• 대한한의학방제학회지
• /
• 제27권3호
• /
• pp.189-197
• /
• 2019

Objectives : The purpose of this study was to confirm whether Codonopsis Radix(CR) could be used in the same way for expected indications or diseases of adaptation instead of Ginseng Radix(GR), which acts as a principal herb in Sagunja-tang. Methods : The Traditional Chinese Medicine Systems pharmacology(TCMSP), a database for the study of systems biology related to Chinese medicine, screened potential active compounds in each quartet. By searching for all the proteins that each compound provides, the target of Sagunja-tang with GR(GRST) and the target of Sagunja-tang with CR(CRST) were compared using the network analysis method, and the top ranked target of each serving was selected. Results : Through TCMSP, a Chinese medicine database, the potential effective ingredients of GRST or CRST screened, and the target proteins related to these substances were found to be the most affected by Glycyrrhizae Radix et Rhizome, an herbal medicine mixed in Sagunja-tang, and the target diseases were the same. And the same were found for the target protein, gene and target diseases of GRST and CRST. Conclusions : The prescription with similar composition is likely to have similar network pharmacology analysis results, and the analysis result may be controlled by the herbal medicines which are assumed to be the main function. Therefore, rich and reproducible basic studies is more important because network pharmacological studies can be dominated by data that has been done a lot of previous studies.

• 한국지반환경공학회 논문집
• /
• 제20권3호
• /
• pp.39-46
• /
• 2019

액상화란 느슨한 사질토 지반에서 지진과 같은 큰 진동하중이 발생하여 과잉간극수압이 급격히 증가해 전단강도를 상실하는 현상으로 국내 포항에서 발생한 액상화 현상과 더불어 그 관심이 증가하고 있는 추세이다. 이러한 액상화 평가는 주로 Seed and Idriss(1982)가 제시한 반경험적 방법을 통해 수행할 수 있으며 시추공 DB와 SPT에서 얻어진 관입저항력을 기초로 액상화 위험을 평가할 수 있지만 획득된 시추공 DB는 일정 구역을 대표하지 못하는 문제를 내재하고 있다. 따라서 본 연구는 액상화 평가의 필요한 지반정보를 분류 및 검토하여 지반정보의 DB구축방안을 모색하고 지리정보시스템(GIS)을 활용하여 공간보간을 수행해 액상화 평가 대상이 되는 지층의 대표성 문제를 해소하고자 하였다. 액상화 발생이 예상되는 지층의 두께를 정의하는 방안에 따라 세 가지 지층심도DB구축 방안을 제시하였고 교차검증을 통해 제시한 구축방안의 정밀도를 비교, 분석하여 액상화 평가에 적합한 지층심도DB구축 방안을 제시하였다.

• Molecules and Cells
• /
• 제44권1호
• /
• pp.1-12
• /
• 2021

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the master transcriptional regulator in adipogenesis. PPARγ forms a heterodimer with another nuclear receptor, retinoid X receptor (RXR), to form an active transcriptional complex, and their transcriptional activity is tightly regulated by the association with either coactivators or corepressors. In this study, we identified T-cell death-associated gene 51 (TDAG51) as a novel corepressor of PPARγ-mediated transcriptional regulation. We showed that TDAG51 expression is abundantly maintained in the early stage of adipogenic differentiation. Forced expression of TDAG51 inhibited adipocyte differentiation in 3T3-L1 cells. We found that TDAG51 physically interacts with PPARγ in a ligand-independent manner. In deletion mutant analyses, large portions of the TDAG51 domains, including the pleckstrin homology-like, glutamine repeat and proline-glutamine repeat domains but not the proline-histidine repeat domain, are involved in the interaction with the region between residues 140 and 506, including the DNA binding domain, hinge, ligand binding domain and activation function-2 domain, in PPARγ. The heterodimer formation of PPARγ-RXRα was competitively inhibited in a ligand-independent manner by TDAG51 binding to PPARγ. Thus, our data suggest that TDAG51, which could determine adipogenic cell fate, acts as a novel negative regulator of PPARγ by blocking RXRα recruitment to the PPARγ-RXRα heterodimer complex in adipogenesis.

