• 대한임상전기생리학회지
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• 제1권2호
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• pp.61-68
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• 2003

The purpose of this study was to compare the application method of ultrasound on the alteration of pressure pain threshold of myofascial trigger points. We used thirty patients with mayofascial pain syndrome in upper trapezius. Participants classified according to each group in non noxious dose, noxious dose by the ultrasound. The test was measured continuously pre test, post-test by algometer. The following results were obtained; 1. Pressure pain threshold were significantly increased in non-noxious dose and noxious dose group(p<.001). 2. In noxious dose group, pressure pain threshold were more significantly increased than non-noxious dose group(p<.001). These results lead us to the conclusion that non-noxious dose and noxious dose were significantly increased pressure pain threshold of upper trapezius trigger points. Therefore, a further direction of this study will be to provide more evidence that noxious dose have more effect on pressure pain threshold of myofascial trigger points.

• 대한한의학방제학회지
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• 제11권2호
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• pp.83-94
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• 2003

This study aimed to investigate the effects of each constituent-herb of Sagoonja- Tang on the plasma corticosterone level in mice exposed to cold stress. Sagoonja-Tang is composed of Ginseng Radix, Atractylodis Radix, Poria, and Glycyrrhizae Radix. Each constisuent-herb(0.5g/kg, 1.0g/kg) was administered intragastrically to mice 1hr prior to expose to forced cold water swimming($4{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 30 minutes after the cold stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group(PGR group) didn't show any significant changes. 3. Atractylodis group(AR group) showed significant decrease at 0.5g/kg dose (P<0.01). But it didn't show significant changes at 1.0g／kg dose. 4. Poria group(P group) didn't show significant changes. But it showed slightly increase at 1.0g/kg dose. 5. Glycyrrhizae group(GR group) didn't show significant changes. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level and the dose of herbs had a different effect on the plasma corticosterone level in mice exposed to cold stress.

• 생물정신의학
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• 제18권1호
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• pp.36-45
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• 2011

Objectives : Though a proportion of Alzheimer's disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders' characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods : Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG, same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results : After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions : This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.

• 공업화학
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• 제33권3호
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• pp.322-327
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• 2022

Fucoidans were degraded by hydrogen peroxide under the electron beam (2.5 MeV) with various radiation doses (5 kGy, 10 kGy, 15 kGy, and 20 kGy) at room temperature. The degradation property was analyzed with a gel permeation chromatography (GPC-MALLS) method. An average molecular weight of fucoidan decreased from 99,956 at the irradiation dose of 0 kGy to 6,725 at the irradiation dose of 20 kGy. The solution viscosity of fucoidans showed a similar pattern to the molecular weight change. The number of chain breaks per molecule (N) increased with increasing the irradiation dose and concentration of hydrogen peroxide. The radiation yield of scission value markedly increased with increasing the irradiation dose up to 15 kGy. Also a 10% hydrogen peroxide concentration was more efficient than that of 5%. The structures of degraded fucoidan samples were studied with Fourier transform infrared spectroscopy (FT-IR). The results showed that the degradation process did not significantly change the chemical structure or the content of sulfate group. The sulfur content of each sample was determined with an Elemental Analyzer. With increasing the concentration of hydrogen peroxide, the ratios of sulfur/carbon, hydrogen/carbon, and nitrogen/carbon slightly decreased. The antioxidant activities of fucoidans were investigated based on hydroxyl radical scavenging activities. The ability of fucoidan to inhibit the hydroxyl radical scavenging activity was depended on its molecular weight.

• Journal of Radiation Protection and Research
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• 제48권1호
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• pp.20-27
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• 2023

Background: As the number of nuclear facilities nearing their pre-determined design life increases, demand is increasing for technology and infrastructure related to the decommissioning and decontamination (D&D) process. It is necessary to consider the nature of the dismantling environment constantly changing and the worker doing new tasks. A method was studied that can calculate the effect of learning and the change in work time on the work process, according to the learning-forgetting curve model (LFCM). Materials and Methods: The LFCM was analyzed, and input values and scenarios were analyzed for substitution into the D&D process of a nuclear facility. Results and Discussion: The effectiveness and efficiency of the training were analyzed. It was calculated that skilled workers can receive a 16.9% less collective radiation dose than workers with only basic training. Conclusion: Using these research methods and models, it was possible to calculate the change in the efficiency of workers performing new tasks in the D&D process and the corresponding reduction in the work time and collective dose.

