• Journal of Korean Society of Transportation
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• v.19 no.4
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• pp.7-18
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• 2001

This study represents a first attempt in Korea to develop the simultaneous freight supply-demand model which considers the relationship between freight supply and demand. As the existing study was limited in one area, or the supply and the demand was separated and assumed not to affect each other, this study take it into consideration the fact that the demand affects supply and simultaneously vice versa. This approach allows us to diagnose a policy carried on and helps us to make a resonable alternative for the effectiveness of freight transportation system. To find a relationship between them, we use a method of econometrics. a structural equation theory and two stage least-squares(2SLS) estimation technique, to get rid of bias which involves two successive applications of OLS. Based on the domestic freight data, this study consider as explanatory variables a number of population(P), industry(IN), the amount of production of the mining and manufacturing industries(MMI), the rate of the effectiveness of freight capacity(LE) and the distance of an empty carriage operation(VC). This study describes well the simultaneous process of freight supply-demand system in that the increase of VC from the decrease of VC raises the cargo capacity and cargo capacity also augments VC. By the way. it is analyzed that the increment of VC due to the increase of the cargo capacity is larger than the reduction of VC owing to the increase of the quantify of goods. Therefore an alternative policy is needed in a short and long run point of view. That is to say, to promote the effectiveness of the freight transportation system, a short term supply control and a long run logistic infrastructure are urgent based on the restoration of market economy by successive deregulation. So we are able to conclude that gradual deregulation is more desirable to build effective freight market.

• Korean journal of applied entomology
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• v.22 no.2 s.55
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• pp.138-146
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• 1983

With the increase of pesticide consumption, not only pesticide handling population would grow greater but also the chances to be exposed to the pesticides would be also increased. Thus, safe use and handling of the pesticides are becoming more important and serious in these days. The pesticides are well known to most pepole, however there are very limited number of persons who have correct understanding of chamicals. Intoxication cases caused by pesticides have been reported very rarely through the mess media, even they were lack of scientific evidences. In this paper, problems related to pesticide manufacture, transportation, storage, sprays, and residues and their countermeasures were discussed in connection with public health and enviromental aspects. Acute intoxication cases by pesticide handling might be caused accidently either through manufacture, marketing, transportation, or spraying. Safety aspects of workers in manufacturing plants include not only exposure to toxic chemicals, but also posibilities of of explosion and brought about by pesticides and their diluents. The problems of water pollution by waste chemicals from the manufacturing factories were discussed. Packing and loading methods of pesticides for transportation are considered in safety scheme and discussions are given in association with traffic accidents. With regard to warehouse, the pesticide storage, location structure, keepers, and standing materials for emergency are concerned with safety aspects. Concerning the spraying of chemicals, there are some problems to be discussed about clothes, spray equipment, wind direction, spray period, and spray workers condition. After the spray, treatment of used containers, remainder of Pesticides, and spray tools are also discussed. For the dissolutions of problems on public health and environmental danger arising from pesticide residues, there are two legal sanctions; 'Pesticide Tolerances' and 'Pesticide Safe Use Standards'. These regulations are legally effective, however, some problems still remain in practices to implement the acts properly, because these provisions are followed by the far mers mostly. With these regards, most problems are concerned with various sectors and persons, affecting public health and environment from the producers to the end users and consumers. As a whole persons concerned with pesticides, every possible effort has to be assembled to protect hazards from the chemicals. For the foremost place, special training and education are required for managing groups; such as factory managers and agricultural extension workers who are responsible for training the factory workers and farmers. The education is the only way to solve the hazard problems caused by the pesticides.

• Journal of Veterinary Clinics
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• v.27 no.2
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• pp.147-153
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• 2010

Bio-integration of cartilage grafts with subchondral bone is a significant clinical challenge. To date, the use of demineralized bone matrix (DBM) has been one of the most effective strategies for bone cell proliferation in vivo. Here, we investigated whether coculture of chondrocytes and DBM could serve as a single-platform system containing all the essential elements for purposive bone and cartilage induction. The aim of this study was to evaluate and compare the phenotype and proliferation of bovine chondrocytes cocultured with DBM in two different culture systems, pellet and alginate bead culture. In alginate bead culture, we observed an increase in chondrocyte number and formation of cell clusters. Typical chondrocytic phenotype was maintained for entire eight weeks. Histological analysis showed that chondrocytes maintained a typical round, plump morphology and there was a gradual increase in lacunae. Both coculture systems yielded an expanded cell population as compared to the controls (chondrocytes alone). The production of glycosaminoglycans was also increased in the coculture systems as compared to controls.

