DOI QR코드

DOI QR Code

Literature Review on Korean Medicine Treatment for Alopecia

  • Leem, Seul Woo (Korean Mecince, College of Korean Medicine, Woosuk University) ;
  • Kim, Min Kyeong (Korean Mecince, College of Korean Medicine, Woosuk University) ;
  • Ko, Seo Lim (Korean Mecince, College of Korean Medicine, Woosuk University) ;
  • Jeong, Hye In (Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Kyeong Han (Woosuk Institute of Smart Convergence Life Care (WSCLC), Woosuk University)
  • Received : 2021.07.07
  • Accepted : 2021.08.23
  • Published : 2021.09.30

Abstract

This study aimed to analyze the use of Korean medicine treatments for alopecia in among clinical studies. We identified and analyzed 22 studies from Korean databases; Oriental Medicine Advanced Searching Integrated System (OASIS), Science ON, Korean Studies Information Service System (KISS), and Research Information Sharing Service (RISS) and international database; PubMed. We analyzed the Korean medical treatment in each case and determined the tendency to use each intervention. We analyzed 1,464 patients from 22 selected studies. Herbal medicine, acupuncture, external medicine or products, pharmacopuncture, and phototherapy were used for alopecia treatment. The herbal medicines mainly used to treat alopecia were Gagam Cheongyoung-tang, Gagam Hwajung-hwan, and Yukmijihwang-tang·hwan. The acupoints primarily used were GV20, EX-HN1, GB5, KI3, PC6, ST36, GV22, and A-shi. The most commonly used pharmacopuncture therapies were Hwangryunhaedoktang (HH), Carthami Fructus (CF), Bee Venom (BV), and Hominis placenta (HP). The Korean medical treatment for alopecia improved the condition of patients. However, seven studies reported the occurrence of side effects such as pruritus, dazed, drowsiness, headache, pain, and diarrhea. This study shows the potential of Korean medicine for the treatment of alopecia. Further studies with a large sample size and long-term follow-up are warranted to establish the primary treatment guidelines and objective outcome measures for alopecia.

Keywords

Acknowledgement

This paper was supported by Woosuk University.

