Journal of Hospice and Palliative Care

Korean Society for Hospice and Palliative Care (한국호스피스완화의료학회)
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Two Cases of Opioid-Induced Hyperalgesia in Cancer Patients Treated with Opioids for Pain Management

아편유사제를 사용한 암환자에서 발생한 통각과민 2례

  • Hong, Sukchul (Department of Internal Medicine, Kangdong Sacred Heart Hospital) ;
  • Kwon, Jung Hye (Department of Internal Medicine, Kangdong Sacred Heart Hospital) ;
  • Han, Su Jung (Palliative Care Clinic, Kangdong Sacred Heart Hospital)
  • Received : 2018.11.08
  • Accepted : 2019.05.15
  • Published : 2019.06.01
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Abstract

Opioids are important drugs for the management of severe cancer pain without a ceiling effect. However, opioid administration leads to dose-limiting complications including drowsiness, hallucinations, delirium, respiratory depression, cognitive impairment, seizure, myoclonus, and hyperalgesia. Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon as opioid exposure increases pain sensitivity. Reducing or stopping opioids, opioid rotation, or co-administration of N-methyl-D-aspartate (NMDA) antagonists have been suggested for the management of OIH. In this study, we report two clinical cases of successful management of OIH in cancer pain patients that were treated with opioids.

아편유사제는 중증의 암성통증 조절의 중요한 약제이며 천장효과가 없다. 그러나 의식저하, 인지기능 저하, 환각, 섬망, 호흡저하, 근간대경련, 발작, OIH 등의 합병증으로 인해 용량증량에 제한이 있다. 아편유사제 유발 OIH증은 아편유사제에 노출된 환자에서 역설적으로 통증이 증가하는 현상이다. 이 경우 아편유사제의 용량을 줄이거나, 중단하거나 다른 종류의 아편유사제로 변경하거나 NMDA 길항제를 추가하는 것이 조절에 도움이 된다. 아편 주사제에 노출된 이후 발생한 OIH를 조절한 증례를 보고하고자 한다.

Keywords

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