• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.353-364
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• 2021

The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the GI tract can lead to GI disorders. GI disorders are highly prevalent in the population and account for substantial morbidity, mortality, and healthcare utilization. GI disorders can be functional, or organic with structural changes. Functional GI disorders include functional dyspepsia and irritable bowel syndrome. Organic GI disorders include inflammation of the GI tract due to chronic infection, drugs, trauma, and other causes. Recent studies have highlighted a new explanatory mechanism for GI disorders. It has been suggested that autophagy, an intracellular homeostatic mechanism, also plays an important role in the pathogenesis of GI disorders. Autophagy has three primary forms: macroautophagy, microautophagy, and chaperone-mediated autophagy. It may affect intestinal homeostasis, host defense against intestinal pathogens, regulation of the gut microbiota, and innate and adaptive immunity. Drugs targeting autophagy could, therefore, have therapeutic potential for treating GI disorders. In this review, we provide an overview of current understanding regarding the evidence for autophagy in GI diseases and updates on potential treatments, including drugs and complementary and alternative medicines.

• Korean Journal of Psychosomatic Medicine
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• v.25 no.2
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• pp.185-192
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• 2017

Objectives : The aims of present study was to investigate clinical characteristics of male patients with eating disorders. Methods : The present study included 32 male patients with eating disorders and 75 female patients with eating disorders, recruited from an eating disorders specialized clinic in a university hospital, Seoul, Korea. We compared clinical characteristics of eating disorders and comorbid conditions of depression and anxiety between men and women with eating disorders. Correlations between eating disorders psychopathology in men with eating disorders and their weight suppression(WS) were investigated. Results : There was no difference in age at presentation, age of onset, illness duration, and body mass index at presentation between genders. Male patients with eating disorders had higher rates of premorbid overweight or obesity than female patients with eating disorders had. WS in the male patients was associated with the severity of their eating disorders. Conclusions : The present study provides grounds for improved understanding for clinical features of eating disorders in males.

• Journal of the Korea Safety Management & Science
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• v.11 no.4
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• pp.85-91
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• 2009

While musculoskeletal disorders increased, its prevention efforts were rather decreased or its operation was insufficient. This study aims to examine the actual conditions of musculoskeletal disorders at Electronics Company in Korea, analyze occupational danger factors related to musculoskeletal disorders through analysis of components of wrong workplaces and works, evaluate degree of danger of factors examined, analyze association between danger factors and musculoskeletal disorders, accumulate data of musculoskeletal disorders which are not enough in Korea and further prepare the foundation of improving working environment and developing prevention/management program of musculoskeletal disorders.

• Anxiety and mood
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• v.3 no.1
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• pp.15-19
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• 2007

Substantial rates of comorbid anxiety disorders have been found using structured research diagnostic interviews in depressed outpatients. Comorbid anxiety disorders is underrecognized in routine clinical settings, in which clinicians usually use unstructured diagnostic interviews. Recognition of comorbid conditions such as anxiety disorders in patients seeking treatment for depression is clinically important because the presence of these disorders might influence selection of treatment options or predict the chronicity of the depression. A reliable and valid self-report screening questionnaire, such as the Psychiatric Diagnostic Screening Questionnaire (PDSQ), would potentially enhance usual clinical practice as a useful diagnostic aid.

• Korean Journal of Biological Psychiatry
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• v.20 no.3
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• pp.74-79
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• 2013

Objectives This paper aims to understand the emotional-biological pathogenesis of eating disorders, and translate the understanding into new brain directed treatments. Methods The first part of the review sets the eating behavior into the context of what is now understood about the central control of appetite and molecular biology. The second part of the review sees how emotion relates to the brain circuit involving eating disorders. Results In general, patients with anorexia nervosa restricting type were less sensitive to reward, whereas patients with bulimia nervosa and anorexia nervosa binge purging type were more sensitive to it. The emotional life of people with eating disorders centers on food, weight, and shape. The abnormalities in social and emotional functioning both precede and persist outside of eating disorders. Conclusions Research into understanding the biological framework of the brain in eating disorders suggests that abnormalities may exist in emotional and information processing. This aspect can be translated into novel brain-directed treatments, particularly in anorexia nervosa.

