• 한국동물위생학회지
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• 제36권4호
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• pp.233-242
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• 2013

The genus Taraxacum, known by the common name Dandelion, is a medicinal herb in the family Asteraceae. It has been traditionally used as a folk medicine for the treatment or prevention of various diseases due to its anti-inflammatory and anti-oxidative properties. In this study, we attempted to evaluate protective effects of Dandelion related with anti-oxidative activity to Thioacetamide (TAA)-induced liver damage. 36 rats were randomly assigned to six experimental groups : Control, Dandelion water extract (DWE), TAA, TAA&DWE 300, TAA&DWE 600, TAA&DWE 1,200 groups. Rats in DWE and TAA&DWE groups were pretreated with DWE (300, 600 or 1,200 mg/kg BW) by gavage for 7 days. All rats were treated intraperitoneally with TAA (200 mg/kg BW) or normal saline at 12 hours after last oral administration and sacrificed at 12 hours after last treatment. Levels of WBC and Neutrophil count were significantly decresed in TAA&DWE 1,200 group compared with that in TAA group (P<0.05). In TAA&DWE 600 and TAA&DWE 1,200 groups, serum AST, ALT, GGT levels were lower than TAA group (P<0.05). The serum TG level was significantly elevated in TAA&DWE groups compared with those in TAA group. Liver tissues from TAA group showed extensive histopathological changes, characterized by moderate or severe hepatocytes degeneration, inflammatory cell infiltration, and congestion. In the TAA&DWE group, The severity of histopathological lesions were decreased compared to those in the TAA group. The MDA concentration was significantly decreased and GSH content was significantly increased in the TAA&DWE 1,200 group compared to those in the TAA group. GR, CAT and GST activities in the TAA&DWE 1,200 group were significantly increased compared to those in the TAA group.

• Archives of Pharmacal Research
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• 제22권4호
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• pp.354-360
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• 1999

Inflammatory bowel disease (IBD) is a multifactorial disorder with unknown etiology and pathogenesis. DA-6034,$ 7-carboxymethyloxy-3^{l}, 4^{l},$ 5-trimethoxy flavone, is a synthetic flavonoid known to possess anti-inflammatory activity. This study was performed to evaluate the oral therapeutic effect of DA-6034 in three experimental animal models of IBD : two chemical-induced IBD models of rats and the human leukocyte antigen (HLA)-B27 transgenic rat model known to develop spontaneous colitis without the use of exogenous agents. Acute chemical colitis was induced by intracolonic instillation of 1.2 ml of 4% acetic acid solution. Prednisolone (1 mg/kg), sulfasalazine (100 mg/kg) and DA-6034 (0.3~3 mg/kg) were orally administered twice daily for 6 days in these rats. In addition, chronic chemical colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid (TNBS) 30 mg in 50% ethanol and agents were orally administered for 6 or 20 days. In chemical-induced IBD models, all of these agents reduced the severity of colitis and specially, DA-6034 (3 mg/kg) showed more potent effect than other drugs in macroscopic lesion score. In HLA-B27 transgenic rats, DA-6034 (3 mg/kg) and prednisolone (0.5 gm/kg) were treated orally twice daily for 6 weeks. The HLA-B27 transgenic rats showed only mild colitis, compared with the chemical-induced colitis models. DA-6034 ameliorated the loose stool and decreased microscopic damage, which is the important indicator of this model. In conclusion, oral therapy of DA-6034 attenuated the macroscopic and histologic damages of the colon in all three experimental models of IBD, which suggest that DA-6034 could be a promising drug in the treatment of IBD.

• 한국컴퓨터정보학회논문지
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• 제12권1호
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• pp.161-168
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• 2007

