• Tuberculosis and Respiratory Diseases
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• 제40권4호
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• pp.367-377
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• 1993

연구배경 : 절제가 불가능한 비소세포 폐암 환자에 대한 복합화학요법의 유용성은 아직도 분명치 않다. 그러나, cisplatin을 주축으로하는 복합화학요법의 반응율은 항암제 단독 투여시의 반응율 보다, 또한 high-dose cisplatin군의 반응율이 low-dose cisplatin군의 반응율보다 높은 것으로 최근 보고되고 있다. 복합화학요법(high VPP), 복합화학요법과 방사선 치료의 병행요법이 진행된 비소세포 폐암에서 생존율을 증가시키는지 알아보기 위해 본 연구를 시작하였다. 방법 : 조직학적으로 비소세포 폐암으로 진단된 stage III이상의 환자 35명을 대상으로 하였다. 이들중, 19명은 VP-16과 high-dose cisplatin(100 $mg/m^2$)으로 구성되는 복합화학요법 그리고 복합화학요법과 방사선 치료를 시행받았으며, 나머지 16명은 치료를 받지 않았다. 두군간의 생존율과 반응율의 차이 및 치료에 다른 부작용을 알아보기 위해 환자의 병록 일지를 검토하였다. 결과: 1) 전체적인 객관적 반응율은 한명의 완전관해를 포함하여 47%(9/19) 였다. 2) 복합화학요법과 방사선 치료를 병행하여 받은 환자군에서의 반응율은 한명의 완전관해를 포함하여 60%(6/10) 였으며, 3개월, 6개월 및 127개월 생존율은 각각 100%, 70% 및 40% 였다. 3) 복합화학요법을 받은 환자군에서의 반응율은 완전관해 없이 33%(3/9) 였으며, 3개월, 6개월 및 12개월 생존율은 각각 78%, 67% 및 33% 였다. 4) 전체적으로 치료군에서 비치료군에 비해 통계적으로 유의하게 (p<0.05) 생존기간이 연장되었다(중앙생간 307일과 95일). 5) 여러 예후인자에 따른 분석에서 운동능력이 좋을수록, stage III에서 그리고 편평상피암에서 좋은 반응율을 보였다. 6) 부작용으로서는 오성과 구토(100%), 탈모증(90%), 빈혈(79%), 백혈구 감소증 (69%), 혈소판 감소증(2%), creatinine의 증가(16%) 그리고 신경독성(5%) 등이 있었다. 결론 : 이상의 결과로 진행된 비소세포 폐암 환자에 대한 hign VPP 복합화학요법은 비치료군에 비해 치료군에서 생존율을 높이는 비교적 좋은 효과가 있으므로 좋은 적응증을 가진 환자들을 선택하여 효과적인 항암치료 및 방사선 치료를 시행하여야 할 것으로 사료된다. 그러나, hign VPP 복합화학요법에 따른 효과 개선은 본 연구 결과에선 뚜렷하지 않으므로 보다 많은 증례에서 추구 연구가 필요하리라 생각된다.

• 한국대기환경학회지
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• 제5권1호
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• pp.62-67
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• 1989

The clastogenic effects of the diesel emission particle extract (DEPE), mercuric chloride and lead acetate were examined by the mouse bone marrow micronucleus test. DEPE had a potent clastogenic effect by intraperitoneal injection with dose-response between 100 and 300mg/kg b.w.. Mercuric chloride and lead acetate also gave a clastogenic effects but mercuric chloride only had a dose-response between 1 and 3mg/kg b.w.. When DEPE was administrated with mercuric chloride or lead acetate, the frequency of micronucleated cells was slight but not significant increase in comparision to a single treatment with DEPE alone.

• Environmental Analysis Health and Toxicology
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• 제25권1호
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• pp.69-77
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• 2010

The purpose of this study is to evaluate the effectiveness of Scirpi rhizoma ethanol extract (SREE) on skin whitening using in vitro test. In the antioxidative activities, it was found that SREE contains 38.9 mg/g of polyphenol and 74.5 mg/g of flavonoid in total. In the electron donating ability, SREE showed a dose-dependent response, showing a high antioxidative capacity of 86.1% at 1000 ppm. It was found that the maximum permissible level of SREE to Melan-a cells was over 200 ppm, showing a quite low toxicity of SREE against Melan-a cells. Both in the inhibitory measurement for tyrosinase activity and melanogenesis using Melan-a cells, SREE presented a dose-dependent response with excellent efficacy.

