• Title/Summary/Keyword: false negative

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Association Between Body Mass Index and Breast Density Using Digital Mammography (체질량지수와 디지털유방촬영술상의 유방밀도와의 연관성)

  • Kim, Mi-Young;Kim, Hwa-Sun
    • Journal of radiological science and technology
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    • v.37 no.4
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    • pp.267-272
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    • 2014
  • It is well known that low body mass index and younger age are associated with high breast density. Mammographic dense breast has been reported both as a cause of false-negative findings on mammography and as an indicator of increased breast cancer risk. The purpose of this study was to evaluate the association between breast density and body mass index. Furthermore, we considered proper screening method of breast cancer in Korean women. The study was performed on 496 women who underwent health checkup in a university hospital. Age and body mass index were negatively associated with breast density respectively. In postmenopausal women, age and body mass index showed statistically significant association with breast density. Therefore, we should consider sensitive additional method for breast cancer screening especially in younger age and underweight women.

Real-time Abnormal Behavior Detection System based on Fast Data (패스트 데이터 기반 실시간 비정상 행위 탐지 시스템)

  • Lee, Myungcheol;Moon, Daesung;Kim, Ikkyun
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.25 no.5
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    • pp.1027-1041
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    • 2015
  • Recently, there are rapidly increasing cases of APT (Advanced Persistent Threat) attacks such as Verizon(2010), Nonghyup(2011), SK Communications(2011), and 3.20 Cyber Terror(2013), which cause leak of confidential information and tremendous damage to valuable assets without being noticed. Several anomaly detection technologies were studied to defend the APT attacks, mostly focusing on detection of obvious anomalies based on known malicious codes' signature. However, they are limited in detecting APT attacks and suffering from high false-negative detection accuracy because APT attacks consistently use zero-day vulnerabilities and have long latent period. Detecting APT attacks requires long-term analysis of data from a diverse set of sources collected over the long time, real-time analysis of the ingested data, and correlation analysis of individual attacks. However, traditional security systems lack sophisticated analytic capabilities, compute power, and agility. In this paper, we propose a Fast Data based real-time abnormal behavior detection system to overcome the traditional systems' real-time processing and analysis limitation.

Construction & Evaluation of GloSea5-Based Hydrological Drought Outlook System (수문학적 가뭄전망을 위한 GloSea5의 활용체계 구축 및 예측성 평가)

  • Son, Kyung-Hwan;Bae, Deg-Hyo;Cheong, Hyun-Sook
    • Atmosphere
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    • v.25 no.2
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    • pp.271-281
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    • 2015
  • The objectives of this study are to develop a hydrological drought outlook system using GloSea5 (Global Seasonal forecasting system 5) which has recently been used by KMA (Korea Meteorological Association) and to evaluate the forecasting capability. For drought analysis, the bilinear interpolation method was applied to spatially downscale the low-resolution outputs of GloSea5 and PR (Predicted Runoff) was produced for different lead times (i.e., 1-, 2-, 3-month) running LSM (Land Surface Model). The behavior of PR anomaly was similar to that of HR (Historical Runoff) and the estimated values were negative up to lead times of 1- and 2-month. For the evaluation of drought outlook, SRI (Standardized Runoff Index) was selected and PR_SRI estimated using PR. ROC score was 0.83, 0.71, 0.60 for 1-, 2- and 3-month lead times, respectively. It also showed the hit rate is high and false alarm rate is low as shorter lead time. The temporal Correlation Coefficient (CC) was 0.82, 0.60, 0.31 and Root Mean Square Error (RMSE) was 0.52, 0.86, 1.20 for 1-, 2-, 3-month lead time, respectively. The accuracy of PR_SRI was high up to 1- and 2-month lead time on local regions except the Gyeonggi and Gangwon province. It can be concluded that GloSea5 has high applicability for hydrological drought outlook.