References

  1. Min BG. [Diagnosis and treatment of hair & scalp disorders]. Seoul: Hanmi Book; 2005. p. 21-30. Korean.
  2. Kim GO, Kim GO, Kim HK, Kim HR, Im EJ, Kim TY, Jung KS, et al. Scalp hair care for trichologists. Seoul: Chungram Publisher; 2010. p. 52-60.
  3. Healthcare Bigdata Hub [Internet]. Wonju: Health Insurance Review & Assessment Service; c2021 [cited 2021 Jun 24]. Available from: http://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfo.do.
  4. So HR, We SY, Im EJ. Comparison of hair loss factors by sex in Korean adult. J Korean Soc Cosmetol. 2011;17(2):286-96.
  5. Jung JY, Han KH. Common skin diseases in Korea. Seoul: MD World; 2009. p. 495-522.
  6. Hanneken S, Ritzmann S, Nothen MM, Kruse R. [Androgenetic alopecia. Current aspects of a common phenotype]. Hautarzt. 2003;54(8):703-12. German. https://doi.org/10.1007/s00105-003-0561-y
  7. Alkhalifah A. Alopecia areata update. Dermatol Clin. 2013;31(1):93-108. https://doi.org/10.1016/j.det.2012.08.010
  8. Libecco JF, Bergfeld WF. Finasteride in the treatment of alopecia. Expert Opin Pharmacother. 2004;5(4):933-40. https://doi.org/10.1517/eoph.5.4.933.30158
  9. Kim DY, Park SJ. Pharmacological therapeutics in androgenetic alopecia. J Korean Med Assoc. 2020;63(5):277-85. https://doi.org/10.5124/jkma.2020.63.5.277
  10. Pinnell SR, Murad S. Effects of minoxidil on cultured human skin fibroblasts. Dermatologica. 1987;175 Suppl 2:12-8. https://doi.org/10.1159/000248891
  11. Ha WH, Park DH. Effect of seaweed extract on hair growth promotion in experimental study of C57BL/6 mice. Arch Craniofac Surg. 2013;14(1):1-10. https://doi.org/10.7181/acfs.2013.14.1.1
  12. Jang HY, Choi KH, Kim SH, Kwon KR, Kim BW. Bibliographic studies of depilation. J Pharmacopuncture. 2002;5(2):92-108. https://doi.org/10.3831/KPI.2002.5.2.092
  13. Kim YJ, Moon JB, Yi TH. The study of literature on meridians and acupoints about acupuncture treatment of alopecia. J Korean Orient Med. 2006;27(3):212-21.
  14. Choi SB, Kang JA, Lee JH. Five cases of severe alopecia areata treated with Gagamhwajung-hwan. J Korean Med Ophthalmol Otolaryngol Dermatol. 2017;30(3):239-49. https://doi.org/10.6114/jkood.2017.30.3.239
  15. Ha KS, Song IS, Lee JL, Na HS, Shin JN. A case report of a child in alopecia totalis. J Korean Orient Pediatr. 2004;18(2):191-200.
  16. Lee SW, Ko JM, Lee SY, Lee MH, Kim YJ, Lee SH, et al. A case study of beevenom effect on Alopecia Universalis started from alopecia areata. J Korean Acupunct Moxib Soc. 2008;25(6):163-73.
  17. Kim CY, Seo HS, Lee DJ, Kwon K. Case study on treating scarring alopecia and alopecia arreata using low level laser therapy and acupuncture. J Korean Med Ophthalmol Otolaryngol Dermatol. 2016;29(4):182-8. https://doi.org/10.6114/jkood.2016.29.4.182
  18. Ju BH, Choi YK, Yu SA, Lee SY. A case report on child with different types of alopecia. J Pediatr Korean Med. 2013;27(3):53-64. https://doi.org/10.7778/jpkm.2013.27.3.053
  19. Yoon HJ. A case study of androgenetic alopecia in woman improved by pharmacopuncture therapy and needle-embedding therapy. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):162-70. https://doi.org/10.6114/JKOOD.2014.27.3.162
  20. Choi JW, Lee JH, Jung BY, Ji YJ, Lee KS. Retrospective study about the effectiveness of Korean medical treatment on 222 patients with alopecia areata. J Korean Med Ophthalmol Otolaryngol Dermatol. 2019;32(4):13-28.
  21. Yun JH, Kim KH, Jang SJ, Sin MS. One case treated alopecia areata with herbal acupuncture. J Orient Med Surg Ophthalmol Otolaryngol. 2001;14(1):105-10.
  22. Kim KW, Seo JC, Lee KM, Lim SC, Jung TY, Han SW. A case of alopecia areata treated with bee venom and carthami flos herbal acupuncture. J Pharmacopuncture. 2004;7(2):91-6. https://doi.org/10.3831/KPI.2004.7.2.091
  23. Lee IJ, Kim HJ. The case study of Korean medicine on patients with alopecia areata accompanied by atrophodermia. Semyung Orient Med Inst. 2009;12:39-52.
  24. Hwang BM, Jeong MJ, Seo HS. A case report of child with alopecia areata. J Korean Orient Pediatr. 2012;26(2):47-52. https://doi.org/10.7778/jpkm.2012.26.2.047
  25. Ko SJ, Park JW. A case study of male pattern alopecia in man improved by V and HA Yakchim and Korean medicine treatments. J Korea Immuno-Yakchim Soc. 2016;5(1):47-55.
  26. Kim JS, Park SY. A case of alopecia areata treated with Korean medical treatment. Herb Formula Sci. 2016;24(2):124-30. https://doi.org/10.14374/HFS.2016.24.2.124
  27. Yoon YJ, Kwon NH, Shin HJ, Jang JY. Four cases of androgenetic alopecia patient using Korean medicine treatment and Western treatment. J Korean Med Ophthalmol Otolaryngol Dermatol. 2017;30(2):170-7. https://doi.org/10.6114/jkood.2017.30.2.170
  28. Choi HS, Lee SJ, Kim BNR. A case report of the retreatment with the same herbal medicine after the treatment of alopecia areata in a child. J Pediatr Korean Med. 2019;33(4):89-99.
  29. Zhang YM, Liu CH, Wang YC, Teng HL, Meng XL, Han XJ. Medicated thread moxibustion for alopecia areata: a case report. Medicine (Baltimore). 2019;98(44):e17793. https://doi.org/10.1097/md.0000000000017793
  30. Yun GW, Jeong SH, Shin KS. Two cases of androgenetic alopecia patients treated with traditional oriental hair care products and Yukmijihwang-huan. J Korean Med Ophthalmol Otolaryngol Dermatol. 2020;33(1):75-82. https://doi.org/10.6114/JKOOD.2020.33.1.075
  31. Kim MY, An BJ. A study of hair loss prevention and hair growth promotion by Korean traditional fomular. Korea J Herbol. 2004;19(2):9-20.
  32. Yi TH, Moon JB, Kim YJ, An KE. Oriental medicine therapy in the treatment of men with androgenetic alopecia. J Korean Acupunct Moxib Soc. 2006;23(1):179-86.
  33. Lee JH, Jang JY, Yoon YJ, Cho AR, Shin HJ, Jung SU, et al. Retrospective study about the causes and the effects of Korean medicine treatment on alopecia- focused on acquired febrile alopecia. J Korean Med Ophthalmol Otolaryngol Dermatol. 2013;26(2):30-44. https://doi.org/10.6114/jkood.2013.26.2.030
  34. Hong JA, Kang SJ, Jang JY, Kang YR. A clinical trial on efficacy of Gagamchengyoung-tang(Jiajianqingying-tang) in the alopecia patients with febrile tendency. J Korean Med Ophthalmol Otolaryngol Dermatol. 2013;26(2):19-29. https://doi.org/10.6114/jkood.2013.26.2.019
  35. Starace M, Alessandrini A, Brandi N, Piraccini BM. Preliminary results of the use of scalp microneedling in different types of alopecia. J Cosmet Dermatol. 2020;19(3):646-50. https://doi.org/10.1111/jocd.13061
  36. Wu T. Wenbingtiaobian. Seoul: Jipmoondang; 2004. 738 p.
  37. Park YY. Medicine wire Injection therapy. Seoul: Haeng Lim Seo Wen; 2003. p. 19, 23.
  38. Han JS, Lee KR. A research of the effectiveness of far infrared ray and TDP therapy on the hair loss treatment. Asian J Beauty Cosmetol. 2010;8(1):187-99.
  39. Kweon SH, Hong SH. The current status of Korean medicine treatment of alopecia: focusing on case reports. J Korean Med Ophthalmol Otolaryngol Dermatol. 2019;32(3):164-85. https://doi.org/10.6114/JKOOD.2019.32.3.164