• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.10
• /
• pp.5973-5981
• /
• 2013

At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

• ETRI Journal
• /
• v.38 no.4
• /
• pp.622-633
• /
• 2016

A discontinuous reception (DRX) operation is included in the Long Term Evolution (LTE) system to achieve power saving and prolonged battery life of the user equipment. An improvement in DRX power saving usually leads to a potential increase in the packet delay. An optimum DRX configuration depends on the current traffic, which is not easy to estimate accurately, particularly for non-real-time applications. In this paper, we propose a novel way to vary the DRX cycle length, avoiding a continuous estimation of the data traffic when only non-real-time applications are running with no active real-time applications. Because a small delay in non-real-time traffic does not essentially impact the user's experience adversely, we deliberately allow a limited amount of delay in our proposal to attain a significant improvement in power saving. Our proposal also improves the delay in service resumption after a long period of inactivity. We use a stochastic analysis assuming an M/G/1 queue to validate this improvement.

• Journal of Power Electronics
• /
• v.9 no.6
• /
• pp.823-834
• /
• 2009

This paper proposes a high-efficiency single-stage ac/dc converter. The proposed converter features low voltage stresses and reduced switching losses. It operates at the boundary of discontinuous- and continuous-conduction modes by employing variable switching frequency control. The turn-on switching loss of the switch can be reduced by turning it on when the voltage across it is at a minimum. The voltage across the bulk capacitor is independent of the output loads and maintained within the practical range for the universal line input, so the problem of high voltage stress across the bulk capacitor is alleviated. Moreover, the voltage stress of the output diodes is clamped to the output voltage, and the output diodes are turned off at zero-current. Thus, the reverse-recovery related losses of the output diodes are eliminated. The operational principles and circuit analysis are presented. A prototype circuit was built and tested for a 150 W (50V/3A) output power. The experimental results verify the performance of the proposed converter.

• Journal of Power Electronics
• /
• v.14 no.5
• /
• pp.890-898
• /
• 2014

Critical conduction mode boost power factor correction converters operating at the boundary of continuous conduction mode and discontinuous conduction mode have been widely used for power applications lower than 300W. This paper proposes an enhanced variable on-time control method for the critical conduction mode boost PFC converter to improve the total harmonic distortion characteristic. The inductor current, which varies according to the input voltage, is analyzed in detail and the optimal on-time is obtained to minimize the total harmonic distortion with a digital controller using a TMS320F28335. The switch on-time varies according to the input voltage based on the computed optimal on-time. The performance of the proposed control method is verified by a 100W PFC converter. It is shown that the optimized on-time reduces the total harmonic distortion about 52% (from 10.48% to 5.5%) at 220V when compared to the variable on-time control method.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.15 no.5
• /
• pp.889-896
• /
• 2020

In general, there are various types of boost converters such as Boost converters, Buck-Boost converters, Flyback converters, Push-Pull converters, etc. Among them, Boost converters are the most widely used and step up converters in a very simple form. However, Boost converter has DCM mode operation, big ripple problem and RHPZ problem. In order to solve these problems, a converter to which the new topology was applied was presented, but among them, the KY converter improved the Boost converter's DCM mode operation, the big ripple problem and the RHPZ problem. However, the conventional KY converter has a drawback that the voltage gain is relatively lower than that of the Boost converter. Therefore, in this paper, we proposed a new KY converter that solves the problem of low voltage gain while having the advantages of the conventional KY converter.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.13 no.3
• /
• pp.163-170
• /
• 2008

Switching characteristics in both linear and nonlinear loads are analysed for a 3-phase voltage disturbance generator applicable to the performance test of custom power devices. Since the line current of the linear load is continuous the natural commutation of the SCR thyristors comprising the generator is carried out with ease. However, in case of nonlinear load the natural commutation scheme is different from that of the linear load due to the discontinuous load current. Through the analysis it is found that a specific switching condition can provide the voltage sag, swell, outage, and voltage unbalance generation in nonlinear load too. The operation of the voltage disturbance generation is described and the usefulness of the generator is verified through simulation and experimental results. It is expected that the generator can be used in the performance test of the custom power devices with low implementation cost and easy control.