• Wind and Structures
• /
• 제33권6호
• /
• pp.463-470
• /
• 2021

This study investigates the aerodynamic characteristics of NACA series airfoil by altering the trailing edge in the form of extended and serrated sections. This contemporary advent examined NACA 0020 airfoil experimentally at the angle of attack ranging from 0° to 45° and for the Reynolds number of 2.46 × 105. To figure out the flow behaviour, the standard average pressure distribution over the airfoil surface is estimated with 50 pressure taps. The time series surface pressure is recorded for 700 Hz of sampling frequency. The extended trailing edge of 0.1 c, 0.2 c and 0.3 c are attached to the base airfoil. Further, the triangular serration is introduced with the base length of 2 cm, 4 cm and 6 cm. Each base length with three different amplitudes of 0.1 c, 0.2 c and 0.3 c were designed and equipped with the baseline case at the trailing edge and tested. The aerodynamic force coefficient, as well as pressure coefficient are presented. The obtained data advises that modification in the trailing edge will reflect the aerodynamic characteristics and the flow behaviour over the section of a wing. Resultantly, the extended trailing edge as a thin elongated surface attached to a base airfoil without revising the main airfoil favors good lift increment. The serrated trailing edge acts as a flow control device by altering the flow pattern results to delay the stall phenomenon. Besides it, improves lift co-efficient with less amount of additional drag. This extended and serrated trailing edge approach can support for designing the future smart airfoil.

• 아태비즈니스연구
• /
• 제12권3호
• /
• pp.281-294
• /
• 2021

Purpose - The purpose of this study was verifying the policy effects by field of innovative growth engines, focusing on the discussion of the relationship between government support and corporate R&D activities (substitute/complementary goods), and based on the results, policy recommendations for promoting private R&D were carried out. Design/methodology/approach - Through literature research, academic/theoretical discussions about relationship between government support and corporate R&D activities were synthesized. Next, survey data were collected for companies engaged in the field of innovative growth engines and empirical analysis was conducted on the relationship between government support and R&D activities in 13 major sectors. Findings - First, as a result of analyzing all companies regardless of sector, government R&D subsidies had a positive (+) relationship with R&D activities of companies engaged in innovative growth engines, that is, a complementary relationship. Next, as a result of performing empirical analysis by dividing the 13 fields, it was found that 9 fields were complementary goods in which government support had a positive (+) effect on the R&D activities of companies. On the other hand, in the remaining four fields, the effect of government support on corporate R&D activities was not statistically significant. Research implications or Originality - In order to promote R&D activities of companies in the 9 fields where government support acts as a complementary product, it is necessary to establish policies centered on direct government support. On the other hand, it would be more desirable to seek indirect support rather than direct support in the 4 fields where government support did not have a statistically significant effect on corporate R&D activities.

• 대한물리치료과학회지
• /
• 제29권3호
• /
• pp.63-74
• /
• 2022

Purpose: The purpose of this study is to examine the mediating effect of children's perceived peer attachment on children's subjective well-being and the effects of self-esteem, one of the variables of individual personality characteristics, on peer attachment and subjective well-being. Design: Data from the 2018 Panel Study on Korean Children were used. Methods: The survey method was conducted by the investigator, and the total number of cases was 1,434 people. Results: First, the higher the child's peer attachment leads to higher subjective well-being and self-esteem, and the higher the self-esteem leads to higher subjective well-being. Second, in the relationship between peer attachment and subjective well-being, self-esteem acts as a mediator variable. Third, children's peer attachment affects subjective well-being and self-esteem, and self-esteem affects subjective well-being. The results explain that the degree of children's peer attachment itself affects subjective well-being and self-esteem, and self-esteem also affects children's subjective well-being. Conclusion: Self-esteem is an important factor influencing subjective well-being and has a mediating effect on the relationship between peer attachment and subjective well-being. In other words, it can be understood that children feel subjective well-being through positive interactions with peers, not only in parent relationships. Based on these results, it is necessary to suggest practical interventions to enhance children's subjective sense of well-being and to develop various programs that can strengthen the sub-factors of peer attachment.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제17권2호
• /
• pp.369-390
• /
• 2023

Technologies for disaster management are highly sought areas for research and commercial deployment. Landslides, Flood, cyclones, earthquakes, forest fires and road/train accidents are some causes of disasters. Capturing video and accessing data in real time from the disaster site can help first responders make split second decisions which may save human lives and valuable resource destructions. In this context the communication technologies performing the task should have high bandwidth and low latency which only 5G can deliver. But unfortunately in India, deployment of the 5G mobile communication systems is yet to give a shape and again in remote areas unavailability of 4G signals is still severe. In this situation the authors have proposed, simulated and experimented a 4G-5G communication scheme where from the disaster site the signals will be transmitted by a 5G terminal to a nearby 4G-5G gateway installed in a mobile vehicle. The received 5G signal will be further relayed by the 4G-5G gateway to the fixed 4G base station for onward transmission towards the disaster management station for decision making, deployment and relief monitoring. The 4G-5G gateway acts as a relay and converter of 5G signal to 4G signal and vice versa. This relayed system can be further mounted on a vehicle mounted relay (VMR) as proposed by 3GPP in Release 18. The scheme is also in the same line of context with Verizon's, "Tactical Humanitarian Operations Response" (THOR) vehicle concept. The performance of the link is studied in different channel conditions, the throughput achieved is superb. The authors have implemented the above mentioned system towards smart campus networking and monitoring landslides activities which are common in their regions.

