• 대한약침학회지
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• 제18권2호
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• pp.86-87
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• 2015

Objectives: Condurango is widely used in various systems of complementary and alternative medicine (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats in vivo to validate its use as a traditional medicine. Methods: After one month of scheduled BaP feeding (50 mg/kg body-weight), lung cancer developed after four months. BaP-intoxicated rats were then treated with Condurango (0.06 mL) twice daily starting at the end of the four months for an additional one, two and three months, respectively. Effects of Condurango were evaluated by analyzing lung histology, reactive oxygen species (ROS) and antioxidant biomarkers, DNA-fragmentation, RT-PCR (Reverese Transcriptase-Polymerase Chain Reaction), ELISA (Enzyme linked immunosorbent assay) and western blot of several apoptotic signalling markers and comparing the results against those obtained for controls. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate ROS, which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer-cell death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusions: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• Journal of Microbiology and Biotechnology
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• 제16권10호
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• pp.1491-1498
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• 2006

The feasibility of pullulan acetate nanoparticles (PAN) with ionic strength (IS) sensitivity as a radioisotope carrier to inhibit tumor growth is demonstrated. PAN was radiolabeled with rhenium 188 (Re-188) without any chelating agents. The labeling efficiency of Re-188 into PAN (Re-188PAN) was $49.3{\pm}4.0%$ as determined by TLC. The tumor volumes of mice treated with 0.45 mCi of Re-188-PAN were measured and compared with that of free Re-188 after 5 days of intratumoral injection. For the histological evaluation of apoptotic nuclei of tumor cells, hematoxylin and eosin (H&E), and terminal deoxynucleotidyl transferase biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) staining were performed. The mean tumor volume of the Re-188-PAN-treated group was decreased by 36% after 5 days, whereas that the free Re-188-treated group was decreased by only 15% (P<0.05). The mean number of TUNEL-positive cells in Re-188-PAN-treated tumors at $144.3{\pm}79.9$ cells/section was significantly greater than the control ($26.7{\pm}7.9$ cells/section, P=0.03). The numbers of leukocyte and lymphocyte were decreased in both free Re-188- and Re-188-PAN-treated mice. These results indicated that the intratumoral injection of Re-188-PAN effectively inhibits the tumor growth by prolonging Re-188 retention time in tumor site induced by the IS sensitivity.

• Steel and Composite Structures
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• 제18권2호
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• pp.497-517
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• 2015

This study evaluates behavior of the Y-type perfobond rib shear connector proposed by Kim et al. (2013). In addition, an empirical shear resistance formula is developed based on push-out tests. Various types of the proposed Y-type perfobond rib shear connectors are examined to evaluate the effects of design variables such as concrete strength, number of transverse rebars, and thickness of rib. It is verified that higher concrete strength increases shear resistance but decreases ductility. Placing transverse rebars significantly increases both the shear resistance and ductility. As the thickness of the ribs increases, the shear resistance increases but the ductility decreases. The experimental results indicate that a Y-type perfobond rib shear connector has higher shear resistance and ductility than the conventional stud shear connector. The effects of the end bearing resistance, resistance by transverse rebars, concrete dowel resistance by holes, and concrete dowel resistance by Y-shape ribs on the shear resistance are estimated empirically based on the push-out test results and the additional push-out test results by Kim et al. (2013). An empirical shear resistance formula is suggested to estimate the shear resistance of a Y-type perfobond shear connector for design purposes. The newly developed shear resistance formula is in reasonable agreement with the experimental results because the average ratio of measured shear resistance to estimated shear resistance is 1.024.

• 한국지반공학회논문집
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• 제35권1호
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• pp.17-30
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• 2019

본 연구는 3차원 수치해석을 통해 기존말뚝과 보강말뚝의 하중분담율(Load Distribution Ratio)과 근사적 해석 기법으로 보강말뚝의 축방향 강성(Axial Stiffness)을 산정하였다. 시공단계를 고려하여 말뚝기초의 LDR에 영향을 미치는 인자를 파악하기 위해서 1) 말뚝기초의 강성, 2) 말뚝기초의 선단지지조건, 3) 기초판 접촉효과, 4) 보강말뚝의 설치위치에 따라 해석을 수행하여 기존말뚝과 신설말뚝의 하중분담율 거동을 확인하였다. 또한 5) 기존말뚝의 축방향 강성($K_{ve}$)를 사용하여 말뚝지지 전면기초의 3차원 근사적 해석기법(YSPR)으로 보강말뚝의 직경에 따른 강성($K_{vr}$)을 산정하고, 장기간 사용으로 인한 경화를 고려하여 $K_{ve}$를 3단계로 나누어 감소시켜 보강말뚝의 강성 변화의 경향을 살펴보고, 신설 말뚝의 강성 산정방법을 제시하였다.

