• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.10a
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• pp.9-15
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• 1995

When quiescent cells ate stimulated to enter the cell cycle, the thymidine kinase(TK) gene is transcriptionally activated at the border of Gl and 5. In this report we show that the human TK promoter contains multiple protein-binding sites. By site-directed mutagenesis, we identified a protein-binding site on the human TK promoter requited for conferring Gl-S-regulated transcription to a heterologous promoter and dissociated it functionally from an adjacent protein-binding domain containing an inverted CCAAT motif requited for high basal level expression. Substitution-mutation of this site results in constitutive expression of the neo reporter gene in serum-stimulated fibroblasts, as well as in cells arrested in mid-Gl by a temperature-sensitive mutation. The regulatory domains for the human TK promoter exhibit interesting symmetrical features, including a set of CCAAT motifs and sites similar to the novel Yi protein-binding site recently discovered in the mouse TK promoter. Thus, components of the hTK complex is important for hTK gene regulation.

• International Journal of Contents
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• v.6 no.3
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• pp.5-9
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• 2010

To manage large database system with video, effective video indexing and retrieval are required. A large number of video retrieval algorithms have been presented for frame-wise user query or video content query, whereas a few video identification algorithms have been proposed for video sequence query. In this paper, we propose an effective video identification algorithm for video sequence query that employs the Cauchy function of histograms between successive frames and the modified Hausdorff distance. To effectively match the video sequences with a low computational load, we make use of the key frames extracted by the cumulative Cauchy function and compare the set of key frames using the modified Hausdorff distance. Experimental results with several color video sequences show that the proposed algorithm for video identification yields remarkably higher performance than conventional algorithms such as Euclidean metric, and directed divergence methods.

• Journal of the Korean Operations Research and Management Science Society
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• v.30 no.1
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• pp.187-198
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• 2005

The structure of a Web site can prevent the search robots or crawling agents from confusion in the midst of huge forest of the Web pages. We formalize the view on the World Wide Web and generalize it as a hierarchy of Web objects such as the Web as a set of Web sites, and a Web site as a directed graph with Web nodes and Web edges. Our approach results in the optimal hierarchical structure that can maximize the weight, tf-idf (term frequency and inverse document frequency), that is one of the most widely accepted content centric measures in the information retrieval community, so that the measure can be used to embody the semantics of search query. The experimental results represent that the optimization model is an effective alternative in the dynamically changing Web environment by replacing conventional heuristic approaches.

• International Journal of Precision Engineering and Manufacturing
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• v.8 no.3
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• pp.3-7
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• 2007

There have been numerous studies directed toward the development of driving mechanisms for off-road mobility and rescue robots. To achieve surveillance, reconnaissance, and rescue, it is necessary for robots to have a driving mechanism that can handle off-road environments, We propose a new type of single-track driving mechanism with a variable geometry for a rescue robot, This mechanism has a symmetric configuration so that the robot can advance in two directions and also remain operable when overturned. By transforming its geometry, the robot can reduce energy consumption in steering and rotating as well as maximize its ability to climb obstacles such as stairs. The robot is also designed to have a compact size and low center of gravity to facilitate driving when on a set of stairs. In this paper, we analyzed the design parameters of the robot for the four phases of climbing stairs and determined the specifications needed to enhance its adaptability.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1992.10a
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• pp.79-89
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• 1992

This study is directed to propose a stability analysis and Design Criteria for Bridge Caisson foundations, with Could possibly replace the traditionals W.S.D. provisions of the Current Code, based on the FBOR(Load Factors based on optimum Reliability). The optimum reliability indices(Vertical bearing Capacity : $\beta$opt : 3.19, Lateral bearing Capacity : $\beta$opt= 3.15(ordinary), $\beta$opt : 2.93 (earthquake), Shearing resistance Capacity ; $\beta$opt : 2.87) are Selected as optimal Values Considering our practice base on the Calibration with the current Bridge Caisson foundation design Safety provisions, Load and resistance factors are measure by Using the proposed uncertainties and the Selected optimum reliability indices. furthermore, a set of nominal safety factors are proposed for the U.S.D. design provisions.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.5 no.7
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• pp.33-42
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• 1982

