• Molecules and Cells
• /
• v.45 no.5
• /
• pp.306-316
• /
• 2022

Chronic stress contributes to the risk of developing depression; the habenula, a nucleus in epithalamus, is associated with many neuropsychiatric disorders. Using genome-wide gene expression analysis, we analyzed the transcriptome of the habenula in rats exposed to chronic restraint stress for 14 days. We identified 379 differentially expressed genes (DEGs) that were affected by chronic stress. These genes were enriched in neuroactive ligand-receptor interaction, the cAMP (cyclic adenosine monophosphate) signaling pathway, circadian entrainment, and synaptic signaling from the Kyoto Encyclopedia of Genes and Genomes pathway analysis and responded to corticosteroids, positive regulation of lipid transport, anterograde trans-synaptic signaling, and chemical synapse transmission from the Gene Ontology analysis. Based on protein-protein interaction network analysis of the DEGs, we identified neuroactive ligand-receptor interactions, circadian entrainment, and cholinergic synapse-related subclusters. Additionally, cell type and habenular regional expression of DEGs, evaluated using a recently published single-cell RNA sequencing study (GSE137478), strongly suggest that DEGs related to neuroactive ligand-receptor interaction and trans-synaptic signaling are highly enriched in medial habenular neurons. Taken together, our findings provide a valuable set of molecular targets that may play important roles in mediating the habenular response to stress and the onset of chronic stress-induced depressive behaviors.

• Applied Chemistry for Engineering
• /
• v.18 no.3
• /
• pp.205-212
• /
• 2007

In this work, polyacrylonitrile (PAN) fiber was prepared by electrospinning methods from dimethyl formamide solutions with various conditions, such as 8~20 kV applied voltage, 5~15 wt% PAN concentration, and 15 cm tip-to-collector distance (TCD). The nanofibers were stabilized by oxidation at $250^{\circ}C$ for 1 h, and then subsequently carbonized at $800{\sim}1000^{\circ}C$ for 1 h. The structured characteristics of the nanofibers before and after carbonization were studied by Fourier transform infrared spectroscopy. The resulting diameter distribution and morphologies of the nanofiber were evaluated by scanning electron microscope analysis. The electrochemical behaviors of the nanofiber were observed by cyclic voltammetry tests. From the results, the diameter of electrospinning nanofibers was predominantly influenced by the concentration of polymer solution and the applied voltage. The average diameter of the fibers was decreased with increasing the polymer concentration up to 10wt%. It was also found that the nanofibers with uniform diameter distribution and fine diameter could be achieved at 15kV input voltage and 15 cm TCD.

• Korean Chemical Engineering Research
• /
• v.55 no.5
• /
• pp.593-599
• /
• 2017

In order to enhance ultra battery performances, the electrochemical characteristics of nano Pb/AC anode composite was investigated. Through nano Pb adsorption onto activated carbon, nano Pb/AC was synthesized and it was washed under vacuum process. The prepared anode materials was analysed by SEM, BET and EDS. The specific surface area and average pore size of nano Pb/AC composite were $1740m^2/g$ and 1.95 nm, respectively. The negative electrode of ultra battery was prepared by nano Pb/AC dip coating on lead plate. The electrochemical performances of ultra battery were studied using $PbO_2$ (the positive electrode) and prepared nano Pb/AC composite (the negative electrode) pair. Also the electrochemical behaviors of ultra battery were investigated by charge/discharge, cyclic voltammetry, impedance and rate capability tests in 5 M $H_2SO_4$ electrolyte. The initial capacity and cycling performance of the present nano Pb/AC ultra battery were improved with respect to the lead battery and the AC-coated lead battery. These experimental results indicate that the proper addition of nano Pb/AC into the negative electrode can improve the discharge capacity and the long term cycle stability and remarkably suppress the hydrogen evolution reaction on the negative electrode.

• Journal of the Korea Concrete Institute
• /
• v.16 no.5 s.83
• /
• pp.581-589
• /
• 2004

