• Title/Summary/Keyword: eIF2

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A CHARACTERIZATION OF GAMMA DISTRIBUTION BY INDEPENDENT PROPERTY

  • Lee, Min-Young;Lim, Eun-Hyuk
    • Journal of the Chungcheong Mathematical Society
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    • v.22 no.1
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    • pp.1-5
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    • 2009
  • Let {$X_n,\;n{\geq}1}$ be a sequence of independent identically distributed(i.i.d.) sequence of positive random variables with common absolutely continuous distribution function(cdf) F(x) and probability density function(pdf) f(x) and $E(X^2)<{\infty}$. The random variables $\frac{X_i{\cdot}X_j}{(\Sigma^n_{k=1}X_k)^{2}}$ and $\Sigma^n_{k=1}X_k$ are independent for $1{\leq}i if and only if {$X_n,\;n{\geq}1}$ have gamma distribution.

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ON CHARACTERIZATIONS OF THE NORMAL DISTRIBUTION BY INDEPENDENCE PROPERTY

  • LEE, MIN-YOUNG
    • Journal of applied mathematics & informatics
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    • v.35 no.3_4
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    • pp.261-265
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    • 2017
  • Let X and Y be independent identically distributed nondegenerate random variables with common absolutely continuous probability distribution function F(x) and the corresponding probability density function f(x) and $E(X^2)$<${\infty}$. Put Z = max(X, Y) and W = min(X, Y). In this paper, it is proved that Z - W and Z + W or$(X-Y)^2$ and X + Y are independent if and only if X and Y have normal distribution.

THE NUMBER OF POINTS ON ELLIPTIC CURVES E0a3:y2=x3+a3 OVER Fp MOD 24

  • You, Soon-Ho;Park, Hwa-Sin;Kim, Hyun
    • Honam Mathematical Journal
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    • v.31 no.3
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    • pp.437-449
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    • 2009
  • In this paper, we calculate the number of points on elliptic curves $E^{a^3}_0:y^2=x^3+a^3$ over ${\mathbb{F}}_p$ mod 24 and $E^b_0:y^2=x^3+b$ over ${\mathbb{F}}_p$ mod 6, where b is cubic non-residue in ${\mathbb{F}}^*_p$. For example, if p ${\equiv}$ 1 (mod 12) is a prime, and a and a(2t - 3) are quadratic residues modulo p with $3t^2{\equiv}1$ (mod p), then the number of points in $E^{a^3}_0:y^2=x^3+a^3$ is congruent to 0 modulo 24.

Purification and Characterization of the Functional Catalytic Domain of PKR-Like Endoplasmic Reticulum Kinase Expressed in Escherichia coli

  • Yun Jin-A;Chung Ho-Young;Kim Seong-Jun;Cho Hyun-Soo;Oh Jong-Won
    • Journal of Microbiology and Biotechnology
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    • v.16 no.9
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    • pp.1453-1458
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    • 2006
  • PKR-like endoplasmic reticulum (ER) kinase (PERK) is a type I transmembrane ER-resident protein containing a cytoplasmic catalytic domain with a Ser/Thr kinase activity, which is most closely related to the eukaryotic translation initiation factor-$2{\alpha}$ ($eIF2{\alpha}$) kinase PKR involved in the antiviral defense pathway by interferon. We cloned and expressed the PERK C-terminal kinase domain (cPERK) in Escherichia coli. Like PERK activation in cells under ER stress, wild-type cPERK underwent autophosphorylation when overexpressed in E. coli, whereas the cPERK(K621M) with a methionine substitution for the lysine at amino acid 621 lost the autophosphorylation activity. The activated form cPERK which was purified to near homogeneity, formed an oligomer and was able to trans-phosphorylate specifically its cellular substrate $eIF2{\alpha}$. Two-dimensional phosphoamino acids analysis revealed that phosphorylation of cPERK occurs at the Ser and Thr residues. The functionally active recombinant cPERK, and its inactive mutant should be useful for the analysis of biochemical functions of PERK and for the determination of their three-dimensional structures.

LONG PATHS IN THE DISTANCE GRAPH OVER LARGE SUBSETS OF VECTOR SPACES OVER FINITE FIELDS

  • BENNETT, MICHAEL;CHAPMAN, JEREMY;COVERT, DAVID;HART, DERRICK;IOSEVICH, ALEX;PAKIANATHAN, JONATHAN
    • Journal of the Korean Mathematical Society
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    • v.53 no.1
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    • pp.115-126
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    • 2016
  • Let $E{\subset}{\mathbb{F}}^d_q$, the d-dimensional vector space over the finite field with q elements. Construct a graph, called the distance graph of E, by letting the vertices be the elements of E and connect a pair of vertices corresponding to vectors x, y 2 E by an edge if ${\parallel}x-y{\parallel}:=(x_1-y_1)^2+{\cdots}+(x_d-y_d)^2=1$. We shall prove that the non-overlapping chains of length k, with k in an appropriate range, are uniformly distributed in the sense that the number of these chains equals the statistically correct number, $1{\cdot}{\mid}E{\mid}^{k+1}q^{-k}$ plus a much smaller remainder.

