• 한국지역지리학회지
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• 제15권5호
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• pp.525-536
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• 2009

급속한 경제성장의 시기에는 요소투입에 의한 성장정책과 성장의 지역적 분배에 기초한 지역개발정책이 가능하였다. 그러나 국가간 경쟁이 심화되고 불확실성의 증대로 성장의 원동력이 크게 약화된 시기에 이러한 모델은 이론적, 실용적 권위를 잃고 있다. 세계화된 경쟁적 환경과 불확실한 세계경제 변화에 신속하고 효율적으로 대처할 수 있는 내생적인 지역혁신역량 구축이 성장과 지역개발정책의 새로운 대안으로 등장하였다. 중앙집권적인 성장정책과 지역개발정책으로 수도권의 과밀화와 지방의 과소화 문제를 겪었던 프랑스는 지방의 내생적인 혁신역량 구축을 위해 지난 1970년대부터 단계적인 지역혁신체계 구축 정책을 실행해 오고 있다. 지방의 내생적인 혁신역량 구축을 위해 계획적인 지식창출과 지역개발을 동시에 추구해온 프랑스의 지역혁신체계의 구축 수단과 방식은 지역의 내생적인 혁신역량 강화와 지역간 불균형 문제를 해소하려는 정부의 정책에 많은 시사점을 제공한다.

• 성인간호학회지
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• 제22권1호
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• pp.90-102
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• 2010

Purpose: The purpose of this study was to identity factors affecting patient adherence and to develop an explanatory model for patient adherence in patients with spinal cord injury. 8 Variables that were based on the previous research and a review of literature were used to construct hypothetical model. Social support, economic status, perceived barrier, patient provider relationship and rehabilitation related knowledge were the exogenous variables, depression, self-efficacy and patient adherence were the endogenous variables. Methods: Data form 117 patients with SCI were analysed to test the hypothetical model, using SAS and LISREL 8.53 program. Results: The overall fitness of the model was good (GFI=.991, AGFI=.915, NNFI=1.299, NFI=.953, p=.632) Depression, powerlessness, economic status were the strong factors influencing patient adherence. Powerlessness was significant factors for self-efficacy. Conclusion: To improve of patient adherence should focus on nursing intervention for depression, powerlessness and economic status.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2007년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
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• pp.15-22
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• 2007

Increasing evidence indicates that microglia-driven chronic inflammatory responses playa pathological role in the central nervous system. Activation of microglia is pivotal in the initiation and progression of neuroinflammation. Inhibition of the microglial activation may provide an effective therapeutic intervention that alleviates the progression of the neurodegenerative diseases. Anti-inflammatory agents may be a useful candidate for such a therapeutic approach. Continual investigation of the mechanisms underlying microglial activation and regulation of neuroinflammation by endogenous or exogenous factors would not only lead to the discovery of novel neuroprotective agents, but also help to understand complex pathophysiology of neurodegenerative diseases.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.309.1-309.1
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• 2002

Ginsan, a polysaccharide extracted from Panax ginseng. was earlier scrutinized for a biological-response modifier. We further studied the protective and restorative activity of Ginsan against sublethal dose irradiation owing to increase production of endogenous hematopoietic growth factors such as IL-1. TNF-${\alpha}$. IL-6, GM-CSF. Which induce strong redox-emzyme elevation. Exposing to radiation induces reactive oxygen species (ROS). which play an important causative role in radiation damage. (omitted)

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 춘계학술대회
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• pp.1-4
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• 1998

Impaired insulin action in Type 2 diabetes is thought to lead to hyperglycemia, with both environmental and complex genetic factors playing key roles. Although the primary lesion in Type 2 diabetes is unknown, a number of studies suggest that metabolic defects in the liver, skeletal muscle and fat, and pancreatic ${\beta}$-cells contribute to the disease. These metabolic abnormalities are characterized by the overproduction of hepatic glucose, impaired insulin secretion, and peripheral insulin resistance. In current pharmacological treatment of Type 2 diabetes, sulfonylurea (SU) drugs have mainly been used as oral hypoglycemic drugs to stimulate endogenous insulin secretion from ${\beta}$ cells. SU drugs, however, sometimes aggravate the disease by causing fatigue of the pancreatic ${\beta}$ cells, which leads to reduced drug efficacy after long-term treatment. This class of drugs also leads to enhanced obesity arising from the stimulation of endogenous insulin secretion in obese Type 2 diabetic patients, plus an increased incidence of SU-induced hypoglycemia. Since 1980, a major challenge has been made by us to develop a potential pharmacological therapy for the treatment of insulin resistance in peripheral tissues and/or suppression of abnormal hepatic glucose production in Type 2 diabetic patients. Such a drug would be expected to have fewer side effects and retain long-term efficacy.

• Molecules and Cells
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• 제24권1호
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• pp.148-151
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• 2007

Porcine endogenous retroviruses (PERVs) in the pig genome represent a potential risk of infection in pig-to-human transplantation and are transmitted vertically. The solitary long terminal repeat (LTR) elements of the PERVs affect the replication properties of the individual viruses via their repeat sequences and by encoding a set of specific transcription factors. We examined the promoter activities of solitary LTR elements belonging to the PERV-A and -B families of the Korean domestic pig (KDP) using luciferase reporters. Three of the LTR structures (of PERV-A5-KDP, PERV-A7-KDP, PERV-A8-KDP) had different promoter activities in human HCT116 cells and monkey Cos7 cells, and potential negatively and positively acting regions affecting transcription were identified by deletion analysis. These data suggest that specific sequences in the U3 region of a given LTR element can affect the activities of promoter or enhancer elements in the PERV.

