• BMB Reports
• /
• v.55 no.11
• /
• pp.541-546
• /
• 2022

The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is crucial for maintaining genomic integrity and is involved in numerous fundamental biological processes. Post-translational modifications by proteins play an important role in regulating DNA repair. Here, we report that the methyltransferase SET7 regulates HR-mediated DSB repair by methylating TIP60, a histone acetyltransferase and tumor suppressor involved in gene expression and protein stability. We show that SET7 targets TIP60 for methylation at K137, which facilitates DSB repair by promoting HR and determines cell viability against DNA damage. Interestingly, TIP60 demethylation is catalyzed by LSD1, which affects HR efficiency. Taken together, our findings reveal the importance of TIP60 methylation status by SET7 and LSD1 in the DSB repair pathway.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.38 no.3
• /
• pp.220-228
• /
• 2001

Simulation of an instruction set is essential to design and optimize new microprocessors, and to develop application programs. Though many simulation tools are widely used, their low-level description and simulation make users construct simulators difficult and spend a lot of time for simulation. We developed an automatic generator of instruction set simulators that perform register-transfer-level simulation. This automatic generator might be adaptable so as to be suitable for new modification or different conditions in designing microprocessors. In this paper, we describe a structure of automatic generation system and an implementation details.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 2002.05a
• /
• pp.201-204
• /
• 2002

Kansei design knowledge acquisition stage is a crucial stage in kansei designing process and kansei engineering (KE) methodology. In kansei engineering methodology, it is essential to extract design knowledge or rules on relationships between customer's kansei and product design element. We attempt to construct a more powerful melted for extracting the design rules from kansei expremental data. We constucted a kansei experiment concerning color kansei evaluation, and analyzed the sane data by both conventional quantification theory type I and rough set theory. Finally, we compared the effectiveness of both methods for extracting rules and examined the extensions of rough set theory in kansei engineering.

• Environmental and Resource Economics Review
• /
• v.29 no.1
• /
• pp.47-89
• /
• 2020

We introduce a simple theoretical model to analyze the welfare impact of a competition policy in the natural gas market in South Korea. An incumbent monopolistic firm currently owns essential facilities, but the competition policy mandates that the firm provide open access to any entrant firm, charging an access fee. When no regulation is imposed on the fee pricing, this policy increases social welfare as well as the profit of the incumbent firm. When the pricing is regulated, however, social welfare depends on whether there is information asymmetry between the government and the firm regarding the operating cost of the facilities. If the government has complete information, social welfare can be maximized by choosing the optimal prices. Otherwise, the government has to set the prices based on the information that the firm delivers. We formulate a Bayesian game to analyze this case and identify a set of perfect Bayesian equilibria to compare social welfare.

• Journal of architectural history
• /
• v.21 no.2
• /
• pp.7-20
• /
• 2012

As the corner of wooden pagoda forms the roof by closely bordering left and right eaves on the various purlins and angle rafters, it is designed for every face to be recognized as front whose structure system increases load to bear proportionally. The corner of wooden pagoda is inseparable with the corner bracket set as it becomes stable thanks to the corner bracket set structurally and load burden under restrained structure makes the corner bracket set really important. Accordingly, this study could figure out some facts by analyzing corner bracket sets of Palsangjeon of Beobjusa Temple in Korea, Seokgatap of Bulgungsa Temple in China and Ojungtap of Beobryungsa Temple in Japan which were constructed with pure wooden structure. This study demonstrated that corner bracket set played a pivotal role in keeping balance of concentrated load of corner (corner of opening) in each floor that contributed to the stability of wooden pagoda structurally despite multiple duplications of floors and also figured out the outfit of corner bracket set was subject to the floor type and the cross section of Gongpo installed on top of Pyeongju. Wooden pagodas in 3 countries were two floor types of octagon and square, and employed different connection method between upper and lower floors. The difference between floor and duplication method determines the method of corner, but even different methods were sufficient to have entirety in every side by completing dynamic principle of corner bracket set even though old method had to solve the problem of concentrated load and it also confirms that it was essential Gongpo to prevent any deformation of corner.