• 한국지반환경공학회 논문집
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• 제23권5호
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• pp.25-32
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• 2022

최근 우리나라에 리히터 규모 5.0 이상의 지진발생 2건과 규모가 낮은 지진발생이 많아짐에 따라 지진피해가 늘어나면서 내진설계에 대한 많은 연구와 관심이 높아지고 있으며, 그 중 최근 발생한 포항지진으로 인해 항만시설물에 대한 내진설계에도 관심이 높아졌다. 본 연구에서는 1g 진동대시험을 통하여 항만구조물 중 직립식, 경사식 방파제에 대한 지진 시 발생하는 동적거동에 대해서 실험 및 분석을 하였다. 이를 위해 사상법칙을 적용한 모델에 장주기(Hachinohe), 단주기(Ofunato), 인공지진파 총 세가지 지진파를 적용하고, 연약지반의 DCM 공법 보강 여부를 고려하여 실험하였다. 진동대시험결과를 기초로 지진 시 DCM 공법 보강 여부에 따라 직립식과 경사식 방파제의 동적거동에 대하여 가속도 및 수평·수직 변위를 분석하였다. 검토 결과 직립식 및 경사식 방파제 동적거동은 DCM 공법 보강을 한 경우에 지지력 및 강성이 높아짐에 따라 가속도의 증폭이 억제되는 경향을 나타내었다.

• Earthquakes and Structures
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• 제24권5호
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• pp.353-364
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• 2023

In this study, a method has been proposed for the static and dynamic nonlinear analysis of multi-storey buildings, which takes into account the contribution of axial deformations in vertical load-bearing elements, which are especially important in tall and narrow structures. Shear deformations on the shear walls were also taken into account in the study. The presented method takes into account the effects that are not considered in the fishbone and flexural-shear beam models developed in the literature. In the Fishbone model, only frame systems are modeled. In the flexural shear beam model developed for shear wall systems, shear deformations and axial deformations in the walls are neglected. Unlike the literature, with the model proposed in this study, both shear deformations in the walls and axial deformations in the columns and walls are taken into account. In the proposed model, multi-storey building is represented as a sandwich beam consisting of Timoshenko beams pieced together with a double-hinged beam. At each storey, the total moment capacities of the frame beams and the coupled beams in the coupled shear walls are represented as the equivalent shear capacity. On the other hand, The sums of individual columns and walls moment at the relevant floor level are represented as equivalent moment capacity at that floor level. At the end of the study, examples were solved to show the suitability of the proposed method in this study. The SAP2000 program is employed in analyses. In a conclusion, it is observed that among the solved examples, the proposed sandwich beam model gives good results. As can be seen from these results, it is seen that the presented method, especially in terms of base shear force, gives very close results to the detailed finite element method.

• Nuclear Engineering and Technology
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• 제55권7호
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• pp.2578-2590
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• 2023

In this work, a 24-month two-batch fuel management strategy for the APR1400 using LEU + has been investigated, where enrichments of 5.9 and 5.2 w/o are utilized in lieu of the conventional 4-5 w/o UO₂ fuel. In addition, an Accident Tolerant Fuel (ATF) clad based on the swaging technology is applied to APR1400 fuel assemblies. In this special ATF clad design, both outer and inner SS316 layers protect the conventional zircaloy clad. Erbia (Er₂O₃) is introduced as a burnable absorber with two-fold goals to lower the critical boron concentration in the long-cycle LEU + loaded core as well as to handle the LEU + fuel in the existing front-end fuel facilities without renewing the license. Two types of fuel assemblies with different loading of gadolinia (Gd₂O₃) are considered to control both the reactivity and the core radial power distribution. The erbia burnable absorber is uniformly admixed with UO₂ in all fuel pins except for the gadolinia-bearing ones. In this study, two core designs were devised with different erbia loading, and core performance and safety parameters were evaluated for each case in comparison with a core design without any burnable absorbers. The core analysis was done using the two-step method. First, cross-sections are generated by the SERPENT 2 Monte Carlo code, and the 3-D neutronic analysis is performed with an in-house multi-physics nodal code KANT.