• Journal of Radiation Protection and Research
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• 제44권4호
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• pp.128-148
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• 2019

Massive environmental monitoring has been conducted continuously since the Fukushima Daiichi Nuclear Power accident in March of 2011 by different monitoring methods that have different features together with migration studies of radiocesium in diverse environments. These results have clarified the characteristics of radiological environments and their temporal change around the Fukushima site. At three months after the accident, multiple radionuclides including radiostrontium and plutonium were detected in many locations; and it was confirmed that radiocesium was most important from the viewpoint of long-term exposure. Radiation levels around the Fukushima site have decreased greatly over time. The decreasing trend was found to change variously according to local conditions. The air dose rates in environments related to human living have decreased faster than expected from radioactive decay by a factor of 2-3 on average; those in pure forest have decreased more closely to physical decay. The main causes of air dose rate reduction were judged to be radioactive decay, movement of radiocesium in vertical and horizontal directions, and decontamination. Land-use categories and human activities have significantly affected the reduction tendency. Difference in the air dose rate reduction trends can be explained qualitatively according to the knowledge obtained in radiocesium migration studies; whereas, the quantitative explanation for individual sites is an important future challenge. The ecological half-lives of air dose rates have been evaluated by several researchers, and a short-term half-life within 1 year was commonly observed in the studies. An empirical model for predicting air dose rate distribution was developed based on statistical analysis of an extensive car-borne survey dataset, which enabled the prediction with confidence intervals. Different types of contamination maps were integrated to better quantify the spatial data. The obtained data were used for extended studies such as for identifying the main reactor that caused the contamination of arbitrary regions and developing standard procedures for environmental measurement and sampling. Annual external exposure doses for residents who intended to return to their homes were estimated as within a few millisieverts. Different forms of environmental data and knowledge have been provided for wide spectrum of people. Diverse aspects of lessons learned from the Fukushima accident, including practical ones, must be passed on to future generations.

• 한국의학물리학회지:의학물리
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• 제28권1호
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• pp.27-32
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• 2017

We investigated the effect of a commercial iterative reconstruction technique (iDose, Philips) on the image quality and the dose calculation for the treatment plan. Using the electron density phantom, the 3D CT images with five different protocols (50, 100, 200, 350 and 400 mAs) were obtained. Additionally, the acquired data was reconstructed using the iDose with level 5. A lung phantom was used to acquire the 4D CT with the default protocol as a reference and the low dose (one third of the default protocol) 4D CT using the iDose for the spine and lung plans. When applying the iDose at the same mAs, the mean HU value was changed up to 85 HU. Although the 1 SD was increased with reducing the CT dose, it was decreased up to 4 HU due to the use of iDose. When using the low dose 4D CT with iDose, the dose change relative to the reference was less than 0.5% for the target and OARs in the spine plan. It was also less than 1.1% in the lung plan. Therefore, our results suggests that this dose reduction technique is applicable to the 4D CT image acquisition for the radiation treatment planning.

• 대한디지털의료영상학회논문지
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• 제15권2호
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• pp.13-18
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• 2013

