• Advances in Traditional Medicine
• /
• 제7권3호
• /
• pp.274-279
• /
• 2007

The crude ethanol extract of leaves of Sonneratia caseolaris Linn. (Sonneratiaceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500 mg/kg body weight (P<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 500 mg/kg body weight (P < 0.05) comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.

• Advances in Traditional Medicine
• /
• 제7권3호
• /
• pp.280-285
• /
• 2007

The methanol extract of leaves of Bruguiera gymnorrhiza (L.) Lam. (Rhizophoraceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant inhibition in acetic acid-induced writhing in mice at dose of 250 and 500 mg/kg body weight (P < 0.001), comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (P < 0.001). When tested for its antidiarrhoeal effects on castor oil-induced diarrhea in mice, it increased mean latent period (P < 0.02) and decreased the frequency of defecation (P < 0.01) significantly at the dose of 500 mg/kg body weight, comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.

• 한국산학기술학회논문지
• /
• 제13권5호
• /
• pp.2267-2277
• /
• 2012

본 연구는 배변 문제가 있는 뇌 병변 장애 입원 환자에게 자원봉사자들이 주 3회의 아로마 복부경락마사지 중재(7분/1회)를 4주간 적용하여 변비완화에 미치는 효과를 검정하고자 시도되었다. 연구 설계는 단일군 전후설계의 원시실험연구이며, 연구대상은 5개월 이상 입원중이며 배변문제가 있는 뇌 병변 장애환자 38명이었다. 연구기간은 2011년 5월 9일부터 6월 19일까지 총 6주간 이었다. 변비완화 효과는 좌약 또는 관장 적용 횟수, 배변 횟수, 배변 양으로 측정 하였으며, 수집된 자료를 SPSS 19.0을 이용하여 기술통계와 Repeated Measures ANOVA로 분석한 결과는 다음과 같다. 첫째, 시간의 경과에 따라 좌약 또는 관장횟수가 감소한 것으로 나타났으나 통계적으로 유의하지 않았다(F=1.03, p=.361). 둘째, 시간의 경과에 따라 배변 횟수가 증가한 것으로 나타났으나 통계적으로 유의하지 않았다(F=2.14, p=.133). 셋째, 시간의 경과에 따라 배변 양이 유의하게 증가한 것으로 나타났다(F=3.56, p=.033). 시점 간을 비교 분석한 결과 사전시기 보다 중재 1-2주(p<.05)와 중재 3-4주(p<.01)에 배변 양이 증가하여 유의한 차이가 있었다. 이상의 결과를 통해 자원봉사자에 의한 주 3회의 아로마 복부경락마사지는 입원 뇌 병변 장애 환자의 변비완화에 효과가 있는 비 침습적인 간호중재라고 결론지을 수 있으며, 간호실무 현장에서 아로마 복부경락마사지 중재를 적용할 수 있는 경험적 근거와 지침을 제공한 점에서 그 의의가 있다. 추후 본 연구결과의 확산을 위해 다양한 대상자에게 반복 연구를 실시하여 경험적 증거를 축적할 것을 제언한다.

• 대한한의학방제학회지
• /
• 제29권4호
• /
• pp.321-329
• /
• 2021

This case study reports the effects of complex Korean medicine treatment, including Nangan-jeon, on Lambert-Eaton myasthenic syndrome (LEMS) accompanied by chronic constipation and abdominal pain as the main symptoms. A 39-year-old woman diagnosed with LEMS with major symptoms, including chronic constipation and acute abdominal pain, received Western treatment. The treatment efficacy was weak and symptoms recurred, so the patient received outpatient treatment and 13 days of hospitalization for active Korean medicine treatment, including Nangan-jeon. During outpatient treatment and hospitalization, defecation frequency and the numeric rating scale (NRS) for abdominal pain and abdominal cold feeling were measured. The NRS for abdominal pain and cold decreased from 8 at admission to 3 and 0, respectively, at discharge. Defecation frequency increased significantly from once or twice a month to once every 2-3 days during hospitalization. This study results that complex Korean medicine treatment, including Nangan-jeon may be useful for treating patients who mainly complain of autonomic neurological symptoms, among patients diagnosed with LEMS. In addition, it is believed that it could be basic data applicable to more LEMS patient treatment cases.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제23권6호
• /
• pp.511-520
• /
• 2020

