• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집A
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• pp.746-752
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• 2001

Design sensitivity analysis for nonlinear structural problems has been emerged in the last decade as a glowing area of engineering research. As a result, theoretical formulations and computational algorithms have already developed for design sensitivity of nonlinear structural problems. There is not enough research for practical nonlinear problems using multi-element, due to difficulties of implementation into FEA. Therefore, nonlinear response analysis for stiffened shell which consists of Mindlin plate and Timoshenko beam, was considered. Specially, it presents the backward-Euler method which is adopted to describe an exact yield state in the stress computation procedure. Then, design sensitivity analysis of nonlinear structures, particularly elasto-perfectly-plastic structure, is developed using direct differentiation method. The accuracy of the developed sensitivity analysis was compared with the central finite difference method. Finally, on the basis of above results, design improvement for stiffened shell is suggested.

• BMB Reports
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• 제45권10호
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• pp.577-582
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• 2012

single-minded (sim) is a master regulatory gene that directs differentiation in the central nervous system during Drosophila embryogenesis. Recent identification of the mesectoderm enhancer (MSE) of sim has led to the hypothesis that two Snail (Sna)-binding sites in the MSE may repress sim expression in the presumptive mesoderm. We provide evidence here that three Sna-binding sites proximal to the sim promoter, but not those of the MSE, are responsible for the mesodermal repression of sim in vivo. Using transgenic embryos injected with lacZ transgenes, we showed that sim repression in the mesoderm requires the three promoter-proximal Sna-binding sites. These results suggest that Sna represses the mesectodermal expression of sim by directly repressing the nearby promoter, and not by quenching adjacent transcriptional activators in the MSE. These data also showed how the MSE, lacking the three proximal Sna-binding sites, reproduced the endogenous pattern of sim expression in transgenic embryos.

• 대한기계학회논문집
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• 제19권8호
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• pp.1822-1831
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• 1995

A general formulation of the design optimization problem with the random parameters is presented here. The formulation is based on the stochastic finite element second-order perturbation method ; it takes into full account of the stress and displacement constraints together with the rates of change of the random variables. A method of direct differentiation for calculating the sensitivity coefficients in regard to the governing equation and the second-order perturbed equation is derived. A gradient-based nonlinear programming technique is used to solve the problem. The numerical results are specifically noted, where the stiffness parameter and external load are treated as random variables.

• BMB Reports
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• 제29권5호
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• pp.474-480
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• 1996

We present a study of evolutionary changes in expression of actin genes among closely related sea urchin species that exhibit different modes of early development. For this purpose, polyclonal antisera raised against peptides from the carboxyl terminus of the HeCyI cytoskeletal actin of Heliocidaris erythrogramma were used. H. erythrogramma is a direct developing sea urchin that proceeds from embryonic to adult stages without an intervening feeding larval stage. Expression patterns of the CyI actin isoform were compared with those of Heliocidaris tuberculata and to a related sea urchin Strongylocentrotus purpuratus, which both produce a feeding pluteus larval stage. The CyI actin of all three species is expressed in the same cell types. However, its expression patterns have been changed with reorganization of early cell lineage differentiation, which is apparent among the three species. Thus. evolutionary changes in CyI actin gene expression patterns are correlated with not only phylogenetic relationship, but developmental mode. The implication of this observation is that evolutionary changes in expression patterns of histospecific genes may underlie the emergence of novel developmental processes.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1455-1457
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• 2008

Cell adhesion is a coordinated process involving initial binding of integrin receptors to extracellular matrix (ECM), recruitment of adhesion proteins, and focal adhesion assembly. The formation of mechanically stable focal adhesion assembly of cells within surrounding ECM is a key parameter to direct numerous cellular functions including cell migration, differentiation, and apotosis. With current cell adhesion assays, it is difficult to understand contributions of each coordinated event on evolution of cell adhesion strengthening since cells spontaneously spread upon their adhesion to the substrate, thus remodeling their cytoskeletal structure. In this presentation, novel approaches for analysis of cell adhesion strengthening process based on the combination of mechanical device, micro-patterned substrates, and molecular biological techniques will be discussed.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집A
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• pp.602-606
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• 2000

A general procedure for the design sensitivity analysis of structural dynamic problems has been presented in frame of the FRF-based substructuring formulation. In the procedure, the direct differentiation method is used for the sensitivity formula. For a system response function, the proposed method gives a parametric design sensitivity formula in terms of the partial derivatives of the connection element properties and the transfer matrix of the subsystems. The derived design sensitivity formula is applied to a numerical example. The comparison of sensitivities derived by the proposed method and the finite difference method shows that the proposed method is efficient and accurate.

