• Title/Summary/Keyword: development factor

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Development and Validation of Place Attachment to Childhood Home Scale (아동기 집에 대한 장소애착 척도 개발과 타당화 연구)

  • Lee, Jin-Suk;Choi, Byung-Sook;Han, Ji-Hyeon;Han, Young-Sook
    • Korean Journal of Child Studies
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    • v.30 no.6
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    • pp.549-566
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    • 2009
  • This study developed the Place Attachment to Childhood Home Scale and evaluated its validity and reliability. Samples consisted of 418 college students of four universities. Data were collected by questionnaire based on retrospective questions about the childhood home. Factor analysis resulted in 5 dimensions of place attachment : affection, place identity, place rootedness, playfulness, and place dependence. Especially, playfulness was a unique finding. The result of confirmatory factor analysis supported the five-factor structure. There were also significant correlations among sub-factors. The reliability of the scale appeared high (Cronbach's ${\alpha}$ = .948). Criterion-related validity was confirmed by significant correlations of the present scale with Attachment Scale to Place (Hess, 1997) and the Inventory of Parent Attachment (Armsden & Greenberg, 1987).

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Effect of Platelet-Activating Factor (PAF) on Murine Ovulation, Early Embryo Development and Implantation (Platelet-Activating Factor (PAF)가 생쥐의 배란, 초기배아의 발달 및 착상에 미치는 영향)

  • Kang, Kil-Chun;Lee, Young-Il
    • Clinical and Experimental Reproductive Medicine
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    • v.18 no.2
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    • pp.143-151
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    • 1991
  • An embryo-derived platelet activating factor (PAF) has been demonstrated to play an important role in reproduction. This report examined the effect of PAF on ovulation, fertilization, embryo development, implantation and fetal viability by using murine model. PAF had no stimulatory effect on ovulation and fertilization. But PAF had stimulatory effect on embryo development in in-vitro test, in spite of no effect on implantation and fetal viability. These results demonstrate that exogenous PAF could enhance embryo development and implantation and give suggestion that PAF may play an role in human IVF program.

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DEVELOPMENT OF FEASIBILITY ANALYSIS MODEL FOR DEVELOPER-REQUESTED HOUSING PROJECTS

  • Young-Ki Huh;Bon-Gang Hwang;Joong-Seok Lee
    • International conference on construction engineering and project management
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    • 2009.05a
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    • pp.847-855
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    • 2009
  • While many studies on feasibility analysis for housing projects have been released, the main focus was on economic feasibility and factors related to developers were not clearly identified enough to be used in practice. In order to establish a feasibility analysis model for apartment development projects requested by developers in Korea, 31 driving factors behind projects' success were identified under seven different categories. Criterions of the each factor were also developed, and weight of each factor was assigned by applying the Analytical Hierarchy Process(AHP). Finally, based on the Monte Carlo simulation, the feasibility analysis model was established, providing probability distribution of project's grade. The model was applied to 12 housing projects to verify its reliability, and found that the model properly filtered projects that are unlikely to be profitable, indicating reasonable reliability of the model. The model can be a useful tool for contractors, especially with less experience in analyzing project development feasibility.

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Theoretical Calculation and Experimental Verification of the Hf/Al Concentration Ratio in Nano-mixed $Hf_xAl_yO_z$ Films Prepared by Atomic Layer Deposition

  • Kil, Deok-Sin;Yeom, Seung-Jin;Hong, Kwon;Roh, Jae-Sung;Sohn, Hyun-Cheol;Kim, Jin-Woong;Park, Sung-Wook
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.5 no.2
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    • pp.120-126
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    • 2005
  • We have proposed a characteristic method to estimate real composition when multi component oxide films are deposited by ALD. Final atomic concentration ratio was theoretically calculated from the film densities and growth rates for $HfO_2$ and $Al_2O_3$ using ALD processed HfxAhOz mms.W e have transformed initial source feeding ratio during deposition to fins] atomic ratio in $Hf_xAl_yO_z$ films through thickness factors ($R_{HFO_2}$ ami $R_{Al_2O_3}$) ami concentration factor(C) defined in our experiments. Initial source feeding ratio could be transformed into the thickness ratio by each thickness factor. Final atomic ratio was calculated from thickness ratio by concentration factor. It has been successfully confirmed that the predicted atomic ratio was in good agreement with the actual measured value by ICP-MS analysis.

Protein variation and involvement of insulin-like growth factor during embryonic development in the olive flounder Paralichthys olivaceus

  • Kim, Kang-Woong;Nam, Taek Jeong;Choi, Youn Hee
    • Fisheries and Aquatic Sciences
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    • v.21 no.2
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    • pp.4.1-4.5
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    • 2018
  • Insulin-like growth factors (IGFs), along with IGF-binding protein and IGF receptor, are well-known regulators in the growth and survival of vertebrates. In this study, we investigated the involvement of IGFs and protein variation during embryonic development of the olive flounder (Paralichthys olivaceus). Morphological stages were divided into six main developments as blastula, gastrula, cephalization, cranial regionalization, tail lift, and hatch. During embryonic development, protein variation was investigated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electrospray ionization quadrupole time-of-flight mass spectrometry/mass spectrometry. In addition, the mechanism of signaling of IGF-I receptor was examined using immuno-blot analysis. We found marked changes in protein expression at four stages of embryonic development and identified proteins as belonging to the vitellogenin 2 family. As development progresses, expression of IGF-II, phosphotyrosine, and phospho-Akt increased, while expression of growth factor receptor-bound protein 2 (GRB2) and one of guanine-nucleotide-binding proteins (Ras) decreased. These results provide basic information on the IGF system in the embryonic development of the olive flounder.