This paper compares the fatigue behaviors of concretes subjected to flexural and split-tensional loadings, and proposes the fatigue reliability models based on experimental results and reliability analysis. The fatigue tests were performed for the specimens of $150 mm{\times}75 mm$ split tensional cylinders and $150 mm{\times}150 mm{\times}550 mm$ flexural beams under constant loadings at three levels (70, 80 and $90\%$) with 0.1 stress ratio, 20 Hz loading speed and sine wave. The reliability analysis on fatigue data was based on Weibull distribution of two-parameters. From fatigue test results, two criteria were proposed to reject the experimental fatigue data because of statistical variation of concrete fatigue data. Two parameters ($\alpha$and u) of Weibull distribution were obtained using graphical method, moment method and maximum likelihood method. The probability density function(P.D.F) and cumulative distribution function(C.D.F) of the Weibull distribution for fatigue life of pavement concrete were derived for various stress levels using parameters, $\alpha$ and u. The goodness-of-fit test by Kolmogorov-Smirnov test was acceptable at $5\%$ level of significance. Based on reliability analysis, a fatigue model for pavement concrete was proposed and compared from existing models.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.6 no.5
• /
• pp.53-58
• /
• 2002

A recent development, a concrete-filled steel(CFS) pier is an alternative to a reinforced concrete bridge pier in an urban area, because of its fast construction and excellent ductility against earthquakes. The capacity of CFS piers has not been used to a practical design, because there is no guide of a seismic design for CFS piers. Therefore, the guide of a seismic design value is derived from tests of CFS piers in order to apply it to a practical seismic design. Steel piers and concrete-filled steel piers are tested with constant axial load using quasi-static cyclic lateral load to check ductile capacity and using the real Kobe ground motion of pseudo-dynamic test to verify seismic performance. The results prove that CFS piers have more satisfactory ductility and strength than steel piers and relatively large hysteretic damping in dynamic behaviors. The seismic performance of steel and CFS piers is quantified on the basis of the test results. These results are evaluated through comparison of both the response modification factor method by elastic response spectrum and the performance-based design method by capacity spectrum and demand spectrum using effective viscous damping. The response modification factor of CFS piers is presented to apply in seismic design on a basis of this evaluation for a seismic performance.

• Korean Journal of Adult Nursing
• /
• v.12 no.4
• /
• pp.690-705
• /
• 2000

This ethnography was based on Kleinman's explanatory model of a health care system. It is conducted to make thick discription of illness conception of the elderly in a sociocultural context. The basic assumptions were as follows. 1) A health care system is a cultural system, and as with any other cultural system, it is a system of symbolic meanings anchored in a particular arrangement of social institutions and patterns of interpersonal relationships; 2) In all societies health care activities are more or less interrelated. Therefore, they need to be in a holistic manner as socially organized responses to disease that constitute a special cultural system; health care system; 3) Health and illness experiences are the natural process of disease. Individuals who recognized a for state of health, their family, neighbors, and communities define the state, search for causes of the health problems, and response to it. According by, they proceed to search for healing stratagies. So, understanding of the illness experience is the starting point for health care. The study participants were 12 elders aged 60 or more. The fieldwork was conducted in an agricultural clan village of Namwon city. The data collection and analysis were cyclic, from descriptive observation, domain analysis, focused observation, taxanomic analysis, selected observation, componential analysis, and finally cultural themes were all analysed. Proxemic and text analysis techniques were used according to the characteristics of the data. The data of sociocultural context and descriptive data were collected from 1990 to 1992. Informations on illness concepts were collected during 1994 using focused observation. Data confirming and contrast observations were conducted from 1997 and 1999. Illness concepts of the elderly were taxonomized supernatural cause, non-supernatural cause, immediate cause, and ultimate cause. The supernatural ones were ancestors, god of home, god of village, and ghost such as 'sal(evil force of dead man)' and 'gagqui(ghost of begger)'. The non-supernatural ones were Ki, natural phenomenones, natural objects, foods, human and human behaviors. Immediate ones were insufficiency and overflows, discretion and consolidation, disorder and out of order, cloudness and contamination, and fluctuation and stagnation of supernatural cause and non-supernatural ones. Ultimate causes were intrusion and loss of supernatural and nonsupernatural ones. The cultural themes of illness concepts of the elderly are: 1) illness concepts are not based on causality principle, but on reciprocal principle; 2) illness concepts are affected by social level and charicteristics of the patients; 3) the causes of disease are recognized as imposed both positive and negative effects on health based on interpretation of the indiviuals; 4) illness concepts reflects on principles of everyday life of the society members such as hierachial structure and group cohesiveness; 5) illness concepts are ruled on principle of reciprocity and spread; 6) illness concepts are interrelated with physical environment of the participants. It can be concluded that the illness concepts of the elderly in a traditional clan village are a component of health care system as a cultural system based on these results. The these results can be a useful basis for gerontological nursing practice and education.

