• BMB Reports
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• v.50 no.11
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• pp.539-545
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• 2017

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated $eIF2{\alpha}$ kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understand how stressed cells coordinate gene expression at translational and transcriptional levels. The translational attenuation associated with this pathway has been largely attributed to the phosphorylation of the translational initiation factor $eIF2{\alpha}$. However, independent studies are now pointing to a second translational regulation step involving a downstream ISR target, 4E-BP, in the inhibition of eIF4E and specifically cap-dependent translation. The activation of 4E-BP is consistent with previous reports implicating the roles of 4E-BP resistant, Internal Ribosome Entry Site (IRES) dependent translation in ISR active cells. In this review, we provide an overview of the translation inhibition mechanisms engaged by the ISR and how they impact the translation of stress response genes.

• Korean Journal of Mathematics
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• v.20 no.4
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• pp.517-524
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• 2012

In this paper, we first show that for any space X, there is a Boolean subalgebra $\mathcal{G}(z_X)$ of R(X) containg $\mathcal{G}(X)$. Let X be a strongly zero-dimensional space such that $z_{\beta}^{-1}(X)$ is the minimal cloz-coevr of X, where ($E_{cc}({\beta}X)$, $z_{\beta}$) is the minimal cloz-cover of ${\beta}X$. We show that the minimal cloz-cover $E_{cc}(X)$ of X is a subspace of the Stone space $S(\mathcal{G}(z_X))$ of $\mathcal{G}(z_X)$ and that $E_{cc}(X)$ is a strongly zero-dimensional space if and only if ${\beta}E_{cc}(X)$ and $S(\mathcal{G}(z_X))$ are homeomorphic. Using these, we show that $E_{cc}(X)$ is a strongly zero-dimensional space and $\mathcal{G}(z_X)=\mathcal{G}(X)$ if and only if ${\beta}E_{cc}(X)=E_{cc}({\beta}X)$.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4717-4721
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• 2013

Complete surgical resection of the primary tumour is a crucial predictive step for head and neck squamous cell carcinoma (HNSCC), because incomplete resection may lead to increase in the recurrence rate. Molecular cancer markers have been investigated as potential predictors of prognosis marker, to identify patients who are at high risk of local recurrence. This retrospective study aimed to determine the prognostic correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival. Forty eight HNSCC patients were selected between 2006 and 2009 diagnosed at the Royal Darwin Hospital, Darwin, Northern Territory, Australia. Out of 48, only those 24 with negative surgical margins with hematoxylin and eosin (HandE) were chosedn for further analysis. A total of 77 surgical margins were obtained and subsequently analysed by immunohistochemical (IHC) staining with monoclonal p53 and polyclonal eIF4E antibodies. Contingency table and ${\chi}^2$-test were used to investigate the correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival of the HNSCC patients. The follow up period was 74 months (range 1-74 months). The Kaplan-Meier method was used to generate recurrence and survival curves. This is a first retrospective study of Northern Territory patients, including Indigenous and non-Indigenous Australians. Molecular study of surgical margins could help to identify patients with and without clear margins after surgery and help in choice of the most appropriate adjuvant treatment for HNSCC patients.

• Journal of Integrative Natural Science
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• v.12 no.4
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• pp.127-132
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• 2019

Programmed cell death 4 (PDCD4) is a novel tumor suppressor that function in the nucleus and the cytoplasm and appears to be involved in the regulation of transcription and translation. Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate when cells exposed to environmental stresses. Since PDCD4 has implicated in translation repression through direct interaction with eukaryotic translation initiation factor 4A (eIF4A), we here investigated if PDCD4 has a functional role in the process of SG assembly under oxidative stresses. Using immunofluorescence microscopy, we found that PDCD4 is localized to SGs under oxidative stresses. Next, we tested if knockdown of PDCD4 has an effect on the assembly of SG using PDCD4-specific siRNA. Interestingly, SG assembly was accelerated and this effect was caused by sensitization of phosphorylation of eIF2α and dephosphorylation of eIF4E binding protein (4E-BP). These results suggest that PDCD4 has an effect on SG dynamics and possibly involved in cap-dependent translation repression under stress conditions.

• Honam Mathematical Journal
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• v.28 no.4
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• pp.533-541
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• 2006

let E be a Finsler modules over $C^*$-algebras. A with norm-map $\rho$ and L(E) set of all A-linear bonded operators on E. We show that the canonical homomorphism ${\phi}:L(E){\rightarrow}L(E_I)$ sending each operator T to its restriction $T|E_I$ is injective if and only if I is an essential ideal in the underlying $C^*$-algebra A. We also show that $T{\in}L(E)$ is a bounded below if and only if ${\mid}{\mid}x{\mid}{\mid}={\mid}{\mid}{\rho}{\prime}(x){\mid}{\mid}$ is complete, where ${\rho}{\prime}(x)={\rho}(Tx)$ for all $x{\in}E$. Also, we give a necessary and sufficient condition for the equivalence of the norms generated by the norm map.

