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http://dx.doi.org/10.5762/KAIS.2020.21.2.595

A Study of Dexibuprofen Loaded Solid Dispersion Using Rotary Hot-melt Granulation  

Kim, Dong-Wook (Division of BT Convergence, Cheongju University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.21, no.2, 2020 , pp. 595-600 More about this Journal
Abstract
The purpose of this paper was to prepare and evaluate solid dispersions (SD) that can increase the dissolution rate of dexibuprofen as a model drug with low solubility in water using saccharides and sugar alcohols as dispersion materials. DSC, XRD, content and content uniformity test, dissolution test, and disintegration test were conducted for physicochemical evaluation of the prepared SD. For the results, it was confirmed using differential scanning calorimetry that fructose, which has a melting point around 120 ℃ of the device operating temperature range, is a suitable excipient for the preparation of SD by the rotary hot-melt granulation (RHMG) method. X-ray diffraction analysis was conducted to confirm that the crystallinity of dexibuprofen was reduced. Disintegration test of the prepared tablet using SD-containing dexibuprofen and fructose confirmed a very fast disintegration time within 1~2 seconds and also showed that the dissolution rate was about 20% faster than that of the dexibuprofen raw material. Dexibuprofen with reduced crystallinity by SD confirmed through the RHMG method can be used to increase the dissolution rate of the drug and increase the disintegration time of the tablet. Thus, it can be used in the manufacturing of various solid preparations.
Keywords
Dexibuprofen; Fructose; Solid Dispersion; Rotary Hot-melt Granulation; Dissolution;
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