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http://dx.doi.org/10.5223/pghn.2020.23.6.511

Effectiveness and Tolerance of a Locust Bean Gum-Thickened Formula: A Real-Life Study  

Tounian, Patrick (Nutrition et Gastroenterologie Pediatriques, Hopital Trousseau, APHP, Sorbonne Universite)
Meunier, Leo (Danone Food Safety Centre)
Speijers, Gerrit (General Health Effects Toxicology Safety Food (GETS))
Oozeer, Raish (Nutricia Research)
Vandenplas, Yvan (KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.23, no.6, 2020 , pp. 511-520 More about this Journal
Abstract
Purpose: Thickened infant formulas reduce regurgitation frequency and volume. Because the digestive tolerance of locust bean gum-containing formulas is controversial, the effectiveness and tolerance of a locust bean gum-thickened formula in infants presenting with regurgitation was evaluated. No other interventions were allowed during the 1 month follow-up period. Methods: We conducted an open, prospective, observational study of a locust bean gum-thickened formula administered to infants presenting with moderate to severe regurgitation according to parents during 1 month. Effectiveness and tolerance were assessed by evaluating gastrointestinal symptoms and quality of life indicators. Results: A total of 2,604 infants with an average age of 9.3±4.3 weeks were included in this 1 month trial. Regurgitation frequency and estimated volume decreased significantly (p<0.001) and the episodes were resolved completely in 48% of the infants. A significant decrease in duration of crying and episodes of gas (p<0.001), with improvement in quality of life parameters, was observed. Stool frequency increased and stool consistency softened (p<0.001) to levels within the physiologic range, consistent with the increased fiber load (0.42 g/100 mL). Conclusion: Locust bean gum-thickened formula decreased infant regurgitation, was well tolerated, and improved parental quality of life. Stool composition and frequency of the infants remained within the physiologic range.
Keywords
Locust bean gum; Quality of life; Gastro-esophageal reflux; Infant formula; Defecation; Diarrhea; Crying;
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