A Study on Ways to Improve Participation in Vocational Competency Development Training (직업능력개발훈련 참여도 향상을 위한 방안 연구)

  • Kim, Tae-Bok;Kim, Kwang-Soo
    • Journal of the Korea Safety Management & Science
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    • v.23 no.2
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    • pp.9-17
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    • 2021
  • As interest in vocational competency development projects increases, support is increasing. In this study, in order to study ways to improve participation in vocational competency development training, related factors are selected and the main factors influencing them are derived. The main factors were influencing factors were identified and ways to improve participation rate of vocational competency development were studied. Variables were selected through prior research, and data were collected and analyzed through in-depth group interviews. Based on factor analysis and reliability analysis, as a result of confirming the factors that influence the plan for improving participation in vocational competency development training by applying the backward stage selection (condition) method of logistic regression analysis, the case of respect for minorities in the 7-point Likert scale The closer to 7 was, the higher the probability of being classified as having never participated, and the other factors except minority respect, Likert scale closer to 7 indicates higher probability of bening classified as having never participated, except for the minority respect factor. Therefore, it was confirmed that lowering the scale of the factor of respect for minority, which is job satisfaction, and increasing the factors of individual characteristics such as annual salary and organizational commitment, training system for job satisfaction, and quality assurance have effects on improving participation rates in vocational competency development training.

Inhibitory effects of Oxya chinensis sinuosa ethanol extract on RANKL-induced osteoclast differentiation

  • Ra-Yeong Choi;Bong Sun Kim;Sohyun Park;Minchul Seo;Joon Ha Lee;HaeYong Kweon;In-Woo Kim
    • International Journal of Industrial Entomology and Biomaterials
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    • v.48 no.1
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    • pp.13-18
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    • 2024
  • The rice field grasshopper, Oxya chinensis sinuosa (OC), has traditionally been utilized in Korea for various purposes; however, its potential benefits in the context of osteoporosis remain unclear. The results revealed that OC ethanol extract (OCE) significantly inhibited the formation and activity of tartrate-resistant acid phosphatase (TRAP)-positive cells in receptor activator of nuclear factor-κB ligand (RANKL)-stimulated RAW264.7 cells. Furthermore, OCE, at concentrations ranging from 100 to 400 ㎍/mL, demonstrated a dose-dependent reduction in the protein expression of osteoclast-specific markers, including nuclear factor of activated T cell cytoplasmic 1, c-Src, and TRAP, when compared to RANKL stimulation alone. Additionally, OCE significantly inhibited RANKL-induced activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) but not the activation of extracellular signal-regulated kinase. Collectively, these results indicate that OCE suppresses osteoclastogenesis by attenuating the phosphorylation of p38 MAPK and JNK. Consequently, these findings suggest that OCE holds promise for the prevention of osteoporosis.

Characterization of Binding Mode for Human Coagulation Factor XI (FXI) Inhibitors

  • Cho, Jae Eun;Kim, Jun Tae;Jung, Seo Hee;Kang, Nam Sook
    • Bulletin of the Korean Chemical Society
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    • v.34 no.4
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    • pp.1212-1220
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    • 2013
  • The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

Preservice Teachers' Beliefs about Integrating Artificial Intelligence in Mathematics Education: A Scale Development Study

  • Sunghwan Hwang
    • Research in Mathematical Education
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    • v.26 no.4
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    • pp.333-349
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    • 2023
  • Recently, AI has become a crucial tool in mathematics education due to advances in machine learning and deep learning. Considering the importance of AI, examining teachers' beliefs about AI in mathematics education (AIME) is crucial, as these beliefs affect their instruction and student learning experiences. The present study developed a scale to measure preservice teachers' (PST) beliefs about AIME through factor analysis and rigorous reliability and validity analyses. The study analyzed 202 PST's data and developed a scale comprising three factors and 11 items. The first factor gauges PSTs' beliefs regarding their roles in using AI for mathematics education (4 items), the second factor assesses PSTs' beliefs about using AI for mathematics teaching (3 items), and the third factor explores PSTs' beliefs about AI for mathematics learning (4 items). Moreover, the outcomes of confirmatory factor analysis affirm that the three-factor model outperforms other models (a one-factor or a two-factor model). These findings are in line with previous scales examining mathematics teacher beliefs, reinforcing the notion that such beliefs are multifaceted and developed through diverse experiences. Descriptive analysis reveals that overall PSTs exhibit positive beliefs about AIME. However, they show relatively lower levels of beliefs about their roles in using AI for mathematics education. Practical and theoretical implications are discussed.