• 디지털융복합연구
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• 제17권9호
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• pp.291-299
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• 2019

본 연구는 대학생을 대상으로 윤리적 딜레마 토의 프로그램을 적용하여 대상자의 인권감수성, 윤리적 가치관에 미치는 효과를 파악하기 위한 비동등성 대조군 전후설계이다. G도, C대학교 대학생을 대상으로 윤리적 딜레마 토의프로그램을 8주간 제공하고 그 효과를 검증하였다. IBM SPSS 24.0을 이용하여 자료 분석하였다. 변수들의 정규성 검증은 Shapiro-Wilk 검증, 동질성은 실수와 백분율, Fisher's exact probability test와 Independent t-test, 프로그램의 효과검정은 paired t-test를 이용하여 분석하였다. 연구결과, 실험군은 윤리적 딜레마 토의 프로그램 후 인권감수성(t=-2.32, p=.025), 윤리적 가치관(t=-2.43, p=.020)이 대조군보다 통계적으로 유의하게 높았다. 본 연구의 윤리적 딜레마 토의 프로그램은 대상자의 인권감수성, 윤리적 가치관 향상에 유의한 효과를 나타냈다. 추후 다양한 계층의 대상자를 대상으로 윤리교육의 효과를 검증하는 추후 연구가 필요하리라 생각된다.

• 전산구조공학
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• 제6권4호
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• pp.57-66
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• 1993

적분형 르장드르 다항식과 가상균열확장법을 사용한 p-version균열모델이 선형 탄성파괴력학에서 응력확대계수를 산정할 수 있도록 제안되었다. 이 모델의 큰 장점은 소수의 요소를 사용하기 때문에 입력재료를 최소화 할 수 있고 균열선단 부근에서 높은 정확도와 빠른 수검율을 얻을 수 있다는 것이다. 이 연구를 통해 얻어진 두 가지 결론은 다음과 같다. 첫째, 변형에너지의 정해인 극한치가 수검구간에 있는 연속된 3개의 p-version 유한요소 결과로 부터 확정 할 수 있다는 것이다. 둘째, 인장력을 받는 균열판 해석에서 p-version의 수검율은 균등 또는 유사균등 요소분할에 근거를 둔 h-version모델에 비해 거의 2배 가량 빠름을 알 수 있다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2003년도 봄 학술발표회 논문집
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• pp.288-295
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• 2003

An adaptive procedure in finite element analysis is presented by p-refinement of meshes in conjunction with a posteriori error estimator that is based on the recovery technique. In case of the recovery technique, the SPR(superconvergent patch recovery) approach has been modified for p-adaptive mesh refinement. The strategy of finding a nearly optimal distribution of polynomial degrees on a fixed finite element mesh is discussed such that a particular element has to be refined automatically to obtain an acceptable level of accuracy by increasing p-levels non-uniformly. To verify the proposed algorithm, the limit value approach is proposed which utilizes the exact strain energy computed from the extrapolation equation. A new pre-processor is developed for the p-version finite element program in which the vector graphic editor is used for the automatic generation of node connection and coordinate by halfedge solid data structure according to uniform or nonuniform p-distribution. The general 2-D algorithm is also developed to generate face modes and internal modes in accordance with different mesh types. The quality of the error estimator is investigated with the help of two mumerical examples. The results show that the sequences of p-distributions obtained by the proposed error indicator closely follow the optimal trajectory.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2711-2715
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• 2013

Background: Cancer of the gallbladder is a relatively rare neoplasm with a poor prognosis. The exact mechanisms of its genesis are not known and very little information is available on molecular events leading to labeling this as an orphan cancer. Materials and Methods: In this prospective case control study we evaluated the expression of p16, pRb and cyclin D1 by immunohistochemistry to study the G1-S cell-cycle check point and its possible role in gallbladder carcinogenesis. A total of 25 patients with gallbladder carcinoma (group I), 25 with cholelithiasis (group II) and 10 normal controls. were enrolled Results: Cyclin D1 expression was seen in 10 (40%) patients each with carcinoma and cholelithiasis while only in 2 (20%) of the normal gallbladders but differences were not statistically significant (p value=0.488). p16 was expressed in 12% patients of carcinoma of the gallbladder and 28% of cholelithiasis, however this difference was not statistically significant (p value=0.095). Retinoblastoma protein was found to be expressed in 50% of normal gallbladders and 6 (24%) of carcinoma and 8 (32%) of gallstones. The present study failed to demonstrate any conclusive role of cyclin D1/RB/ p16 pathway in carcinoma of the gallbladder. Conclusions: The positive relation observed between tumor metastasis and cyclinD1 expression and p16 with nodal metastasis suggested that higher cyclin D1/p16 expression may act as a predictive biomarker for aggressive behavior of gallbladder malignancies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.1053-1057
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• 2012