• Journal of the Korean Mathematical Society
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• v.60 no.5
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• pp.1087-1107
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• 2023

Let E be an elliptic curve defined over ℚ of conductor N, c the Manin constant of E, and m the product of Tamagawa numbers of E at prime divisors of N. Let K be an imaginary quadratic field where all prime divisors of N split in K, P_K the Heegner point in E(K), and III(E/K) the Shafarevich-Tate group of E over K. Let 2u_K be the number of roots of unity contained in K. Gross and Zagier conjectured that if P_K has infinite order in E(K), then the integer c · m · u_K · |III(E/K)| $\frac{1}{2}$ is divisible by |E(ℚ)_tor|. In this paper, we prove that this conjecture is true if E(ℚ)_tor ≅ ℤ/2ℤ or ℤ/4ℤ except for two explicit families of curves. Further, we show these exceptions can be removed under Stein-Watkins conjecture.

• Honam Mathematical Journal
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• v.41 no.4
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• pp.799-812
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• 2019

We introduce flat e-covers of modules and define e-perfect rings as a generalization of perfect rings. We prove that a ring is right perfect if and only if it is semilocal and right e-perfect which generalizes a result due to N. Ding and J. Chen. Moreover, in the light of the fact that a ring R is right perfect if and only if flat covers of any R-module are projective covers, we study on the rings over which flat covers of modules are (generalized) locally projective covers, and obtain some characterizations of (semi) perfect, A-perfect and B-perfect rings.

• The Plant Pathology Journal
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• v.23 no.4
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• pp.281-286
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• 2007

Interactions between viral proteins and host proteins are essential for virus replication. Especially, translation of viral genes completely depends on the host machinery. In potyviruses, interactions of genome-linked viral protein (VPg) with host translation factors including eIF4E, eIF(iso)4E, and poly(A)-binding protein (PABP) has previously been characterized. In this study, we investigated interactions between Soybean mosaic virus (SMV) viral proteins and host translation factors by yeast two-hybrid system. SMV VPg interacted with eIF4E, eIF(iso)4E, and PABP in yeast two-hybrid system, while SMV helper component proteinase (HC-pro) interacted with neither of those proteins. The interaction between SMV NIb and PABP was also detected. These results are consistent with those reported previously in other potyviruses. Interestingly, we found reproducible and specific interactions between SMV coat protein (CP) and PABP. Deletion analysis showed that the region of CP comprising amino acids 116 to 206 and the region of PABP comprising amino acids 520 to 580 are involved in CP/PABP interactions. Soybean library screening with SMV NIb by yeast two-hybrid assay also identified several soybean proteins including chlorophyll a/b binding preprotein, photo-system I-N subunit, ribulose 1,5-biphosphate carboxylase, ST-LSI protein, translation initiation factor 1, TIR-NBS type R protein, RNA binding protein, ubiquitin, and LRR protein kinase. Altogether, these results suggest that potyviral replicase may comprise a multi-protein complex with PABP, CP, and other host factors.

• Korean Journal of Mathematics
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• v.20 no.4
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• pp.423-431
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• 2012

There have been some study characterizing monoids by homological classification using the properties around projectivity, injectivity, or regularity of acts. In particular Kilp and Knauer([4]) have analyzed monoids over which all acts with one of the properties around projectivity or injectivity are regular. However Kilp and Knauer left over problems of characterization of monoids over which all regular right S-acts are (weakly) at, (weakly) injective or faithful. Among these open problems, Liu([3]) proved that all regular right S-acts are (weakly) at if and only if es is a von Neumann regular element of S for all $s{\in}S$ and $e^2=e{\in}T$, and that all regular right S-acts are faithful if and only if all right ideals eS, $e^2=e{\in}T$, are faithful. But it still remains an open question to characterize over which all regular right S-acts are weakly injective or injective. Hence the purpose of this study is to investigate the relations between regular right S-acts and weakly injective right S-acts, and then characterize the monoid over which all regular right S-acts are weakly injective.

• Bulletin of the Korean Mathematical Society
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• v.53 no.1
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• pp.195-204
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• 2016

We prove, in this note, that a Zabavsky ring R is an elementary divisor ring if and only if R is a $B{\acute{e}}zout$ ring. Many known results are thereby generalized to much wider class of rings, e.g. [4, Theorem 14], [7, Theorem 4], [9, Theorem 1.2.14], [11, Theorem 4] and [12, Theorem 7].