• Journal of Environmental Science International
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• v.23 no.8
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• pp.1429-1436
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• 2014

In this study, we investigated the effects of dietary supplementation (n = 40 pigs/treatment) with bamboo powder (0, 1, 2 and 3%) for 38 days. We evaluated growth performance, blood metabolites, and carcass characteristics of fattening pigs and gas emission and microbial populations in pig manure, to obtain data on pork producers for environmental management. We obtained the following results. First, supplementation with increasing amounts of bamboo powder had a significant (P < 0.05) effect on feed intake, feed efficiency, and glucose contents (except for initial and final body weight, weight gain, carcass characteristics, and blood urea nitrogen). In terms of blood metabolites, glucose and blood urea nitrogen tended to decrease with increasing amounts of bamboo powder. Second, the amounts of ammonia, methane, amine, hydrogen sulfide, and acetic acid were reduced by increasing amounts of bamboo powder when compared with the controls (P < 0.05). However, there were no significant differences in pH, propionic acid, iso-butyric acid, butyric acid, iso-valeric acid, and valeric acid among all treatments. The lowest gas emission was observed when 3% bamboo powder was used. Third, supplementation with increasing amounts of bamboo powder tended (P < 0.05) to increase the total number of bacteria, Lactobacillus spp., and yeast, but E. coli, Salmonella spp., and Shigella spp. were not detected in any treatment. In conclusion, the results of this study suggest that supplementation with bamboo powder was effective in reducing gas emission and inhibiting pathogen populations in pig manure by lowering the pH of the manure.

• The Journal of the Korea Contents Association
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• v.17 no.1
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• pp.58-68
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• 2017

Atopic dermatitis (AD) is prevalent in preschoolers and schoolchildren. The utilization of complementary and alternative medicine (CAM) is increasing in patients with AD as well as the general population. This study is based on the utilization of CAM for children with AD. Subjects were children suffering from AD who participated in the project of 'Seoul Atopy Asthma Free School'. In 6,800, the number of subject available data to final analysis was 4,985 for children with AD. Independent variables were age, monthly income of households, sleep disturbance, and dependent variables were medical treatment (MT), oriental medicine clinic (OMC), home remedy (HR) use experience during the past 12 months. As a result, MT was 76.5%, OMC was 24.6%, and HR was 62.3%, while multiple treatment from OMC and HR was 34.2%, and MT with OMC and HR was 18.8%. And variables influenced on CAM were age, monthly income of households, and sleep disturbance. However, some parents, tended to recognize that home remedy was effective and safe than other treatments. Therefore, it is recommended to counsel with physician about the merits and demerits of CAM.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9327-9333
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• 2014

Breast cancer is the second most common cancer and second leading cause of cancer deaths in women. Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene mutations have been observed in 25-45% of breast cancer samples. Insulin growth factor binding protein-5 (IGFBP-5) can show different effects on apoptosis, cell motility and survival in breast cancer. We here aimed to determine the association between PIK3CA gene mutations and IGFBP-5 expressions for the first time in breast cancer patients. Frozen tumor samples from 101 Turkish breast cancer patients were analyzed with high resolution melting (HRM) for PIK3CA mutations (exon 9 and exon 20) and 37 HRM positive tumor samples were analyzed by DNA sequencing, mutations being found in 31. PIK3CA exon 9 mutations (Q546R, E542Q, E545K, E542K and E545D) were found in 10 tumor samples, exon 20 mutations (H1047L, H1047R, T1025T and G1049R) in 21, where only 1 tumor sample had two exon 20 mutations (T1025T and H1047R). Moreover, we detected one sample with both exon 9 (E542Q) and exon 20 (H1047R) mutations. 35% of the tumor samples with high IGFBP-5 mRNA expression and 29.4% of the tumor samples with low IGFBP-5 mRNA expression had PIK3CA mutations (p=0.9924). This is the first study of PIK3CA mutation screening results in Turkish breast cancer population using HRM analysis. This approach appears to be a very effective and reliable screening method for the PIK3CA exon 9 and 20 mutation detection. Further analysis with a greater number of samples is needed to clarify association between PIK3CA gene mutations and IGFBP-5 mRNA expression, and also clinical outcome in breast cancer patients.