Evaluation of ROC Curve in High Kilovoltage Technique Using Simulated Nodules on Chest (고관전압 흉부촬영의 가상결절을 이용한 ROC평가)

  • Ahn, Jin-Shin;Chang, Myung-Mi;Chung, Kyung-Mo;Cheung, Hwan;Lim, Jung-Ki;Kim, Jong-Hyo
    • Journal of radiological science and technology
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    • v.15 no.2
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    • pp.25-30
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    • 1992
  • With transmitted dose through chest which has the problem of wide variations in absorption, simple film/screen combination method makes it diffucult to image lung field, mediastinum and retrocardiac areas. In order to overcome this, it is very common to use the high kilovoltage technique in diminishing the differences between high and low contrast. We have been adopting this method at department of diagnostic radiology, Seoul National University Hospital. To compare the image of it with that of low kilovoltage technique, we did radiographic tests using beans on the skin. We marked off into three anatomical categories such as lungs, mediastinum and near diaphragm, then attached a bean on a marked area at random. In order to compare with high and low, we took a radiography of high($120{\sim}140\;kVp$) and low($70{\sim}90\;kVp$) kilovoltage tehchniques, respectively at the same time. We have done experiments 320 cases. We evaluated the results of test in response to sensitivity(true positive) and specificity(true negative). In evaluating, we gave them points from 1 to 5 according to true or false. With given points by a radiologist having much experiences, we could acquire the percentage of sensitivity and specificity. The percentage made us to get the schematic table of ROC curve of those two methods. Consequently, high kilovoltage technique appeared 18% better than low kilovoltage technique for detecting beans with our apparatus.

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TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea

  • Chung, Mi Hae;Shin, Chan Ok;Lee, Juyoung
    • Clinical and Experimental Pediatrics
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    • v.61 no.4
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    • pp.114-120
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    • 2018
  • Purpose: Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed. Methods: The clinical data of the 126 IUGR or SGA neonates were gathered, including gestational age, Apgar scores, neonatal sonographic findings, chromosome study, morbidities, developmental follow-up, and growth catch-up. Maternal factors including underlying maternal disease and fetal sonography were collected, and placental findings were recorded when available. TORCH screening was done using serum IgM, CMV urine culture, quantification of CMV DNA with real-time polymerase chain reaction, and rapid plasma reagin qualitative test for syphilis. Tests were repeated only for those with positive results. Results: Of the 119 TORCH screenings, only one was positive for toxoplasmosis IgM. This result was deemed false positive due to negative IgM on repeated testing and the absence of clinical symptoms. Conclusion: Considering the incidence and risk of TORCH in Korea, the financial burden of TORCH screening, and the single positive TORCH finding in our study, we suggest disease-specific screening based on maternal history and the clinical symptoms of the neonate. Regarding CMV, which may present asymptomatically, universal screening may be appropriate upon cost-benefit analysis.

The Processing of Spatial Joins using a Bit-map Approximation (비트맵 근사 표현을 이용한 효율적인 공간 조인)

  • 홍남희;김희수
    • Journal of the Korea Computer Industry Society
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    • v.2 no.2
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    • pp.157-164
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    • 2001
  • This paper studies on the processing of spatial joins. The spatial join operation is divided into filters and refinement steps in general. The processing of spatial joins can be greatly improved by the use of filters that reduce the polygons in order to find the intersecting ones. As a result, three possible sets of answers are identified: the positive one, the negative one and the inconclusive one. To identify all the interesting pairs of polygons with inconclusive answers, it is necessary to have access to the representation of polygons so that an exact geometry test can take place. We introduce a bit-map approximation technique to drastically reduce the computation required by the refinement step during refinement processing. Bit-map representation are used for the description of the internal, the external and the boundary regions of the polygon objects. The proposed scheme increases the chance of trivial acceptance and rejection of data objects, and reduces unnecessary disk accesses in query processing. It has been shown that the reference to the object data file can be cut down by as much as 60%.

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Radiographic Uterine Diameter Evaluation for the Detection of Uterine Disease in Dogs: A Retrospective Study

  • Yun, Sookyung;Lee, Jeosoon;Choi, Mincheol;Yoon, Junghee
    • Journal of Veterinary Clinics
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    • v.34 no.6
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    • pp.420-424
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    • 2017
  • Cystic endometrial hyperplasia (CEH) and uterine dilation (hydro-, muco-, hemato- and pyometra) are common uterine diseases in intact female dogs. The aim of the present study was to assess the usefulness of digital abdominal radiography in diagnosing uterine disease in intact female dogs. Two hundred and thirteen intact female dogs were included, and were classified into four groups on the basis of radiographic uterine visibility (visible/invisible) and ultrasonographic findings (normal uterus/abnormal uterine condition including CEH and uterine dilation). For each dog, the ratio of the maximum uterine diameter to the height of the fifth lumbar vertebral body (U/L5 ratio) was calculated on radiographs. There were 78 and 135 dogs in the normal and abnormal groups, respectively; 34.6% normal and 53.5% abnormal uteri were visible on abdominal radiographs. Our results suggested that a mean U/L5 ratio of $1.18{\pm}0.53$ ($mean{\pm}2SD$) indicated a normal radiographic uterus diameter, and that a value of > 1.60 should be used as an indicator of uterine disease in clinical practice. However, because false negative results were noted, radiography cannot replace ultrasonography for assessment of the uterus.