Purpose: Thickened infant formulas reduce regurgitation frequency and volume. Because the digestive tolerance of locust bean gum-containing formulas is controversial, the effectiveness and tolerance of a locust bean gum-thickened formula in infants presenting with regurgitation was evaluated. No other interventions were allowed during the 1 month follow-up period. Methods: We conducted an open, prospective, observational study of a locust bean gum-thickened formula administered to infants presenting with moderate to severe regurgitation according to parents during 1 month. Effectiveness and tolerance were assessed by evaluating gastrointestinal symptoms and quality of life indicators. Results: A total of 2,604 infants with an average age of 9.3±4.3 weeks were included in this 1 month trial. Regurgitation frequency and estimated volume decreased significantly (p<0.001) and the episodes were resolved completely in 48% of the infants. A significant decrease in duration of crying and episodes of gas (p<0.001), with improvement in quality of life parameters, was observed. Stool frequency increased and stool consistency softened (p<0.001) to levels within the physiologic range, consistent with the increased fiber load (0.42 g/100 mL). Conclusion: Locust bean gum-thickened formula decreased infant regurgitation, was well tolerated, and improved parental quality of life. Stool composition and frequency of the infants remained within the physiologic range.

• 한국환경생태학회지
• /
• 제31권2호
• /
• pp.127-134
• /
• 2017

본 연구는 2013년 번식기 동안 광주광역시에서 제비의 번식행동을 밝히기 위하여 이루어졌다. 오전시간에 영소 빈도는 14.2~31.0 trips/h 범위, 성별로는 수컷 10.2~19.8 trips/h, 암컷 4.0~11.4 trips/h을 보였다. 영소 시간은 7.6~15.9 min/h 범위였고, 성별로는 수컷 4.8~8.1 min/h, 암컷 2.8~8.0 min/h 으로 조사되었다. 한 회 영소 시간은 수컷 $26.1{\pm}15.5sec/trip$, 암컷 $40.0{\pm}27.9sec/trip$으로 암컷이 수컷보다 약 1.5배 길었다(p<0.001). 포란은 암컷이 전담하였으며, 6h에 $50.6{\pm}17.5min/h$ (84%), 7h에 24.5 min/h(40.8%)이었고, 그 이후로는 대략 15.6 min/h (26.0%)로 조사되었다. 주간시간 암컷의 포란시간은 시간대별로 고도로 유의한 차이를 보였으며(p<0.001), 6h의 포란시간은 다른 시간보다 특히 높은 것으로 나타났다. 암컷의 포란시간과 평균 기온간에는 유의한 음의 상관관계가 있었다(p<0.05). 주간시간에 급이 빈도는 총 $385.2{\pm}66.9trips/nest$, 성별로는 수컷 $219.2{\pm}37.1trips/nest$, 암컷 $166.0{\pm}30.8trips/nest$으로 나타났다. 시간당 급이 빈도는 $32.1{\pm}12.3trips/h$, 성별로는 수컷 $18.3{\pm}7.8trips/h$, 암컷 $14.3{\pm}4.5trips/h$ 이었다. 시간당 급이 빈도는 성별로 10h(p<0.05)와 15h(p<0.01)에서 유의한 차이가 있었다. 한 회 급이 시간은 수컷 $12.3{\pm}31.0sec/trip$, 암컷 $40.9{\pm}83.3sec/trip$로 암컷이 수컷보다 유의하게 투자하는 것으로 나타났다(p<0.001). 새끼의 배변 빈도는 $45.6{\pm}8.4times/nest$이었으며, 급이 빈도와 양의 상관관계를 보였다(p<0.05). 본 연구의 결과는 한국의 서식환경에 적응하여 번식하는 제비의 번식행동학적 정보를 이해하는데 도움이 될 것으로 판단된다.

