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Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients

  • Kim, Shin-Hyuk;Ahn, Byung-Kyu;Nam, Young-Su;Pyo, Joo-Youn;Oh, Young-Ha;Lee, Kang-Hong
    • Journal of Gastric Cancer
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    • v.10 no.4
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    • pp.149-154
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    • 2010
  • Purpose: Replication error is an important mechanism in carcinogenesis. The microsatellite instability (MSI-H) of colorectal cancers is associated with the development of multiple cancers. The influence of MSI-H on the development of multiple gastric cancers in sporadic gastric cancer patients has not been defined. This study was performed to reveal the association between the clinicopathologic features and MSI in sporadic gastric cancers. Materials and Methods: Between July 2004 and March 2009, the clinicopathologic characteristics, including MSI status, were evaluated in 128 consecutive patients with sporadic gastric cancers. None of the patients had hereditary non-polyposis colorectal cancer of familial gastric cancer. The markers that were recommended by the NCI to determine the MSI status for colorectal cancers were used Results: MSI-H cancers were found in 10.9% of the patients (14/128). Synchronous gastric cancers were shown in 4 patients (3.1%). Synchronous cancers were found in 2 of 14 patients with MSI-H gastric cancer (14.3%) and 2 of 114 patients with MSS gastric cancer (1.8%; P=0.059, Fisher's exact test). Among the patients with synchronous cancer 50% (2/4) had MSI-H cancer, but 9.7% of the patients (12/124) without synchronous cancer had MSI-H cancer. MSI-H (RR, 24.7; 95% CI, 1.5~398.9; P=0.024) was related with to synchronous gastric cancer, but age, gender, family history, histologic type, location, gross morphology, size, and stage were not related to synchronous gastric cancer. Conclusions: MSI is associated with the intestinal-type gastric cancer and the presence of multiple gastric cancers in patients with sporadic gastric cancer. Special attention to the presence of synchronous and the development of metachronous multiple cancer in patients with MSI-H gastric cancer is needed.

VERIFICATION OF DATES IN THE CALENDAR SHEET (年曆張) FOR THE 31ST YEAR OF THE REIGN OF KING GOJONG (1894) (고종 31년(1894) 연력장(年曆張)의 역일 검증)

  • BAHK, UHN MEE;MIHN, BYEONG-HEE;LEE, KI-WON;KIM, YONG GI
    • Publications of The Korean Astronomical Society
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    • v.35 no.1
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    • pp.1-16
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    • 2020
  • We report a calendar sheet for the 31st year of the reign of King Gojong (1894) (hereafter, calendar sheet 1894) in Korea, which calendrical data in a single page. This calendar sheet 1894 is composed of 14 rows by 14 columns (about 190 cells), and various calendrical data are recorded such as the sexagenary circle of the first day in each month, 24 solar terms, full moon day. In this paper, we compare calendrical data of 1894 calendar sheet with those of the almanac based on the Shixian calendar (hereafter, annual almanac) of the same year. Our findings are as follows. First, we find that the year is expressed using the reign-year of the king of the Joseon dynasty differently from using the reign-style of China in the annual almanac those times. Other calendar days of this calendar sheet are the same as those of the annual almanac in term of lunar dates, 24 solar terms, sexagenary days and so forth. Second, we find that the calendar sheet 1894 contains memorial days for 64 lineally ancestors of the Joseon royal family. These royal memorial days appears in the annual almanac two years later (i.e., 1896). Third, as the most distinctive feature, we find that the symbol of 工 kept every two cells. It was found that the cells can be filled with three days as the maximum number of days and then are labelled the same symbol 工 every second cell. This feature allows us to get the first year in which this kind of calendar sheet was published. It is conjectured one of 11 years, such as 1845, 1846, 1847, 1873, 1874, 1875, 1876, 1877, 1878, 1879 or 1880. We also think that the format of the calendar sheet 1894 has influenced on the Daehan-Minryeok (Korean civil calendar sheet) of 1920.