The standard theory of production treats human and non-human inputs in the same way. Inert Areas Theory drops this assumption. One distinction is obvious. Human capital, the source of human inputs, can not be purchased outright by firms. Usually what is purchased are units of labor time. What is critical is directed effort, at or beyond some level of skill. Direct effort, however, involves choice and motivation, and these are the critical variables left out of the standard theory. Leibenstein introduces the concept of "inert areas" by which he means "a set of effort positions whose associated levels of utility are not equal but in which the action required to go from a lower to a higher utility level involves a utility cost that is not compensated for by the gain in utility." This idea is used when discussing the behavior of firm's management.f firm's management.

• Tuberculosis and Respiratory Diseases
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• v.77 no.2
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• pp.60-64
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• 2014

MicroRNAs (miRNAs) are a class of small noncoding RNAs that modulate target gene activity, and are aberrantly expressed in most types of cancer as well in lung cancer. A miRNA can potentially target a diverse set of mRNAs; further, it plays a critical role in lung tumorigenesis as well as affects patient outcome. Previous studies focused mainly on abnormal miRNAs expressions in lung cancer tissues. Interestingly, circulating miRNAs were identified in human plasma and serum in 2008. Since then, considerable effort has been directed to the study of circulating miRNAs as one of the biomarkers of lung cancer. miRNAs expression of tissues and blood in lung cancer patients is being analyzed by more researchers. Recently, to overcome the high false-positivity of low-dose chest computed tomography scan, miRNAs in lung cancer screening are being investigated. This article summarizes the recent researches regarding clinical applications of miRNAs in the diagnosis and management of lung cancer.

• Proceedings of the KIEE Conference
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• 1987.07a
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• pp.226-229
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• 1987

This paper was aimed to, using a new data structure, develop a set of algorithms to execute the output function of Digital System. These functions were represented as directed, acyclic graphs. by applying many restrictions on vertices on graph, the efficient manipulation of boolean function was accomplished. The results were as follows; 1. A canonical representation of a boolean function was created by the reduction algorithm. 2. The operation of two functions was accomplished using t he apply algorithm, according to the binary operator. 3. The arguments having 1 as the value nf function were enumerated using the satisfy algorithm. 4. Composing TTL 74181 4-bit ALU and 74182 look-ahead carry generator, the ALU having 4-bit and 16-bit as word size was implemented.

• Journal of Technologic Dentistry
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• v.44 no.3
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• pp.97-103
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• 2022

Purpose: This study sought to identify the factors influencing learning motivation and demotivation in online dental technology students. Methods: A survey was conducted from October 1 to 30, 2021, on 188 dental technology students. The collected data were processed using the IBM SPSS IBM SPSS Statistics ver. 22.0 statistical program (IBM), and frequency, factor, and one-way ANOVA analyses were performed, for which the significance was set at 0.05. Results: It was found that the main online learning motivation factors were the usefulness of the learning content, interest, and confidence in the activities, the relationships with the teachers and friends, the feedback, and learning satisfaction. The factors that reduced the students' online learning motivation were interaction difficulties, maladaptation to the self-directed learning environment, the inadequate number of learning activities, and activity difficulty. Conclusion: Based on the identified online class motivation and demotivation factors, better systematic management and increased research are needed to improve the quality of non-face-to-face classes.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.46 no.3
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• pp.86-95
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• 2009

Efficient DAG scheduling is critical for achieving high performance in heterogeneous computing environments. Finding an optimal solution to the problem of scheduling an application modeled by a directed acyclic graph(DAG) onto a set of heterogeneous machines is known to be an NP-complete problem. In this paper we propose a new list scheduling algorithm, called the Heterogeneous Rank-Path Scheduling(HRPS) algorithm, to exploit all of a program's available parallelism in distributed heterogeneous computing system. The primary goal of HRPS is to minimize the schedule length of applications. The performance of the algorithm has been observed by its application to some practical DAGs, and by comparing it with other existing scheduling algorithm such as CPOP, HCPT and FLB in term of the schedule length. The comparison studies show that HRPS significantly outperform CPOP, HCPT and FLB in schedule length.