Purpose: The purpose of this study was to examine the health behaviors and health status of adolescents in multicultural families according to gender. Methods: The study used raw data of the Korean Youth Risk Behavior Web-Based Survey performed in 2016. The 12th survey was conducted on 67,983 adolescents in 400 middle schools and 400 high schools. Among them, 759 adolescents were included in this study. Their data were analyzed using descriptive statistics, $x^2$-test, and Pearson's correlation. Results: There were significant differences in economic status, smoking experience, age of drinking onset, vigorous physical activity, soft drink consumption, toothbrushing after lunch, handwashing with soap before eating at school and eating at home and after coming home, BMI, subjective health status, stress, depression, and allergic rhinitis according to gender in multicultural adolescents. For boys, significant positive correlations were found between age and the age of drinking onset, between academic achievement and economic status, and between the age of smoking initiation and the age of drinking onset. However, there were significant negative correlations between economic status and stress and between subjective health status and stress. For girls, age had positive correlations with academic achievement, the age of drinking onset, BMI, and stress and economic status had positive correlations with academic achievement, the age of smoking initiation, and subjective health status. Also, the age of smoking initiation had positive correlations with the age of drinking onset and BMI. Lastly, there were negative correlations between age and economic status, between age and subjective health status, academic achievement and the age of smoking initiation, economic status and stress, and subjective health status and stress. Conclusion: The results of this study are expected to be useful as basic data for planning health interventions for boys and girls in multicultural families.