the suggested conceptual model by utilizing AMOS program. The measurement models and conceptual model fit well with the collected data set. As results of this study, 5 domains of SERVQUAL were produced including accountability, trustiness, responsiveness, sympathy, and assurance. The results of structural modeling with latent variables confirmed that SERVQUAL were influenced perceived educational satisfaction as well as occupational readiness. Among the SERVQUAL domains, accountability, trustiness, responsiveness, and assurance had significant impacts on the educational satisfaction while accountability, trustiness and responsiveness had significant direct effects on the occupational readiness. The trustiness had significant indirect effects on the occupational readiness via the educational satisfaction. Hence, the educational satisfaction had the significant impacts on the occupational readiness. Based on the findings of this study, we suggest to intense the educational program or curricular focusing on the SERVQUAL elements. Those changes will enhance self-confidence among the prospective home-health-care workers as well as public trustiness on the national long-term care program.

• 가족자원경영과 정책
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• 제15권3호
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• pp.131-151
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• 2011

This study attempted to estimate the level of perceived lack of time in Korean society, to link it to time management and to identify the possible association that accounts for time shortage. I employed the gender perspective in order to reveal the dynamics and complexity of the perception of a lack of time in the population. The sample for the study was drawn from the 1999 and 2009 Korean time diary data collected by the Korean National Statistical Office. From the original data, I selected a sample of second shift families(men and women who are presently working and raising children) living in metropolitan areas(including Seoul and six major urban areas in Korea). The dependent variable was time pressure measured by a single-item question on a four-point likert scale. The results of the study showed that working mothers perceived a greater time shortage as compared to working fathers. The time use pattern showed change during the periods, indicating that people worked fewer hours in paid labor and enjoyed more leisure hours and personal care hours. However, on average, people seemed to have experienced a greater time lack in 2009 as compared to 1999. The results from the ordered logistic regression model revealed that even though there were similarities in the impact of relevant factors, men's perception of a lack of time was more closely linked with their work role and social status, while for women, this perception was influenced by work and family duties. This indicates that Korean working mothers and fathers are facing a double jeopardy of time shortage in terms of combining their work and family roles. As a result, the level of time pressure by gender is converging toward a "never enough" phase. These findings generated policy implications and detailed suggestions.

• 대한가정학회지
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• 제39권1호
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• pp.151-167
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• 2001

This study tests the path model which examines how the variables of past and present family dynamics, school adjustment, filed life events affect the adolescents'depression which in tum influencing their suicidal ideation. In the path model, the exogenous varialbes were negative parenting experience in childhood, maladjustment history of the family (e.g., alcohol, divorce), present parent-adolesecent communication, school adjustment, filed life events were used, whereas the adolescent depression was used as the mediated variable. The endogenous variable was the adolescent suicidal ideation. The respondents of the survey were 635 adolescent who were 1st and 2nd grade of high school located in Seoul and Busan. Using SPSS for Windows, the path analysis was done for male and female adolescents separately, since female adolescents were found to report significantly higher degree of depression and suicidal ideation then were male adolescents. The results of the path analysis were as followings. First, for both the male and female adolescents, depression was the strongest predictor of their suicidal ideation. Also, school adjustment strongly affected the adolescents'depression as well as their suicidal ideation. Meanwhile, filed life events indirectly influenced the suicidal ideation only through the depression. Second, for the male adolescents, negative parenting experience in childhood affected both the depression and suicidal ideation, while the parent-adolescent communication directly affected the suicidal ideation. Third, for the female adolescents, maladjustment family history and negative parenting experience did not affect their depression, but the suicidal ideation. Meanwhile, parent-adolescent communication was a significant predictor of female adolescents'suicidal ideation as well as their depression. In conclusion, discussion on different path of male and female adolescents'suicidal ideation was provided.

• 한국가족관계학회지
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• 제22권3호
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• pp.131-153
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• 2017

Objective: This study aimed to examine the effects of adult children's marriage-delay on their parents' mental health. Furthermore, this study investigated how the influence of adult children's marriage-delay on parents' mental health could vary depending on the coresidence and employment status of the marriage-delayed adult children. Method: Two waves of Korean Longitudinal Study of Ageing (KLoSA) were used for the analyses. Multiple regression models were conducted with 2,938 Korean parents who had at least one child, regardless of gender (aged 33~44). Results: First, adult children's marriage-delay was related to lower levels of parents' life satisfaction. Second, the levels of parents' life satisfaction were low regardless of residing with their marriage-delayed adult children, and the parents who were not living with their marriage-delayed adult children showed lower levels of life satisfaction than parents living with marriage-delayed adult children. Third, only the parents with unemployed marriage-delayed adult children showed significantly higher levels of depression. However, the levels of parents' life satisfaction were low regardless of the employment of marriage-delayed adult children, and the parents of unemployed marriage-delayed adult children showed lower levels of life satisfaction than the parents of employed marriage-delayed adult children. Conclusions: It is necessary to consider the effects of marriage, employment and coresidence of adult children on their parents in order to enhance the mental health of the parents. Also, the effects of marriage-delay on intimate relationships, such as family dynamics, need to be explored more in further research.