• Communications for Statistical Applications and Methods
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• 제8권3호
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• pp.581-588
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• 2001

The $ED_{100p}$ is that value of the dose associated with 100p% response rate in the analysis of quantal response data. Brand, Pinnock, and Jackson (1973) studied the confidence bands of $ED_{100p}$ obtained by solving extremal values algebraically on the ellipsoid confidence region of the parameters in the simple logistic regression model. In this paper, we develope and illustrate a simpler method for obtaining confidence bands for $ED_{100p}$ based on the rectangular confidence region of parameters.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 춘계학술대회논문집
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• pp.1280-1284
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• 2006

This paper describes the methodology for environmental assessments of traffic noise sources. An attempt is made to establish evaluation scale relationships between noise quality Parameters and subjective degrees annoyance. Subjective experimental was conducted to determine the subjective degrees annoyance that scaling score compare with reference and varieties noise source about modified traffic noises with $40{\sim}85dB$. Also a correlation analysis between noise rating index and satisfactory percentage of the noise dose response curves varied with response was conducted. As a result of study, subjective annoyance degree has not correlation of proportional linearity to the A weight noise level, but has correlation of proportional linearity to the index composed to loudness and tonality. It is suggested to be resonable level 4.9 (equivalence about 53dB) index on the out door noise limits for traffic noise and to be 6 step scale base on the linearity for evaluation traffic noise.

• 한국환경보건학회지
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• 제19권3호
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• pp.64-73
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• 1993

The study was conducted to investigate the mechanism of tumor promotion as the time courses and the doses of promoter, and the effect of plant fiavonoids on the TPA-induced ODC responses. The results are summarized as follows: 1. A single, toppical application of 17 nmole of the potent tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate, resulted in an induction of mouse epidermal Ornithine Decarboxylase with a peak at 5 hours after treatment and maximized 5.1 times as large as ODC activities of control. 2. Dose-response curve indicated that the tumor promotion increases proportionally between 1.7 and 170 nmole of TPA. This dose dependency relationship indicated that the ability of TPA to stimulate ODC is linked its ability to promote tumors. 3. Naturally occurring plant fiavonoids with anticarcinogenic and antipromotional activities were tested for their abilities to inhibit ODC response induced by skin tumor promoter TPA. Intra peritoneal administration of fiavonoids compounds (rutin, naphthofiavone, baicalein, quercitrin) and herbal drugs (sophorae rios, crataegi fructus, armeniacae semen) inhibited 17 nmole TPA-induced ODC activities in mouse epidermis in vivo.

• Biomolecules & Therapeutics
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• 제27권5호
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• pp.435-441
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• 2019

The capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) has been an object of intense interest for pharmacological development on account of its critical role in nociception. In the course of structure activity analysis, it has become apparent that TRPV1 ligands may vary dramatically in the rates at which they interact with TRPV1, presumably reflecting differences in their abilities to penetrate into the cell. Using a fast penetrating agonist together with an excess of a slower penetrating antagonist, we find that we can induce an agonist response of limited duration and, moreover, the duration of the agonist response remains largely independent of the absolute dose of agonist, as long as the ratio of antagonist to agonist is held constant. This general approach for limiting agonist duration under conditions in which absolute agonist dose is variable should have more general applicability.

• 대한수의학회지
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• 제27권1호
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• pp.19-25
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• 1987

