• Journal of Microbiology and Biotechnology
• /
• v.16 no.10
• /
• pp.1491-1498
• /
• 2006

The feasibility of pullulan acetate nanoparticles (PAN) with ionic strength (IS) sensitivity as a radioisotope carrier to inhibit tumor growth is demonstrated. PAN was radiolabeled with rhenium 188 (Re-188) without any chelating agents. The labeling efficiency of Re-188 into PAN (Re-188PAN) was $49.3{\pm}4.0%$ as determined by TLC. The tumor volumes of mice treated with 0.45 mCi of Re-188-PAN were measured and compared with that of free Re-188 after 5 days of intratumoral injection. For the histological evaluation of apoptotic nuclei of tumor cells, hematoxylin and eosin (H&E), and terminal deoxynucleotidyl transferase biotinylated deoxyuridine triphosphate nick end labeling (TUNEL) staining were performed. The mean tumor volume of the Re-188-PAN-treated group was decreased by 36% after 5 days, whereas that the free Re-188-treated group was decreased by only 15% (P<0.05). The mean number of TUNEL-positive cells in Re-188-PAN-treated tumors at $144.3{\pm}79.9$ cells/section was significantly greater than the control ($26.7{\pm}7.9$ cells/section, P=0.03). The numbers of leukocyte and lymphocyte were decreased in both free Re-188- and Re-188-PAN-treated mice. These results indicated that the intratumoral injection of Re-188-PAN effectively inhibits the tumor growth by prolonging Re-188 retention time in tumor site induced by the IS sensitivity.

• Steel and Composite Structures
• /
• v.18 no.2
• /
• pp.497-517
• /
• 2015

This study evaluates behavior of the Y-type perfobond rib shear connector proposed by Kim et al. (2013). In addition, an empirical shear resistance formula is developed based on push-out tests. Various types of the proposed Y-type perfobond rib shear connectors are examined to evaluate the effects of design variables such as concrete strength, number of transverse rebars, and thickness of rib. It is verified that higher concrete strength increases shear resistance but decreases ductility. Placing transverse rebars significantly increases both the shear resistance and ductility. As the thickness of the ribs increases, the shear resistance increases but the ductility decreases. The experimental results indicate that a Y-type perfobond rib shear connector has higher shear resistance and ductility than the conventional stud shear connector. The effects of the end bearing resistance, resistance by transverse rebars, concrete dowel resistance by holes, and concrete dowel resistance by Y-shape ribs on the shear resistance are estimated empirically based on the push-out test results and the additional push-out test results by Kim et al. (2013). An empirical shear resistance formula is suggested to estimate the shear resistance of a Y-type perfobond shear connector for design purposes. The newly developed shear resistance formula is in reasonable agreement with the experimental results because the average ratio of measured shear resistance to estimated shear resistance is 1.024.

• Journal of the Korean Geotechnical Society
• /
• v.35 no.1
• /
• pp.17-30
• /
• 2019

This study presents the application of the numerical and analytical technique to simulate the Load Distribution Ratio (LDR) and to define axial stiffness on reinforcing pile foundation ($K_{vr}$) in vertical extension remodeling structure. The main objective of this study was to investigate the LDR between existing piles and reinforcing piles. Therefore, to analyze the LDR, 3D FEM analysis was performed as variable for elastic modulus, pile end-bearing condition, raft contacts, and relative position of reinforcing pile in a group. Also, using the axial stiffness ($K_{ve}$) of existing piles, the axial stiffness of reinforcing pile was defined by 3D approximate computer-based method, YSPR (Yonsei Piled Raft). In addition $K_{vr}$ was defined by reducing the $K_{ve}$considering the degradation of the existing piles.