• Journal of the Korean Geographical Society
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• v.29 no.3
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• pp.360-368
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• 1994

To this day, a number of quantitative analytical methods have been employed in clarifying regional characteristics in the discipline of geography. This paper attempted, as a part of application of those quantitative analyses, to make clear the urban functions and consequently the urban characteristics statistically by adopting newly-introduced CHAID, a sort of discriminant analyis technique. The processing of data was sonducted in two phases. To begin with, the urban functions were classified after designating twenty cities - the population of each city counting 250, 000 or more - as predictor variable, and at the same time four major urban functions like administration, marketing, finance and production as response variable. And then, preeminent functions of individual region were discriminated and concurrently classified by treating the remaining traffic, education, medicare, culture and transportation functions as predictor variable, and the following five regions as response variable: Metropolitan Seoul Area. Pusan region, Taegu region, Kwangju region and Chungcheong region. According to the result of this analysis, marketing and administration are emereed as meaningful functions in Seoul and Taegu respectively. As for the finance function only Pusan and Pucheon can be discriminated. Seoul, Pusan and Seongnam reveal their dominancy in production function. To take a look at the result of the latter analysis, the Metropolitan Seoul area shows, among other functions, strong traffic and finance functions. When it comes fo Pusan region, adminstration, education and finance functions are recorded as a leading ones, and Taegu region is preferable in education, medicare and transportation functions. In case of Kwangju region adminstration, production and education functions are discriminated from any other functions. Chungcheong region shows similar aspect with only traffic function replacing the production function of Kwangju region. Based on aforementioned anlysis, it can be said that the CHAID technique, which is capable of processing large amount of categorical data and, by presenting its outcome in the form of dendrogram, facilitates the interpretation work, is an effective, meaningful means to classify and discriminate certain geographical regions and their characteristics.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.5
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• pp.671-676
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• 2005

A total of 50 individual catfish, the Tra (Pangasius hypophthalmus) cultivated in either floating cages (Tra-c) or in ponds (Tra-p) and the Basa (Pangasius bocourti) raised in three floating cages, were collected in two of the Mekong Delta provinces. The caudal fin of each individual fish was used for protein electrophoresis employing the SDS-PAGE method. The one fillet sides were used as a representative sample to determine the dry matter (DM), crude protein (CP), ether extract (EE) and amino acids (AAs). The catfish oil was extracted from the belly fats, and the fatty acid (FA) composition was analyzed. There were 21 bands of the Tra and the Basa. Protein bands of the two varieties were 28.6-33.3% polymorphic, while polymorphic individuals of the Tra ranged from 80.0 to 100.0%, and the Basa was 90.0% polymorphic. The phenotypic diversity (Ho) of the Tra ranged from 1.71 to 1.80, while the Basa ranged as high as 2.14%. Diversity values (H$_{EP}$) for genetic diversity markers were equal in the Tra and the Basa. The sum of the effective number of alleles (SENA) of both varieties ranged from 3.40 to 3.83 for the Basa and the Tra, respectively. The lower values of Ho and SENA, as compared with those of the fresh water prawn (Macrobrachium equidens) in the area, would suggest that the species with the low values will become extinct due to inbreeding; the gene pools of each observed population were below a suitable threshold. Many of the differences in the nutritional values of the Tra-c, the Tra-p and the Basa were measured; their nutrient values were comparable to fishmeal or fish oil. Most of the DM, CP, and EE were higher in the Tra, especially in the Tra-c. The essential AA content, especially that of lysine, was highest in the Tra-c, next highest in the Tra-p, and lowest in the Basa. Therefore, the amino acid patterns were closer to the ideal patterns in the same sequences. In contrast, the essential FAs were concentrated in the Basa fish oil. It was found that suitable selection of parents for seed production is required to avoid inbreeding. Catfish may be valuable sources of nutrition for both humans and animals, and the differences in their nutritional values by variety and/or management must be taken into account.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5075-5079
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• 2015