Three Cases of Chronic Adult Atopic Dermatitis (만성 성인형 아토피 피부염의 한방 치험 3례)

  • Ku, Young-Hui;Choi, In-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.15 no.1
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    • pp.140-150
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    • 2002
  • Introduction: Atopic dermatitis is chronic eczematous dermatosis which is related strongly to a family history of atopic disease and hereditary disposition. Its threshold of itching is low so that severe itching occurs and causes secondary eczema. Adult atopic dermatitis has mostly severe symptoms and progresses to chronic relapsing. Objective: The purpose of this study was to estimate the efficacy of oriental medical treatment and management on chronic adult atopic dermatitis. Subject: We studied 3 patients who visited Dongguk University Gangnam Oriental Hospital Dept. of Dermatol. with chronic adult atopic dermatitis from August 2001 to April 2002 and were observed for over 4 months. Methods: We treated them with herb-medication, acupuncture, negative therapy, aroma therapy, full spectrum visible ray therapy(by carbon arc) and external application(Jaun-go). We used the SCORAD index to assess the severity of atopic dermatitis. Results: There were 3 patients with chronic adult atopic dermatitis we could check for over 4 months by clinical scoring using the SCORAD system. 1. The grades of the severity of atopic dermatitis were lower only by the oriental medical treatments and management. 2. Intensities of relapse cases were lower then before the oriental medical treatments. 3. The secondary treatment term for relapse cases was shorter then the first treatment term after oriental remedies were used. Conclusion: Considering the above results, more study is needed on the chronic relapse cases with adult atopic dermatitis, the factors of increasing seventy of adult atopic dermatitis, the prognostic factors of adult atopic dermatitis, and the clinical interchange of chronic adult atopic dermatitis between oriental medicine and western medicine.

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The Characteristics of Obesity-Related Factors, Perceptions of Body Image, and Psychological Eating Behaviors in Married Obese Women Living in the Seoul Area (서울 근교 지역에 거주하는 비만 여성의 비만 관련 요인, 체형 인지도 및 심리적 섭식 행동)

  • Ha, Ae-Wha;Han, In-Kyung
    • Journal of the East Asian Society of Dietary Life
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    • v.19 no.3
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    • pp.327-338
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    • 2009
  • The purpose of this study was to obtain information from married women regarding obesity-related factors and psychological eating behaviors, and to compare those variables among three groups, namely underweight, normal, and obese. The participants completed questionnaires regarding general obesity-related factors, major food servings/day, physical activity, dieting behaviors, perceptions of body image, and psychological eating behaviors. The results were as follows: The obese women reported a higher percentage of family history of obesity (74.8%) than the normal (43.5%) or underweight (28.2%) women. Most of the obese women (90.0%) accurately perceived their body image compared to 72.5% of the underweight and 56.6% of the normal weight women(p<0.001). No significant differences were found among the three groups for daily hours of exercise or computer use. In the case of hours of television watched daily, significant differences were found among the groups (obese 104 min/day, normal 87 min/day, underweight 76/min, p<0.05). Only 17.9% of the obese women reported eating 2 servings of milk products/day and only 23.2% of them reported eating 3 servings of protein foods/day as compared to the normal (25.4%, 18.0%) and underweight (29.4%, 41.7%) (p<0.01) women. About 98% of the obese and 78.5% of the normal weight women wanted to loose weight compared to only 10% of the underweight women (p<0.001). Psychological eating behavior was significantly correlated with subject BMI ($r^2$=0.32, p<0.01). Also, more obese women were unsatisfied with their body and had emotional eating behaviors as compared to the normal and underweight women, and this was statistically significant (p<0.001). In conclusion, the obese women had high perception rates of their body image, but had negative-psychological eating behaviors. Special behavior therapy is needed for obese women who show body dissatisfaction, emotional eating behaviors, long hours of daily TV viewing, and low intakes of protein and milk products.

