• International journal of advanced smart convergence
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• 제10권2호
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• pp.21-30
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• 2021

With the rapid development of artificial intelligence and big data, a lot of medical data is effectively used, and the diagnosis and analysis of diseases has entered the era of intelligence. With the increasing public health awareness, ordinary citizens have also put forward new demands for panic disorder health services. Specifically, people hope to predict the risk of panic disorder as soon as possible and grasp their own condition without leaving home. Against this backdrop, the smart health industry comes into being. In the Internet age, a lot of panic disorder health data has been accumulated, such as diagnostic records, medical record information and electronic files. At the same time, various health monitoring devices emerge one after another, enabling the collection and storage of personal daily health information at any time. How to use the above data to provide people with convenient panic disorder self-assessment services and reduce the incidence of panic disorder in China has become an urgent problem to be solved. In order to solve this problem, this research applies the context awareness to the automatic diagnosis of human diseases. While helping patients find diseases early and get treatment timely, it can effectively assist doctors in making correct diagnosis of diseases and reduce the probability of misdiagnosis and missed diagnosis.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.415-421
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• 2018

Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social skills and communication with repetitive behaviors. Etiology is still unclear although it is thought to develop with interaction of genes and environmental factors. Oxytocin has extensive effects on intrauterine brain development. Vitamin D, affects neural development and differentiation and contributes to the regulation of around 900 genes including oxytocin receptor gene. In the present study, the contribution of D vitamin receptor and oxytocin receptor gene polymorphisms in the development of ASD in Turkish community was investigated. To our knowledge, this is the first study examining these two associated genes together in the literature. Methods: Eighty-five patients diagnosed with ASD according to DSM-5 who were referred to outpatient clinics of Child and Adolescent Psychiatry of Başkent University and Mersin University and 52 healthy, age and gender-matched controls were included in the present study. Vitamin D receptor gene rs731236 (Taq1), rs2228570 (Fok1), rs1544410 (Bsm1), rs7975232 (Apa1) polymorphisms and oxytocin receptor gene rs1042778 and rs2268493 polymorphisms were investigated using real time polymerase chain reaction method. Results: No significant difference between groups in terms of distribution of genotype and alleles in each of polymorphisms for these genes could be found. Conclusion: Knowledge of genes and polymorphisms associated with the development of ASD may be beneficial for early diagnosis and future treatment. Further studies with larger populations are required to demonstrate molecular pathways which may play part in the development of ASD in Turkey.

• 한국콘텐츠학회논문지
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• 제16권12호
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• pp.327-345
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• 2016

본 연구는 인간발달 과정을 신경과학, 심리학, 운동학습, 근육 생리학 등의 행동과학 자료와 생체역학, 인체운동 분석, 운동조절 기반의 인지 동작치료 프로그램을 정서 행동장애 아동들에게 실시하여 표정에 따른 얼굴 움직임이 감정과 정서변화에 따라 어떤 특성을 갖는지를 표정 움직임의 변화로 정량화 하고자 하였다. 본 연구에서는 영상측정 및 키네마틱 분석의 정서 행동장애 아동의 표정변화를 중재 프로그램 피드백 자료로 활용하였고, 표정 변화를 통해 인지동작 치료프로그램 효과를 알 수 있었다. 또한 정서 및 행동치료의 영상분석과 키네마틱 분석의 정량적 데이터를 통하여 인간발달에 대한 융 복합적 측정 및 분석법을 적용하여 발달장애의 조기발견과 치료과정에 따른 데이터를 축적하는 것도 기대할 수 있었다. 따라서 본 연구의 결과는 아동뿐만이 아니라 자기표현이 부족한 장애와 노인, 환자에게도 확대 적용할 수 있을 것이다.

