• Journal of Periodontal and Implant Science
• /
• 제26권4호
• /
• pp.933-948
• /
• 1996

The purpose of this study was to examine the anatomic structures of the mandible-inferior alveolar canal, mental foramen, mental canal-with panoramic radiography and conventional tomography and to compare both radiographic techniques in conjunction with endosseous implants. In this study 14 adult dentulous mandibles -27 cases of right and left side of mandibles- were examined and the results were as follows. 1. The distance between superior border of the inferior alveolar canal and the alveolar ridge crest showed a decreasing tendency from the mental foramen to 4cm posterior to the mental foramen. 2. The mean diameter of the inferior alveolar canal was $4.11{\pm}0.50mm$ with panoramic radiography and $3.29{\pm}0.59mm$ with conventional tomography. 3. The inferior border of the inferior alveolar canal and inferior border of the mandible was closest at 2cm posterior to the mental foramen but it was not statistically significant. the mean distance was $1l.64{\pm}2.95mm$ in panoramic radiography and $1l.68{\pm} 2.91mm$ in conventional tomography. 4. The inferior alveolar canal located lingually in bucco-lingual direction 16%(mental foramen), 54%(lcm posterior to the mental foramen), 68%(2cm posterior to the mental foramen), 50%(3cm posterior to mental foramen), 55%(4cm posterior to the mental foramen). 5. Mean length of the anterior loop of the mental canal was 2.73mm, and the loop below 2mm was 35% and 15% of mental canal was invisible in panoramic radiography. 6. The minimum interforaminal distance was 56.7mm, the maximum distance was 73.2mm and the mean distance was 66.42mm in panoramic radiography. 7. The mean distance between midpoint of the mental canal and alveolar ridge crest was 16.24mm and the mean buccolingual angulation of the mental canal was $52.98^{\circ}$ in conventional tomography. 8. In comparison of panoramic radiography and conventional tomography, inferior alveolar canal is better visualized with conventional tomography than panoramic radiography from the mental foramen to the 2cm posterior to the mental foramen, while visiblity of conventional tomography prominently decreased in 4cm posterior to the mental foramen and alveolar ridge crest is better visualized with panoramic radiography than conventional radiography at the mental foramen and at 4cm posterior to the mental foramen. In radiologic examination of anatomic structures of the mandible for endosseous implants, panoramic radiography and conventional tomography can be effectively used when it is used to overcome the anatomic limitations.

• 대한치과보철학회지
• /
• 제39권6호
• /
• pp.659-681
• /
• 2001

Platelet-rich plasma(PRP) has been known to increase the rate and degree of bone formation by virtue of growth factors in concentrated platelets. Although its great healing effect on bone defect or pre-implantation site preparation in conjunction with bone substitute has been reported, the effect associated with implant is unknown. The purpose of this study was to investigate the effect of PRP on rapid osseointegration of endosseous dental implants in the rabbit tibiae. Twenty two adult female New Zealand white rabbits, weighing approximately 2.7-3.3kg, were used for this study. Twelve of the 22 animals were used for histomorphometric analysis and ten of the 22 were for removal torque test. Each animal received two implants in each tibia (two treated with PRP and two as control) and was given fluorochrome intramuscularly. For histomorphometric analysis, rabbits were divided into four groups according to the healing period. At 1 week, 2 weeks, 4 weeks and 8 weeks postoperatively, each three animals were sacrificed serially and the amount and rate of bone formation around dental implant were examined on the undecalcified sections under fluorescent microscope, polarized microscope and light microscope connected to a personal computer equipped with image analysis system. For removal torque test, rabbits were divided into two groups and removal torque tests were performed at 4 weeks, 10 weeks after implant placement. In total, 88 screw shaped, commercially pure titanium implants (Neoplant, Neobiotech, Seoul, Korea) were used in this study. Labeling pattern reflected differences of two groups in bone formation rate at each period. Histomorphometrically, PRP group showed significantly higher bone volume within threads compared to control group at 2 weeks ($70.30{\pm}4.96%$ vs. $50.68{\pm}6.33%$; P < .01) and 4 weeks ($82.59{\pm}5.94%$ vs. $72.94{\pm}4.57%$; P < .05 ). PRP group at 1, 2 and 4 weeks revealed similar degree of bone volume formation comparable to control group at 2, 4 and 8 weeks, respectively. On the other hand, while PRP group showed higher bone-implant contact ($47.37{\pm}8.09%$) than control group ($33.16{\pm}13.47%$) at 2 weeks, there were no significant differences between PRP group and control group for any experimental period. Removal torque values also showed no significant differences between PRP group and control group at any experimental period (P > .05). These findings imply that PRP could induce rapid, more bone formation around implant during early healing period and get faster secondary stability for reducing healing period, though it has not induced bone maturation enough to resist functional loading.