• Korean Chemical Engineering Research
• /
• v.43 no.6
• /
• pp.756-760
• /
• 2005

In this study, the effect of $N_2$-plasma treatment on carbon blacks (CBs) was investigated by analyzing acid-base surface values and surface functional groups of CBs. The surface characteristics of the CBs were determined by fourier transformed-infrared (FT-IR) spectrometer, X-ray photoelectron spectroscopy (XPS), and Boehm's titration method. Electrochemical properties of the plasma-treated CBs-supported Pt (Pt/CBs) catalysts were analyzed by cyclic voltammetry (CV) experiments. From the results of FT-IR and acid-base values, $N_2$-plasma treatment at 300 W intensity on the CBs led to the formation of the free radical. The peak intensity was increased with increasing the treatment time due to the formation of new basic functional groups(such as C-N, C=N, $-NH_3{^+}$, -NH, and =NH) by the free radical. Accordingly, the basic values were increased by the basic functional groups. However, after a specific reaction time, $N_2$-plasma treatment could hardly influence change of surface functional groups of CBs, due to the disappearance of free radical. Consequently, it was found that optimal treatment time was 30 second for electro activity of Pt/CBs catalysts.

• Journal of the Korean Electrochemical Society
• /
• v.2 no.1
• /
• pp.31-37
• /
• 1999

Copper-containig enzyme, laccase (Rhus vernicifera) was immobilized onto gold electrode using self-assembly technique and its surface properties and catalytic activities were examined. Laccase is an oxidoreductase capable to oxidize diphenols or diamines by 4-electron reduction of molecular oxygen without superoxide or peroxide intermediates. The electrode surface were modified by $\beta-mercaptopropionate$ to have a net negative charge in neutral solution and positively charged laccase (pI=9) was immobilized by electrostatic interaction. The successful immobilization was confirmed by cyclic voltammograms which showed typical surface-confined shapes and behaviors. The amount of charge to reduce the surface was similar to the charge calculated assuming the surface being covered by monolayer. The activity of the immobilized enzyme was tested by the capbility of oxidizing a substrate, ABTS (2,2-azine-bis-(3-ethylbenzthioline-6-sulfonic acid) and it was maintained for $2\~3$ days at $4^{\circ}C$. The immobilzed laccase showed about $10\~15\%$ activity compared to that in solution. The laccase-modified electrode showed the activity of elefoocatalytic reduction of oxygen in the presence of mediator, $Fe(CN)_6^{3-}$ The addtion of azide which is an inhibitor of laccase compeletly eliminated the catalytic current.

• Polymer(Korea)
• /
• v.35 no.1
• /
• pp.35-39
• /
• 2011

In this work, mesoporous carbons (CMK-3) were prepared by a conventional templating method using mesoporous silica (SBA-15) for using catalyst supports in polymer electrolyte membrane fuel cells (PEMFCs). The CMK-3 were chemically activated to obtain high surface area and small pore diameter with different potassium hydroxide (KOH) amounts, i.e., 0, 1, 3, and 4 g as an activating agent. And then Pt-Ru was deposited onto activated CMK-3 (K-CMK-3) by a chemical reduction method. The characteristics of Pt-Ru catalysts deposited onto K-CMK-3 were determined by surface area and pore size analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and inductive coupled plasma-mass spectrometry (ICP-MS). The electrochemical properties of Pt-Ru/K-CMK-3 catalysts were also analyzed by cyclic voltammetry (CV). From the results, the K3g-CMK-3 carbon supports activated with 3 g KOH showed the highest specific surface areas. In addition, the K3g-CMK-3 led to uniform dispersion of Pt-Ru onto K-CMK-3, resulted in the enhancement of elelctro-catalystic activity of Pt-Ru catalysts.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.16 no.5
• /
• pp.1-11
• /
• 2012

In this paper, non-linear analysis was performed for Reinforced Concrete (RC) walls using different macroscopic models subjected to cyclic loading, and the analytical results were compared with previous experimental studies of RC walls. ASCE41-06 (American Society of Civil Engineers) specifies that the hysteresis behaviors of RC walls are different due to the aspect ratio of the walls. For a comparison between analytical and experimental results, a slender wall with an aspect ratio exceeding 3.0 and a squat wall with an aspect ratio of 1.0 were selected among previous research works. For the non-linear analysis, each test specimen was modeled using two different macroscopic methods: the first representing the flexural behavior of the RC wall, and the second considering the diagonal shear in the web of the wall. Through nonlinear analysis of the considered RC walls, the analytical difference of a slender wall was negligible due to the different macroscopic modeling methods. However, the squat wall was significantly affected by the considered components of the modeling method. For an accurate performance evaluation of the RC building with squat walls, it would be reasonable to use a macroscopic model considering diagonal shear.