• Sleep Medicine and Psychophysiology
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• v.1 no.1
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• pp.76-86
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• 1994

Objectives: This research was performed in order to observe the neuropsychological implication and functional anatomical source of event related potentials(ERP) by studying of correlations between event related potentials and neuropsychological tests. Methods: The latency and voltage of P100 of visual evoked potential (VEP), and N120 and P300 of event related potentials were studied in 56 patients and their correlations with neuropsychological tests were computed. Results: The tests showing significant correlation with latency P100 were visual continous performance test(VCPT) and contingent continous performance test(CCPT) without any significant correlation with voltage of P100. In latency of N120 category test and verbal IQ of KWIS showed significant correlation, and in voltage of N120, finger tapping test, VCPT, CCPT and digit symbol test displayed significant correlations. The latency of P300 had significant correlation with trail making A test and Stroop test. In the voltage of P300 significant correlations were shown with trail making B test, digit symbol test and Wechsler memory scale, finger tapping test, stroop test, VCPT and CCPT. Conclusion : N120 may be considered to reflect the function of medial frontal lobe and P300 may be considered to be developed from the subcortical connection of medial temporal lobe, hippocampus, thalamus, basal ganglia and medial frontal lobe.

• The Journal of the Korea Contents Association
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• v.16 no.5
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• pp.242-250
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• 2016

This study was conducted to investigate whether Stroop-related cognitive task will be affected according to the preceding affective valence factored by matchedness in response time(RT) and whether facial recognition will be indexed by specific event-related potentials(ERPs) signature in normal person as in patients suffering from affective disorder. ERPs primed by subliminal(30ms) facial stimuli were recorded when presented with four pairs of affect(positive or negative) and cognitive task(matched or mismatched) to get ERP effects(N2 and P300) in terms of its amplitude and peak latency variations. Behavioral response analysis based on RTs confirmed that subliminal affective stimuli primed the target processing in all affective condition except for the neutral stimulus. Additional results for the ERPs performed in the negative affect with mismatched condition reached significance of emotional-face specificity named N2 showing more amplitude and delayed peak latency compared to the positive counterpart. Furthermore the condition shows more positive amplitude and earlier peak latency of P300 effect denoting cognitive closure than the corresponding positive affect condition. These results are suggested to reflect that negative affect stimulus in subliminal level is automatically inhibited such that this effect had influence on accelerating detection of the affect and facilitating response allowing adequate reallocation of attentional resources. The functional and cognitive significance with these findings was implied in terms of subliminal effect and affect-related recognition modulating the cognitive tasks.

• Korean Journal of Biological Psychiatry
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• v.20 no.4
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• pp.119-128
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• 2013

Objectives Memory impairment is a very important mental health issue for elderly and adults. Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Early detection of the prodromal stage of patients with AD is an important topic of interest for both mental health clinicians and policy makers. Methods Electroencephalograpgy (EEG) has been used as a possible biological marker for patients with MCI, and AD. In this review, we will summarize the clinical implications of EEG and ERP as a biological marker for AD and MCI. Results EEG power density, functional coupling, spectral coherence, synchronization, and connectivity were analyzed and proved their clinical efficacy in patients with the prodromal stage of AD. Serial studies on late event-related potentials (ERPs) were also conducted in MCI patients as well as healthy elders. Even though these EEG and ERP studies have some limitations for their design and method, their clinical implications are increasing rapidly. Conclusion EEG and ERP can be used as biological markers of AD and MCI. Also they can be used as useful tools for early detection of AD and MCI patients. They are useful and sensitive research tools for AD and MCI patients. However, some problems remain to be solved until they can be practical measures in clinical setting.

