• 대한한방내과학회지
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• 제41권5호
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• pp.926-932
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• 2020

This report presents examples of the use of Korean medicine to treat diarrhea after colon hemicolectomy. The patient was a male in his 80s who had undergone hemicolectomy 3 years previously for colon cancer. He complained of diarrhea and fecal incontinence and had attempted suicide. He was admitted to the internal medicine ward through the emergency room. Treatment did not improve his diarrhea, even with the use of antidiarrheal drugs, so he was transferred to the Korean Medicine Hospital, where he received daily acupuncture and medicine treatment. After Korean medicine treatment, his symptoms improved rapidly and his fecal incontinence stopped after one week of hospitalization. Two weeks after hospitalization, his stool had improved to normal stool, his hypotonia had also improved, and he was discharged. This report shows that Korean medicine treatment can be effective in treating patients with diarrhea. In the future, related cases will need to be accumulated.

• 한국임상수의학회지
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• 제27권6호
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• pp.635-639
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• 2010

경북지역에서 설사증상을 보이는 한우송아지를 대상으로 소 바이러스성 설사 바이러스의 유병률이 조사되었다. 75두의 송아지가 소 바이러스성 설사 바이러스에 양성 반응을 나타내는 것으로 확인되었다. 계통발생 분석시 양성반응을 보이는 75두 송아지가 BVDV-2a로 분류되었다. BVDV-2a로 분류된 대부분은 수양성 설사의 임상증상을 나타내는 송아지로부터 채취한 것이었다. 우리의 결과에 따르면 모든 BVDV-2 감염이 심각한 임상증상을 보이지 않는 것으로 나타났다. 이 연구는 경북지역에서 BVDV-2 감염의 높은 발생률을 보여준 것으로, 이 연구 결과는 백신개발 및 예방 전략이 대한민국에서 BVDV 감염의 효과적인 근절을 위해 필요한 것으로 사료된다.

• 한국동물위생학회지
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• 제14권2호
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• pp.159-174
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• 1991

A field trial of norfloxacin on bovine 206, swine 222 and poultry 205 with respiratory diseases and diarrhea was conducted from Sept 1, 1990 to Jan 30, 1991 in Inchon and Kyonggi-do. The results are as follows. 1. Guinea pigs and rabbits were dosages 10 and 20 times normal. Ten days of observation saw no side effect. 2. Oral treatment on bovine, swine and poultry showed a curing rate of 82.00∼89.06%(Mean 86.00%), compared with 87.27∼96.36%(Mean 92.24%) by Injection. 3. The curing rate was 81.92% by the fourth treatment. 4. The curing rate with and without the use of adjuvant was 80.00∼100% and 83.60∼93. 10%, respectively, for swine, and 81.82∼100% and 82.00∼97.14% for bovine. 5. The curing rate was more dependent on seriousness of illness, environment and time than age. 6. The main disease causing bacteria of bovine respiratory diseases： Haemolytic Sta 27.62%, Haemolytic Str 33.33%, sum of this bacteria is 60.95%, diarrhea: Haemolytic coliform 80.20%, swine respiratory diseases； Haemophilus Spp 20.95%, Haemolytic Sta 72%, Haemolytic Str 21.90%, Sum of these bacteria is 68.57％, diarrhea; Haemolytic coliform 57.26%, poultry respiratory diseases； mycoplasma Spp 29.52%, Haemolytic Sta 13.33％, Sum of this bacteria is 42.85%, diarrhea； Haemolytic coliform 53.00%. 7. The curing rate of norfloxacin by species of strain, the unidentified bacteria on bovine respiratory diseases was the lowest with 77.78％, the others ranged from 84.21％ to 100％ with most of them over 90%. 8. The loss of clinical sign on bovine and swine was the highest when after 2∼4 application. 9. In terms of antibiotic sensitivity test, norfloxacin was the highest with 84.62∼100％ (mean 90.09％) among eight bacterias, only 5 of 15 antibiotics had a sensitivity of over 56.25%, showing a high degree of tolerance.

• Journal of Yeungnam Medical Science
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• 제13권2호
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• pp.251-260
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• 1996