Purpose : Fluoroscopy equipment, depending on the type of changes that occur in the patient's position ESD and study the patient's scatter ray of ESD Practitioners considered a comparative analysis was to evaluate the correct dose. Materials and Methods : HITACHI four overtube type TU-8000 Flat Detector and Under tube C-Arm Philips' Multi Diagnost Eleva with Flat Detector type were measured by. Each devices is a measure of the patient's esd randophantom position in tabel unfors Xi multi funtion then fixed to the abdomen fluoroscopy and 10 seconds, spot was measured three times, practitioners of the incident surface dose by considering the patient's scatter ray of the table for each device in the average human stomach 21cm thickness acrylic phantom ($25cm{\times}25cm$) Place the practitioner position after position randophantom unfors Xi multi funtion in the thyroid and stomach 1 minute by a fixed one-time fluoroscopy and measured. Results : 10 seconds and the patient perspective of the c-arm ESD 1.2 times smaller on the AP and oblique measurements were measured in the 6-13 times smaller. spot positions to changes in the measured three times on the AP of the abdomen, ESD is 18 times smaller c-arm measurements and the oblique measurement was 19-30 times smaller. And 1 minute at practitioners fluoroscopy esd in the thyroid 2.12 times the c-arm, chest 1.75 times less the dose was measured. On the AP, depending on the device, but the lack of dose difference oblique positions of the two devices depending on changes in the area due to changes in both the AP than on the dose increased, the difference in dose between the two devices, the maximum difference was approximately 27 times. Conclusion : Fluoroscopic equipment at the time of inspection in accordance with changes in dose according to the patient and the patient's positions changes, because the area of the scatter ray considering the change of dose measurements be made, and study of the equipment according to the characteristics of the efficiency and the exposure of the patient and practitioner is considered smooth study equipment manufacturers that can be done is to build the system and think that is also important. Various fluoroscopy when you check future changes in many factors of change in dose for the equipment in the laboratory system by considering the scatter ray radiation shielding for the management to take advantage of reckless undertube have been utilized as more exposure Reduction activities can help is considered as the direction.

• 한국방사선학회논문지
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• 제7권4호
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• pp.307-311
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• 2013

본 논문에서는 피폭선량 절감을 위해 기존의 선량보다 낮은 선량으로 CT검사를 했을 경우에 병변의 유무를 충분히 가릴 수 있는지 scan parameter(절편두께, Helical Pitch)와 3차원으로 영상재구성시 threshold값의 설정에 따른 영상의 변화정도를 3차원 영상화를 통하여 시료의 체적 변화를 알아보고, 피폭선량절감을 위한 CT에서 허용 가능한 scan parameter를 찾고자 연구를 시도하였다. 실험방법으로는 실리콘을 이용하여 시료를 제작하였으며, 이때 시료의 크기는 직경이 50, 40, 30, 20, 10mm로 10mm 간격으로 5개의 구형 모형을 제작하였고, 5개의 시료를 관전압, 관전류를 각각 120Kvp, 50mA로 고정하고, 단면두께(1.0, 2.0, 3.0, 5.0, 7.0mm), Helical Pitch(1.5, 2.0, 3.0)를 각각 변화시켜 Scan 하고 영상 간의 interval은 (1.0, 2.0, 3.0, 5.0, 7.0mm)로 구성하여, 영상을 workstation으로 전송하고, Volume Rendering Technique를 사용하여 threshold(-200,-50,50 ~1,000) 값을 변화시키면서 3차원 영상으로 재구성하고, 시료의 체적을 측정하였다. 실험결과 Helical pitch가 1.5일 때 체적변화가 가장 적었고, Helical pitch가 3.0일 때 체적변화가 가장 많이 감소하였으며, 절편두께가 증가할수록 시료의 체적도 실측치보다 감소한다는 것을 실험을 통해 확인 할 수 있었다. 또한 3차원 영상재구성시 threshold 범위를 -200~1,000으로 설정한 경우, 시료의 체적의 변화가 가장 적은 것으로 나타났다.

• Journal of Astronomy and Space Sciences
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• 제31권1호
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• pp.33-39
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• 2014

This paper describes an experimental approach to evaluate the effective doses of space radiations at high-altitude by combining the measured data from the Liulin-6K spectrometer loaded onto the air-borne RC-800 cockpit and the calculated data from CARI-6M code developed by FAA. In this paper, 15 exposed dose experiments for the flight missions at a high-altitude above 10 km and 3 experiments at a normal altitude below 4 km were executed over the Korean Peninsula in 2012. The results from the high-altitude flight measurements show a dramatic change in the exposed doses as the altitude increases. The effective dose levels (an average of $15.27{\mu}Sv$) of aircrew at the high-altitude are an order of magnitude larger than those (an average of $0.30{\mu}Sv$) of the normal altitude flight. The comparison was made between the measure dose levels and the calculated dose levels and those were similar each other. It indicates that the annual dose levels of the aircrew boarding RC-800 could be above 1 mSv. These results suggest that a proper procedure to manage the exposed dose of aircrew is required for ROK Air Force.