• Imaging Science in Dentistry
• /
• 제36권1호
• /
• pp.25-32
• /
• 2006

Purpose : To investigate the validity of digital image processing on panoramic radiographs in estimating bone quality before endosseous dental implant installation by correlating bone quality in radiographic images with clinical bone quality classification. Materials and Methods : An experienced surgeon assessed and classified bone quality for implant sites with tactile sensation at the time of implant placement. Including fractal dimension eighteen morphologic features of trabecular pattern were examined In each anatomical sites on panoramic radiographs. Finally bone quality of 67 implant sites were evaluated in 42 patients. Results : Pearson correlation analysis showed that three morphologic parameters had weak linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.276, -0.280, and - 0.289, respectively (p<0.05). And other three morphologic parameters had obvious linear negative correlation with clinical bone quality classification showing correlation coefficients of -0.346, -0.488, and -0.343 respectively (p<0.05). Fractal dimension also had a linear correlation with clinical bone quality classification with correlation coefficients -0.506 significantly (p<0.05). Conclusion : This study suggests that fractal and morphometric analysis using digital panoramic radiographs can be used to evaluate bone quality for implant recipient sites.

• Journal of Periodontal and Implant Science
• /
• 제37권4호
• /
• pp.825-838
• /
• 2007

Endosseous implants are used in the treatment of various types of tooth loss, and numerous long-term studies have demonstrated the excellent reliability of this method of treatment. However, the increase of implant failure are associated with inadequate quality and/or height of bone. At the end of the 1980s, Wide(>3.75mm) implants were initially used for managing these difficult bone situations. The recommended indications for its use included poor bone quality, inadequate bone height. immediate placement in fresh extraction sockets, and immediate replacement of failed implants. At the 2000s, wider implants(6.0mm and 6.5mm) were used in a few studies. Although good clinical outcomes have been reported in recent years, there is still a controversy on this topic. Therefore, the purpose of this study was to estimate the survival rate of wide implants($6.0{\sim}8.0mm$) in molar regions, evaluating the clinical outcome. In this study, 1135 RBM surfaced wide implants($Rescue^{TM}$, MEGAZEN Co., Korea/595 maxillary, 540 mandibular) were placed in 650 patients(403 male, 247 female/age mean: $51.2{\pm}11.1$ years, range 20 to 83 years). Of the total, 68.3% were used to treat fully or partially edentulous situations, including single-tooth losses and 31.7% were placed immediately after teeth extraction or removal of failed implants, of which all were in the molar regions. Implant diameter and length ranged from 6.0 to 8.0mm and from 5.0 to 10.0mm respectively. The implants were followed for up to 42 months (mean: $14.6{\pm}9.5$ months). Of 1135 placed implants, 58 implants were lost. Among them, 53 implants were lost within 12 months after implant placement. The survival rate was 93.6% in the maxilla and 96.3% in the mandible, yielding an overall survival rate of 94.9%, for up to 42 months. As the result of Cox regression model, prosthetic type, sinus graft, and patient gender have an statistical significance on the implant survival rate in this study. This study suggests that the use of wide implants($6.0{\sim}8.0mm$) would provide a predictable treatment alternative in posterior areas.

• 대한치과보철학회지
• /
• 제47권4호
• /
• pp.385-393
• /
• 2009

연구목적: 임플란트 경부 디자인의 차이가 경부 치밀골의 응력분포에 미치는 영향을 유한요소법을 이용하여 분석하고자 한다. 연구재료 및 방법: 몸체 형상은 유사 (직경 4.3 mm, 길이 10 mm)하나 경부 디자인이 internal형, external형, 및 submerged형으로 다른 3종의 임플란트 시스템 ((주)덴티스, 대구, 대한민국)에 대하여 축대칭 유한요소모델을 사용하여 해석하였다. 악골 폭경은 7 mm로 동일하게 모델링하였고 하중 조건으로는 임플란트 장축에 평행한 수직하중 50 N, 임플란트 장축에 $45^{\circ}$방향으로 작용하는 경사력 50N을 설정하였다. 결과: 해석한 3종의 임플란트 모두 경부 피질골에 응력집중을 발생시켰으며 디자인 차이에 따른 응력 수준의 차이가 관찰되었다. 경부 피질골의 최대 응력은 수직력 조건에서 internal형, submerged형, external형의 순으로 컸으며, 그 값은 각각 2.71, 2.60, 2.48 MPa였다. 경사력 조건에서는 internal형, external형, submerged형의 순으로 컸으며 그 값은 각각 9.30, 9.14, 8.97 MPa였다. 결론: 임플란트 경부 디자인이 주위 치밀골의 응력 분포에 영향을 미칠 수 있지만 그 차이는 크지 않은 것으로 분석되었다.

