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Korean medicine treatment, including Nangan-jeon, of chronic constipation and abdominal pain in Lambert-Eaton myasthenic syndrome : A case report

Lambert-Eaton myasthenic syndrome 환자의 만성 변비 및 복통에 대한 난간전을 포함한 한방 치료 증례보고

  • Han, Ji Hoon (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University) ;
  • Woo, Sang Ha (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University) ;
  • Park, Yu-kyeong (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University) ;
  • Choi, Seong-Hun (Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University) ;
  • Lee, Yun-kyu (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University) ;
  • Lee, Jung Hee (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Jae Soo (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University) ;
  • Lee, Hyun-Jong (Department of Acupuncture &Moxibustion, College of Korean Medicine, Daegu Haany University)
  • 한지훈 (대구한의대학교 부속 대구한방병원 한의과대학 침구의학교실) ;
  • 우상하 (대구한의대학교 부속 대구한방병원 한의과대학 침구의학교실) ;
  • 박유경 (대구한의대학교 부속 대구한방병원 한의과대학 침구의학교실) ;
  • 최성훈 (대구한의대학교 부속 대구한방병원 한의과대학 해부학교실) ;
  • 이윤규 (대구한의대학교 부속 포항한방병원 한의학과 침구의학교실) ;
  • 이정희 (대구한의대학교 부속 대구한방병원 한의과대학 침구의학교실) ;
  • 김재수 (대구한의대학교 부속 대구한방병원 한의과대학 침구의학교실) ;
  • 이현종 (대구한의대학교 부속 대구한방병원 한의과대학 침구의학교실)
  • Received : 2021.10.29
  • Accepted : 2021.11.30
  • Published : 2021.11.30

Abstract

This case study reports the effects of complex Korean medicine treatment, including Nangan-jeon, on Lambert-Eaton myasthenic syndrome (LEMS) accompanied by chronic constipation and abdominal pain as the main symptoms. A 39-year-old woman diagnosed with LEMS with major symptoms, including chronic constipation and acute abdominal pain, received Western treatment. The treatment efficacy was weak and symptoms recurred, so the patient received outpatient treatment and 13 days of hospitalization for active Korean medicine treatment, including Nangan-jeon. During outpatient treatment and hospitalization, defecation frequency and the numeric rating scale (NRS) for abdominal pain and abdominal cold feeling were measured. The NRS for abdominal pain and cold decreased from 8 at admission to 3 and 0, respectively, at discharge. Defecation frequency increased significantly from once or twice a month to once every 2-3 days during hospitalization. This study results that complex Korean medicine treatment, including Nangan-jeon may be useful for treating patients who mainly complain of autonomic neurological symptoms, among patients diagnosed with LEMS. In addition, it is believed that it could be basic data applicable to more LEMS patient treatment cases.

Keywords

References

  1. Titulaer MJ, Lang B, Verschuuren JJ. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol 2011;10(12): 1098-1107. https://doi.org/10.1016/S1474-4422(11)70245-9
  2. Kesner VG, Oh SJ, Dimachkie MM, Barohn RJ. Lambert-Eaton myasthenic syndrome. Neurol Clinics 2018;36(2):379-394. https://doi.org/10.1016/j.ncl.2018.01.008
  3. Tarr TB, Wipf P, Meriney SD. Synaptic pathophysiology and treatment of Lambert-Eaton myasthenic syndrome. Molec Neurobiol 2015;52(1):456-463. https://doi.org/10.1007/s12035-014-8887-2
  4. Tadashi Y. Illustrated acupuncture and moxibustion technology guide, Vol. 2. Japan : Bunkodo shoten ; 2012. 42 p.
  5. Korean Acupuncture and Moxibustion Society Textbook Compilation Committee. Acupuncture medicine . 4th ed. Seoul (Korea): Hanmi Medicine Publish Company; 2016. 696-698 p. [in Korean].
  6. Schoser, B, Eymard, B, Datt, J, &Mantegazza, R. Lambert-Eaton myasthenic syndrome (LEMS): a rare autoimmune presynaptic disorder often associated with cancer. Journal of neurology 2017;264(9), 1854-1863. https://doi.org/10.1007/s00415-017-8541-9
  7. Daniel BD, Anthony AA. Chapter 461: Myasthenia gravis and other diseases of the neuromuscular junction, In Harrison's principles of internal medicine. 19th ed. Korea: McGraw-Hill Education; 2017. 3871 p. [in Korean]
  8. Andersen JB. Epidemiology, comorbidity and clinical course of myasthenia gravis. A registry-based study [Internet]. The University of Bergen. [cited 2016]. Available from: http://hdl.handle.net/1956/11708.
  9. Waterman SA. Autonomic dysfunction in Lambert-Eaton myasthenic syndrome. Clinic Autonomic Res 2001;11(3):145-154. https://doi.org/10.1007/bf02329922
  10. Choi KL, Kwon YG, Lee JS, Lee BC, Ahn YM, Ahn SY, Doo HK. An Improved Case of Genital Cold Syndrome Confirmed by Infrared Thermography. The Journal of Oriental Chronic Diseases 2001; 7(1):87-91.
  11. Department of Herbal Formula College of Korean Medicine. Herbal Formula Science. Younglimsa. 1999. 390-391 p. [in Korean]
  12. Choi CW, Lee MY. Effects of Ponciri Fructus on spontaneous phasic contractions of colon in rats. J Physiol &Pathol in Korean Med 2008;22(6): 1518-1524.
  13. Department of Herbology College of Korean Medicine. Herbology. Younglimsa. 2009. 218-220, 392-394, 392-394 p. [in Korean]
  14. Du WF, Yu L, Yan XK, Wang, FC. Met-analysis on randomized controlled clinical trials of acupuncture and moxibustion on constipation. Zhongguo zhen jiu (Chinese acupuncture &moxibustion) 2012; 32(1):92-96.