• 대한토목학회논문집
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• 제26권5A호
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• pp.881-885
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• 2006

사장교 케이블은 구조적으로 휨강성과 감쇠력이 작아 풍우에 의해 쉽게 유해진동이 발생한다. 이러한 풍우진동을 저감시키기 위한 효과적인 방법으로 부가댐퍼를 장착하여 케이블의 감쇠력을 증가시키는 제어시스템이 널리 사용되어왔다. 그러나 사장교의 장대화로 인해 구조적으로나 미적으로 충분한 감쇠력을 제공할 수 있는 위치에 부가댐퍼를 장착하기 어렵게 되었다. 그러므로 본 논문은 사장교의 미관을 해치지 않으면서 기존의 제어시스템보다 효과적으로 케이블의 진동을 저감시킬 수 있는 새로운 개념의 제어시스템을 제안하였다. 제안된 시스템은 케이블 앵커리지에 적층고무베어링과 같은 유동이 가능한 장치와 내부댐퍼로 구성되었으며, 제어성능평가를 위해 해석모델을 개발하였다. 제안된 시스템의 제어성능 분석을 위해 수치해석을 수행하였으며 기존의 부가 댐퍼시스템과 진동 저감효과를 비교하였다. 제안된 제어시스템은 기존의 부가댐퍼 시스템 보다 효과적으로 진동을 저감시킬 수 있었으며 사장교 케이블의 풍우진동 저감을 위해 효과적인 시스템으로 사료된다.

• Geomechanics and Engineering
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• 제34권2호
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• pp.209-220
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• 2023

In this study, a series of three-dimensional numerical analyses were carried out to investigate the penetration performance of a dynamically installed Hall anchor. The advanced coupled Eulerian-Lagrangian (CEL) technique was adopted to accurately simulate the large soil deformation during the vertical penetration of a Hall anchor. In total, 52 numerical analyses were conducted to investigate the relationship between anchor penetration depth and the initial kinematic energy. Moreover, a sensitivity analysis was performed to investigate the effects of soil shear strength and soil type on the penetration mechanism of a drop anchor under self-weight. There is a monotonic increase in the penetration depth with an increasing anchor weight when the topsoil of the riverbed is not subjected to erosion. On the other hand, all the computed depths significantly increase when soil erosion is taken into consideration. This is mainly due to an enhanced initial kinematic energy from an increased dropping depth. Both depths increase exponentially with the initial kinematic energy. An enhanced shear strength can potentially increase the side resistance and end-bearing pressure around a drop anchor, thus significantly reducing the downward penetration of a hall anchor. Design charts are developed to directly estimate penetration depth and associated plastic zone due to dynamically installed anchor at arbitrary soil shear strength and anchor kinematic energy.

• Tribology and Lubricants
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• 제40권2호
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• pp.54-60
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• 2024

This study experimentally identifies the effects of end shape, clearance, total damper length, journal eccentricity ratio, oil supply pressure, and oil flow rate on the damping coefficient of a squeeze film damper (SFD) with piston ring seal ends and a central groove. The SFD is composed of a lubricating fluid flowing between the outer race of a rolling element bearing and cartridge, along with an anti-rotation pin to prevent the rotation of the outer race. The device provides additional viscous damping to a rotating system. Additionally, piston ring seals attached at both ends of the damper increase the damping coefficient of the rotating system by reducing oil leakage. Because these different design conditions affect the damping coefficient of an SFD, we perform experiments including different conditions. Tests show that the damping coefficient increases significantly in the SFD with piston ring seal ends compared with the SFD with open ends. The damping coefficient also increases with increasing total damper length and journal eccentricity ratio, and decreases with increasing clearance. Additionally, in contrast to the trend observed for the SFD with open ends, the damping coefficient for the SFD with piston ring seal ends increases with increasing supply pressure and flow rate as the frequency decreases but shows consistent results as the frequency increases.