To evaluate the effect of low lactose special formula (MF-1) for the treatment of acute diarrhea, we studied thirty nine infants who were admitted with acute diarrhea to the Department of Pediatics, Yeungnam University Hospital. 39 infants of under 6 months of age who had been fed on formula feeds were randomly allocated to receive either a diluted regular formula milk or a low lactose special formula. Each infant received intravenous rehydration during fasting for 6-12 hours. Group 1 (n=15) was fed half strength of regular formula (80-100cc/kg/day) for the first 24 hours, three quarters strength formula (100-120cc/kg/day) for the next 24 hours, and continued feeding with the full strength regular formula milk. Group 2 (n=24), who fed the same amount of milk as Group 1, continued feeding with the full strength low lactose special formula from the start of feeding. Male to female sex ratio was 1.6 to 1. The characteristics of infants on admission were comparable in the age, the duration of diarrhea and the stool frequency before admission, the degree of dehydration. There were no significant differences in the duration of hospitalization, changes in stool weight and stool frequency after admission between two groups.(p>0.05) The Body weight and skin fold thickness were increased in group 2 who fed low lactose formula, but those who fed diluted regular formula showed reduction of body weight and skin fold thickness ($64.2{\pm}51.4g$ vs $-11.4{\pm}52.2g$, $0.6{\pm}0.8mm$ vs $-0.1{\pm}0.3mm$ respectively) during hospitalization. (p<0.05) We conclude that low lactose special formula milk can be recommended instead of diluted regular formula for acute diarrhea treatment in infants.

• 한국동물위생학회지
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• 제21권2호
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• pp.117-126
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• 1998

This study was performed to investigate the immunogenicity of autogenous E coli vaccines and their preventive effects on diarrhea in suckling piglets. Autogenous E coli live and killed vaccines were made from the E coli strains isolated from piglets showing diarrhea in field. In group I, pregnant sows were administered with live and killed vaccines at 4 and 2 weeks before parturition, respectively, Killed vaccines were administered twice to pregnant sows at 4 and 2 weeks before parturition in group II, and saline instead of autogenous E coli vaccines was administered to pregnant sows in group III for the control. After parturition, antibody titers in colostrum and milk from sows, incidence of diarrhea in suckling piglets, and immunoreactivity in the ileum of piglets from each treatment group were examined. The results were as follows ; 1. Sixty-two strains of E coli were isolated from suckling piglets with diarrhea. Of the strains, K88 pilus and K99 pilus antigens were identified in 6(9.8%) and 4(6.5%), respectively. Molecular weights of K88 and K99 pilus were 27,500 and 18,500 daltons, respectively. 2. Antibody titers in colostrum from sows after parturition were 1 : 512 to 1 : 1,024 in group I, 1.256 to 1.512 in group II, and 1 : 4 to 1 : 16 in group III. 3. The incidences of diarrhea In suckling piglets of group I, II and III were 3.3%, 9.4% and 21.4%, respectively. 4. When the immunoreactivity in the ileum of piglets from each group was examined, the proportion of IgG-immunoreactivity cells in group I or II was higher than that in group III. In conclusion, administration of autogenous E coli vaccines to pregnant sows before parturition can be an effective way to prevent diarrhea in suckling piglets.

• 농업과학연구
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• 제42권3호
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• pp.201-205
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• 2015

The experiment was conducted to evaluate the effects of pathogenic Escherichia coli on diarrhea, growth performance, and blood profile of weaned pigs. A total of 48 pigs were used and housed in individual pens of disease containment chambers for 16 d (4 d before and 12 d after the first challenge [d0]). The treatments were with or without the pathogenic E. coli challenge (F-18 E. coli strain; heat-labile, heat-stable, and Shiga-like toxins). Pigs were orally inoculated with a dose of $10^{10}cfu$ E. coli per 3 mL PBS daily for 3 days. The common nursery diet and water were available at all times. The ADG, ADFI, G:F, diarrhea score, ratio of fecal ${\beta}$-hemolytic coliforms from total coliforms (RHT), and blood profile were measured. The pathogenic E. coli reduced (P < 0.05) ADG from d0 to 6 (117 vs. 297 g/d) and from d0 to 12 (377 vs. 238 g/d) compared with the control. Meanwhile, the pathogenic E. coli increased (P < 0.05) diarrhea score (average 3.4 vs. 1.4) and RHT (average 82 vs. 11%) on d3, 6, and 9 and the number of white blood cells (17.59 vs. $13.48{\times}10^3/{\mu}L$) on d6 compared with the control. No differences were found on ADFI and others in the blood profile (total protein and hematocrit). In conclusion, pathogenic E. coli used in this experiment successfully caused mild diarrhea, increased number of white blood cells, and adversely affected growth rate of weaned pigs.

• Parasites, Hosts and Diseases
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• 제53권6호
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• pp.705-712
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• 2015

Intestinal parasitic infections are one of the major causes of diarrhea in human immunodeficiency virus (HIV) seropositive individuals. Antiretroviral therapy has markedly reduced the incidence of many opportunistic infections, but parasite-related diarrhea still remains frequent and often underestimated especially in developing countries. The present hospital-based study was conducted to determine the spectrum of intestinal parasitosis in adult HIV/AIDS (acquired immunodeficiency syndrome) patients with or without diarrhea with the levels of $CD4^+$ T-cell counts. A total of 400 individuals were enrolled and were screened for intestinal parasitosis. Of these study population, 200 were HIV seropositives, and the remaining 200 were HIV uninfected individuals with or without diarrhea. Intestinal parasites were identified by using microscopy as well as PCR assay. A total of 130 (32.5%) out of 400 patients were positive for any kinds of intestinal parasites. The cumulative number of parasite positive patients was 152 due to multiple infections. A significant association of Cryptosporidium (P<0.001) was detected among individuals with $CD4^+$ T-cell counts less than $200cells/{\mu}l$.