• 동의신경정신과학회지
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• 제28권3호
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• pp.217-230
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• 2017

Objectives: This study was conducted to review studies on somatization disorder in traditional Chinese medicine. Methods: We reviewed studies in the China National Knowledge Infrastructure (CNKI) to 2017. Keywords were 軀體化障碍, Somatization disorder, somatic symptom disorder. We included Randomized Controlled Trial (RCT), and excluded non-Randomized Controlled Trial (nRCT), non-related somatization disorder or traditional Chinese medicine, non-clinical trials, dissertations for degrees. Jadad scale and Cochrane Library's Risk of Bias (RoB) were used for assessment of the quality of studies. Results: Twelve studies were selected. The Chinese Classification of Mental Disorders-3 (CCMD-3) was most frequently used as diagnostic criteria for somatization disorder. As for outcome measurement, Hamilton Rating Scale for Depression (HAMD) was used most commonly. Meta-analysis of 10 studies revealed effective rate of Chinese Herbal Medicine groups (CHM) was significantly higher than Western Medicine groups (WM) (RR: 1.14, 95% CI: 1.02 to 1.27, p=0.02, $I^2=40%$). There was no significant difference in effective rate of CHM+WM and WM (RR: 1.12, 95% CI: 0.84 to 1.49, p=0.46, $I^2=83%$). And also, effective rate of Acupuncture group (Acu) revealed no significant difference compared to that of WM (RR: 1.17, 95% CI: 0.95 to 1.44, p=0.13, $I^2=84%$). For HAMD, there was significant difference in CHM vs, WM group and Acu vs. WM group. Quality of selected 12 RCTs was low. Conclusions: Therapies practiced in traditional Chinese medicine may be effective options for somatization disorder. treatment. For further clinical studies in Korean medicine, this study could be groundwork for development of diagnosis and treatment on somatization disorder.

• 한국게임학회 논문지
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• 제21권4호
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• pp.59-72
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• 2021

본 연구는 청소년 발달이론에 근거하여 초등학생과 부모와의 관계 및 부부간의 친밀도가 초등학생 게임 장애에 어떤 영향을 미치는지 분석하였다. 학교생활 및 또래집단의 요인을 통제한 후, 성별 조절 효과와 부모 간 관계에 초점을 맞추었다. 연구 결과, 초등학교 여학생은 엄마와의 관계가 밀접할수록, 남학생은 부모 간 관계가 좋을수록 게임 장애가 감소했다. 여학생은 어머니에게 애정을 많이 느낄수록 심리적 안정감이 높아져 게임 장애의 위험 가능성이 낮아졌으며, 남학생은 부부갈등을 높게 지각하는 경향으로 부부간 친밀도가 게임 장애에 영향 주었다. 게임 장애 예방을 위해 부모 간 관계의 중요성에 대해 논의한 데에 연구의 의의가 있다.

• 말소리와 음성과학
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• 제15권2호
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• pp.53-59
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• 2023

Detection of children with autism spectrum disorder (ASD) based on speech has relied on predefined feature sets due to their ease of use and the capabilities of speech analysis. However, clinical impressions may not be adequately captured due to the broad range and the large number of features included. This paper demonstrates that the knowledge-driven speech features (KDSFs) specifically tailored to the speech traits of ASD are more effective and efficient for detecting speech of ASD children from that of children with typical development (TD) than a predefined feature set, extended Geneva Minimalistic Acoustic Standard Parameter Set (eGeMAPS). The KDSFs encompass various speech characteristics related to frequency, voice quality, speech rate, and spectral features, that have been identified as corresponding to certain of their distinctive attributes of them. The speech dataset used for the experiments consists of 63 ASD children and 9 TD children. To alleviate the imbalance in the number of training utterances, a data augmentation technique was applied to TD children's utterances. The support vector machine (SVM) classifier trained with the KDSFs achieved an accuracy of 91.25%, surpassing the 88.08% obtained using the predefined set. This result underscores the importance of incorporating domain knowledge in the development of speech technologies for individuals with disorders.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제30권1호
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• pp.19-26
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• 2024

Purpose: Autism spectrum disorder impacts children's social, sensory, and language development, necessitating specialized educational support. Special classrooms play a crucial role in providing an appropriate learning environment for children with autism. However, there is a lack of systematic research on creating effective environments in these special classrooms. Methods: This study aims to gain a comprehensive and systematic understanding of the environmental composition of special classrooms for children with autism spectrum disorder, using the following systematic methodologies including literature review and case study. Results: Sensory spaces in special classrooms for children with autism help regulate sensory stimuli and promote sensory development. They provide stability, reducing stress from excessive stimuli, and enhance emotional stability. These spaces also promote communication and interaction among children and expand the diversity of learning activities, enriching experiences and stimulating interest in learning. Implications: Based on the results, we propose suggestions for improving the environment of special classrooms for children with autism spectrum disorder and provide direction for the design of such environments.