To validate the comparision of proximal and distal large intestinal motility, the amplitude and frequency of spontaneous motility, the effect of acetylcholine, the effect of atropine on the response of acetylcholine, the effect of histamine and the effect of pyrilamine and cimetidine on the response of histamine were investigated in rabbit. The results were summarized as follows: 1. The amplitude of spontaneous motility was more powerful on the proximal large intestine than that of the distal large intestine, but the frequency of spontaneous motility was similar on the both proximal and distal large intestine in rabbit. 2. Acetylcholine caused the contraction of proximal and distal large intestine, and the contractile response were increased between the concentration of acetylcholne $10^{-9}$ and $5{\times}10^{-6}M$ and $10^{-7}$ and $10^{-4}M$ on the proximal and distal large intestine, respectively, with dose-dependent manner in rabbit. 3. The contractile response induced by acetylcholine was completely blocked by the post-treatment with cholinergic receptor blocker, atropine $10^{-6}M$. 4. Histamine caused the contraction of proximal and distal large intestine and the contractile response were increased between the concentration of histamine $10^{-9}$ and $5{\times}10^{-5}M$ and $10^{-5}$ and $10^{-3}M$ on the proximal and distal large intestine, respectively, with dose-depend ent manner in rabbit. 5. The contractile response induced by histamine was completely blocked by the pretreatment with $H_1$-receptor blocker, pyrilamine $10^{-6}M$, but not blocked by the pretreatment with $H_2$-receptor blocker, cimetidine $10^{-6}M$.

• Radiation Oncology Journal
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• 제36권2호
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• pp.153-162
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• 2018

Purpose: We aimed to evaluate clinical outcomes including progression-free survival (PFS), overall survival (OS), partial response, and complete response in patients who underwent radiation therapy (RT) for mycosis fungoides (MF). Also, we sought to find prognostic factors for clinical outcomes. Materials and Methods: Total 19 patients confirmed with MF between 1999-2015 were retrospectively reviewed. Clinical and treatment characteristics, clinical outcomes, and and toxicities were analyzed. Results: Eleven patients were treated with total skin electron beam radiotherapy (TSEBT) and 8 patients with involved field radiation therapy (IFRT) with median dose of 30 Gy, respectively. The median time interval from diagnosis to RT was 2.6 months (range, 0.4 to 87.3 months). The overall response rate was 100%; 11 patients (57.9%) had a complete response and 8 patients (42.1%) a partial response. The presence of positive lymph node at the time of consultation of RT was associated with lower OS (p = 0.043). In multivariate analysis, PFS was significantly lower for patients with increased previous therapies experienced following RT (p = 0.019) and for patients showing PR during RT (p = 0.044). There were no reported grade 3 or more skin toxicities related with RT. Conclusion: Both IFRT and TSEBT are effective treatment for MF patients. Patients with short disease course before RT or complete response during RT are expected to have longer PFS. Positive lymph node status at the initiation of RT was associated woth poor OS, suggesting other treatment modalities such as low-dose RT for patients with low life-expectancy.

• The Korean Journal of Physiology
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• 제30권1호
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• pp.11-20
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• 1996

To investigate the properties of cromakalim-opened $K^{+}\;channels$ in aorta of spontaneously hypertensive rats (SHR), the effect of cromakalim on tension was compared in endothelium-rubbed aortic rings from SHR and normotensive Wistar-Kyoto rats (WKY). 1. Cromakalim relaxed the aortic ring contracted by $10^{-7}$ M norepinephrine (NE) dose-dependently, and this relaxant response to cromakalim was blocked by $10^{-5}$ M glybenclamide. 2. Cromakalim also relaxed the contraction induced by high $K^{+}$-solution or 10 mM tetraethylammonium dose-dependently. However, the relaxant response to cromakalim was decreased by raising the $K^{+}$ concentration. 3. SHR aorta exhibited myogenic tone in resting state which was inhibited by cromakalim, verapamil or $Ca^{2+}-free\;PSS.$ Whereas, WKY aorta did not exhibit any myogenic tone in resting state. 4. When aortic rings from both strains were contracted by $20\;mM\;K^{+}\;or\;NE$, relaxant responses to low concentration of cromakalim $(below\;10^{-7}\;M)$ were not different between WKY and SHR, but maximum relaxant response to cromakalim $(above\;3{\times}10^{-7} \;M)$ was greater in SHR than in WKY. 5. When the relaxant response to cromakalim was expressed as percent of maximum relaxation induced by $Ca^{2+}-free\;PSS$, relaxant response to cromakalim in 20 mM $K^{+}-induced$ contraction was not different between WKY and SHR. From the above result, it is suggested that relaxant responses to cromakalim are greater in SHR than WKY, and this may be due to the myogenic tone of aortic rings from SHR.