웹에 대한 공격은 웹 서버 자체의 취약점 보다 웹 어플리케이션의 구조, 논리, 코딩상의 오류를 이용한다. OWASP에서 웹 어플리케이션 취약점을 10가지로 분류하여 발표한 자료에 의하면 웹 해킹의 위험성과 피해가 심각함을 잘 알 수 있다. 이에 따라 웹 해킹에 대한 탐지능력 및 대응이 절실히 요구된다. 이러한 웹 공격을 방어하기 위해 패턴 매칭을 이용한 필터링을 수행하거나 코드를 수정하는 방법이 있을 수 있지만 새로운 공격에 대해서는 탐지 및 방어가 어렵다. 또한 침입탐지시스템이나 웹 방화벽과 같은 단위보안 제품을 도입할 수 있지만 운영과 지속적인 유지를 위해서는 많은 비용과 노력이 요구되며 많은 탐지의 오류를 발생한다. 본 연구에서는 웹 어플리케이션의 구조와 파라미터 입력 값에 대한 타입, 길이와 같은 특성 값들을 추출하는 프로파일링 기법을 이용하여 사전에 웹 어플리케이션 구조 데이터베이스를 구축함으로서 사용자 입력 값 검증의 부재에 대한 해결과 비정상적인 요청에 대해 데이터베이스의 프로파일 식별자를 이용하여 검증하고 공격 탐지가 가능하다. 통합보안관리시스템은 현재 대부분 조직에서 도입하여 운영하고 있으며 일반화 되어있다. 그래서 통합보안관리시스템의 보안 감사 로그 수집 에이전트에 웹 어플리케이션 공격 탐지 기능을 추가한 모델을 제시함으로서 추가 단위보안제품을 도입하지 않고서도 웹 어플리케이션 공격을 탐지할 수 있도록 하였다.

• 동의생리병리학회지
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• 제20권6호
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• pp.1678-1727
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• 2006

This study was perfromed to develop the assessment guideline and endpoints for clinical trial with anticancer herbal medicine. The botanical products used to humans for long time may be applied to phase 3 clinical trial after submitting the evidences for safety and efficacy of them or completion of basic requirement of phase 1 and phase 2 for safety confirmation and dose determination. Syndrome improvement was chiefly evaluated by Zubrod and karnofsky(%) methods. We suggest the general clinical trial assessment with botanical products, by following assessment points, that is, tumor size for 50 points, survival fate for 10 points, major syndromes for 40 points. It is recommendable that the each symptom of Qi deficiency syndrome, blood deficiency syndrome and Qi stagnation syndrome was allocated by assessment points, Similarly, the each symptom was given the assessment points according to the severity of symptom, for example, slight for 3 points, moderate for 2 points and severe for 1 point in hepatocelluar carcinoma and lung cancer. Then, the efficacy of botanical products was evaluated by the difference between pre-treatment and post-treatment. Asking the neoplastic patients of questionnaire on physical, emotional, cognitive, social and role subjects availability, three more syndromes (Fatigue, Pain and Nausea/Vomit), quality of life(QOL) will be evaluated by GLM statistics. In addition, in case of lung cancer, 13 questions will be asked by the EORTC QLQ-C13 forms. As the assessment of endpoints for efficacy to reduce side effects induced by chemotherapy and radiotherapy, the data of image scanning and hemato-urinalysis can be usefully applied on immune response, weight loss, indigestion, hemopoietic damage and injury of liver and kidney, while the changes of syndromes of side effect can be evaluated by differentiation methods of Qi and blood and five viscera. However, it is still necessary to determine the ratio between scientific analytical method and Oriental differentiation method as well as confirm the Oriental assessment endpoints by clinical trial. In addition, we suggest the continuous development of assessment endpoints on other carcinomas except of hepatocelluar carcinoma and lung cancer in future.

• 한국산학기술학회논문지
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• 제17권10호
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• pp.403-411
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• 2016

최근 도시 지역에서 엄청난 집중 호우의 빈도가 높아지고 불투수면적의 비율이 증가하면서 침수 발생 횟수 및 침수로 인한 피해가 급증하고 있다. 대부분의 지방자치단체에서는 도시의 침수를 방어하기 위해 빗물펌프장 설치, 우수관거 개량, 빗물저류조 설치 등의 구조적인 대책을 마련하고 있으나 치수시설의 포화로 치수대책의 효과가 줄어들고 있다. 이를 보완하기 위해 다양한 홍수 예보 및 내배수시설 운영 등과 같은 비구조적인 대책이 마련되고 있다. 본 연구에서는 구조적인 대책의 한계점을 보완하기 위해 현행 빗물저류조 운영방법이 아닌 새롭게 제시된 빗물저류조 운영방법의 펌프정지수위를 결정하였다. 새롭게 제시된 빗물저류조 운영에서 펌프정지수위 결정을 위해 Huff 분포에 의해 생성한 총 48개의 강우를 생성하였다. 먼저 생성된 강우를 빈도, 분위 및 지속시간 별로 구분하였다. 생성된 강우를 적용하여 실시한 강우-유출 모의를 토대로 평균 탄력성을 산정하고 1.2 m에서 1.5 m의 범위를 결정하였다. 결정된 범위에서 하수도 시설 기준에 의한 안전율 1.25를 고려하여 최종적으로 1.2 m를 적정 펌프정지수위로 결정하였다.