• 대한치과보철학회지
• /
• 제33권3호
• /
• pp.492-516
• /
• 1995

This study evaluated the responses of mandibular bones of mongrel dogs to loaded hydro xylapatite(HA) and titanium plasma spray(TPS) coated endosseous dental implants, using unloaded ones as the control group. after HA and TPS coated implants were implanted, their bone reactions with vital bones have been observed with light and scanning electron microscope(SEM) at the three periods of the 4th, 12th and 20th week. These reactions have been also compared in a histomorphometric method. The elemental distribution state of implants and the interface neighboring bone tissues have been measured with the energy dispersive analysis of X-rays(EDAX). The following results were obtained ; 1. The light microscopic analysis showed osseointegration in both the control group and the occlusal force loaded group ; Its degree was shown to be higher in the long-maintained and occlusal force groups. 2. The SEM analysis showed that both groups had osseointegration, In the case of TPS-coated implants, the coated layer was divided on the bone interface. In the case of HA-coated implants, there appeared a division between the metal and coated interface. 3. In the histomorphometric analysis, the measured ratio contaction bone of TPS-coated implants was $70{\pm}19$% in the case of no occlusal force ; it was $84{\pm}13$% in the case of occlusal force. The measured ratio contacting bone of HA-coated implants was $75{\pm}18$% in the case of no occlusal force ; it was $94{\pm}9$% in the case of occlusal force. However, there was no significant difference statistically(p>0.05). 4. Both groups showed that the ratio of calcium and phosphorous increased more in the bone tissues than on the bone to implant interface.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제28권2호
• /
• pp.127-135
• /
• 2006

Objectives: The extent of bone formation that occurs at the interface of metallic implants and bone is determined by the number and activity of osteoblastic cells. Stress proteins may be contributing determinants of cell viability in altered environments. Hsp27 is a small Mr hsp which is known as a molecular chaperone. Methods: To better understand how heat shock protein 27 contributes to endosseous implant - associated metal ions affects on osteoblastic cell viability, the effect of chromium and titanium ions were compared to effects of cadmium ions in the ROS17/2.8 osteoblastic cell line. Results: ROS17/2.8 osteoblastic cell line demonstrated ion - specific reductions in growth; reductions were significantly greater for cadmium than for chromium or titanium. Chromium impaired growth of cultures without altering cell viability measured using the MTT assay. A stable transformed cell line expressing additional hsp27(clone "A7") was resistant to the toxic effects of titanium and partially protected from cadmium toxicity. Conclusions: A role for hsp27 in protection of osteoblastic cells from metal ion toxicity is supported by the chromium - induced elevations in hsp27 abundance and the behavior of the A7 cell line in response to metal ions in culture. Similar biochemical responses to altered cellular environments may contribute to the fate of tissues adjacent to select metallic implants.