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Freshwater algal flora and environmental factor at crater of Cheju parasite volcano (제주 기생화산 화구호의 환경과 식물성 플랑크톤상)

  • Kim, Eun-Hee;Lee, Ho-Won;Lee, Sang-Myung;Kang, Hyun-Mu
    • Journal of Wetlands Research
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    • v.4 no.1
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    • pp.1-19
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    • 2002
  • This study was carried out to provide basic data for biodiversity about phytoplankton at crater of Cheju parasite volcano from March to November 2000. In the study area, we identified 6 class 12 order 23 family 44 genus 87 species 13 variety 2 forma, Which were totally 102 taxa. Those were composed of 40 taxa(39.2%) of Chlorophyceae, 34 taxa(33.3%) of Bacillariophyceae, 14 taxa(l3.7%) of Canophyceae, 9 taxa(8.8%) of Euglenophyceae, 3 taxa(3.0%) of Dinophyceae, 2 taxa(2.0%) of Chrysophyceae, respectably. Monthly appearance of phytoplankton were 74 taxa on March, 46 taxa on May, 21 taxa on August, 22 taxa on November. Biodiversity of phytoplankton by station was 54 taxa in Moolchat, 22 taxa in Moolyoungari, 26 taxa in Mooljangauri, 12 taxa in Dongsuack, 6 taxa in Asungseang, 27 taxa in Samiaorum, respectably.

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Assessment of Nutrient Intake and ADHD Score in Atopic Dermatitis Preschoolers (아토피 피부염 미취학 아동의 식행동, 영양 섭취 상태 및 주의력 결핍 과잉 행동 점수 평가)

  • Kang, Myung-Hwa;Kim, Eun-Young;Choi, Mi-Kyeong
    • Journal of the East Asian Society of Dietary Life
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    • v.19 no.4
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    • pp.493-502
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    • 2009
  • This study aimed to examine the relationship between nutrient intake and attention deficit hyperactivity (ADH) of children suffering atopic dermatitis. We examined clinical symptoms as well as the status of ADH and the dietary intake of 47 children with atopic dermatitis aged between 4 and 6 against 84 children in the control group. Family history of the atopic dermatitis group was significantly higher than the control group. There was no significant difference between the diet habit of the two groups. The daily energy intake of the atopic dermatitis group and the control group were 1,189.7 kcal and 1245.0 kcal, respectively. There was no significant difference between the nutrient intake of the two groups. In regards to the clinical symptom items, the point for 'anxieties' was 0.5 in the atopic dermatitis group, which was significantly higher than 0.3 of the control group (p<0.05). In terms of the detailed items in ADH assessed by kindergarten teachers, the point for 'changeable feeling' was 0.8 in the atopic dermatitis group, which was significantly higher than 0.5 of the control group (p<0.05). As for the correlation among nutrient intake, the ADH score and clinical symptoms, total fat intake (p<0.05) and animal fat intake (p<0.05) showed a significantly negative correlation with the point of ADH assessed by the teachers, while the intake of fiber (p<0.05) displayed a significantly negative correlation with the point of ADH assessed by the parents. Since atopic dermatitis and ADH may be caused by the same dietary factors, it will be necessary to conduct more studies in this field in the future. In addition, appropriate nutrition management will be necessary for children in the growing period who suffer from atopic dermatitis.

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The Nutritional Status of a Diabetes Mellitus Risk Group and a Control Group in Kangbukgu (서울 강북구 지역 당뇨병위험군과 대조군의 영양상태 비교)

  • 김명희;문현경
    • Korean Journal of Community Nutrition
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    • v.7 no.2
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    • pp.219-231
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    • 2002
  • The purpose of this study was to collect basic data on the prevention of and education about diabetes mellitus for the nutritional management of a diabetes mellitus risk group. The study which took place in Kangbukgu, Seoul, involved a diabetes mellitus risk group (DMR $\geq$ 110 mg/dL, 61), of males and females, aged 36 to 68 years, and a group of healthy people as a control group ( < 110 mg/dL, 183), using luting blood sugar (FBS) levels. The proportion of people in the abnormal range was higher in the DMR than that of control group for total cholesterol, high-density lipoproteins-cholesterol (HDL-C), total protein, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and creatinine. Particularly with respect to serum protein the proportion in the DMR in abnormal range (p < 0.05) was significantly higher than that of the control group. The proportion in the DMR with a family history of disease was significantly higher than that of the control group (p < 0.01). Using body mass index (BMI), waist-hip ratio (WHR) and relative body weight (RBW), the obesity indices in the DMR was higher than that of the control group. Comparing the DMR and the control group with respect to dietary habits, it seems that the DMR had more undesirable dietary habits than the control group. When the intake of each nutrient for the DMR and the control group was compared to the Korean recommended dietary allowances (RDA), the proportion of excess intake and deficient intake in the DMR was higher than that of the control group. The DMR showed a greater undesirable dietary intake pattern as compared to that of the control group, based on the RDA. With respect to the dietary diversity score (DDS) and the mean adequacy ratio (MAR) for quality estimation of the overall flood intake, the DMR showed a feater undesirable pattern than the control group. According to the above results, the DMR tended to have more undesirable eating habits when compared to the control group. Therefore, to provide a more efficient nutritional education program for the DMR we must conduct lurker studies on eating habits, so as to provide systematic nutritional management based on theme differences between the DMR and the control group.

