• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.3
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• pp.167-177
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• 2009

Objective : Bell's palsy is common and has many clinic study. but bell's palsy sequela is not enough study until now. So this study was evaluated bell's palsy sequela, catamnesis, demonstrator and herb. Methods : From December 2007 to November 2008, patients who visited Dong-seo Oriental Medicine ENT. A clinic study was done on patient who were diagosed bell's palsy, onset 2months over when first visited OPD and treated 3weeks over in Dong-seo Oriental Medicine Cental. To evaluate grade of paralysis, House-Brackman Scale was used. We classified period of improving, sequelas symptom except of facial muscle paralysis, Oriental Medicine diagnosis and herb. Results & Conculsion : 1. The distribution of sex : male 38.88%, female 61.11%. The distribution of age was presented that forty to fifty was the most in 10case(55.55%) 2. The distribution of the region of facial palsy : Rt(55.55%), Lt(44.44%) 3. In distribution of period of first HB-Scale improving : 1~2month was most in 10case(55.55%) 4. In distribution of symptom except of facial muscle paralysis : Dryness of eye 33.33%, Tearling 22.22%, Facial hypoesthesia 22.22%, Mastoid pain 22.22% 5. The distribution of demonstrator : Gi Deficiency and Deficiency of Both Gi and Blood was most in 11case(50%) 6. The distribution of treatment : Palmul-tang and Bojungikki-tang was the most herb in 6case(33.33%) and only acupuncture treatment and rehabilitation treatment was 5case(27.77%).

• Journal of Korean Medical Ki-Gong Academy
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• v.11 no.1
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• pp.1-58
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• 2009

1. The rapid increasing elderly population represents a significant increase in the population with dementia. So, studies on the method for the prevention of dementia are necessary. 2. In oriental medicine, the causes of dementia are based on the deficiency of Jeong(精;essence of the body), the lack of bone marrow, and abnormal brain function. Emotional stress, bad habits of lifestyle including eating habits are also responsible for dementia. They causes dementia by blocking the circulation of Gi(氣) such as Suseunghwagang(水升火降;ascending kidney water and descending heart fire) and suppressing the function of Danjeon(丹田; the hypogastric center). 3. Gochi(叩齒) is a sort of mastication that facilitate salivation and secretion of parotin, next step is swallowing saliva. These supplement Jeong(精) of the five viscera and the six entrails(五臟六腑), promote Suseunghwagang(水升火降), and advance the function of the hypogastric center (丹田) and activate the brain. 4. So this paper draw a conclusion that Gochi(叩齒) is negatively related to the causes of dementia and it will be useful in preventing dementia.

• Journal of Pharmacopuncture
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• v.9 no.1
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• pp.59-67
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• 2006

Objectives : This study planed to evaluate effect of oriental medicine therapy treatment method of dyspnea that happen from cancer of the pancreas patient who accompany Multiple metasis Methods : Patient complained dyspnoea during admission into dept. Of internal medicine, college of oriental medicine, Dong-eui Univ, was appealed patient treated by Oriental medicine therapy that is of use Herb Medication and Herbal -acupuncture Treatment being diagnosed in lung asthenia including deficiency of Eum and insufficiency of Gi of the lung(肺虛), the fire due to deficiency(虛火), and loving warfare of symptoms evaluated through VAS (visual analog scales). Results & Conclusion : Patient's difficulty in breathing symptoms took a favorable turn after treatment. This study means that Oriental medicine therapy that is difficulty in breathing symptoms that happen from patient surely has effectiveness.

