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http://dx.doi.org/10.4150/KPMI.2021.28.3.227

Fabrication and Characterization of Bangpungtongseong-San Extract-loaded Particles for Tablet Dosage Form  

Park, Jinwoo (Department of Pharmaceutical Engineering, Dankook University)
Jin, Sung Giu (Department of Pharmaceutical Engineering, Dankook University)
Publication Information
Journal of Powder Materials / v.28, no.3, 2021 , pp. 227-232 More about this Journal
Abstract
The purpose of this study is to optimize the powder formulation and manufacturing conditions for the solidification of an extract of the herb Bangpungtongseong-san (BPTS). To develop BPTS-loaded particles for the tablet dosage form, various BPTS-loaded particles composed of BPTS, dextrin, microcrystalline cellulose (MCC), silicon dioxide, ethanol, and water are prepared using spray-drying and high shear granulation (high-speed mixing). Their physical properties are evaluated using scanning electron microscopy and measurements of the angle of repose, Hausner ratio, Carr's index, hardness, and disintegration time. The optimal BPTS-loaded particles exhibit improved flowability and compressibility. In particular, the BPTS-loaded particles containing silicon dioxide show significantly improved flowability and compressibility (the angle of repose, Hausner ratio, and Carr's index are 35.27 ± 0.58°, 1.18 ± 0.06, and 15.67 ± 1.68%, respectively), hardness (18.97 ± 1.00 KP), and disintegration time (17.60 ± 1.50 min) compared to those without silicon dioxide. Therefore, this study suggests that particles prepared by high-speed mixing can be used to greatly improve the flowability and compressibility of BPTS using MCC and silicon dioxide.
Keywords
Bangpungtongseong-san extract; Microcrystalline cellulose; Silicon dioxide; High shear granulation; High speed mixer;
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