• 환경생물
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• 제39권1호
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• pp.1-5
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• 2021

무는 중요한 채소작물 중 하나이며 강원도 고랭지에서는 시들음병 Fusarium oxysporum f. sp. raphani에 의해 지속적으로 경제적인 피해를 받아왔다. 최근에는 정선군의 고랭지에서 배추과 작물을 기주로 하는 클로버씨스트선충(Heterodera trifolii)이 발생하여 무 생산에도 위협을 가하고 있다. 이 선충은 무에 직접적인 피해뿐만 아니라 다른 병원균과 복합감염에 의한 2차 피해를 일으킬 수 있는 것으로 잘 알려져 있다. 따라서, 본 연구에서는 무시들음병균의 발병에 있어 클로버씨스트선충이 미치는 영향을 알아 보고자 하였다. 무시들음병균과 클로버씨스트선충을 복합감염시킨 처리구의 식물 초장은 무시들음병균을 단독감염시킨 처리구의 식물 초장보다 더 낮은 경향을 보였으나 통계적인 유의성은 없었다. 반면, 무시들음병균과 클로버씨스트선충을 복합감염시킨 처리구의 발병도(1.60±0.97)는 무시들음병균을 단독감염시킨 처리구(0.20±0.42)보다 더 높은 것으로 나타났다. 발병률도 무시들음병균과 클로버씨스트선충 복합처리구(80%)가 무시들음병균 단독처리구(44%)보다 2배 정도 높은 것으로 나타났다. 본 연구 결과에 따라 강원도 고랭지에서 무시들음병의 방제전략 수립 시에는 클로버씨스트선충의 방제도 함께 고려해야 할 것으로 생각된다.

• 한국물환경학회지
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• 제36권6호
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• pp.546-558
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• 2020

While industrialization has provided in abundance, the pollution it creates has caused untold damage to the environment, increasing the frequency and severity of natural disasters through changes in global climate patterns. The World Risk Forum's (WEF) World Risk Report presented the results of a survey of experts from around the world detailing the most influential risk factors over the next decade. Notably, the failure to respond to climate change ranked first and the global water crisis third. The extreme drought in the western Chungnam province was unexpected in 2016. At the time, the water level of Boryeong Dam was drastically decreased due to receiving less than half the average recorded rainfall in the region that year. The Boryeong Dam diversion pipeline has the capacity to solve the water shortage problem between these two regions by providing water from Geumgang to the western part of Chungnam, including Boryeong City. Current weather trends suggest drought is likely to continue in western Chungnam, which uses the Boryeong Dam as an intake source. This makes it necessary to operate Boryeong Dam diversion pipeline in an efficient and effective manner. SWAT is a watershed scale model developed to predict the impact of land management practices on water. The SWAT model was used in this study to evaluate the adequacy of the Boryeong Dam diversion pipeline operational plan by comparing it to present Boryeong Dam diversion pipeline operation. By investigating the number of days required to reach each reservoir stage, we determined that the number of days required to reach the boundary stage was less than that of the current operation. This determination accounts for the caveats that the Boryeong Dam waterway was not operated and only one pump will be operated from October to May of next year. As our results suggest, the most stable operation scenario is to operate two pumps at all times. This can be accomplished by operating two pumps from the caution stage to increase the number of pumps whenever the stage is raised. In addition to the stable operation of the Boryeong Dam pipeline, policy considerations are required with regard to imposing a water use charge on users of the Boryeong Dam region.