• Composites Research
• /
• v.32 no.6
• /
• pp.403-407
• /
• 2019

Long-fiber-reinforced composites have the advantages of cost-competitiveness and high degree of freedom of molding compared to continuous-fiber-reinforced composites. On the other hand, it is difficult to ensure uniform characteristics due to the randomly distributed fiber orientation incurred from the process of manufacturing intermediate materials. In this study, the effect of the directionality of LFPS (Long Fiber Prepreg Sheet) materials on the mechanical properties was analyzed. The eddy current measurement method was used to analyze fiber orientations, and tensile and compression tests on LFPS materials were performed according to ASTM standards. In addition, the test results and theoretical values of LFPS materials were verified using the ROM (rule-of-mixtures) theory. These results confirmed the effect of fiber orientation on mechanical properties of discontinuous-fiber-reinforced composites.

• Journal of Welding and Joining
• /
• v.26 no.5
• /
• pp.79-89
• /
• 2008

With the increased use of surface textured steel sheet in body-in-white assembly, resistance spot weldability of these steels is considered to be an important subject. This study evaluated nugget formation and weldability by measuring dynamic resistance with various weld pressure, current, and weld time for steel sheet with two different surface roughnesses. The surface roughness for T-H steel ($R_{a}=1.70\;{\mu}m$) was higher than that for T-L steel ($R_{a}=1.33\;{\mu}m$), and resulted in increased contact resistance and heating for T-H steel spot welding. Therefore, at low weld current and weld cycle ranges, the T-H steel showed better weldability over the T-L steel. The evaluations of weld interface showed that the fusion zone in the T-H steel sheet was continuous in contrast to discontinuous fusion zone for T-L steel sheet at the same welding conditions. A comparison of dynamic resistance and tensile-shear strength (TSS) between T-H and T-L steel sheet suggested that high surface roughness provided larger heating at early cycle of welding and larger TSS.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.52 no.2
• /
• pp.89-96
• /
• 2015

This paper presents a high efficiency, PSM/DCM/CCM triple mode boost DC-DC converter for mobile application. This device operates at Pulse-Skipping Mode(PSM) when it enters light load, and otherwise operate the operating frequency of 1.4MHz with Pulse-Width Modulation(PWM) mode. Especially in order to improve the efficiency during the Discontinuous-Conduction Mode(DCM) operation period, the reverse current prevention circuit and oscillations caused by the inductor and the parasitic capacitor to prevent the Ringing killer circuit is added. The input voltage of the boost converter ranges from 2.5V ~ 4.2V and it generates the output of 4.8V. The measurement results show that the boost converter provides a peak efficiency of 92% on CCM and 87% on DCM. And an efficiency-improving PWM operation raises the efficiency drop because of transition from PWM to PFM. The converter has been fabricated with a 0.18um Dongbu BCDMOS technology.

• Journal of Satellite, Information and Communications
• /
• v.9 no.3
• /
• pp.86-90
• /
• 2014

A DC-DC Converter operates in CCM(Continuous Coundcution Mode), DCM(Discontinuous Conduction Mode), CRM(Critical Conduction Mode). The CRM is boundary between CCM and DCM. If a DC-DC converter is designed to operate in CRM, its inductor volume can decrease and power loss which caused by switch and diode can decrease. In this paper, the DC-DC converter which operates in CRM is applied to a solar array regulator(SAR) for the satellite. The switching frequency of the CRM boost SAR changes according to input and output condition. The switching frequency limit logic is applied to limit the maximum switching frequency. Meanwhile, the small signal transfer function of the CRM boost SAR is simple, so the controller design is also simple. In this paper, the small signal transfer function from control reference to solar array voltage is induced. And the voltage controller is designed based on the small signal transfer function. Finally, the CRM boost SAR is verified by simulation.