• Journal of Korean Medical classics
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• v.24 no.5
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• pp.131-145
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• 2011

I had come at the conclusion of the development history of Disease Bi(痞病) reflected in Yi Cheon (李梴)'s work, "Euhakibmun(醫學入門)" in the respects of the causes, mechanism, symptoms, differential diagnosis and treatments. The causes of Disease Bi(痞病) mentioned at "Euhakibmun(醫學入門)" followed the Ju Dan-Gyeo(朱丹溪)'s theory. The mechanism of it went after the viewpoints of "Nae-Gyeong(內經)", Jang Jung-Gyeong(張仲景), Yi Dong-Won(李東垣) and Wang Ho-Go(王好古). The symptoms of it kept the Ju Dan-Gyeo(朱丹溪)'s theory. Yi Cheon distinguished Disease Bi(痞病) from Gyeol-Hyung(結胸) according to Jang Jung-Gyeong's theory. He knew it from abdominal dropsy(脹滿) according to Ju Dan-Gyeo's theory. He also divided it into two respects of deficiency(虛) and excessive(實) from Yi Dong-Won's viewpoint. Jang Jung-Gyeong first suggested that treatments of it could be selected according to the difference of deficiency, excessive(實), cold(寒), hot(熱), sputum(痰), fluid(飮), blood(血) and food(食). Yi Dong-Won insisted many doctors could make a mistake because they only used herbs for Gi(氣藥) instead of herbs for blood(血藥) together. Wang Ho-Go(王好古) maintained his opinion that treatments of both digestion(消導) and assistance(補益), remedies of bitter and hot herbs can recover patients from Disease Bi(痞病). Yi Cheon followed their theories properly.

• The Journal of Internal Korean Medicine
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• v.11 no.1
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• pp.1-13
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• 1990

We objerved the following results from The Yellow Emperior's Canon of Internal medicine through the investigation of literature about fever. 1. Fever is divieded two type asthenic fever sthenic heat and It accused two type of excess of Yang-exoganous heat, deficiency of Yin-internal fever 2. The cause of fever is divieded three type, exoganous cause, internal cause non-exoganouse and internal cause Among the cause of fever Exoganous cause is almost affected by cold-evil Internal cause is affected by deficiency of Yin and seven emotion caused by having sex after intoxigation or over-exertion, and non-exoganous and internal cause bring about the difference of a personal life and food and drink 3. The sympton produced by fever is appeared differently through-pulse and meridian and they are indication of Diagnosis 4. The theory of treatment about fever are as follows Drinking cold-water Practising acupuncture Trerating hot-evil by cold Dispel cold by warm Treating cold-evil by heat Promote vital energy circulation by cold Treating warm-evil by cold Promating circulation by cold Treating cold-evil by warm Promoting circulation by heat.

• Clinical and Experimental Reproductive Medicine
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• v.43 no.4
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• pp.199-206
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• 2016

Objective: This study was carried out to investigate the correlations of the sperm DNA fragmentation index (DFI) with semen parameters and apoptosis, and to investigate the effects of density-gradient centrifugation (DGC) and magnetic-activated cell sorting (MACS) on reducing the proportion of sperm with DNA fragmentation and protamine deficiency. Methods: Semen analysis and a sperm DNA fragmentation assay were performed to assess the correlations between semen parameters and the DFI in 458 semen samples. Sperm with progressive motility or non-apoptosis were isolated by DGC or MACS, respectively, in 29 normozoospermic semen samples. The effects of DGC or MACS alone and of DGC and MACS combined on reducing the amount of sperm in the sample with DNA fragmentation and protamine deficiency were investigated. Results: The sperm DFI showed a significant correlation (r=-0.347, p< 0.001) with sperm motility and morphology (r=-0.114, p< 0.05) but not with other semen parameters. The DFI ($11.5%{\pm}2.0%$) of semen samples was significantly reduced by DGC ($8.1%{\pm}4.1%$) or MACS alone ($7.4%{\pm}3.9%$) (p< 0.05). The DFI was significantly further reduced by a combination of DGC and MACS ($4.1%{\pm}1.3%$, p< 0.05). Moreover, the combination of DGC and MACS ($1.6%{\pm}1.1%$, p< 0.05) significantly reduced the protamine deficiency rate of semen samples compared to DGC ($4.4%{\pm}3.2%$) or MACS alone ($3.4%{\pm}2.2%$). Conclusion: The combination of DGC and MACS may be an effective method to isolate high-quality sperm with progressive motility, non-apoptosis, high DNA integrity, and low protamine deficiency in clinical use.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1375-1387
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• 2006