• 대한본초학회지
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• 제37권3호
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• pp.29-39
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• 2022

Objective : This study is aimed to evaluate the protective effects of Rehmanniae Radix, Mori Folium, and Liriopie Tuber mixture (RML) on lung injury of Particulate matter less than 10 um in diameter and diesel exhaust particles (PM10D) mice model. Methods : To investigate the anti-inflammatory activity of RML, PM10D was diluted in aluminum hydroxide (Alum) in 7-week-old male mice and induced by Intra-Nazal-Tracheal (INT) injection method. Animal experiments were divided into 5 groups. Nor (normal mice), CTL (PM10D-induced mice with the administration of distilled water), DEXA (PM10D-induced mice with the administration of 3 mg/kg Dexamethasone), RML 100 (PM10D-induced mice treated with RML 100 mg/kg weight), and RML 200 (PM10D-induced mice treated with RML 200 mg/kg body weight). After 11 days administration, mice were sacrificed and inflammation-related immune cells in broncho-alveolar lavage fluid (BALF) were analyzed. Inflammation-related biomarkers were also analyzed in blood and lungs. Lung tissue was observed through histological examination. Results : In the PM10D induced model, the PML showed decreases in CXCL-1 and IL-17A in BALF. Expression of inflammatory cytokines and cough-related mRNA genes was significantly decreased in serum and lung tissue. The mixture treatment of RML significantly improved the immune related cells in the serum. In addition, histological observations showed a tendency to decrease the severity of lung injury. Conclusions : Overall, these results confirmed the respiratory protective effect of the RML mixture in a model of lung injury induced by air pollution (PM10+DEP), suggesting that it is a potential treatment for respiratory damage.

• 인터넷정보학회논문지
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• 제22권6호
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• pp.51-57
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• 2021

기업의 세금을 절약 혹은 회피하는 행동은 과세관청에 의해 합법적 절세가 아닌 탈세로 판단될 경우 기업은 조세적 비용뿐 아니라 일련의 탈세관련 보도 기사로 인해 기업이미지 손상 및 주가하락과 같은 비조세적 비용까지 부담하게 된다. 이에 본 연구는 인터넷 뉴스 포털에 나타난 탈세 논란 키워드들의 출현빈도를 해당 사건의 심각성을 측정하는 요인으로 정하고 이러한 출현빈도가 기업가치에 미치는 영향을 분석한다. 우리나라 유가증권시장에서 시가총액기준 상위 업체들을 대상으로 탈세 논란 키워드들을 활용하여 인터넷 뉴스 포털로부터 관련 기사를 크롤링하고, 기업별로 탈세 논란 키워드들의 출현빈도에 대한 시계열을 생성하여 출현빈도가 장부가 대비 시가총액에 미치는 영향을 분석한다. 패널회귀분석과 충격반응분석을 통해 분석한 결과 출현빈도는 기업가치에 부정적인 영향을 미치며 12개월까지 점진적으로 효과가 감소되는 것으로 분석된다. 이 연구는 한국기업들을 대상으로 탈세 논란 사안이 기업가치에 영향을 미치는지를 실증적으로 분석한 연구로서, 경영자는 절세전략을 수립 시 이러한 영향력을 고려하는 것이 필요하다는 것을 시사한다.

• The Korean Journal of Physiology and Pharmacology
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• 제27권2호
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• pp.143-155
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• 2023

Percutaneous coronary intervention and acute coronary syndrome are both closely tied to the frequently occurring complication of coronary microembolization (CME). Resveratrol (RES) has been shown to have a substantial cardioprotective influence in a variety of cardiac diseases, though its function and potential mechanistic involvement in CME are still unclear. The forty Sprague-Dawley rats were divided into four groups randomly: CME, CME + RES (25 mg/kg), CME + RES (50 mg/kg), and sham (10 rats per group). The CME model was developed. Echocardiography, levels of myocardial injury markers in the serum, and histopathology of the myocardium were used to assess the function of the cardiac muscle. For the detection of the signaling of TLR4/MyD88/NF-κB along with the expression of pyroptosis-related molecules, ELISA, qRT-PCR, immunofluorescence, and Western blotting were used, among other techniques. The findings revealed that myocardial injury and pyroptosis occurred in the myocardium following CME, with a decreased function of cardiac, increased levels of serum myocardial injury markers, increased area of microinfarct, as well as a rise in the expression levels of pyroptosis-related molecules. In addition to this, pretreatment with resveratrol reduced the severity of myocardial injury after CME by improving cardiac dysfunction, decreasing serum myocardial injury markers, decreasing microinfarct area, and decreasing cardiomyocyte pyroptosis, primarily by blocking the signaling of TLR4/MyD88/NF-κB and also reducing the NLRP3 inflammasome activation. Resveratrol may be able to alleviate CME-induced myocardial pyroptosis and cardiac dysfunction by impeding the activation of NLRP3 inflammasome and the signaling pathway of TLR4/MyD88/NF-κB.