• Preventive Nutrition and Food Science
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• 제18권2호
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• pp.104-110
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• 2013

Presence of Helicobacter pylori is associated with an increased risk of developing upper gastrointestinal tract diseases. Antibiotic therapy and a combination of two or three drugs have been widely used to eradicate H. pylori infections. Due to antibiotic resistant drugs, new drug resources are needed such as plants which contain antibacterial compounds. The aim of this study was to investigate the ability of GutGard$^{TM}$ to inhibit H. pylori growth both in Mongolian gerbils and C57BL/6 mouse models. Male Mongolian gerbils were infected with the bacteria by intragastric inoculation ($2{\times}10^9$ CFU/gerbil) 3 times over 5 days and then orally treated once daily 6 times/week for 8 weeks with 15, 30 and 60 mg/kg GutGard$^{TM}$. After the final administration, biopsy samples of the gastric mucosa were assayed for bacterial identification via urease, catalase and ELISA assays as well as immunohistochemistry (IHC). In the Mongolian gerbil model, IHC and ELISA assays revealed that GutGard$^{TM}$ inhibited H. pylori colonization in gastric mucosa in a dose dependent manner. The anti-H. pylori effects of GutGard$^{TM}$ in H. pylori-infected C57BL/6 mice were also examined. We found that treatment with 25 mg/kg GutGard$^{TM}$ significantly reduced H. pylori colonization in mice gastric mucosa. Our results suggest that GutGard$^{TM}$ may be useful as an agent to prevent H. pylori infection.

• 생물정신의학
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• 제22권4호
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• pp.205-215
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• 2015

Objectives Sex hormones exposure during the prenatal period has an effect on cerebral lateralization. Male brains are thought to be more lateralized than female brains. Bipolar disorder was known to show abnormalities in cerebral laterality whose characteristics could be estimated by electroencephalography (EEG) coherences. We studied sex-related differences of EEG coherences between healthy controls and patients with bipolar disorder to examine the sex effects in the genesis of bipolar disorder. Methods Participants were 25 patients with bipolar disorder (11 male, 14 female) and 46 healthy controls (23 male, 23 female). EEG was recorded in the eyes closed resting state. To examine dominant EEG coherence associated with sex differences in both groups within five frequency bands (delta, theta, alpha, beta, and gamma) across several brain regions, statistical analyses were performed using analysis of covariance. Results Though statistically meaningful results were not found, some remarkable findings were noted. Healthy control females showed more increased interhemispheric coherences than control males in gamma frequency band. There were no differences in the intrahemispheric coherences between the healthy control males and females. In patients with bipolar disorder, female dominant pattern in interhemispheric coherences was attenuated compared with healthy control. Conclusions Sex differences of EEG coherences, which could be a marker for cerebral laterality, were attenuated in patients with bipolar disorder compared with healthy controls. These results imply that abnormal sex hormone exposure during early development might play some role in the pathogenesis of bipolar disorder.

• Journal of Acupuncture Research
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• 제27권2호
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• pp.43-49
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• 2010

Objectives : Among young generation, the prevalence of spinal disorders is known to be increasing. This study aimed to analyze the clinical data of spinal disorder in young ages in Korea. Methods : Number of patient, kinds of disorder, and medical cost were analyzed for patients(7~18 years) underwent spinal disorders using computerized database of Health Insurance Review and Assessment Service(HIRAS) from 2004 to 2008. We included dorsopathies as spinal disorder according to Korean Classification of Diseases(KCD) and excluded spinal disorder caused by trauma. We compared the data of traditional Korean medicine treatment with that of western medical care. Results : 4.8% of the children and adolescents had medical treatment with spinal disorder in 2008. The claim number and medical cost for both traditional Korean medicine and western medicine treatment are increasing 1.8 and 1.3 times respectively over 5 years. Total medical spent of western clinic was 2.1 times than those of traditional Korean clinic. The most common spinal disorder was dorsalgia(31.8%) and scoliosis(13.5%) in western clinics while back pain(29.0%) and neck pain(10.8%) in oriental clinic. Conclusions : We first reported the clinical tendency of spinal disorder in Korean children adolescents from 2004 to 2008. This study will support the development of a strategy for traditional Korean medicine-based prevention or treatment of spinal disorders in young generation.