• Anxiety and mood
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• v.5 no.1
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• pp.3-7
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• 2009

In this article, we review research on how normal personality traits and personality disorder traits may relate to anxiety disorders ; as predisposing factors, 2) as complications, 3) as pathoplastic factors, and 4) as manifestations of common underlying etiologies. Based on current literatures, we draw a conclusion as follows : 1) Normal personality traits such as high neuroticism and low extraversion and personality disorder traits, especially cluster C traits, are at least risk factors for certain anxiety disorders ; 2) Anxiety disorders in early life might influence a later development of personality disorder ; 3) Personality disorder traits may have negative influence on the outcome of anxiety disorders ; 4) Personality and anxiety disorders may be manifestations of common genetic and environmental etiologies.

• Journal of mucopolysaccharidosis and rare diseases
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• v.4 no.1
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• pp.1-6
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• 2018

Lysosomal storage disorders are a group of rare inherited metabolic disorders with protean manifestations and variable severity ranging from attenuated forms to severe ones. It is necessary to diagnose and manage these disorders timely before irreversible damage occurs. Prior to the era of enzyme replacement therapy and newer therapeutics, only treatment option available was palliative care. Over the past two decades, extensive research in the lysosomal storage disorders has led to substantial expansion of our understanding about them. This mini review focusses on the spectrum, challenges faced in the diagnosis and therapy and remedial actions taken so far in lysosomal storage disorders in resource constrained country like India.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.358-363
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• 1998

These studies were performed to investigate what genital diseases could be diagnosed by ultrasonography in the mares associated with infertility. Of 159 thoroughbred breeders(4 to 18 years old), 31 mares which had been considered as the mares with reproductive disorders were examined by ultrasonography during the breeding season. 1. Hematoma in ovarian disordersl endometritis and pyometra in uterine disorders could be diagnosed by ultrasonography. 2.The rate of infertility was 19.5% out of 159 breeders and the rate of uterine disordres was 71.0% among the whole reproductive disorders. 3.Of 31 mares considered as the mares with infertilityi 26 mares were diagnosed by ultrasonography denoting 83.9% of diagnosis rate. 4.The highest average age of mares among the mares with reproductive disorders was 11.7 years in the mares with uterine disorders. The average age of the mares diagnosed as concepted was 7.5 years, which was much lower than that of the mares with reproductive disorders.5.Crushing one of twin vesicles was confirmed by ultrasonography. In conclusions ultrasonography was feasible for diagnosis of the mares with reproductive problems.

• Journal of the Korea Safety Management & Science
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• v.9 no.4
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• pp.29-38
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• 2007

We adapted association rules of data mining in order to investigate the relation among the factors of musculoskeletal disorders and proposed the method of preventing the musculoskeletal disorders associated with multiple logistic regression in previous study. This multiple logistic regression was difficult to establish the method of preventing musculoskeletal disorders in case factors can't be managed by worker himself, i.e., age, gender, marital status. In order to solve this problem, we devised association rules of factors of musculoskeletal disorders and proposed the interactive method of preventing the musculoskeletal disorders, by applying association rules with the result of multiple logistic regression in previous study. The result of correlation analysis showed that prevention method of one part also prevents musculoskeletal disorders of other parts of body.

• Phonetics and Speech Sciences
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• v.3 no.1
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• pp.111-116
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• 2011

The purpose of this study was to analyze the association between self-reported voice problems and voice disorders in the Korean adult population. Data were collected from the 4th Korea National Health and Nutritional Examination Survey (2008) from 3,135 subjects (1,310 men and 1,825 women) aged 19 years and older. Multi-nominal logistic regression analyses were used to examine the association between self-reported voice problems and voice disorders in the Korean adult population. Adjusting for covariates (age, sex, education level, job, smoking, alcohol drinking, thyroid disorders, pain and discomfort during the last 2 weeks), self-reported voice problems included independently associated functional voice disorders (OR=4.70, 95% CI: 3.14-7.03) and organic voice disorders (OR=3.89, 95% CI: 1.57-9.65). The results of the present study verified that self-reported voice problems are valuable indicators for voice disorders. Further research is needed to ascertain the effect of self-reported voice problems on voice disorder in adults.