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http://dx.doi.org/10.4014/jmb.1701.01016

Roles of Budding Yeast Hrr25 in Recombination and Sporulation  

Lee, Min-Su (Department of Life Science, Chung-Ang University)
Joo, Jeong Hwan (Department of Life Science, Chung-Ang University)
Kim, Keunpil (Department of Life Science, Chung-Ang University)
Publication Information
Journal of Microbiology and Biotechnology / v.27, no.6, 2017 , pp. 1198-1203 More about this Journal
Abstract
Hrr25, a casein kinase $1{\delta}/{\varepsilon}$ homolog in budding yeast, is essential to set up mono-orientation of sister kinetochores during meiosis. Hrr25 kinase activity coordinates sister chromatid cohesion via cohesin phosphorylation. Here, we investigated the prophase role of Hrr25 using the auxin-inducible degron system and by ectopic expression of Hrr25 during yeast meiosis. Hrr25 mediates nuclear division in meiosis I but does not affect DNA replication. We also found that initiation of meiotic double-strand breaks as well as joint molecule formation were normal in HRR25-deficient cells. Thus, Hrr25 is essential for termination of meiotic division but not homologous recombination.
Keywords
Hrr25; meiosis; homologous recombination;
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