• The Plant Pathology Journal
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• 제17권1호
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• pp.45-51
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• 2001

A root rot/vine decline disease occurred naturally on bottle gourd-stocked watermelon, melon, oriental melon and squash grown in greenhouses, but not on these plants grown in fields. Self-rooted watermelon, cucumber, pumpkin and luffa were also proven to be hosts of the pathogen by artificial inoculation in this experiment. The pathogen was identified as Monosporascus cannonballus by comparing microscopic characteristics of fungal structures with those of previously identified fungal strains. Our field investigations showed that the temperature and electric conductivity of soil in infected greenhouses were higher and the soil moisture content was lower than in noninfected greenhouses. To investigate soil-environmental factors affecting disease development, greenhouse trials and inoculation experiments were conducted. The host plants inoculated and grown under conditions of high soil temperature and electrical conductivity ($35\pm2^{\circ}$, 3.2-3.5 mS) and with low soil moisture content (pF 3.0-4.5) were most severely damaged by the fungal disease. Since plants growing in greenhouses ae usually exposed to such environmental conditions, this may be the reason why the monosporascus root rot/vine decline disease has occurred only on cucurbits cultivated in greenhouses but not in field conditions.

• Integrative Medicine Research
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• 제5권3호
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• pp.176-181
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• 2016

Recent studies have focused on evidence-based interventions to prevent mobility decline and enhance physical performance in older adults. Several modalities, in addition to traditional strengthening programs, have been designed to manage age-related functional decline more effectively. In this study, we reviewed the current relevant literatures to assess the therapeutic potential of eccentric exercises for age-related muscle atrophy (sarcopenia). Age-related changes in human skeletal muscle, and their relationship with physical performance, are discussed with reference to in vitro physiologic and human biomechanics studies. An overview of issues relevant to sarcopenia is provided in the context of the recent consensus on the diagnosis and management of the condition. A decline in mobility among the aging population is closely linked with changes in the muscle force-velocity relationship. Interventions based specifically on increasing velocity and eccentric strength can improve function more effectively compared with traditional strengthening programs. Eccentric strengthening programs are introduced as a specific method for improving both muscle force and velocity. To be more effective, exercise interventions for older adults should focus on enhancing the muscle force-velocity relationship. Exercises that can be performed easily, and that utilize eccentric strength (which is relatively spared during the aging process), are needed to improve both muscle force and velocity.

• Advances in aircraft and spacecraft science
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• 제6권5호
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• pp.349-369
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• 2019

In the design of flight control systems there are issues that deserve special consideration and attention such as external perturbations or systems failures. A Simple Adaptive Controller (SAC) that does not require a-priori knowledge of the faults is proposed in this paper with the aim of realizing a fault tolerant flight control system capable of leading the pitch motion of an aircraft. The main condition for obtaining a stable adaptive controller is the passivity of the plant; however, since real systems generally do not satisfy such requirement, a properly defined Parallel Feedforward Compensator (PFC) is used to let the augmented system meet the passivity condition. The design approach used in this paper to synthesize the PFC and to tune the invariant gains of the SAC is the Population Decline Swarm Optimization ($P_DSO$). It is a modification of the Particle Swarm Optimization (PSO) technique that takes into account a decline demographic model to speed up the optimization procedure. Tuning and flight mechanics results are presented to show both the effectiveness of the proposed $P_DSO$ and the fault tolerant capability of the proposed scheme to control the aircraft pitch motion even in presence of elevator failures.

• 대한건축학회논문집:계획계
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• 제34권3호
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• pp.93-104
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• 2018

This study is about occurrence pattern of vacant spaces as a urban decline indicator to consider a decline of old hillside residential area from spatial structure perspective. For investigation based upon vacant space and the street structure, this study selects Ami Chojang-dong in Seo-gu, Busan, of which 79.7% of total area is over a gradient of $10^{\circ}$. Focused on relationship between occurrence pattern of vacant spaces and 'vertical alleys(link)' serving as main movement path of local residents in hillside residential area, the length, numbers, slopes, and use characteristic of vertical alleys were analyzed using Arc GIS 9.3 program to classify characteristic zone types of spacial structure in hillside residential area. After the occurrence pattern of vacant space are interpreted in relation with building density, vertical alleys' number length slope, the social and economic issues have been considered as well. After analyzing the occurrence pattern of vacant space, this study argues that the occurrence pattern of vacant space in old hillside residential area is rather affected by street structure system consisting of vertical alleys than the impacts of social economical issues.