• Journal of the Korean GEO-environmental Society
• /
• v.23 no.5
• /
• pp.25-32
• /
• 2022

As recently, there have been two earthquakes with a magnitude of 5.0 or greater in Korea and the number of smaller earthquakes has increased, a lot of research and interest in earthquake-resistant design are increasing. Especially, the Pohang earthquake has also raised interest in earthquake-resistant design of port facilities. In this study, experiments and analysis were conducted on the dynamic behavior of upright and inclined breakwaters during earthquakes among port structures through the 1g shaking table test. To this end, three seismic waves were applied to the model to which the similarity law (scale effect) was applied: long period (Hachinohe), short period (Ofunato) and artificial seismic waves. The acceleration and displacement of the upright and inclined breakwaters were analyzed according to whether the DCM method was reinforced during earthquakes based on the results of shaking table test. As the result, the dynamic behavior of the upright and inclined breakwater shows a tendency to suppress the amplification of acceleration as bearing capacity and rigidity increase when DCM method is reinforced.

• Earthquakes and Structures
• /
• v.24 no.5
• /
• pp.353-364
• /
• 2023

In this study, a method has been proposed for the static and dynamic nonlinear analysis of multi-storey buildings, which takes into account the contribution of axial deformations in vertical load-bearing elements, which are especially important in tall and narrow structures. Shear deformations on the shear walls were also taken into account in the study. The presented method takes into account the effects that are not considered in the fishbone and flexural-shear beam models developed in the literature. In the Fishbone model, only frame systems are modeled. In the flexural shear beam model developed for shear wall systems, shear deformations and axial deformations in the walls are neglected. Unlike the literature, with the model proposed in this study, both shear deformations in the walls and axial deformations in the columns and walls are taken into account. In the proposed model, multi-storey building is represented as a sandwich beam consisting of Timoshenko beams pieced together with a double-hinged beam. At each storey, the total moment capacities of the frame beams and the coupled beams in the coupled shear walls are represented as the equivalent shear capacity. On the other hand, The sums of individual columns and walls moment at the relevant floor level are represented as equivalent moment capacity at that floor level. At the end of the study, examples were solved to show the suitability of the proposed method in this study. The SAP2000 program is employed in analyses. In a conclusion, it is observed that among the solved examples, the proposed sandwich beam model gives good results. As can be seen from these results, it is seen that the presented method, especially in terms of base shear force, gives very close results to the detailed finite element method.

• Nuclear Engineering and Technology
• /
• v.55 no.7
• /
• pp.2578-2590
• /
• 2023

In this work, a 24-month two-batch fuel management strategy for the APR1400 using LEU + has been investigated, where enrichments of 5.9 and 5.2 w/o are utilized in lieu of the conventional 4-5 w/o UO₂ fuel. In addition, an Accident Tolerant Fuel (ATF) clad based on the swaging technology is applied to APR1400 fuel assemblies. In this special ATF clad design, both outer and inner SS316 layers protect the conventional zircaloy clad. Erbia (Er₂O₃) is introduced as a burnable absorber with two-fold goals to lower the critical boron concentration in the long-cycle LEU + loaded core as well as to handle the LEU + fuel in the existing front-end fuel facilities without renewing the license. Two types of fuel assemblies with different loading of gadolinia (Gd₂O₃) are considered to control both the reactivity and the core radial power distribution. The erbia burnable absorber is uniformly admixed with UO₂ in all fuel pins except for the gadolinia-bearing ones. In this study, two core designs were devised with different erbia loading, and core performance and safety parameters were evaluated for each case in comparison with a core design without any burnable absorbers. The core analysis was done using the two-step method. First, cross-sections are generated by the SERPENT 2 Monte Carlo code, and the 3-D neutronic analysis is performed with an in-house multi-physics nodal code KANT.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.26 no.5A
• /
• pp.881-885
• /
• 2006

Rain-wind induced cable vibration can cause serious problems in cable-stayed bridges. Externally attached dampers have been used to provide an effective means to suppress the vibration of relatively short stay-cables. For very long stay-cables, however, such damper systems are rendered ineffective, as the dampers need to be attached near the end of cables for aesthetic reasons. This paper investigates a new control system to mitigate the cable vibration. The proposed control system which consists of a laminated rubber bearing and an internal damper may be installed inside of the cable anchorage. A simple analytical model of the cable-damper system is developed first based on the taut string representation of the cable. The response of a cable with the proposed control system is obtained and then compared to those of the cable with and without an external passive damper. The proposed stay-cable vibration control system is shown to perform better than the optimal passive viscous damper, thereby demonstrating its applicability in large cable-stayed bridges for mitigation of rain-wind induced vibration of stay-cables.