• 대한치과교정학회지
• /
• 제37권3호
• /
• pp.171-181
• /
• 2007

마이크로 임플란트의 식립 혹은 제거 시의 토오크는 안정성과 기계적 파절 가능성에 대한 척도가 되므로 골조건 및 임플란트의 디자인과 연계한 생역학적 분석을 통해 이를 해석적으로 예측하는 수단을 갖는 것이 의미 있는 과제라 사료된다. 이에 본 연구에서는, 국산 Absoanchor (Dentos Inc. Daegu, Korea) 마이크로 임플란트 모델을 대상으로 하여 기본적 디자인 변수(design parameter)인 길이, 직경, 나사산 크기와 토오크 및 임플란트의 비틀림 파절강도와의 역학적 상관관계에 대해 해석하였으며, 골특성이 미치는 영향을 고려하기 위해서 임플란트/해면골 계면의 저항력$(S_{can})$을 $1.0{\sim}2.5MPa$ 범위로 설정하였다. 분석을 위해 임플란트 디자인 변수들만의 함수인 토오크 지수와 비틀림 파절 강도의 지표인 강도 지수를 정의하였다. 분석결과, 임플란트 직경이 증가할수록 토오크 지수가 증가하지만 강도 지수가 토오크 지수보다 증가율이 커서 비틀림 파절에 대한 안전영역이 증가하였으며, 나사산 높이가 커지면 토오크 지수가 증가하지만 강도 지수는 감소되는 것을 관찰하였다. Absoanchor 마이크로 임플란트는 해면골과 계면에서의 저항력$(S_{can})$이 1.0 MPa 이하에서는 전 모델이 토오크에 의한 비틀림 파절로부터 안전한 것으로 분석되었으나 $(S_{can})$이 증가하면 일부 모델에서는 파절 위험성이 있는 것으로 분석되었다. $S_{can}$이 1.5 MPa수준에서는 경부직경이 1.5 mm 이상이면 전체 길이$(5{\sim}12mm)$에서 안전하였다. 또한, $S_{can}$이 2.0 MPa 수준에서 식립깊이 8 mm를 가지려면 경부직경이 1.5 mm 이상인 모델을 선정하는 것이 안전한 것으로 분석되었다. 항불안을 측정하는 EPM 실험에서도 1회나 2주간 SCE 10mg/kg과 100mg/kg을 투여 받은 생쥐에서 생리 식염수만 투여 받은 생쥐보다 open arms에서 머무는 시간이 유의하게 증가되어 SCE가 단기 또는 장기간의 항불안에 효과가 있음을 나타냈다. 시험관내 실험 결과에서는, SCE와 SCE-40이 SERT, NET, 그리고 GABA ligand의 결합 억제능이 있음이 확인되었고, SCE와 SCE-40은 serotonin(5-hydroxytryptamine: 5-HT)과, norepinephrine의 uptake를 억제하는 것으로 나타났다. 그러므로 본 연구는 효모 추출물(SCE)과 그 분획(SCE-40)이 행동적, 신경학적으로 항우울, 항불안에 효과가 있음을 확인하였으며, 효모 추출물(SCE)과 그 분획(SCE-40)이 안전한 천연식품으로서 우울증, 불안증 등의 관련 질환의 예방, 치료용 의약품 개발과 기능성 식품에 효과적으로 이용될 수 있음을 시사한다.tall fescue 23%, Kentucky bluegrass 6%, perennial ryegrass 8%) 및 white clover 23%를 유지하였다. 이상의 결과를 종합할 때, 초종과 파종비율에 따른 혼파초지의 건물수량과 사료가치의 차이를 확인할 수 있었으며, 레드 클로버 + 혼파 초지가 건물수량과 사료가치를 높이는데 효과적이었다.\ell}$ 이었으며 , yeast extract 첨가(添加)하여 배양시(培養時)는 yeast extract 농도(濃度)가 증가(增加)함에 따라 단백질(蛋白質) 함량(含量)도 증가(增加)하였다. 7. CHS-13 균주(菌株)의 RNA 함량(含量)은 $4.92{\times}10^{-2 }\;mg/m{\ell}$이었으며 yeast extract 농도(濃度)가 증가(增加)함에 따라 증가(增加)하다가 농도(濃度) 0.2%에서 최대함량(最大含量)을 나타내고 그후는 감소(減少)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제26권5호
• /
• pp.527-532
• /
• 2000

A review of the literature, provided by a MEDLINE search from 1980 through June 1999, was performed. This study was screened that 649 patients received 679 sinus lift grafts in which 2056 implants were placed. The types of grafts in sinus augmentation were autogenous bone, corticocancellous block bone, allogenic bone, and a variety of alloplastic materials. Results of these grafts are presented. The most frequent complications was the infection of maxillary sinus. Long-term follow-up is necessary to advance the sinus elevation and to support posterior maxillary restorations.

• 대한치과보철학회지
• /
• 제47권4호
• /
• pp.394-405
• /
• 2009

연구목적: 임플란트 경부의 치은관통부 형상이 주위골 응력분포에 미치는 영향에 대해 조사하고자 한다. 연구재료 및 방법: 높이 2.8 mm, 상부 직경 4 mm, 하부 직경 2.7 mm 인 직선형 치은관통부를 가지는 ITI의 일체형(one piece) 임플란트 (Straumann, Waldenburg, Switzerland)를 Base Model로 사용하여, 치은관통부 외형에 함몰부를 부여하여 곡선형으로 수정한 4개의 해석 모델 (Model-1, -2, -3, -4)을 설정하였다. Base Model을 포함, 모두 5개의 경우에 대해 축대칭 유한요소모델링을 통해 임플란트 장축에 평행인 수직 방향과 임플란트 장축에 $30^{\circ}$ 경사진 방향으로 각각 50 N의 힘이 작용할 때 발생되는 임플란트 주위골의 응력을 해석하여 비교하였다. 체계적인 응력비교를 위해 임플란트 주위에 19개의 절점을 응력 관찰점으로 선정하였으며, 경부 치밀골에 설정된 5개 관찰점의 응력으로부터 회귀분석법으로 임플란트/골 사이에서 생기는 최대응력값을 추정하여 정량적인 비교를 실행하였다. 결과: 최대 골응력은 치은관통부가 직선인 기본모델에서 가장 컸으며, 치은 관통부를 곡선으로 설계한 경우 응력이 감소되었다. 치은 함몰부가 클수록 응력감소 정도가 커졌으며 함몰부의 수직위치가 몸체부에 가장 가까운 Model-4에서 응력감소 정도가 전체의 약5%로 가장 컸다. 결론: 임플란트의 경부 형상은 골응력에 영향을 미치며, 이를 곡선형으로 함으로써 또한 그 함몰부를 몸체부에 근접하게 함으로써 경부골 응력감소를 효과적으로 도모할 수 있다.