• Biomedical Science Letters
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• v.26 no.1
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• pp.14-21
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• 2020

Quantitative evaluation of the sense of smell is done by the olfactory event-related potential (OERP) test. OERP consists of N1, P1, N2, P2, and P3, of which N1 and P1 latency are known to be affected by the concentration of odor stimuli associated with the pre-sensory phase and P2 and P3 are the stages at which odors are perceived and are known to change by subjective evaluation of the stimulus. The purpose of this study was to clarify the correlation between the expression of OERP and the subjective evaluation of the object on the fragrance stimulus using various fragrances. Therefore, the study examined the relative waveform power ratio, preference for each scent stimulus, and finally the amplitude and latency change of the components of OERP, N1 and P2. In contrast, it was found that the late P2 response waveform was an effective aroma stimulus recognition waveform in OERP compared to the initial response waveforms.

• Journal of Ginseng Research
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• v.36 no.2
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• pp.190-197
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• 2012

Ginseng has a long history of use for health enhancement, and there is some evidence from animal studies that it has a beneficial effect on cognitive performance. The purpose of this study was to investigate the effect of Korean red ginseng on cognitive performance in humans. A total of 15 healthy young males with no psychiatric or cognitive problems were selected based on an interview with a board-certified psychiatrist. The subjects were randomly assigned to receive a daily dose of 4,500 mg red ginseng or placebo for a 2-week trial. There were 8 subjects in the red ginseng group and 7 subjects in the placebo group. All of the subjects were analyzed with the Vienna test system and a P300 event-related potential (ERP) test. There were no significant differences in the Vienna test system scores between the red ginseng group and the placebo group. In the event-related potential test, the C3 latency of the red ginseng group tended to decrease during the study period (p=0.005). After 2 wk, significant decreases were observed in the P300 latencies at Cz (p=0.008), C3 (p=0.005), C4 (p=0.002), and C mean (p=0.003) in the red ginseng group. Our results suggest that the decreased latency in ERP is associated with improved cognitive function. Further studies with a higher dosage of ginseng, a larger sample size, and a longer follow-up period are necessary to confirm the clinical efficacy of Korean red ginseng.

• Anxiety and mood
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• v.4 no.1
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• pp.3-10
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• 2008

The purpose of this review was to investigate the neurophysiological and neuroimaging characteristics of patients with depression and anxiety reported in previous studies. A literature search was conducted using Medline and psychiatric textbooks. "Electroencephalography (EEG)", "Event Related Potentials (ERP)", "functional neuroimaging", "heart rate variability (HRV)" and "depression or anxiety" were used as key words. A physiological finding indicated that there was a higher degree of relativity with regards to prefrontal dysfunction in patients with depression. Right prefrontal lobe hyperactivity and left prefrontal hypoactivity were consistently observed, and abnormalities were observed in other regions (ACC, hippocampus, amygdala, etc.). Therefore, dysfunctions in these areas are related to depressive symptoms. In patients with anxiety disorder, each emotional condition showed specific activation patterns in different brain regions, such as the prefrontal cortex, occipital lobe, temporal lobe, hippocampus, and limbic system, including the amygdala. However, in the majority of patients with anxiety disorder, the degree of activation was higher in the right hemisphere than in the left hemisphere. The current data supports that there is a difference in brain dysfunction characteristics between depression and anxiety and that the different activations of various brain regions would play a significant role in the pathophysiology of depression and anxiety disorder.

• Journal of Biomedical Engineering Research
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• v.23 no.4
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• pp.301-308
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• 2002

This research was performed to analyze quantitatively how spiritual stress affects some ERPs on human through sight stimulus after the settlement of visual and auditory integration environment in three dimension space. We measured ERPs in the normal state and spiritual stress sessions separately. The subjects were 10 normal men and women and vital signs was recorded from Fpl, Fz, Cz, Pz, O1, O2's scalps. The experiment was done in isolated room where electro-magnetic effect do not affect. The result showed that P300's amplitude was a little higher under stress session and latent period in this resulted in longer time. We recorded through voltage variation the activity of brain which is in charge of human's perception. cognition, process of action and evaluated the effect of spiritual stress. We expected that the result of this research can be used to evaluate the malfunction of brain.