• Geomechanics and Engineering
• /
• v.34 no.2
• /
• pp.209-220
• /
• 2023

In this study, a series of three-dimensional numerical analyses were carried out to investigate the penetration performance of a dynamically installed Hall anchor. The advanced coupled Eulerian-Lagrangian (CEL) technique was adopted to accurately simulate the large soil deformation during the vertical penetration of a Hall anchor. In total, 52 numerical analyses were conducted to investigate the relationship between anchor penetration depth and the initial kinematic energy. Moreover, a sensitivity analysis was performed to investigate the effects of soil shear strength and soil type on the penetration mechanism of a drop anchor under self-weight. There is a monotonic increase in the penetration depth with an increasing anchor weight when the topsoil of the riverbed is not subjected to erosion. On the other hand, all the computed depths significantly increase when soil erosion is taken into consideration. This is mainly due to an enhanced initial kinematic energy from an increased dropping depth. Both depths increase exponentially with the initial kinematic energy. An enhanced shear strength can potentially increase the side resistance and end-bearing pressure around a drop anchor, thus significantly reducing the downward penetration of a hall anchor. Design charts are developed to directly estimate penetration depth and associated plastic zone due to dynamically installed anchor at arbitrary soil shear strength and anchor kinematic energy.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.28 no.3
• /
• pp.129-139
• /
• 2024

In this study, the SBC system, a new mechanical joint method, was developed to improve the constructability of precast concrete (PC) beam-column connections. The reliability of the finite element analysis model was verified through the comparison of experimental results and FEM analysis results. Recently, the intermediate moment frame, a seismic force resistance system, has served as a ramen structure that resists seismic force through beams and columns and has few load-bearing walls, so it is increasingly being applied to PC warehouses and PC factories with high loads and long spans. However, looking at the existing PC beam-column anchorage details, the wire, strand, and lower main bar are overlapped with the anchorage rebar at the end, so they do not satisfy the joint and anchorage requirements for reinforcing bars (KDS 41 17 00 9.3). Therefore, a mechanical joint method (SBC) was developed to meet the relevant standards and improve constructability. Tensile and bending experiments were conducted to examine structural performance, and a finite element analysis model was created. The load-displacement curve and failure pattern confirmed that both the experimental and analysis results were similar, and it was verified that a reliable finite element analysis model was built. In addition, bending tests showed that the larger the thickness of the bolt joint surface of the SBC, the better its structural performance. It was also determined that the system could improve energy dissipation ability and ductility through buckling and yielding occurring in the SBC.

• Tribology and Lubricants
• /
• v.40 no.2
• /
• pp.54-60
• /
• 2024

This study experimentally identifies the effects of end shape, clearance, total damper length, journal eccentricity ratio, oil supply pressure, and oil flow rate on the damping coefficient of a squeeze film damper (SFD) with piston ring seal ends and a central groove. The SFD is composed of a lubricating fluid flowing between the outer race of a rolling element bearing and cartridge, along with an anti-rotation pin to prevent the rotation of the outer race. The device provides additional viscous damping to a rotating system. Additionally, piston ring seals attached at both ends of the damper increase the damping coefficient of the rotating system by reducing oil leakage. Because these different design conditions affect the damping coefficient of an SFD, we perform experiments including different conditions. Tests show that the damping coefficient increases significantly in the SFD with piston ring seal ends compared with the SFD with open ends. The damping coefficient also increases with increasing total damper length and journal eccentricity ratio, and decreases with increasing clearance. Additionally, in contrast to the trend observed for the SFD with open ends, the damping coefficient for the SFD with piston ring seal ends increases with increasing supply pressure and flow rate as the frequency decreases but shows consistent results as the frequency increases.