• International Journal of Aeronautical and Space Sciences
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• 제2권1호
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• pp.20-27
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• 2001

Aerodynamic sensitivity analysis is performed for the Navier-Stokes equations coupled with two-equation turbulence models using a discrete adjoint method and a direct differentiation method respectively. Like the mean flow equations, the turbulence model equations are also hand-differentiated to accurately calculate the sensitivity derivatives of flow quantities with respect to design variables in turbulent viscous flows. The sensitivity codes are then compared with the flow solver in terms of solution accuracy, computing time and computer memory requirements. The sensitivity derivatives obtained from the sensitivity codes with different turbulence models are compared with each other. The capability of the present sensitivity codes to treat complex geometry is successfully demonstrated by analyzing the flows over multi-element airfoils on Chimera overlaid grid systems.

• 한국정밀공학회지
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• 제20권2호
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• pp.209-217
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• 2003

In this paper, the dynamic system modeling and the state sensitivity analysis of the spin-coater system are proposed for the reduction of the vibration. In the respect of modeling, the spin-coater system is considered to be composed of servomotor, spindle, supporting base and so on. Each component of model is combined and derived to 3 dimensional equations. The combined model is verified by experimental values of actual system in the frequency domain. By direct differentiation of the constraint equations with respect to kinematic design variables, such as eccentricity of spindle, moment of inertia, rotational stiffness and damping of supported base, sensitivity equations are derived to the verified state equations. Sensitivity of design variables could be used for vibration reduction and natural frequency shift in the frequency domain. Finally, dominant design variables are selected from the sensitivity analysis.

• 전산구조공학
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• 제7권3호
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• pp.115-122
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• 1994

불확정 구조계획의 선형 고유치 문제는 재료정수나 경게조건 및 외부하중 등에 결정론적으로 사용할 수 없는 확률량을 포함하고 있다. 변동량을 내포한 고유치 문제의 해석은 기대치에 대한 지배 방정식과 변동량 결정방정식을 고려해야 한다. 비선형성이 심한 구조계를 선형화할 대 일차 및 이차 변동값을 반영함으로 고유치의 정도를 향상시킬 수 있다. 매개변수에 불확정성을 포함한 고유치 문제는 최적설계 정식화에서 변동된 값을 고료해 줌으로 신뢰성 있는 설계가 된다. 최적설계 알고리즘 중에는 목적함수와 제한 조건식의 설계 민감도를 요한다. 이차 기울기에 근거를 둔 최적설계 수행시에 변동량에 고려하여 제한식으로 설정하고, 설계 민감도를 구할 수 있는 방법을 제시하였다.

• Interaction and multiscale mechanics
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• 제1권3호
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• pp.339-355
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• 2008

A Galerkin meshfree method is presented for analyzing shear deformable cylindrical panels. Based upon the analogy between the cylindrical panel and the curved beam a pure bending mode for cylindrical panel is rationally constructed. The meshfree approximation employed herein is characterized by an enhanced moving least square or reproducing kernel basis function that can exactly represent the pure bending mode and thus meets the requirement of Kirchhoff mode reproducing condition. The variational form is discretized using the efficient stabilized conforming nodal integration with a smoothed nodal gradient based curvature. The resulting meshfree formulation satisfies the integration constraint for bending exactness. Moreover, it is shown here that the smoothed gradient preserves several desired properties which are valid for the standard gradient obtained by direct differentiation, such as partition of nullity and reproduction of a constant strain field. The efficacy of the proposed approach is demonstrated by two benchmark cylindrical panel examples.