• 농촌계획
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• 제28권4호
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• pp.1-9
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• 2022

Rural decline due to the decrease of the local population is an inevitable phenomenon, and a vicious cycle has been formed between a lack of basic living services and a population decrease in rural areas. Therefore, the study aims to derive the migration decision-making characteristics based on basic living service infrastructure data in rural areas. To do this, the population change over the past 20 years was categorized into six types, and the relationship between the classified population change types and the number of basic living service infrastructures was analyzed using decision tree analysis. Of the total 3,501 regions, 801 regions were the continuous decline type, of which 740 were rural areas. On the other hand, among 569 regions that were the continuous increase type, 401 regions were urban areas, confirming the population imbalance between rural and urban areas. As a result of the decision tree analysis on the relationship between population change types and the distribution of basic living service infrastructure, the number of daycare centers was derived as an important variable to classify the continuous increase type. Hospitals, parks, and public transportation were also found to be major basic living services affecting the classification of population change types.

• 한국식품과학회지
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• 제54권1호
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• pp.52-58
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• 2022

Phosphatidylserine (PS) is an essential component of the cerebral cortex and is associated with cognitive function. In this systematic review, the effects of PS on cognitive function in the elderly population are examined. The literature search included PubMed, EMBASE, Cochrane, and Web of Science databases. Subsequently, nine studies, including five randomized controlled trials and four pre-post studies, were selected. There were 961 participants in the selected studies; PS dosage varied from 100 to 300 mg/d, and the experimental period ranged from 6 weeks to 6 months. Five out of the nine selected studies were assessed to have a 'low' risk of bias, whereas the other four studies were assessed to have 'some concerns' regarding the risk of bias. The results of the meta-analysis concluded that PS had a positive effect on the memory of older adults with cognitive decline. Thus, PS appears to improve age-associated cognitive decline, especially memory, with no adverse effects.

• International Journal of Oral Biology
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• 제49권3호
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• pp.69-78
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• 2024

Sestrin 2 (SESN2) is a member of the sestrin family of stress-induced proteins that negatively regulate aging-associated biological processes. This study aims to investigate the role of SESN2 in regulating the differentiation potential and senescence of mesenchymal stem cells (MSCs) derived from young and elderly donors. Bulk RNA sequencing revealed a common decline in the SESN2 mRNA levels in MSCs from elderly individuals, which was confirmed via reverse transcription-polymerase chain reaction and western blot analyses. SESN2 knockdown in MSCs from young donors resulted in phenotypic changes similar to those in MSCs from elderly donors, including an enhanced expression of senescence and adipogenic markers and diminished expression of osteogenic markers. To confirm the effect of decreased SESN2 expression on osteogenic and adipogenic differentiation, we induced Sesn2 knockdown in mouse bone marrow-derived MSCs. Sesn2 knockdown suppressed the mRNA expression of osteogenic marker genes, alkaline phosphatase activity, and matrix mineralization. Furthermore, Sesn2 knockdown enhanced mRNA expression of the adipogenic marker genes and intracellular lipid accumulation. These results suggest that a decline in SESN2 expression during aging contributes to the shift of MSC differentiation from osteogenic to adipogenic lineage.

• 한국조경학회지
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• 제43권6호
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• pp.25-40
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• 2015

우리나라 관광지는 관광진흥법에 따라 지정 관리되고 있으며, 1969년 태종대 관광지가 지정된 이후 현재까지 총 230개소의 관광지가 지정, 조성, 운영되고 있다. 최초 관광지가 지정된 이후 46년이라는 시간이 흘렀으며, 이는 Butler가 주장한 관광지 수명주기 이론에 따라 영고성쇠와 같은 수명주기의 흐름을 보이고 있을 것으로 추정된다. 이에, 본 연구에서는 Butler의 관광지 수명주기 이론을 적용하여 국내 관광지의 수명주기 단계를 분석하고, 향후 관광지가 변화 발전되어야 할 방향성을 제시하는데 기초자료로 활용하고자 연구를 진행하였다. 연구방법은 대상 관광지별 연간방문객수 데이터를 기반으로 변화추이곡선을 도출하였으며, 방문객수 변화율을 기준으로 관광지 수명주기 단계를 구분하였다. 분석 결과, 국내 관광지의 3분의 1 이상이 정체 쇠퇴 단계에 도달하고 있는 것으로 분석되었으며, 특히 온천, 해안/해수욕장 자원유형 관광지가 정체 쇠퇴단계 비율이 높은 것으로 분석되었다. 정체 쇠퇴단계에 도달해 있는 관광지는 쇠퇴의 원인 분석과 해결방안 모색, 새로운 혁신요소 도입의 필요성이 대두되었다. 본 연구의 결과가 국내 관광지의 수명주기 단계를 결정하는 절대적인 기준이 되기에는 부족한 점이 있으나, 우리나라 관광지의 수명주기 단계를 현상학적으로 파악하기에는 적절한 것으로 사료되며, 본 연구를 바탕으로 정체 쇠퇴단계에 도달한 관광지들의 원인을 규명하고, 이를 토대로 새로운 혁신 도입을 통해 관광지의 재활성화 방안 마련의 기초 연구로 활용될 수 있을 것으로 생각된다.

