Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Impact of Weight Change on Decline of Cognitive Function Among Korean Adults

체중 변화가 인지기능 저하에 미치는 영향

  • Kim, Seungyeon (College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Shin, Sangyoon (College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Yoo, Hyejin (College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Park, Gi Hyue (College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Lee, Jee-Young (Department of Neurology, SNU-SMG Boramae Medical Center) ;
  • Lee, Jeong Sang (Department of Thoracic & Cardiovascular Surgery, SNU-SMG Boramae Medical Center) ;
  • Lee, Euni (College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University)
  • 김승연 (서울대학교 약학대학) ;
  • 신상윤 (서울대학교 약학대학) ;
  • 유혜진 (서울대학교 약학대학) ;
  • 박기혜 (서울대학교 약학대학) ;
  • 이지영 (서울특별시 보라매병원 신경과) ;
  • 이정상 (서울특별시 보라매병원 흉부외과) ;
  • 김은경 (서울대학교 약학대학)
  • Received : 2019.10.21
  • Accepted : 2019.11.04
  • Published : 2019.12.31
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Abstract

Background: In South Korea, as an aged society, an understanding of dementia and its risk factors is important from clinical and healthcare policy perspectives. Relationship between cognitive impairment and body weight or weight changes have been reported, but these were contradictory. We have evaluated the association between weight changes and cognitive decline using national level longitudinal data. Methods: Data from the Korean Longitudinal Study of Ageing from 2006 to 2012 were used. Association between weight changes and decline in cognitive function as measured by K-MMSE (the Korean version of the Mini-mental state examination) score was assessed by multivariate logistic regression. Weight changes were calculated from 1st wave and 3rd wave survey data, and classified into five groups as stable, increases, decreases of >10%, or 5%-10%. Results: About 37% of the total participants (n=4,512) were 65 years or older. These participants made up the largest proportion of the groups with weight change exceeding 10%. Multivariate logistic regression analyses revealed that weight changes exceeding 10% (10% increase vs stable, adjusted OR [aOR] 1.47, 95% confidence interval (CI) 1.11-1.95; 10% decrease vs stable, aOR 1.44, 95% CI 1.11-1.88) were significant predictive factors for decline in cognitive function. In subgroup analyses, the association between weight changes and cognitive decline was significant in males aged over 65 years and in normal BMI groups. Conclusion: Weight changes, both increases and decreases exceeding 10% of baseline, were significantly associated with declines in cognitive function among older adults in South Korea.

Keywords

References

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