Objective: Identifying cancer-related genes or proteins is critical in preventing and controlling colorectal cancer (CRC). This study was to investigate the clinicopathological and prognostic value of activating transcription factor 1 (ATF1) in CRC. Methods: Protein expression of ATF1 was detected using immunohistochemistry in 66 CRC tissues. Clinicopathological association of ATF1 in CRC was analyzed with chi-square test or Fisher's exact test. The prognostic value of ATF1 in CRC is estimated using the Kaplan-Meier analysis and Cox regression models. Results: The ATF1 protein expression was significantly lower in tumor tissues than corresponding normal tissues (51.5% and 71.1%, respectively, P = 0.038). No correlation was found between ATF1 expression and the investigated clinicopathological parameters, including gender, age, depth of invasion, lymph node status, metastasis, pathological stage, vascular tumoral emboli, peritumoral deposits, chemotherapy and original tumor site (all with P > 0.05). Patients with higher ATF1 expression levels have a significantly higher survival rate than that with lower expression (P = 0.026 for overall survival, P = 0.008 for progress free survival). Multivariate Cox regression model revealed that ATF1 expression and depth of invasion were the predictors of the overall survival (P = 0.008 and P = 0.028) and progress free survival (P = 0.002 and P = 0.005) in CRC. Conclusions: Higher ATF1 expression is a predictor of a favorable outcome for the overall survival and progress free survival in CRC.

• Genomics & Informatics
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• 제18권4호
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• pp.45.1-45.5
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• 2020

With the ongoing rise of coronavirus disease 2019 (COVID-19) pandemic across the globe, interests in COVID-19 antibody testing, also known as a serology test has grown, as a way to measure how far the infection has spread in the population and to identify individuals who may be immune. Recently, many countries reported their population based antibody titer study results. South Korea recently reported their third antibody formation rate, where it divided the study between the general population and the young male youths in their early twenties. As previously stated, these simple point estimates may be misinterpreted without proper estimation of standard error and confidence intervals. In this article, we provide an updated 95% confidence intervals for COVID-19 antibody formation rate for the Korean population using asymptotic, exact and Bayesian statistical estimation methods. As before, we found that the Wald method gives the narrowest interval among all asymptotic methods whereas mid p-value gives the narrowest among all exact methods and Jeffrey's method gives the narrowest from Bayesian method. The most conservative 95% confidence interval estimation shows that as of 00:00 November 23, 2020, at least 69,524 people were infected but not confirmed. It also shows that more positive cases were found among the young male in their twenties (0.22%), three times that of the general public (0.051%). This thereby calls for the quarantine authorities' need to strengthen quarantine managements for the early twenties in order to find the hidden infected people in the population.

• Genomics & Informatics
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• 제18권3호
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• pp.31.1-31.8
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• 2020

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. No specific therapeutic agents or vaccines for COVID-19 are available, though several antiviral drugs, are under investigation as treatment agents for COVID-19. The use of convalescent plasma transfusion that contain neutralizing antibodies for COVID-19 has become the major focus. This requires mass screening of populations for these antibodies. While several countries started reporting population based antibody rate, its simple point estimate may be misinterpreted without proper estimation of standard error and confidence intervals. In this paper, we review the importance of antibody studies and present the 95% confidence intervals COVID-19 antibody rate for the Korean population using two recently performed antibody tests in Korea. Due to the sparsity of data, the estimation of confidence interval is a big challenge. Thus, we consider several confidence intervals using Asymptotic, Exact and Bayesian estimation methods. In this article, we found that the Wald method gives the narrowest interval among all Asymptotic methods whereas mid p-value gives the narrowest among all Exact methods and Jeffrey's method gives the narrowest from Bayesian method. The most conservative 95% confidence interval estimation shows that as of 00:00 on September 15, 2020, at least 32,602 people were infected but not confirmed in Korea.