Background: Adverse effects of treatment prolongation beyond 8 weeks with radiotherapy for cervical cancer have been established. Clinical data also show that cisplatin increases the biologically effective dose of radiotherapy. However, there are no data on the effect of overall treatment time in patients with locally advanced cervical cancer treated with concomitant chemo-radiotherapy (CCRT) in an Indian population. The present study concerned the feasibility of concurrent chemotherapy and interspacing brachytherapy during the course of external radiotherapy to reduce the overall treatment time and compare the normal tissue toxicity and loco-regional control with a conventional schedule. Materials and Methods: Between January 2009 and March 2012 fifty patients registered in the Gynaecologic Oncology Clinic of Institute Rotary Cancer Hospital with locally advanced cervical cancer (FIGO stage IIB-IIIB) were enrolled. The patients were randomly allocated to treatment arms based on a computer generated random number. Arm I (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions, and weekly cisplatin $40mg/m^2$. High dose rate intra-cavitary brachytherapy (HDR-ICBT) was performed after one week of completion of external beam radiotherapy (EBRT). The prescribed dose for each session was 7Gy to point A for three insertions at one week intervals. Arm II (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions. Mention HDR-ICBT ICRT was performed after 40Gy and 7Gy was delivered to point A for three insertions (days 23, 30, 37) at one week intervals. Cisplatin $20mg/m^2/day$ was administered from D1-5 and D24-28. Overall treatment time was taken from first day of EBRT to last day of HDR brachytherapy. The overall loco-regional response rate (ORR) was determined at 3 and 6 months. Results: A total of 46 patients completed the planned treatment. The overall treatment times in arm I and arm II were $65{\pm}12$ and $48{\pm}4$ days, respectively (p=0.001). At three and six months of follow-up the ORR for arm I was 96% while that for arm II was 88%. No statistically significant difference was apparent between the two arms. The overall rate of grade ${\geq}3$ toxicity was numerically higher in arm I (n=7) than in arm II (n=4) though statistical significance was not reached. None of the predefined prognostic factors like age, performance status, baseline haemoglobin level, tumour size, lymph node involvement, stage or histopathological subtype showed any impact on outcome. Conclusions: In the setting of concurrent chemoradiotherapy a shorter treatment schedule of 48 days may be feasible by interspacing brachytherapy during external irradiation. The response rates and toxicities were comparable.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3131-3137
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• 2013

Background: Visual inspection of cervix with acetic acid (VIA) is offered at 252 centers in 64 districts of Bangladesh. VIA+ve women are managed at colposcopy clinics of Bangabandhu Sheikh Mujib Medical University (BSMMU) and 14 Medical College Hospitals (MCHs). This research work has been supported by 'UICC Cancer Prevention Campaign' programme. Objectives: This study explored the role of print materials and electronic media to improve cervical cancer screening in the present socio-cultural context of Bangladesh. Methods: This study was performed from January to August 2011 at two upazilas of Bangladesh (Singair with screening facility and Sonargaon without screening facility). Data were collected by focus group discussion (FGD) with women, husbands and community people before and after intervention. Information on cervical cancer screening and VIA camps was disseminated using advertisement through local cable line of the television, microphone announcement, service providers and leaflet throughout the week prior to a VIA camp. Three-day VIA camps were organized at the upazila health complex (UHC) of both upazilas. Quantitative data was gathered from women at the camps on source of information on VIA and the best method of awareness creation. Results: The population was aware of "cancer" and a notable number knew about cervical cancer. Baseline awareness on prevention and VIA was low and it was negligible where screening services were unavailable. Awareness was increased fourfold in both upazilas after interventions and half of the women and the majority of the community people became aware of screening and available facilities. Cable line advertisement (25.5%), microphone announcement (21.4%), and discussion sessions (20.4%) were effective for awareness creation on VIA. Television was mentioned as the best method (37.4%) of awareness creation. Conclusion: Television should be used for nation-wide awareness creation. For local awareness creation, cable line advertisement, microphone announcements and health education at Uthan Baithaks/ EPI sessions can easily be adopted by the government.