Developing the predictive model for stomach cancer using data mining (데이터마이닝을 이용한 위암 예측모형 개발과 활용)

  • Park, Il-Su;Han, Jun-Tae;Kang, Suk-Bok;Ji, Jae-Hoon
    • Journal of the Korean Data and Information Science Society
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    • v.21 no.6
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    • pp.1253-1261
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    • 2010
  • We develope the predictive model for the incidence of the stomach cancer by utilizing the health screening data of the National Health Insurance in Korea. We also explore the characteristics for the stomach cancer. We perform the logistic regression analysis using the data mining methodology and use SAS Enterprise Miner 4.1. This study shows that there exists a higher rate of the stomach cancer for males than females. Our study confirms that the major influencing factors for the incidence of the stomach cancer are age, drinking and a family history of cancer, lack of exercise. For man, the age is the most important determinant of the stomach cancer incidence, whereas the drinking is the most important determinant of the stomach cancer incidence for women.

A Case of Hereditary Hemorrhagic Telangiectasia Diagnosed through Spontaneous Hemothorax (자발성 혈흉으로 내원하여 진단된 유전출혈모세혈관확장증 1예)

  • Kim, Chong-Whan;Park, Il-Hwan;Kwon, Woo-Cheol;Kim, Young-Joo;Jung, Soon-Hee;Lee, Shun-Nyung;Lee, Seok-Jeong;Lee, Ji-Ho;Jung, Sae-Hyun;Jung, Ye-Ryung;Kim, Sang-Ha
    • Tuberculosis and Respiratory Diseases
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    • v.72 no.1
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    • pp.50-54
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    • 2012
  • Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is a rare autosomal dominant disease characterized by heterogenous multisystemic dysplasia of the vascular tissue. Prevalence of HHT is 1 in 5,000~8,000. HHT commonly presents with recurrent epistaxis, but may have more serious consequences if visceral vascular beds are involved. Approximately 30~50% of HHT cases also present with pulmonary arteriovenous malformation (PAVM). Spontaneous hemothorax is less common, and PAVM is one of the causes leading to hemothorax. Our case involved an 18-year-old female who had suddenly developed right chest pain. The reason for chest pain was due to right spontaneous hemothorax accompanied by PAVM in the right middle lobe. The patient was additionally diagnosed with HHT upon examination of her family history, specifically through her mother's symptom that included recurrent epistaxis and mucosal telangiectasia.

A Study on Serious Game Production Based on Jewish Play (유대인의 놀이를 주제로 한 기능성 게임 제작 방안에 관한 연구)

  • Lee, MyounJae
    • Journal of Digital Convergence
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    • v.11 no.11
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    • pp.725-731
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    • 2013
  • The Jews has been cited as the most influential nations in the world of politics, economy, and culture in many areas. For these reasons, the study of Jewish economic life such as child-rearing, family life, and religious life is getting expanded to various areas. In this paper, we deal with the Jews's play for the various areas. Play is the best way to see the consciousness of a certain age on learning the structure and lifestyle. Therefore, the research is described to produce serious games based on by study of Jewish play using information in the internet, researched paper. Then, the investigated play's role of technology for production of functional game plans are discussed. As a result, the Jews play: 1) the history, traditions of wisdom, tools, 2) a medium for delivering educational messages, 3) the formation of community tools emotions 4) promise to play a role as a tool for learning. The development and Release of serious games based on Jews play can lead to a positive social learning effect.