• 한국융합학회논문지
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• 제12권12호
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• pp.519-528
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• 2021

본 연구는 간호 대학생을 대상으로 시뮬레이션 기반 인수인계 교육프로그램을 적용하여 학생들의 인수인계 수행능력과 인수인계 자신감에 미치는 효과를 검증하고자 한다. K도 소재 P시와 A시 소재 간호 대학생 104명에게 사전·사후 실험설계의 비동등성 대조군 유사 실험연구를 수행하였다. 자료 수집 기간은 2017년 10월 30일부터 11월 10일까지이며, 수집된 자료 분석은 SPSS WIN 21.0 프로그램을 이용하여 x² test, Fisher's exact test, independent t-test, ANCOVA with pretest value as covariate를 실시하였다. 효과를 검증한 결과 인수인계 수행능력에서 유의한 차이가 있는 것으로 나타났다. 본 연구에서 개발된 시뮬레이션 기반 인수인계 교육 프로그램은 간호대학생의 인수인계 수행능력을 증진하는 데 효과적인 인수인계 교육 프로그램으로 적용될 수 있을 것이다.

• Journal of Korean Biological Nursing Science
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• 제23권3호
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• pp.237-246
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• 2021

Purpose: To determine effects of family conflict mitigation documentary programs on conflicts, autonomic nerve activation (ANA), and happiness of elderly in long-term care hospitals. Methods: This study used a non-equivalent control group with a pretest-posttest design. It was conducted on 39 elderly patients (19 in the experimental group and 20 in the control group) in long-term care hospitals. The experimental group (n=19) received family conflict mitigation documentary programs. The family conflict mitigation documentary programs consisted of four sessions (40-50 minutes per session). These programs were implemented in small groups, with each group having five elderly. Data were analyzed by sing the conflict checklist, the Oxford Happiness Questionnaire, Chi-square test with Fisher's exact test, independent t-test, paired t-test, and repeated measure ANOVA using the SPSS/WIN 21.0 program. Results: The participants in the experimental group showed significantly decreased scores of conflict (t=-2.31, p=.028) and the value of sympathetic nervous system activity (t=8.36, p=.007) compared with those of the control group. The participants in the experimental group showed significantly increased the value of parasympathetic nervous system activity (t=-2.91, p=.008) and scores of happiness (t=5.46, p<.001). Conclusion: The family conflict mitigation documentary programs on conflicts, ANA, and happiness of the elderly in long-term care hospitals are effective intervention programs for mitigating conflicts between elderlies and their families and for improving happiness of the elderly in long-term care hospitals.

• 한국인터넷방송통신학회논문지
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• 제15권1호
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• pp.207-215
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• 2015

본 논문은 지금까지 NP-완전 문제로 다항시간 알고리즘이 존재하지 않는 스도쿠 문제의 해를 다항시간으로 구하는 알고리즘을 제안하였다. 제안된 알고리즘은 숫자가 많이 들어 있는 블록 내림차순으로 수행한다. 각 블록에서 빈칸들을 대상으로 행에 들어 갈 수 있는 숫자와 열에 들어갈 수 있는 숫자를 결정한다. 행과 열의 교집합을 구하면 해당 빈칸에 들어갈 수 있는 숫자가 결정된다. 이들 숫자를 대상으로 각 빈칸에 들어 갈 수 있는 숫자를 배정하는 방법을 적용하였다. 제안된 알고리즘은 전통적인 $9{\times}9$ 스도쿠에 적용 결과 블록의 개수인 9회만을 수행하여 해를 구하는데 성공하였다. 또한, 변형 스도쿠인 Jigsaw 스도쿠 (9개 블록)와 Hypersudoku (13개 블록)에 적용 결과 Jigsaw 스도쿠는 9회, Hypersudoku는 13회 수행으로 해를 구하는데 성공하였다. 결국, 제안된 알고리즘은 스도쿠 문제가 P-문제임을 증명하였다.