Journal of Korean Society for Atmospheric Environment (한국대기환경학회지)

Korean Society for Atmospheric Environment (한국대기환경학회)
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Genotoxic Effects of Diesel Emission Particle Extract, $HgCl_2$ and $Pb(Ac)_2$ by the Mouse Bone Marrow Micronucleus Test

마우스 골수 소핵 시험에 의한 디젤분진, $HgCl_2$ 및 $Pb(Ac)_2$의 유전독성효과

  • 허문영 (강원대학교 약학대학교) ;
  • 최성규 (강원대학교 약학대학교) ;
  • 유기선 (강원대학교 약학대학교) ;
  • 손동헌 (중앙대학교 약학대학)
  • Published : 1989.05.01
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Abstract

The clastogenic effects of the diesel emission particle extract (DEPE), mercuric chloride and lead acetate were examined by the mouse bone marrow micronucleus test. DEPE had a potent clastogenic effect by intraperitoneal injection with dose-response between 100 and 300mg/kg b.w.. Mercuric chloride and lead acetate also gave a clastogenic effects but mercuric chloride only had a dose-response between 1 and 3mg/kg b.w.. When DEPE was administrated with mercuric chloride or lead acetate, the frequency of micronucleated cells was slight but not significant increase in comparision to a single treatment with DEPE alone.

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