• 한국지역지리학회지
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• 제23권1호
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• pp.118-135
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• 2017

도시 생애 주기에 따른 도시 노후화와 도시재생 정책에 관한 관심이 최근 급증하고 있고, 도시 쇠퇴의 가시적인 지표로 대표적인 사례인 공폐가의 발생과 활용 방안에 대한 관심 역시 최근 들어 그 중요성이 커지고 있는 실정이다. 본 연구는 2016년 4월 기준 광주광역시 공폐가 데이터를 이용하여 지리정보시스템과 공간통계기법을 활용하여 공폐가 발생의 공간적 분포 특성과 지역에 따른 공폐가 발생의 유형을 분석하였다. 공폐가 발생의 유형은 "도시재생 활성화 및 지원에 관한 특별법"에 의거하여 광주광역시에서 제작한 "2025 광주광역시 도시재생전략계획"의 10가지 도시 쇠퇴 진단 지표를 활용하여 분석하였다. 기존 공폐가 관련 선행연구 대부분이 시군구별 집계 자료에 제한되었던 것을 극복하여, 공폐가의 실제 위치를 행정동 단위로 분석하여 자세하고 신뢰성 있는 분석을 수행하고, 이를 통해 공폐가의 공간적 분포 패턴과 공간적 자기상관 관계 및 공폐가 발생 유형을 미시적으로 분석하였다. 연구 결과를 요약하면, 광주광역시 공폐가의 발생은 행정동 단위에서 정적인 공간적 자기 상관이 통계적으로 유의미하게 나타나고, 국지적 공간적 자기상관 분석 결과 일부 지역에서 공폐가 발생이 집중되어 있었다. 공폐가 발생과 도시 쇠퇴 요인들과의 상관관계는 삼각도표를 이용하여 시각화하고, 공폐가 발생 지역을 원인 유형별로 분류하였다. 본 연구를 통해 광주광역시 공폐가의 발생 현황과 공간적 분포를 파악하고, 지역별 공폐가 발생의 원인을 유형화하여 도시 노후화 현황과 지역별 대응방안에 대한 시사점을 제공할 수 있을 것으로 기대된다.

• 한국임상약학회지
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• 제29권4호
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• pp.238-246
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• 2019

Background: In South Korea, as an aged society, an understanding of dementia and its risk factors is important from clinical and healthcare policy perspectives. Relationship between cognitive impairment and body weight or weight changes have been reported, but these were contradictory. We have evaluated the association between weight changes and cognitive decline using national level longitudinal data. Methods: Data from the Korean Longitudinal Study of Ageing from 2006 to 2012 were used. Association between weight changes and decline in cognitive function as measured by K-MMSE (the Korean version of the Mini-mental state examination) score was assessed by multivariate logistic regression. Weight changes were calculated from 1st wave and 3rd wave survey data, and classified into five groups as stable, increases, decreases of >10%, or 5%-10%. Results: About 37% of the total participants (n=4,512) were 65 years or older. These participants made up the largest proportion of the groups with weight change exceeding 10%. Multivariate logistic regression analyses revealed that weight changes exceeding 10% (10% increase vs stable, adjusted OR [aOR] 1.47, 95% confidence interval (CI) 1.11-1.95; 10% decrease vs stable, aOR 1.44, 95% CI 1.11-1.88) were significant predictive factors for decline in cognitive function. In subgroup analyses, the association between weight changes and cognitive decline was significant in males aged over 65 years and in normal BMI groups. Conclusion: Weight changes, both increases and decreases exceeding 10% of baseline, were significantly associated with declines in cognitive function among older adults in South Korea.