• 정보보호학회논문지
• /
• 제33권4호
• /
• pp.609-619
• /
• 2023

최근 IoT 산업 중 하나인 드론을 사용한 범죄가 지속적으로 보고되고 있다. 특히 드론은 손쉽게 접근하여 자유롭게 움직이는 특징이 있어 폭발물 운반, 마약 운반, 불법 촬영 등 다양한 범죄에 사용된다. 이러한 범죄행위를 분석하고 수사하기 위해 드론 포렌식 연구가 매우 강조되는 상황이다. 드론에서 획득할 수 있는 대표적인 디지털 포렌식 아티팩트로는 미디어 데이터, PII, 비행기록 등이 있으며 특히 비행기록은 드론의 행적을 추적할 수 있는 중요한 아티팩트가 된다. 따라서 본 논문에서는 DJI 드론의 삭제된 비행기록 파일이 갖는 특징을 제시하고 특징의 차이점이 발생하는 세 가지 드론인 Phantom3, Phantom4, Mini2 드론을 이용하여 검증하였다. 또한 비행기록 파일이 갖는 특징을 이용하여 파일 카빙 기법을 통해 복구 정도를 분석하고 최종적으로 드론 모델별로 비행기록의 복구가능성이 존재하는 드론과 그렇지 않은 드론 모델들을 분류한다.

• 무역학회지
• /
• 제46권3호
• /
• pp.119-133
• /
• 2021

After 'Zhou Chuchu (走出去, Go global)' in the early 2000s, and with the 'One-to-One Road' initiative in 2012, China's Overseas Foreign Direct Investment (OFDI) has increased significantly, resulting in high academic interest. The purpose of this study is to analyze the impact of national risks of home country on China's OFDI by using data from 49 countries along the 'One-to-One Road' between 2007 and 2018, and to compare the factors of national risks that attract investment from the world. As a result of the study, market economy companies' perceptions of national risks are mostly negative, so risk acts as a deterrent to investment. On the other hand, national risks of home countries have had positive effects on China's OFDI, which would mean that Chinese investors, mostly state-owned enterprises have a high tendency to invest in regions or countries with high national risks. Other economic factors, such as the size of the investment partner country's market, GNI per capita, and trade openness, had a positive (+) effect, and natural resources had a negative (-) effect on China's OFDI. As dummy variables, FTA, which is an economic and diplomatic factor, SCO, which is a political and diplomatic factor, and bordering which is a geographical factor, were also found to have a positive (+) effect. This study implies the investment pattern of China's OFDI is due to the characteristics of China's unique geopolitical and economic system, and it is judged to be influenced by political and strategic factors, especially the aspects led by state-owned enterprises.

• 한국실내디자인학회논문집
• /
• 제22권6호
• /
• pp.108-118
• /
• 2013

This study has analyzed the process of space information perceived and recognized through the estimation of observation frequency and number according to the time range of observation data acquired from observation experiment with the object of hospital lobby. The followings are the results analyzed at this study. First, the continual observation of 3 and 6 times was attentive and conscious for probing to find an object rather than for acquiring exact information and that of 9 times could be regarded as the time for acquiring visual appreciation. However, the repetitive occurrence of high and low frequencies can be thought of repetitive acts for visual appreciation. Second, the continual observation of 3 and 6 times had the highest observation frequency of II, while that of 9 times had the highest observation frequency of III. In case of 3 and 6 times, the observation frequency had the tendency to become a little higher after being low since V, and in case of 9 times it had the repetition of becoming low and high and from IX it characteristically got higher. This feature can be thought to be the process that the subject repeats the fixation and movement of observation at a visual activity for perception and recognition. In the process of first observation, the observation frequency was the highest after 20 seconds or so, but since then, it gets lower and repeatedly gets higher and lower as time passes. After 90 seconds, the frequency showed the tendency of getting higher continuously. Third, the examination of changing features of frequency may show the characteristics of exploration for and attention to space but if the observation frequency is not associated with observation times for analysis there will a limitation that the features of observation frequency cannot be clarified. Accordingly, the simultaneous analysis of both is very effective for estimating the observation characteristics seen at the processes of perception and recognition. Fourth, the general analysis of the both revealed: with the progress of observation time the discontinuous space exploration decreased, and as the observation time got longer the fixed attention to a specific spot increased. Fifth, in order to estimate the observation characteristics by the change of time range the observation frequency and times by trend line was analyzed, which approach seems to be an appropriate technique that can comprehensively show the overall flow of time series data.