• International Journal of Advanced Culture Technology
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• 제10권4호
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• pp.181-189
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• 2022

The purpose of this study is to verify study models and examine a causal relationship among authenticity, job satisfaction, organizational commitment, quality of life and job achievement for amateur business team player. In order to achieve the purpose, this study conducted structural equation model analysis for study models consisting of extraneous variables after examining the authenticity(organization, leader) that amateur business players perceive and endogenous variables including job satisfaction, organizational commitment, quality of life, and job performance. The object of questionnaires in this study selected sports business team players nationwide as a population and 348 players were chosen as final effective samples by applying a convenient sampling method for offline and online questionnaires. The research tool for this study is a questionnaire. The two dimensions of authenticity were used by developing a scale. For all endogenous variables, the scales used in previous studies were modified and used according to the purpose of the study. This study analyzed the collected data, applying SPSS Win ver. 23.0 and AMOS 20.0 programs in order to analyze the characteristics of the study objects, describe questionnaires, and verify selected study hypothesis, individual hypothesis was verified after identifying the reliability and validity of measurement model, and the fitness verification of study models. In the results, all of the 8 hypothesis were adopted and the reciprocal relationship among each factors in the study model were observed.

• 한국문헌정보학회지
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• 제47권4호
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• pp.275-294
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• 2013

이 연구는 도서관 브랜드 이미지의 구성요소를 분석한 이전 연구의 후속연구로서, 이전 연구에서 확증된 구성요소들이 설정된 개념적 변수(endogenous variables)와 어떠한 관련성을 보이는가를 확인하는 확인적 절차(confirmatory procedure)로 진행되었다. 구조선형 방정식(structural equation modeling)을 이용하였으며, 연구결과 총 3개의 차원과 9개의 하부차원 그리고 20개의 항목이 도서관의 브랜드 이미지를 측정하는데 적합한 것으로 최종 확인되었다. 해당 모델의 핵심개념을 그대로 사용하여 직원집단군에 적용할 수 있는지를 검증한 결과, 해당 모델은 직원집단에 적용되지 않음을 확인할 수 있었고, 각각의 이미지 차원에 대한 두 집단 간의 인식에도 차이가 있는 것으로 확인되었다.

• 대한한방내과학회지
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• 제23권2호
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• pp.280-285
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• 2002

Pruritus is [CHECK DEFN] itchy feeling of one's skin. We often face stroke patients who complain about Pruritus. They occasionally fail to fall asleep or have a secondary infection as a result of scratching. For these reasons, severe Pruritus brings down general condition and interferes with recovery. The causes of Pruritus are distributed to from skin diseases and from internal diseases. Especially among the skin diseases, Xerotic Eczema, which is called Senile Eczema causes the dry skin in the elderly, especially lower limb's extensor part. According to the epidemiology, 20% of the old have Xerotic Eczema. In oriental medicine, Pruritus is called Pungsoyang(風瘙痒), Pungyang(風痒), Yangpung(痒風), Sinyang(身痒). The cause of Pruritus is divided into two. One is endogenous factors and the other is exogenous factors. The former are deficiency of blood(血虛), blood fever(血熱), wind-heat due to internal damage(內傷風熱), damp-heat in the liver and gallbladder(肝膽濕熱), endogenous wind stirring in the liver(肝風內動), deticiency syndrome of the spleen(脾虛), deficiency of Yin of the liver and kidneys(肝腎陰虛) and deficiency of the Penetration and Conception Vessels(衝任不足). The latter are wind-cold due to exogenous affection(外感風寒) and wind-heat due to exogenous affection(外感風寒). We report two stroke patients who complained of severe Pruritus They were diagnosed as having Xerotic Eczema by a dermatologist. We regarded their Pruritus as blood fever(血熱) and wind-heat(風熱) and prescribed Sopung-San to these patients. These patients showed significant improvement.

• 대한영양사협회학술지
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• 제25권2호
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• pp.142-155
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• 2019

The aim of this study was to construct and test a structural equation model for the risk factors of metabolic syndrome in Korean adults. The structural equation model hypothesizes that eating alone and feeling depressed is a risk factor for metabolic syndrome. The data of this study were obtained from the Sixth Korea National Health and Nutrition Examination Survey which was cross-sectional data from the representative national survey. A total of 4,013 subjects replied to the survey item of lifestyle and completed the physical examinations among adults aged 19 years or older in South Korea was in 2015. The structural model in this study was composed of four latent variables: eating alone, depression, negative health behavior, and metabolic syndrome. Two variables, the rate of eating alone and depression, were exogenous variables. Negative health behavior was both a mediating variable and endogenous variable, and metabolic syndrome was the final endogenous variable. The data were analyzed using the Maximum Likelihood method and bootstrapping. The structural model was appropriate for the data based on the model fit indices. The results of this study can be summarized as follows: Eating alone is a direct risk factor of metabolic syndrome in Korean women. Depression can mediate metabolic syndrome through negative health behaviors. Negative health behavior had a direct impact on metabolic syndrome in both men and women. This study may be a guideline for interventions and strategies to reduce the incidence of metabolic syndrome in Korean adults.