QSAR Approach for Toxicity Prediction of Chemicals Used in Electronics Industries (전자산업에서 사용하는 화학물질의 독성예측을 위한 QSAR 접근법)

  • Kim, Jiyoung;Choi, Kwangmin;Kim, Kwansick;Kim, Dongil
    • Journal of Environmental Health Sciences
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    • v.40 no.2
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    • pp.105-113
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    • 2014
  • Objectives: It is necessary to apply quantitative structure activity relationship (QSAR) for the various chemicals with insufficient toxicity data that are used in the workplace, based on the precautionary principle. This study aims to find application plan of QSAR software tool for predicting health hazards such as genetic toxicity, and carcinogenicity for some chemicals used in the electronics industries. Methods: Toxicity prediction of 21 chemicals such as 5-aminotetrazole, ethyl lactate, digallium trioxide, etc. used in electronics industries was assessed by Toxicity Prediction by Komputer Assisted Technology (TOPKAT). In order to identify the suitability and reliability of carcinogenicity prediction, 25 chemicals such as 4-aminobiphenyl, ethylene oxide, etc. which are classified as Group 1 carcinogens by the International Agency for Research on Cancer (IARC) were selected. Results: Among 21 chemicals, we obtained prediction results for 5 carcinogens, 8 non-carcinogens and 8 unpredictability chemicals. On the other hand, the carcinogenic potential of 5 carcinogens was found to be low by relevant research testing data and Oncologic TM tool. Seven of the 25 carcinogens (IARC Group 1) were wrongly predicted as non-carcinogens (false negative rate: 36.8%). We confirmed that the prediction error could be improved by combining genetic toxicity information such as mutagenicity. Conclusions: Some compounds, including inorganic chemicals and polymers, were still limited for applying toxicity prediction program. Carcinogenicity prediction may be further improved by conducting cross-validation of various toxicity prediction programs, or application of the theoretical molecular descriptors.

Cognition of Students Gifted in Science on Pseudo Science (사이비과학에 대한 과학영재들의 인식)

  • Jhun, Young-Seok;Shin, Young-Joon
    • Journal of The Korean Association For Science Education
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    • v.25 no.3
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    • pp.353-363
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    • 2005
  • In this thesis, the cognition of students gifted in science on pseudo science was studied in order to acquire basic data to develop a learning program. As a first step, the difference of cognition on pseudo science between science-gifted students and general students in elementary, middle and high schools was studied. Findings revealed that science-gifted students had more negative thought on pseudo science than general students. In addition, there was no progress in their cognition on pseudo science as entered higher grades. Secondly, the cognition of students in a science high school, three times over a 6-month period, was studied. Through this study, it was found that student concepts of pseudo science was not firm, and it is quite possible to induce students to think logically and rationally with the help of a well-organized learning program. Lastly, the factors that might affect student ideas on pseudo science were researched. Students were affected by media such as television and books and also by personal experience. Therefore, students should be trained to correctly judge information presented in the media as authentic or false. Moreover, they should also be provided chances to look back on positive astrological experiences.

A Unknown Phishing Site Detection Method in the Interior Network Environment (내부 네트워크에서 알려지지 않은 피싱사이트 탐지방안)

  • Park, Jeonguk;Cho, Gihwan
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.25 no.2
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    • pp.313-320
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    • 2015
  • While various phishing attacks are getting to be increased in constant, their response methods still stay on the stage of responding after identifying an attack. To detect a phishing site ahead of an attack, a method has been suggested with utilizing the Referer header field of HTTP. However, it has a limitation to implement a traffic gathering system for each of prospective target hosts. This paper presents a unknown phishing site detection method in the Interior network environment. Whenever a user try to connect a phishing site, its traffic is pre-processed with considering of the characteristics of HTTP protocol and phishing site. The phishing site detection phase detects a suspicious site under phishing with analysing HTTP content. To validate the proposed method, some evaluations were conducted with 100 phishing URLs along with 100 normal URLs. The experimental results show that our method achieves higher phishing site detection rate than that of existing detection methods, as 66% detection rate for the phishing URLs, and 0% false negative rate for the normal URLs.