Through abdominal diagnoses, deficiency and excess, and cold and heat of the eight principles for differentiating syndromes can be determined, pathogens such as fluid retention, dry stool, retention of undigested food, abdominal mass, blood stagnation, stagnation of Gi, deficiency of Kidney Yang, and, spermatorrhea can be identified, nature and stages of the symptoms can be understood and then pathogenesis analyzed. Abdominal diagnosis can be one of primary factors in deciding treatment, expecting prognosis and treatment effect, and choosing herbal prescriptions. Representative herbs for epigastric stuffiness/fullness are Radix Ginseng, Pericarpium Citri, etc; for fullness of epigastrium, Rhizoma Pinelliae, Pericarpium Citri, Rhizoma Rhei, etc.; for severely rigid epigastrium, Radix Glycyrrhizae, Radix Ginseng, etc.; for epigastric pain, Rhizoma Pinelliae, Pericarpium Citri, etc.; for epigastric fullness and rigidity, Rhizoma Coptidis, Radix Ginseng, etc.; for feeling of obstruction in the epigastirum, Radix Bupleuri, Radix Ginseng, etc.; for palpitation in the epigastrium, Radix Glycyrrhizae, Ramulus Cinnamomi, etc. It is essential to rightly diagnose through comprehensive analysis of the data gained by the four methods of diagnosis, and in doing this, further studies on how to utilize abdomen diagnosis for clinical practice.

• Korean Journal of Oriental Medicine
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• v.14 no.2
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• pp.41-46
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• 2008

The study was to investigate the agreement rate between the statistical diagnosis of pattern identification by discriminant analysis and the clinical diagnosis of pattern identification by medical specialist in obese patients with BMI$\geqq$23. The agreement rate of deficiency of the spleen, phlegm-retention, deficiency of Yang, retention of undigested food, stagnation of liver Gi, and blood stagnation are 0.40, 0.33, 0.52, 0.76, 0.71, and 0.66, respectively and accuracy rate and prediction rate using linear discriminant function are 0.59 and 0.61, respectively. Therefore, the complementary management in CRF questionnaires and/or consultation from experts will improve the accuracy and prediction rate, which will be helpful for pattern identification of obesity by clinical experts.

• Journal of Korean Medical classics
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• v.36 no.1
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• pp.79-107
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• 2023

Objectives : This study aims to improve the diagnosis and treatment of contemporary insomnia by examining Zhang Jiebin's discussion on treating insomnia. Methods : The classical texts from the 'Insomnia' chapter of the Jingyue Quanshu were examined threefold in terms of symptom, treatment, and prescription analysis, after which the treatment discussion part was examined within the historical context of discussions on insomnia in major medical texts starting from the Huangdineijing. Results : According to Zhang, the cause of insomnia could be divided into two, after which criteria for diagnosis and treatment were set as excess pathogen and vital qi deficiency. He argued that insomnia could be naturally resolved through improvement of various pathogenic situations. Discussions on insomnia from various medical texts since the Huangdineijing suggest that pathology related to psychological function and emotions gradually increased and expanded over time. Conclusions : Zhang's discussion on symptom, treatment and prescriptions of insomnia suggests a new framework that could improve treatment effects through a Korean Medical Mind-Body approach, rather than the contemporary classification of organic insomnia and non-organic insomnia.

• Molecules and Cells
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• v.21 no.3
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• pp.356-359
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• 2006

The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that $E2F1^{-/-}$ murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor $2{\alpha}$ ($elF2{\alpha}$). These results therefore indicate that E2F1 deficiency increases phosphorylation of $elF2{\alpha}$ in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis in E2F1-deficient cells is related to the high level of $elF2{\alpha}$ phosphorylation.