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Clinical Implications of EEG and ERP as Biological Markers for Alzheimer's Disease and Mild Cognitive Impairment  

Kim, Chang Gyu (Clinical Emotion and Cognition Research Laboratory (CEC Lab), Inje University)
Kim, Hyun-Taek (Department of Psychology, Korea University)
Lee, Seung-Hwan (Clinical Emotion and Cognition Research Laboratory (CEC Lab), Inje University)
Publication Information
Korean Journal of Biological Psychiatry / v.20, no.4, 2013 , pp. 119-128 More about this Journal
Abstract
Objectives Memory impairment is a very important mental health issue for elderly and adults. Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD). Early detection of the prodromal stage of patients with AD is an important topic of interest for both mental health clinicians and policy makers. Methods Electroencephalograpgy (EEG) has been used as a possible biological marker for patients with MCI, and AD. In this review, we will summarize the clinical implications of EEG and ERP as a biological marker for AD and MCI. Results EEG power density, functional coupling, spectral coherence, synchronization, and connectivity were analyzed and proved their clinical efficacy in patients with the prodromal stage of AD. Serial studies on late event-related potentials (ERPs) were also conducted in MCI patients as well as healthy elders. Even though these EEG and ERP studies have some limitations for their design and method, their clinical implications are increasing rapidly. Conclusion EEG and ERP can be used as biological markers of AD and MCI. Also they can be used as useful tools for early detection of AD and MCI patients. They are useful and sensitive research tools for AD and MCI patients. However, some problems remain to be solved until they can be practical measures in clinical setting.
Keywords
EEG; ERP; Mild cognitive impairment; Alzheimer's disease; Early detection;
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