• Title/Summary/Keyword: eIF4E

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CONNECTIONS ON REAL PARABOLIC BUNDLES OVER A REAL CURVE

  • Amrutiya, Sanjay
    • Bulletin of the Korean Mathematical Society
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    • v.51 no.4
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    • pp.1101-1113
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    • 2014
  • We give analogous criterion to admit a real parabolic connection on real parabolic bundles over a real curve. As an application of this criterion, if real curve has a real point, then we proved that a real vector bundle E of rank r and degree d with gcd(r, d) = 1 is real indecomposable if and only if it admits a real logarithmic connection singular exactly over one point with residue given as multiplication by $-\frac{d}{r}$. We also give an equivalent condition for real indecomposable vector bundle in the case when real curve has no real points.

The Effect of Post-Purchase Discount Format on Consumers' Perception of Loss and Willingness to Return

  • Luo, Xueqing;Lee, Jennifer J.
    • The Journal of Asian Finance, Economics and Business
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    • v.5 no.4
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    • pp.101-105
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    • 2018
  • Price discount is one of the commonly used promotion strategies to increase sales and revenue. If a discount is perceived before the purchase (i.e., pre-purchase discount), consumers are likely to perceive it as a potential gain. If it is noticed after making a regular-priced purchase (i.e., post-purchase discount), consumers may develop negative emotions and attitudes. Based on the rising transparency and omnipresence of price and discount information through web and mobile platforms, we attempt to tackle an understudied topic on the negative effect of post-purchase price discount. Specifically, post-purchase discount information may increase consumers' perception of monetary loss, which may affect consumers' decision to return the product, potentially increasing the operating costs borne by retailers. Based on a close scrutinization of the current market environment and previous academic literature, we suggest a novel conceptual framework to understand consumers' perception, attitude, and behavior (perception of loss, willingness to return) upon perceiving various formats of discount promotion (absolute value vs. percentage discount) posterior to the purchase of a product. We also look at the effect of price level (low-priced vs. high-priced). For marketing practitioners, we intend to suggest optimal promotion formats that can alleviate consumers' negative perceptions and prevent additional operation costs.

mTOR signalling pathway - A root cause for idiopathic autism?

  • Ganesan, Harsha;Balasubramanian, Venkatesh;Iyer, Mahalaxmi;Venugopal, Anila;Subramaniam, Mohana Devi;Cho, Ssang-Goo;Vellingiri, Balachandar
    • BMB Reports
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    • v.52 no.7
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    • pp.424-433
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    • 2019
  • Autism spectrum disorder (ASD) is a complex neurodevelopmental monogenic disorder with a strong genetic influence. Idiopathic autism could be defined as a type of autism that does not have a specific causative agent. Among signalling cascades, mTOR signalling pathway plays a pivotal role not only in cell cycle, but also in protein synthesis and regulation of brain homeostasis in ASD patients. The present review highlights, underlying mechanism of mTOR and its role in altered signalling cascades as a triggering factor in the onset of idiopathic autism. Further, this review discusses how distorted mTOR signalling pathway stimulates truncated translation in neuronal cells and leads to downregulation of protein synthesis at dendritic spines of the brain. This review concludes by suggesting downstream regulators such as p70S6K, eIF4B, eIF4E of mTOR signalling pathway as promising therapeutic targets for idiopathic autistic individuals.

Expression of Cytochrome P450 1A1, 1A2, 2C8, 2E1 and 3A4 in Human Brain

  • Yoo, Min
    • Biomedical Science Letters
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    • v.7 no.2
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    • pp.65-70
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    • 2001
  • We have carried out PCR reactions to investigate if cytochrome P450 (P450) enzymes (1A1, 1A2, 2C8, 2E1 and 3A4), which are well hewn to be the key enzymes in detoxification process and/or synthesis of steroids in the liver, are expressed in the human brain, too. P450 1A1, 2C8 and 2E1 were expressed clearly. However, P450 1A2 and 3A4 were not detectable. Their expression levels in the human brain could be extremely low or they were not expressed at all. One base substitution at nucleotide 290 (A->G) was identified in P450 1A1. It is suspected to be an individual polymorphism. Our results should contribute to the better understanding of the role of cytochrome P450 enzymes in the human brain.

