• Journal of the Korean Society for Railway
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• v.14 no.1
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• pp.1-5
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• 2011

High concentration of carbon dioxide at subway cabin is one of the serious environmental concerns because carbon dioxide causes drowsiness, headache, and nervelessness of passengers. Ministry of Environment set a guideline for indoor carbon dioxide levels in train or subway in 2007. In this study, a carbon dioxide removal system for subway cabin was developed and tested using a test subway cabin. Various types of modified zeolites were used as the adsorbent of carbon dioxide. The tested zeolites were applied to the subway cabin, and showed high potential to lower the indoor $CO_2$ level.

• The Korean Journal of Pain
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• v.27 no.2
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• pp.103-111
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• 2014

Nefopam (NFP) is a non-opioid, non-steroidal, centrally acting analgesic drug that is derivative of the nonsedative benzoxazocine, developed and known in 1960s as fenazocine. Although the mechanisms of analgesic action of NFP are not well understood, they are similar to those of triple neurotransmitter (serotonin, norepinephrine, and dopamine) reuptake inhibitors and anticonvulsants. It has been used mainly as an analgesic drug for nociceptive pain, as well as a treatment for the prevention of postoperative shivering and hiccups. Based on NFP's mechanisms of analgesic action, it is more suitable for the treatment of neuropathic pain. Intravenous administration of NFP should be given in single doses of 20 mg slowly over 15-20 min or with continuous infusion of 60-120 mg/d to minimize adverse effects, such as nausea, cold sweating, dizziness, tachycardia, or drowsiness. The usual dose of oral administration is three to six times per day totaling 90-180 mg. The ceiling effect of its analgesia is uncertain depending on the mechanism of pain relief. In conclusion, the recently discovered dual analgesic mechanisms of action, namely, a) descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and b) inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.8
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• pp.3965-3983
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• 2017

We propose a novel eye tracking method that can estimate 3D world coordinates using an infrared (IR) stereo camera for indoor and outdoor environments. This method first detects dark evidences such as eyes, eyebrows and mouths by fast multi-level thresholding. Among these evidences, eye pair evidences are detected by evidential reasoning and geometrical rules. For robust accuracy, two classifiers based on multiple layer perceptron (MLP) using gradient local binary patterns (GLBPs) verify whether the detected evidences are real eye pairs or not. Finally, the 3D world coordinates of detected eyes are calculated by region-based stereo matching. Compared with other eye detection methods, the proposed method can detect the eyes of people wearing sunglasses due to the use of the IR spectrum. Especially, when people are in dark environments such as driving at nighttime, driving in an indoor carpark, or passing through a tunnel, human eyes can be robustly detected because we use active IR illuminators. In the experimental results, it is shown that the proposed method can detect eye pairs with high performance in real-time under variable illumination conditions. Therefore, the proposed method can contribute to human-computer interactions (HCIs) and intelligent transportation systems (ITSs) applications such as gaze tracking, windshield head-up display and drowsiness detection.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.193-198
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• 2018

Recently, the casualties of automobile traffic accidents are rapidly increasing, and serious accidents involving serious injury and death are increasing more than those of ordinary people. More than 70% of major accidents occur in drowsy driving. Therefore, in this paper, we studied the drowsiness prevention system to prevent large-scale disasters of traffic accidents. In this paper, we propose a real-time flicker recognition method for drowsy driving detection system and drowsy recognition according to the increase of carbon dioxide. The drowsy driving detection system applied the existing image detection and the deep running, and the carbon dioxide detection was developed based on the IoT. The drowsy prevention system using both of these techniques improved the accuracy compared to the existing products.

• Journal of Pharmacopuncture
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• v.24 no.3
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• pp.93-106
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• 2021

This study aimed to analyze the use of Korean medicine treatments for alopecia in among clinical studies. We identified and analyzed 22 studies from Korean databases; Oriental Medicine Advanced Searching Integrated System (OASIS), Science ON, Korean Studies Information Service System (KISS), and Research Information Sharing Service (RISS) and international database; PubMed. We analyzed the Korean medical treatment in each case and determined the tendency to use each intervention. We analyzed 1,464 patients from 22 selected studies. Herbal medicine, acupuncture, external medicine or products, pharmacopuncture, and phototherapy were used for alopecia treatment. The herbal medicines mainly used to treat alopecia were Gagam Cheongyoung-tang, Gagam Hwajung-hwan, and Yukmijihwang-tang·hwan. The acupoints primarily used were GV20, EX-HN1, GB5, KI3, PC6, ST36, GV22, and A-shi. The most commonly used pharmacopuncture therapies were Hwangryunhaedoktang (HH), Carthami Fructus (CF), Bee Venom (BV), and Hominis placenta (HP). The Korean medical treatment for alopecia improved the condition of patients. However, seven studies reported the occurrence of side effects such as pruritus, dazed, drowsiness, headache, pain, and diarrhea. This study shows the potential of Korean medicine for the treatment of alopecia. Further studies with a large sample size and long-term follow-up are warranted to establish the primary treatment guidelines and objective outcome measures for alopecia.