• 한국동물위생학회지
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• 제38권1호
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• pp.43-49
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• 2015

Bovine viral diarrhea virus (BVDV) is a very important viral disease virus in cattle, domestic and wild ruminants. The purpose of this study is to investigate the positive rate of bovine viral diarrhea virus antigen by ELISA from Korean native and beef cattle reared in Busan area from March in 2013 to October in 2014. A total of 1,129 bovine blood samples were collected from 140 farms, 1,111 Korean native cattle of 135 farms and 18 beef cattle of 5 farms. Test for antigen was carried out by ELISA method. In general analysis, the positive rate of bovine viral diarrhea virus antigen were 0.7% (8/1,129) cattle and 5.0% (7/140) farm. In regional analysis, the positive rate of BVDV antigen of farm in Kijang-gun, Gangseo-gu, Geumjeong-gu, Saha-gu and Dongnae-gu were 1.4% (2/94), 3.6% (5/37), 0% (0/7), 0% (0/1) and 0% (0/1), respectively, and the positive rate of BVDV antigen of cattle were 0.4% (3/770), 1.5% (5/333), 0% (0/24), 0% (0/1) and 0% (0/1), respectively. The positive rate of BVDV antigen according to sex were 0.6% (6/1,085) female cattle and 4.6% (2/44) male cattle. According to the age of cattle, the positive rate of BVDV antigen in 1 year, 2 years, 3 years and 5 years old were 1.9% (4/215), 0.4% (1/265), 0.9% (2/234) and 1.0% (1/103), respectively, but 4 years (0/198), 6 years (0/55), 7 years (0/24), 8 years (0/14), 9 years (0/10), 10 years (0/7) and 11-15 years (0/3) old were negative, respectively.

• 대한수의학회지
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• 제38권1호
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• pp.201-208
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• 1998

Piglets' diarrhea is one of the major causes of economic loss in Korean swine industry. To prevent this serious and persistant problem, we have developed systemic farm evaluation and analysis program. The program consists of the checklist and the computerized program. The items of the checklist are selected on the basis of various causative factors related with the piglets' diarrhea including sanitational status, nutritional management, or farm environment. The checklist is composed of 30 items including 6 factors on facility, 8 factors on environment, 6 factors on nutrition and 10 factors on sanitation, respectively. Minimum 1 to maximum 10 points was assigned to each item depending on level or status of farm. The scores calculated by sum of points obtained from each item could find out the problems which the farm was confronted with. To investigate the applicability of a program 150 swine farms raising over 500 heads were selected from 7 provinces throughout the country and surveyed. There were significant correlations between the piglets' diarrhea and the scores of the checklist. Based on above results we revised the checklist which consisted of 22 items including 5 factors on facility, 7 factors on environment, 3 factors on nutrition and 7 factors on sanitation. After that we composed a computerized diagram out of each point of an item which showed and indicated weak factors to be improved promptly. Our present study suggested that this newly established swine farm evaluation program would be a very efficient way to find out the problems and support the systemic control program of the piglets' diarrhea for swine farms.

• 동국한의학연구소논문집
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• 제8권1호
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• pp.145-158
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• 1999

본 실험은 사군자탕합창출지유탕(四君子湯合蒼朮地楡湯)의 만성설사(慢性泄瀉)에 미치는 영향을 조사하기 위해 시행되었다. 실험을 위해 흰쥐에 3주일간 castor oil과 대황(大黃)분말을 병행 투여하여 1주일후부터 지속적인 설사를 보인쥐를 선정, 만성설사의 모델로 삼았다. 이를 대조군과 실험군으로 구분하여 위장관 기능과 영양상태를 비교하였고, 개선여부를 알아보기 위해 아무런 처치를 받지 않은 정상군을 검체 체취에 사용하였다. 실험군과 대조군에서 검액 투여전 모두 위장관 기능과 영양상태가 감소한 상태였으며, 검액을 투여한 후 실험군에서 대조군에 비해 위장관 기능과 영양상태가 개선된 경향을 보였는데, 특히 gastrin과 total lipid, 그리고 hematocrit 수치가 유의성 있게 나타나 사군자탕합창출지유탕(四君子湯合蒼朮地楡湯)이 만성설사(慢性泄瀉)에 효과가 있는 것으로 사료된다.