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AC Breakdown Voltage Characteristics of $SF_6/CF_4$ and (E/P)crit in quasi-uniform Field (준평등전계에서 $SF_6/CF_4$ 혼합가스의 절연 파괴 전압 및 임계전계 특성)

  • Lee, Byung-Taek;Hwang, Cheong-Ho;An, Jung-Sik;Huh, Chang-Su
    • Proceedings of the KIEE Conference
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    • 2009.07a
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    • pp.1455_1456
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    • 2009
  • $SF_6$ is the most commonly used insulating gas in electrical systems. But In these days $SF_6$ mixtures and alternative gas has been studied because of global warming. so although many studies have been carried out about binary gas mixtures with $SF_6$, few studies were presented about breakdown characteristics of $SF_6/CF_4$ mixtures. At present study the breakdown characteristics of $SF_6/CF_4$ mixtures in quasi-uniform field was performed. This experiments were carried out under AC voltages. The rod-rod electrode was used with 5 mm gap distance. The mixture of $SF_6/CF_4$ containing 20%,50%,70% of $SF_6$ were compared with pure $SF_6$ and $CF_4$ gas and gas pressure ranged from 0.1 to 0.5 MPa. The show that the breakdown voltages of gas were linearly increased according to the pressure in quasi-uniform field. For breakdown vlotage values of $(E/P)_{crit}$ are important. Because If values of (E/P) is a little more than $(E/P)_{crit}$, electrons rapidly increase and streamer discharge gernerates. Through this experiments values of $(E/P)_{crit}$ are found to vary with the ratio of $SF_6/CF_4$ mixture according to the following relationship. $V_b=(E/P)_{crit}{\cdot}p{\cdot}d$

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SIZE OF DOT PRODUCT SETS DETERMINED BY PAIRS OF SUBSETS OF VECTOR SPACES OVER FINITE FIELDS

  • Koh, Doowon;Pi, Youngjin
    • Journal of the Chungcheong Mathematical Society
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    • v.26 no.4
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    • pp.853-867
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    • 2013
  • In this paper we study the cardinality of the dot product set generated by two subsets of vector spaces over finite fields. We notice that the results on the dot product problems for one set can be simply extended to two sets. Let E and F be subsets of the d-dimensional vector space $\mathbb{F}^d_q$ over a finite field $\mathbb{F}_q$ with q elements. As a new result, we prove that if E and F are subsets of the paraboloid and ${\mid}E{\parallel}F{\mid}{\geq}Cq^d$ for some large C > 1, then ${\mid}{\Pi}(E,F){\mid}{\geq}cq$ for some 0 < c < 1. In particular, we find a connection between the size of the dot product set and the number of lines through both the origin and a nonzero point in the given set E. As an application of this observation, we obtain more sharpened results on the generalized dot product set problems. The discrete Fourier analysis and geometrical observation play a crucial role in proving our results.

SELF-ADJOINT INTERPOLATION ON Ax = y IN ALG$\cal{L}$

  • Kwak, Sung-Kon;Kang, Joo-Ho
    • Journal of applied mathematics & informatics
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    • v.29 no.3_4
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    • pp.981-986
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    • 2011
  • Given vectors x and y in a Hilbert space $\cal{H}$, an interpolating operator is a bounded operator T such that Tx = y. An interpolating operator for n vectors satisfies the equations $Tx_i=y_i$, for i = 1, 2, ${\cdots}$, n. In this paper the following is proved : Let $\cal{L}$ be a subspace lattice on a Hilbert space $\cal{H}$. Let x and y be vectors in $\cal{H}$ and let $P_x$ be the projection onto sp(x). If $P_xE=EP_x$ for each $E{\in}\cal{L}$, then the following are equivalent. (1) There exists an operator A in Alg$\cal{L}$ such that Ax = y, Af = 0 for all f in $sp(x)^{\perp}$ and $A=A^*$. (2) sup $sup\;\{\frac{{\parallel}E^{\perp}y{\parallel}}{{\parallel}E^{\perp}x{\parallel}}\;:\;E\;{\in}\;{\cal{L}}\}$ < ${\infty}$, $y\;{\in}\;sp(x)$ and < x, y >=< y, x >.

AN EXPERIMENTAL STUDY OF THE EFFECT OF CARIDEXTM CARIES REMOVAL SYSTEM ON THE REMOVAL OF CARIOUS DENTIN (CaridexTM Caries Removal System이 우식상아질 제거에 미치는 영향)