• 사상체질의학회지
• /
• 제29권3호
• /
• pp.248-261
• /
• 2017

Objectives The purpose of this study is to analyze the decision making process of prescribing Yeoldahanso-tang and Taeeumjowi-tang Choweseuncheng-tang using decision tree. Methods We used collected the prospective clinical data of TE type from September 2012 to July 2015. In this study, we used gender, BMI, blood pressure, pulse and clinical symptoms (digestion, sweat, defecation, urination, sleep, physical status, emotion, heat-coldness, water consumption, facial color) as variables. Decision trees were analyzed using open source R version 3.3.2. Results & Conclusions We found that the decision trees differed among institutions. However, in all institutions, it was found that stool type (ordinary symptom), urine frequency (ordinary and present symptom) and anxiety (ordinary symptom) were important in the decision of prescription. Besides, clinical informations such as sex, Body Mass Index and blood pressure affected the prescription decision.

• Advances in Traditional Medicine
• /
• 제7권2호
• /
• pp.191-196
• /
• 2007

The ethanol extract of leaves of the mangrove Aegiceras corniculatum Blanco (Myrsinaceae) was screened for its antinociceptive, antidiarrhoeal and cytotoxic activities. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg body weight (P < 0.001), which was comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrhoeal effects on castor oil induced diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the oral dose of 500 mg/kg body weight (P<0.05; P<0.01) comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. Moreover, when tested for toxicity using brine shrimp, the extract showed potent activity against the brine shrimp Artemia salina ($LC_{50}$ 10 mg/ml). The overall results tend to suggest the antinociceptive, antidiarrhoeal and cytotoxic activities of the extract.

• 한국전자통신학회논문지
• /
• 제13권4호
• /
• pp.865-874
• /
• 2018

본 논문은 스마트 베개와 스마트 기저귀에 관한 것이다. 스마트 베개는 아기 울음소리의 주파수를 분석하여 나온 디지털 값을 대역 통과 필터에 적용한다. 만약 300-600Hz 사이라면 백색 소음을 출력한다. 스마트 기저귀는 아기가 배변 시 기저귀 외부의 온도가 $29^{\circ}C$이상, 습도가 99% 이상일 경우에 스마트폰에 경고 알람을 울린다. 또한 스마트 기저귀는 아기가 누워있는 위치를 감지하여 뒤집혔을 시 스마트폰에 경고 알람을 울려 아기의 질식사를 예방한다.

• 생약학회지
• /
• 제5권3호
• /
• pp.159-166
• /
• 1974

The Yellow needle crystal was isolated from Atractylis Rhizoma, having mp $124{\sim}126^{\circ}C$(decomp.), the chemical composition $C_{16}H_{21}N_{3}O_{6}$, and its m.w. 251. The pharmacological actions of this alkaloid were studied by various psycopharmacological experiments. 1) In order to see the effect of this Atractylis(=At.) alkaloid on gross general behaviors in mice, a behavioral analysis experiment was adapted. The occurrence number of sleep and lying in At. alkaloidal animals with the doses 10mg/kg or 20mg/kg was increased but the number of jumping, exploration, rearing and defecation was significantly decreased than those of placebo. 2) The effect of the At. alkaloid on unlearned emotional behaviors of mice was studied with an open-field method. The At. alkaloidal groups with the doses 20mg/kg or 30mg/kg showed less often the frequency of locomotion than that of placebo. 3) To know the effect of the At. alkaloid on the learning, a standard water maze experiment and conditioned avoidance response were conducted. As compared to placebo control, the aquisition rate of the maze learning in the alkaloidal mice with the dose of 10mg/kg or 20mg/kg was significantly impaired and the speed of swimming was also signficantly delayed. In the conditioned avoidance response, the extinction performances of the alkaloidal rats with doses of 20mg/kg or 30mg/kg did not differ significantly than that of placebo.