• Journal of the Korea Society of Computer and Information
• /
• v.26 no.11
• /
• pp.41-49
• /
• 2021

All application programs, including malware, call the Application Programming Interface (API) upon execution. Recently, using those characteristics, attempts to detect and classify malware based on API Call information have been actively studied. However, datasets containing API Call information require a large amount of computational cost and processing time. In addition, information that does not significantly affect the classification of malware may affect the classification accuracy of the learning model. Therefore, in this paper, we propose a method of extracting a essential feature set after reducing the dimensionality of API Call information by applying various feature selection methods. We used CICAndMal2020, a recently announced Android malware dataset, for the experiment. After extracting the essential feature set through various feature selection methods, Android malware classification was conducted using CNN (Convolutional Neural Network) and the results were analyzed. The results showed that the selected feature set or weight priority varies according to the feature selection methods. And, in the case of binary classification, malware was classified with 97% accuracy even if the feature set was reduced to 15% of the total size. In the case of multiclass classification, an average accuracy of 83% was achieved while reducing the feature set to 8% of the total size.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.10
• /
• pp.6185-6187
• /
• 2013

Cervical cancer has emerged as a major public health problem in Lucknow and New York in the $21^{st}$ century. Cancer genetic studies are essential to identify/stratify disease-susceptible individuals in a population-based cohort. Sample size homogeneity and North Indian caste in female urology genetic-studies are significant issues in meaningful interpretation of data. A review of scientific literature using Pubmed database was conducted, including an assessment of cervical cancer genetic studies conducted as part of the author's doctoral dissertation at a premier Lucknow-based medical research Institute. Sample size numbers and caste criteria in the North Indian cohort ($N{\leq}400$ subjects) were evaluated with homogeneity in the sample cohort data set(s). Subgroup caste-stratification of North Indian cohort is equally essential, for instance, Brahmin (e.g. Pandey), Vaishya (e.g. Mittal), Rajput (e.g. Singh) and Kshudra (e.g. Yadav) during the conception and design of genetics-based studies. Sample size homogeneity in histopathologically confirmed case and control numbers and caste-based stratification in a North Indian cohort is essential in single nucleotide polymorphism (SNP) studies in cervical cancer susceptible populations to draw more definitive conclusions.

• Honam Mathematical Journal
• /
• v.28 no.4
• /
• pp.533-541
• /
• 2006

let E be a Finsler modules over $C^*$-algebras. A with norm-map $\rho$ and L(E) set of all A-linear bonded operators on E. We show that the canonical homomorphism ${\phi}:L(E){\rightarrow}L(E_I)$ sending each operator T to its restriction $T|E_I$ is injective if and only if I is an essential ideal in the underlying $C^*$-algebra A. We also show that $T{\in}L(E)$ is a bounded below if and only if ${\mid}{\mid}x{\mid}{\mid}={\mid}{\mid}{\rho}{\prime}(x){\mid}{\mid}$ is complete, where ${\rho}{\prime}(x)={\rho}(Tx)$ for all $x{\in}E$. Also, we give a necessary and sufficient condition for the equivalence of the norms generated by the norm map.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.6
• /
• pp.1198-1203
• /
• 2017

Hrr25, a casein kinase $1{\delta}/{\varepsilon}$ homolog in budding yeast, is essential to set up mono-orientation of sister kinetochores during meiosis. Hrr25 kinase activity coordinates sister chromatid cohesion via cohesin phosphorylation. Here, we investigated the prophase role of Hrr25 using the auxin-inducible degron system and by ectopic expression of Hrr25 during yeast meiosis. Hrr25 mediates nuclear division in meiosis I but does not affect DNA replication. We also found that initiation of meiotic double-strand breaks as well as joint molecule formation were normal in HRR25-deficient cells. Thus, Hrr25 is essential for termination of meiotic division but not homologous recombination.

• The Transactions of the Korea Information Processing Society
• /
• v.4 no.2
• /
• pp.596-605
• /
• 1997

The synamic systrm emplohing the self-squared function, , $f(Z)=z^2+c$, provides the Mandelbrot set which classifies constants c using the divergence of the sequence starting from the origin.To speed-up the generation of Mandelbrot set images, two approaches , called as the divide-and-conquer technique and the triangular boundary tracing technique, have been developed.However , the divede-and-conquer technique genrates sequences of some pixels that so not affect graphical representations of the Mandelbrot set.The triangular boundary tracing tech-mique does noot represent some 8-connected components of the Mandelbrost set.In this paper, we prorose a new ;method which solves the 8-connectivity problem of triangular boundary tracing technique.This algorithm considers the divergence for only pixels which are essential to the graphical repressentation of the Mandelbrot set.It also foves good representations for 8-connected components like hairly structures.