• Journal of the Korea Organic Resources Recycling Association
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• v.18 no.1
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• pp.81-88
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• 2010

Characteristic of hydrogen production was investigated to find the optimum heat pretreatment conditions for the anaerobic fermentation of food waste. The heat pretreatment of food waste enhanced the hydrogen yield due to the increase of soluble chemical oxygen demand (SCOD) and carbohydrate content. This result revealed that the maximum degrees of disintegration of SCOD and carbohydrate content were 55.1% and 223.6%, respectively. On the other hand, the improvement of hydrogen yield was insignificantly affected by heating reaction time at longer than 20 min; the increase of hydrogen yield was only about 7% between 20min and 1 hour. Therefore, the increase of reaction time more than 20min was not necessary.

• Journal of Powder Materials
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• v.28 no.3
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• pp.227-232
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• 2021

The purpose of this study is to optimize the powder formulation and manufacturing conditions for the solidification of an extract of the herb Bangpungtongseong-san (BPTS). To develop BPTS-loaded particles for the tablet dosage form, various BPTS-loaded particles composed of BPTS, dextrin, microcrystalline cellulose (MCC), silicon dioxide, ethanol, and water are prepared using spray-drying and high shear granulation (high-speed mixing). Their physical properties are evaluated using scanning electron microscopy and measurements of the angle of repose, Hausner ratio, Carr's index, hardness, and disintegration time. The optimal BPTS-loaded particles exhibit improved flowability and compressibility. In particular, the BPTS-loaded particles containing silicon dioxide show significantly improved flowability and compressibility (the angle of repose, Hausner ratio, and Carr's index are 35.27 ± 0.58°, 1.18 ± 0.06, and 15.67 ± 1.68%, respectively), hardness (18.97 ± 1.00 KP), and disintegration time (17.60 ± 1.50 min) compared to those without silicon dioxide. Therefore, this study suggests that particles prepared by high-speed mixing can be used to greatly improve the flowability and compressibility of BPTS using MCC and silicon dioxide.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.595-600
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• 2020

The purpose of this paper was to prepare and evaluate solid dispersions (SD) that can increase the dissolution rate of dexibuprofen as a model drug with low solubility in water using saccharides and sugar alcohols as dispersion materials. DSC, XRD, content and content uniformity test, dissolution test, and disintegration test were conducted for physicochemical evaluation of the prepared SD. For the results, it was confirmed using differential scanning calorimetry that fructose, which has a melting point around 120 ℃ of the device operating temperature range, is a suitable excipient for the preparation of SD by the rotary hot-melt granulation (RHMG) method. X-ray diffraction analysis was conducted to confirm that the crystallinity of dexibuprofen was reduced. Disintegration test of the prepared tablet using SD-containing dexibuprofen and fructose confirmed a very fast disintegration time within 1~2 seconds and also showed that the dissolution rate was about 20% faster than that of the dexibuprofen raw material. Dexibuprofen with reduced crystallinity by SD confirmed through the RHMG method can be used to increase the dissolution rate of the drug and increase the disintegration time of the tablet. Thus, it can be used in the manufacturing of various solid preparations.

• Environmental Engineering Research
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• v.19 no.1
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• pp.83-89
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• 2014

The effects of initial solid concentration and microwave irradiation (MWI) time on the hydrolysis of waste activated sludge (WAS) were investigated. MWI time strongly influenced WAS hydrolysis for all initial solid concentrations of 8.20, 31.51, and 52.88 g VSS/L. For all WAS, the volatile suspended solids (VSS) solubilization degree ranged from 35.6% to 38.4% during a total MWI time of 10 min. Soluble chemical oxygen demand (SCOD) concentration increased at a rate proportional to the decrease of VSS during the MWI. However, the clearly different VSS solubilization patterns that were observed during the MWI were explained by the 2-step hydrolysis of WAS, consisting of the initial disintegration of the easily degradable part of the sludge, followed by the subsequent disintegration of the hardly degradable part of the sludge. WAS hydrolysis rates for 3 to 6 min of MWI were significantly lower than those for less than 3 min, or more than 6 min. From these results, 3 min MWI time and WAS of 31.51 g VSS/L (centrifugal thickener WAS) showed the most efficient hydrolysis of WAS at 36.0%. The profiles of total nitrogen (T-N) concentrations corresponded well to the SCOD increases in terms of the empirical formula of bacterial cell mass ($C_5H_7O_2N$). The negligible T-N increase and pH decrease during WAS hydrolysis by MWI will allow the application of this process to subsequent biological processes, such as anaerobic digestion.

• Journal of Environmental Health Sciences
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• v.24 no.1
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• pp.104-111
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• 1998

The utilization of food garbage as composting was investigated by using the batch reactor and by varying the initial temperature of the fermentation reactors. As the straw controlled under 50 to 55% of moisture content and mixed 5% of EM(Effective Micro-organisms) microbial agent. An agitator continuously operated 1 rpm, supplying the amount of air(2l/kg.min). Reactor temperature changed three type of 40$\circ$C, 50$\circ$C, 60$\circ$C. In the case of 50$\circ$C operated 72 hr after organic contents showed lowest 48%, and weight reduction rate of showed 77%. The reaction gas was showed 30 min after 19. 9% of the lowest level at 20.9% concentration of oxygen and CO$_2$ gas was produced 0.9% due to organic disintegration on initial react time. NH$_4$, H$_2$ and CH$_4$ gas concentration showed 589 ppm lhr after, 83 ppm and 0.3%, but 8hr after gas product was complete. As using the straw of bulking agent, the Reduction by disintegration should be more effectively than composting.