Molecular Evidence for the Presence of CYP2E1 Retropseudogene in Human Genome (사람의 게놈에 존재하는 Cytochrome P450 2E1의 Retropseudogene에 대한 분자유전학적 증거)

  • Yoo, Min;Shin, Song-Woo
    • Biomedical Science Letters
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    • v.4 no.2
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    • pp.129-135
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    • 1998
  • We have carried out polymerase chain reaction (PCR) to investigate if retropseudogene for CYP2El is present in human genome. PCR primers were designed based on the structure of functional CYP2El gene and used to amplify both functional gene and retropseudogene in one reaction. From the repeated experiments we were able to amplify a previously unidentified CYP2El retropseudogene that was present in human genome. Its detailed structure was confirmed by Southern blotting and DNA sequencing. Nucleotide sequence of this retropseudogene was completely matched up to human liver CYP2El mRNA suggesting that the development of this retropseudogene might be a relatively recent event.

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A NOTE ON MONOFORM MODULES

  • Hajikarimi, Alireza;Naghipour, Ali Reza
    • Bulletin of the Korean Mathematical Society
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    • v.56 no.2
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    • pp.505-514
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    • 2019
  • Let R be a commutative ring with identity and M be a unitary R-module. A submodule N of M is called a dense submodule if $Hom_R(M/N,\;E_R(M))=0$, where $E_R(M)$ is the injective hull of M. The R-module M is said to be monoform if any nonzero submodule of M is a dense submodule. In this paper, among the other results, it is shown that any kind of the following module is monoform. (1) The prime R-module M such that for any nonzero submodule N of M, $Ann_R(M/N){\neq}Ann_R(M)$. (2) Strongly prime R-module. (3) Faithful multiplication module over an integral domain.

Effect of long term treatment of aqueous extract of Enicostemma littorale in Type 2 diabetic patients

  • Mansuri, Mustakim M;Goyal, Bhoomika R;Upadhyay, Umesh M;Sheth, Jayesh;Goyal, Ramesh K
    • Advances in Traditional Medicine
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    • v.9 no.1
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    • pp.39-48
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    • 2009
  • We have evaluated the effect of long term treatment of Enicostemma littorale (E. littorale) in type 2 diabetic patients taking pills of aqueous extract of E. littorale regularly as a complimentary medicine for at least 9 months. The effects of E. littorale on glycemic control, lipid profile, cardiac function and DNA damage in these patients were compared with those who had not been regular in taking E. littorale but regular in taking other conventional anti-diabetics. Our data suggest that, E. littorale can maintain normal blood glucose, serum insulin, serum triglycerides levels of type 2 diabetic patients if taken regularly. E. littorale also improves insulin sensitivity, and normalize disturbed lipogram and elevated creatinine levels, thereby produces beneficial effect in preventing cardiovascular complications and may preserve the kidney function. The finding that E. littorale also prevents DNA damage suggest a long term effect in diabetic patients. E. littorale thus can be considered as safe supplementary therapy for a long term and effective management of type 2 diabetic patients.

Thermal Design for KOMPSAT-2 Propulsion System (다목적실용위성 2호 추진계의 열설계)

  • Han, Cho-Young;Kim, Jeong-Soo;Lee, Kyun-Ho
    • Proceedings of the KSME Conference
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    • 2001.11b
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    • pp.77-82
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    • 2001
  • Thermal design for KOMPSAT-2 propulsion system has been performed. Overall design requirements and the constitution for propulsion system is described. To meet the thermal design requirements, both a primary and a redundant heater circuit, each with two thermostats placed in series, will protect each hydrazine-wetted components, even if one heater circuit fails to operate. Heater power is turned off if any one of these thermostats is opened at its higher setpoint. Thus, even if one thermostat is failed closed, the second thermostat will turn off the heater. All such components shall be insulated with MLI. Propulsion heater sizing based on the constant worst cold case condition is conducted through thermal analysis. All heaters selected for propulsion components operate to prevent propellant freezing satisfying the thermal requirements for the propulsion subsystem over the worst case average voltage, i.e. 25 volts.

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Distribution of Vancomycin-resistant Enterococci Isolates Using a ChromID VRE Agar

  • Lee, Hyun;Yoon, In-Seon
    • Korean Journal of Clinical Laboratory Science
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    • v.45 no.1
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    • pp.1-4
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    • 2013
  • Vancomycin-resistant enterococci (VRE) have emerged as important healthcare-associated infection since last two decades. ChromID VRE agar (cIDVA) is useful for VRE rectal swab screening. We investigated all VRE were isolated on the cIDVA. A total of 363 rectal swabs of 85 patients to test VRE screening were inoculated into bile-esculin (B-E) broth with $6{\mu}g/mL$ vancomycin. After 24 hours incubation, we subcultured B-E broths were changed to black onto cIDVA. All isolates were identified by the MICROSCAN and VITEK2. The vanA gene and vancomycin minimal inhibition concentration (MIC) were detected by PCR and E-test respectively. 277 E. faecium (84.7%), 16 E. faecalis (4.9%), 25 E. avium (7.6%), 8 E. gallinarum (2.4%) and 1 E. raffinosus (0.3%) were isolated. 10.3% of VRE detected on cIDVA were other than E. faecium and E. faecalis that presented various color from colorless to pale violet. All isolates contained vanA and vancomycin MIC were > $256{\mu}g/mL$. VRE isolates other than E. faecium and E. faecalis should be objective to the contact precautions for healthcare-associated infection control if they possess vanA gene. Due to emerging enterococci carrying vanA such as E. avium, E. gallinarum, and E. raffinosus, VRE surveillance should be expanded to all isolates on chromogenic agar.

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