• Journal of Hospice and Palliative Care
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• v.22 no.2
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• pp.100-104
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• 2019

Opioids are important drugs for the management of severe cancer pain without a ceiling effect. However, opioid administration leads to dose-limiting complications including drowsiness, hallucinations, delirium, respiratory depression, cognitive impairment, seizure, myoclonus, and hyperalgesia. Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon as opioid exposure increases pain sensitivity. Reducing or stopping opioids, opioid rotation, or co-administration of N-methyl-D-aspartate (NMDA) antagonists have been suggested for the management of OIH. In this study, we report two clinical cases of successful management of OIH in cancer pain patients that were treated with opioids.

• Journal of Oral Medicine and Pain
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• v.44 no.3
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• pp.83-91
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• 2019

Purpose: Venlafaxine and duloxetine have been shown to be effective in the treatment of neuropathic pain disorders. However, knowledge about the efficacy of venlafaxine and duloxetine on burning mouth syndrome (BMS) is still insufficient. The purpose of this study was to investigate the efficacy of venlafaxine and duloxetine on refractory BMS patients. Methods: Twelve refractory BMS patients who were prescribed venlafaxine or duloxetine were included in this study. These patients did not respond to previous administration of clonazepam, alpha-lipoic acid, gabapentin, and nortriptyline. All participants were the primary type of BMS patients who had no local and systemic factors related to the oral burning sensation. The intensities of oral symptoms following venlafaxine or duloxetine administration were compared with those before administration and at baseline. Results: Venlafaxine and duloxetine were prescribed to four and nine patients, respectively. One patient was prescribed both medications in turn. Among them, only two patients showed improvement of oral symptoms without side effects. In the other ten patients, symptoms failed to improve. Six of them reported that the drug was ineffective, and four of them stopped taking the medications on their own due to intolerable side effects, such as insomnia, constipation, drowsiness, dizziness, and xerostomia. Conclusions: Venlafaxine and duloxetine may only relieve oral symptoms in a minority of refractory BMS patients. Further large-scale studies are needed to determine the potential clinical factors that could predict the efficacy of venlafaxine and duloxetine.

• CELLMED
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• v.9 no.3
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• pp.4.1-4.8
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• 2019

Now researchers have focused attention on exploring the mechanism of acute responses of heat stress given in heat therapy that ultimately promotes the long term health benefits. Heat therapy is not a new idea rather it was practiced since thousands years back in the form of hot bath, sauna bath, steam room. Similarly in Ayurveda there is very comprehensive description of heat therapy in the form of Svedan karma (Sudation therapy). Svedan is a process to induce sweating artificially in a patient who had already undergone Snehan. Svedan is applied for purification of body, as well as in management of various disorders originated due to vitiation of Vata, Kapha Dosha, Meda Dhatu and musculoskeletal disorders. It produces various beneficial effects by augmenting the Agni like clears the channels, liquefies the deposited Dosha, regulates Vata Dosha, helps in removal and pacification of Dosha, augments metabolism (Agni Deepan), increases appetite, flexibility in body parts, softness and shining of skin, removes coldness, stiffness, drowsiness, improves joint motility. However, Svedana karma is vastly used by Ayurveda Physicians in treatment of various disorders but the mechanisms of beneficial effects produced by Svedan Karma are yet not completely explored on scientific basis. In this article, we will discuss and try to establish a possible mechanism of action of Svedana karma in relation to heat stress, mitochondrial adaptation, heat shock protein (HSP) and glucocorticoids as these are secreted under stressful conditions.

• Journal of Auto-vehicle Safety Association
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• v.13 no.1
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• pp.38-44
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• 2021

This study aimed to verify the criteria of the driver monitoring systems proposed by UNECE ACSF informal working group and the ministry of land, infrastructure, and transport of South Korea using driving behavior data. In order to verify the criteria, we investigated the safety regulations of driver monitoring systems in a conditional autonomous vehicle and found that the driver monitoring measures were related to eye blinks times, head movements, and eye closed duration. Thus, we took two different experimental data including real-world driving and simulator-based drowsy driving behaviors in previous studies. The real-world driving data were used for analyzing blink times and head movement intervals, and the drowsiness data were used for eye closed duration. In the real-world driving study, 52 drivers drove approximately 11.0 km of rural road (about 20 min), 7.9 km of urban road (about 25 min), and 20.8 km of highway (about 20 min). The results suggested that the appropriate number of blinks during the last 60 seconds was 4 times, and the head movement interval was 35 seconds. The results from drowsy driving data will be presented in another paper - part 2.

• Journal of Auto-vehicle Safety Association
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• v.13 no.1
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• pp.45-50
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• 2021

This study aimed to verify the criteria of the driver monitoring systems proposed by UNECE ACSF informal working group and the ministry of land, infrastructure, and transport of South Korea using driving behavior data. In order to verify the criteria, we investigated the safety regulations of driver monitoring systems in a conditional autonomous vehicle and found that the driver monitoring measures were related to eye blinks times, head movements, and eye closed duration. Thus, we took two different experimental data including real-world driving and simulator-based drowsy driving behaviors in previous studies. The real-world driving data were used for analyzing blink times and head movement intervals, and the drowsiness data were used for eye closed duration. In the drowsy driving study, 10 drivers drove approximately 37 km of a monotonous highway (about 22 min) twice. The results suggested that the appropriate duration of eyes continuously closed was 4 seconds. The results from real-world driving data were presented in the other paper - part 1.