Clinical Psychopharmacology and Neuroscience

Korean College of Neuropsychopharmacology (대한정신약물학회)
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No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children

  • Bozdogan, Sevcan Tug (Department of Medical Genetics, School of Medicine, Cukurova University) ;
  • Kutuk, Meryem Ozlem (Department of Child and Adolescent Psychiatry, School of Medicine, Baskent University) ;
  • Tufan, Evren (Department of Child and Adolescent Psychiatry, School of Medicine, Abant Izzet Baysal University) ;
  • Altintas, Zuhal (Department of Medical Genetics, School of Medicine, Mersin University) ;
  • Temel, Gulhan Orekici (Department of Biostatistics and Medical Informatics, School of Medicine, Mersin University) ;
  • Toros, Fevziye (Department of Child and Adolescent Psychiatry, School of Medicine, Mersin University)
  • Received : 2017.05.09
  • Accepted : 2017.07.08
  • Published : 2018.11.30
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Abstract

Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social skills and communication with repetitive behaviors. Etiology is still unclear although it is thought to develop with interaction of genes and environmental factors. Oxytocin has extensive effects on intrauterine brain development. Vitamin D, affects neural development and differentiation and contributes to the regulation of around 900 genes including oxytocin receptor gene. In the present study, the contribution of D vitamin receptor and oxytocin receptor gene polymorphisms in the development of ASD in Turkish community was investigated. To our knowledge, this is the first study examining these two associated genes together in the literature. Methods: Eighty-five patients diagnosed with ASD according to DSM-5 who were referred to outpatient clinics of Child and Adolescent Psychiatry of Başkent University and Mersin University and 52 healthy, age and gender-matched controls were included in the present study. Vitamin D receptor gene rs731236 (Taq1), rs2228570 (Fok1), rs1544410 (Bsm1), rs7975232 (Apa1) polymorphisms and oxytocin receptor gene rs1042778 and rs2268493 polymorphisms were investigated using real time polymerase chain reaction method. Results: No significant difference between groups in terms of distribution of genotype and alleles in each of polymorphisms for these genes could be found. Conclusion: Knowledge of genes and polymorphisms associated with the development of ASD may be beneficial for early diagnosis and future treatment. Further studies with larger populations are required to demonstrate molecular pathways which may play part in the development of ASD in Turkey.

Keywords

Acknowledgement

Supported by : TUBITAK (The Scientific and Technological Research Council of Turkey)

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