  • Kim, Hyeon-Seon;Hong, Chan-Ui
    • Restorative Dentistry and Endodontics
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    • v.15 no.1
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    • pp.129-139
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    • 1990
  • In order to determine if GK-101E(N-monochloro-DL-2-aminobutyrate) solution was effective in the removal of carious dentin, this study was conducted on 75 extracted human carious teeth. GK-101E solution was compared in effectiveness to saline solution.75 extracted human carious teeth were randomly assigned to two groups accordingly : (1) 50 teeth were treated with GK-101E solution : and (2) 25 teeth were treated with saline solution. Teeth in each group were divided into the medium or medium-hard consistency. Treatment consisted of directing the pulsating stream of each coded test solution utilizing the Caridex$^{TM}$ Caries Removal System against the carious surface for 4 mimutes. One operator treated all teeth with corded solution, and four investigators scored on the treated teeth based on visual examination and tactile evaluation with a dental explorer in conjunction with staining method with Caries Detector$^{TM}$ The results were as follows : 1. All groups showed various effect of carious dentin removal. 2. GK-101E solution was statistically superior to physiologic saline solution in the removal of carious dentin, regardless of carious consistency. 3. GK-101E solution in the medium-hard consistency was statistically superior to that in the medium consistency in the caries removal(p=0.001). 4. Saline solution in the medium consistency was equivalent to that in the medium-hard consistency in caries removal(p>0.1).

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A Study on the Operation of Education Using Library Using Flip Learning Techniques: Focusing on ubiquitous E-learning that reflects gaming elements

  • KIM, KiTae;WOO, HoSung
    • Fourth Industrial Review
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    • v.2 no.2
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    • pp.1-9
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    • 2022
  • Purpose - The purpose is to present an efficient library-use education model in the form of flip learning, reflecting traditional teaching methods and gamification elements even in such non-face-to-face and face-to-face situations after COVID-19. Research design, data, and methodology - Research on library use education, research on ubiquitous environment and gamification instructional design, flip the learning, and gamification elements are classified, compared, and analyzed to present educational models for library education, COVID-19 Pandemic situation, and subsequent library use education. Result - We propose an e-learning content development strategy for flipped learning-based library education. First, benchmark and use the existing educational contents. Second, a user-friendly interface is configured so that learners can flexibly organize their learning contents. Third, it allows learners to experience it directly or indirectly in a virtual space. Conclusion - If the e-learning environment can be standardized to the level of schools or educational institutions, a good educational model that can be used not only in library user education but also in other fields will be possible.

The Experimental study of B.E.P.(Biological Energy Projector) on the swimming Time of Mice and on the Recovery of Muscular Fatigue of Rats (B.E.P.가 생쥐의 수영능(水泳能)과 수영부하(水泳負荷)로 야기(惹起)된 흰쥐의 피로회복(疲勞恢復)에 미치는 실험적(實驗的) 연구(硏究))

  • Lee, Cheol-Wan
    • Journal of Haehwa Medicine
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    • v.4 no.1
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    • pp.357-371
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    • 1995
  • We have completed a study to measure the contents of glucose, BUN, creatinine. LDH, and T-protein with respect to a fatigued condition in the bloods of rats which a constant swimming is loaded and to measure the maximun swimming time of mice The test has been carried out as a part of the basic study on the efficacy of B. E. P. (Biological Energy Projector) for emitting a light energy having a specific wavelength out of far-infrared rays. As a result. We have reached the following conclusions: 1. At testing of mice's maximun swimming time, all of B.E.P.(2. 4. 8. 24hrs) treated group have been increased in comparison with the control group, but only 24hrs-B.E.P. treated group significantly increased during 4 weeks. 2. The contents of glucose, BUN. creatinine, LDH, and T-protein measured immediately after the swimming of mice have been distinctly changed but not been significantly changed at their increase and decrease in comparison with the control group. 3. At 3rd day out of the swimming loading, the contents of glucose in the blood serum of the white rat have been distinctly increased in comparison with the control group. And 24hrs-B.E.P treated group surpassed 8hrs-B.E.P. treated group. 4. At 1st and 3rd day, the contents of creatinine in the blood serum of the white rat have been distinctly increased at B.E.P. (8, 24hrs) treated groups in comparison with the control group and have been recovered to the condition of the normal group. 5. After three days, the contents of BUN in the blood serum of the white rat have been significantly decreased in B.E.P.(8, 24hrs) treated groups at 3rd day in comparison with the control group and have been recovered to the condition of the normal group. 6. The contents of LDH in the blood serum of the white rat have been decreased in B.E.P.(8, 24hrs) treated groups at 3rd day in comparison with the control group, in particular 24hrs-B.E.P. treated group has been decreased distinctly than the normal group. 7. The contents of T-protein in the blood serum of the white rat have been distinctly increased in B.E.P. (8, 24hrs) treated groups at 3rd day in comparison with the control and normal group. As the above results, it has been proved that the execise of mice and the fatigue metabolism of rats were influenced by the light energy emitted the B.E.P., and it has been also proved that the external stimulation could be used as a preferable stimulative factor for the biological metabolism. If the clinical training and study are positively achieved, the B.E.P. would be used as curative means and preventive measures for helping human body.

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