• Korean Journal of Cognitive Science
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• v.20 no.1
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• pp.29-49
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• 2009

The purpose of the present research was to examine whether the parietal pathway and the temporal pathway were responsible for the phenomena of the inhibition of return and the facilitation of return respectively and at what stage of the information processing they occurred. The response time and the ERPs(event-related potentials) were examined in the two conditions(the valid condition and the invalid condition) while subjects were doing detection task, location discrimination task, color discrimination task and orientation discrimination task in separate sessions. No significant response time difference was found between the valid and the invalid conditions when subjects did the detection task as well as the location discrimination task. However, significant response time difference was found when they did the color discrimination as well as the orientation discrimination task. Futhermore, there was a significant difference of ERP difference between the two conditions in the Pz area when subjects were doing location discrimination task and significant difference was found in the T7 area when they were doing color discrimination task and marginal difference was found in T7/T8 area when they were doing orientation discrimination task just before they responded. These results imply the possibility that both the inhibition of return and the facilitation of return occur in the parietal and in the temporal pathway respectively in the late stage of information processing.

• Korean Journal of Cognitive Science
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• v.16 no.2
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• pp.141-154
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• 2005

The purpose of this study was to investigate the effects of implicit and explicit situation awareness instruction on decision making and event related brain potentials. Psychophysiological data obtained from 36 intermediated level tennis players whose National Tennis Rating Program(NTTP) belong 2 to 2.5 were compared. Participants were randomly assigned to one of three experimental groups: (1) implicit situation awareness, (2) explicit situation awareness, and (3) control group. A total of 90 clips were presented via a beam project screen, and participants pressed one of three jelly bean buttons to indicate the direction of ball hit. Dependent measures were the latencies and amplitudes of P300 on Pz, Cz, and Fz. The results of this study indicated that participants in the implicit situation awareness produced tenser P300, than participants in the explicit situation awareness group. The findings also indicated that single defense showed longer P300 latencies than single attack as well as double defense. The P300-amplitude of treatment groups were longer than control group. The Cz area showed shorer P300 latencies than Pz and Fz areas. In addition, single defense situation demonstrated longer P300 latencies than single attack and double defence situations. Based on this study, it is believed that implicit and explicit situation awareness instruction influence decision making in different ways.

• Journal of Sasang Constitutional Medicine
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• v.22 no.1
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• pp.41-48
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• 2010

1. Objective There has been a few trials to diagnose Sasang Constitution by using EEG, but has not been studied intensively. For the purpose of practical diagnosis, the characteristics of EEG for each constitution should be studied first. Recently it has been shown that Sasang Constitution might be related to harm avoidance and novelty seeking in temperament and character profiles. Based on this finding, we propose a visual stimulation method to evoke a EEG response which may discriminate difference between constitutional groups. Through the experiment with this method, we tried to reveal the characteristics of EEG of each constitutional groups by the method of event-related potentials. 2. Methods: We used facial visual stimulation to verify the characteristics of EEG for each constitutional groups. To reveal characteristic in sensitivity and latency of response, we added several levels of noise to facial images. 6 male subjects(2 Taeeumin, 2 Soyangin, 2 Soeumin) participated in this study. All subjects are healthy 20's. To remove artifacts and slow modulation, we removed EOG contaminated data and renormalization is applied. To extract stimulation related components, normalized event-related potential method was used. 3. Results: From Oz channels, it is verified that facial image processing components are extracted. For lower level noise, components related to the visual stimulation were clearly shown in Oz, Pz, and Cz channels. Pz and Cz channels show differences among 3 constitutional groups in maximum around 200 msec. Especially moderate level of noise looks appropriate for diagnosis. 4. Conclusion: We verified that the visual stimulation with facial emotion might be a good candidate to evoke the differences between constitutional groups in EEG response. The differences shown in the experiment may imply that the process of emotion has distinct tendencies in latencies and sensitivity for each consitutional group. And this distinction might be related to the temperament profile of consitutional groups.