• Journal of Pharmaceutical Investigation
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• v.24 no.3
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• pp.67-77
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• 1994

The RMS statistical approach has demonstrated its potential in developing pharmaceutical dosage forms and in improving tabletting performance. Using an optimized formula, the tabletting performances of vitamin C-90 such as compressibility, disintegration time, lubrication and friability are significantly enhanced when compared with the performance of a traditional test formula. More important, this method also enables us to serve our customers better. Any customized modification of a suggested formula or any technical problem related performance etc. can be readily resolved by simple examination of the models.

• Journal of Mechanical Science and Technology
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• v.17 no.5
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• pp.766-775
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• 2003

The intermittent spray characteristics of a multi-hole diesel nozzle with a 2-spring nozzle holder were investigated experimentally. Without changing the total orifice exit area, the hole number of the multi-hole nozzle varied from 3 (d$\_$n/=0.42 mm) to 5 (d$\_$n/=0.32 mm). The time-resolved droplet diameters of the spray including the SMD (Saute. mean diameter) and the AMD (arithmetic mean diameter), injected intormittently from the multi-hole nozzles into still ambient ai., were measured by using a 2-D PDPA (phase Doppler particle analyze.). The 5-hole nozzle spray shows the smaller spray cone angle, the decreased SMD distributions and the small difference between the SMD and the AMD, compared with that of the 3-hole nozzle spray. From the SMD distributions with the radial distance, the spray structure can be classified into the three regions : (a) the inner region showing the high SMD distribution , (b) the mixing flow region where the shea. flow structure would be constructed : and (c) the outer region formed through the disintegration processes of the spray inner region and composed of fine droplets. Through the SMD distributions along the spray centerline, it reveals that the SMD decreases rapidly after showing the maximum value in the vicinity of the nozzle tip. The SMD remains the constant value near the Z/d$\_$n/=166 and 156.3 for the 3-hole and 5-hole nozzles, which illustrate that the disintegration processes of the 5-hole nozzle spray proceed more rapidly than that of the 3-hole nozzle spray.

• Journal of Microbiology and Biotechnology
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• v.29 no.2
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• pp.200-208
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• 2019

Probiotics show low cell viability after oral administration because they have difficulty surviving in the stomach due to low pH and enzymes. For the oral delivery of probiotics, developing a formula that protects the probiotic bacteria from gastric acidity while providing living cells is mandatory. In this study, we developed tablets using a new pH-sensitive phthalyl inulin (PI) to protect probiotics from gastric conditions and investigated the effects of different compression forces on cell survival. We made three different tablets under different compression forces and measured survivability, disintegration time, and kinetics in simulated gastric-intestinal fluid. During tableting, there were no significant differences in probiotic viability among the different compression forces although disintegration time was affected by the compression force. A higher compression force resulted in higher viability in simulated gastric fluid. The swelling degree of the PI tablets in simulated intestinal fluid was higher than that of the tablets in simulated gastric fluid due to the pH sensitivity of the PI. The probiotic viability formulated in the tablets was also higher in acidic gastric conditions than that for probiotics in solution. Rapid release of the probiotics from the tablet occurred in the simulated intestinal fluid due to the pH sensitivity. After 6 months of refrigeration, the viability of the PI probiotics was kept. Overall, this is the first study to show the pH-sensitive properties of PI and one that may be useful for oral delivery of the probiotics.

• Bulletin of the Korean Mathematical Society
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• v.42 no.4
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• pp.855-867
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• 2005

Shattering or disintegration of mass is a well known phenomenon in fragmentation processes first introduced by Kol­mogorov and Filippop and extensively studied by many physicists. Though the mass is conserved in each break-up, the total mass decreases in finite time. We investigate this phenomenon in the n particle system. In this system, shattering can be interpreted such that, in uniformly bounded time on n, order n of mass is located in order o(n) of clusters. It turns out that the tagged particle processes associated with the systems are useful tools to analyze the phenomenon. For the newly defined stochastic shattering based on the above ideas, we derive far sharper conditions of fragmentation kernels which guarantee the occurrence of such a phenomenon than our previous work [9].

• Journal of the Korean Mathematical Society
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• v.39 no.4
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• pp.543-558
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• 2002

We investigate the fragmentation process developed by Kolmogorov and Filippov, which has been studied extensively by many physicists (independently for some time). One of the most interesting phenomena is the shattering (or disintegration of mass) transition which is considered a counterpart of the well known gelation phenomenon in the coagulation process. Though no masses are subtracted from the system during the break-up process, the total mass decreases in finite time. The occurrence of shattering transition is explained as due to the decomposition of the mass into an infinite number of particles of zero mass. It is known only that shattering phenomena occur for some special types of break-up rates. In this paper, by considering the n-particle system of stochastic fragmentation processes, we find general conditions of the rates which guarantee the occurrence of the shattering transition.